Ooizumi, H, Umesono, K, DeLuca, H F, ...
The various biological activities of side-chain mobility restricted analogs, four diastereomers at C(20) and C(22) of 22-methyl-1alpha,25-dihydroxyvitamin D3, were evaluated. The relationship between...
The nuclear receptor superfamily: the second decade. (1996)
Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., ...
Cell, 83(1995) S.835-39
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.
Chen, J D, Umesono, K, Evans, R M
Transcriptional repression represents an important component in the regulation of cell differentiation and oncogenesis mediated by nuclear hormone receptors. Hormones act to relieve repression, thus...
Ogawa, H, Inouye, S, Tsuji, F I, Yasuda, K, Umesono, K
The localization, trafficking, and fluorescence of Aequorea green fluorescent protein (GFP) in cultured vertebrate cells transiently transfected with GFP cDNA were studied. Fluorescence of GFP in UV...
Kliewer, S A, Forman, B M, Blumberg, B, Ong, E S, Borgmeyer, U, Mangelsdorf, D J, ...
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and...
Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.
Damm, K, Heyman, R A, Umesono, K, Evans, R M
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by three distinct isoforms of retinoic acid receptors (RARs). These proteins,...
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Kliewer, S A, Umesono, K, Heyman, R A, Mangelsdorf, D J, Dyck, J A, Evans, R M
We have recently described the properties of direct repeats (DRs) of the half-site AGGTCA as hormone response elements (HREs). According to our results, spacing the half sites by 3, 4, or 5...
Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.
Ghazal, P, DeMattei, C, Giulietti, E, Kliewer, S A, Umesono, K, Evans, R M
Reactivation of latent virus is believed to result from a signal transduction event that induces immediate-early (IE) gene transcription. Evidence is presented that the major IE promoter (MIEP) of...
Osawa, S, Ohama, T, Yamao, F, Muto, A, Jukes, T H, Ozeki, H, ...
Bacterial species have diverged into a series of families, some with high G + C content in their DNA, and other with high A + T content, resulting, respectively, from G.C- and A.T-directional...
Umesono, K, Inokuchi, H, Ohyama, K, Ozeki, H
The nucleotide sequence of a region of Marchantia polymorpha chloroplast DNA was determined. On this DNA sequence (3.38kb), three open reading frames (ORFs) and three putative tRNA genes were...
A nicked group II intron and trans-splicing in liverwort, Marchantia polymorpha, chloroplasts.
Kohchi, T, Umesono, K, Ogura, Y, Komine, Y, Nakahigashi, K, Komano, T, ...
The chloroplast gene rps12 for ribosomal protein S12 in a liverwort, Marchantia polymorpha, is split into three exons by two introns, one of which (intron 1) is discontinuous. Exon 1 of rps12 for the...
Makino, Y, Okamoto, K, Yoshikawa, N, Aoshima, M, Hirota, K, Yodoi, J, ...
Adaptation to stress evokes a variety of biological responses, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and synthesis of a panel of stress-response proteins at cellular...
Okuno, A, Tamemoto, H, Tobe, K, Ueki, K, Mori, Y, Iwamoto, K, ...
Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma (PPARgamma), which is expressed primarily in adipose tissues. To elucidate...
Kitabayashi, I, Kawakami, Z, Chiu, R, Ozawa, K, Matsuoka, T, Toyoshima, S, ...
Differentiation of mouse F9 embryonal carcinoma (EC) cells can be induced by exposure to retinoic acid (RA) or by expression of adenovirus E1A. The transcription of the c-jun gene is stimulated by...
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.
Chen, J D, Umesono, K, Evans, R M
Transcriptional repression represents an important component in the regulation of cell differentiation and oncogenesis mediated by nuclear hormone receptors. Hormones act to relieve repression, thus...
Ogawa, H, Inouye, S, Tsuji, F I, Yasuda, K, Umesono, K
The localization, trafficking, and fluorescence of Aequorea green fluorescent protein (GFP) in cultured vertebrate cells transiently transfected with GFP cDNA were studied. Fluorescence of GFP in UV...
Kliewer, S A, Forman, B M, Blumberg, B, Ong, E S, Borgmeyer, U, Mangelsdorf, D J, ...
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and...
Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.
Damm, K, Heyman, R A, Umesono, K, Evans, R M
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by three distinct isoforms of retinoic acid receptors (RARs). These proteins,...
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Kliewer, S A, Umesono, K, Heyman, R A, Mangelsdorf, D J, Dyck, J A, Evans, R M
We have recently described the properties of direct repeats (DRs) of the half-site AGGTCA as hormone response elements (HREs). According to our results, spacing the half sites by 3, 4, or 5...
Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.
Ghazal, P, DeMattei, C, Giulietti, E, Kliewer, S A, Umesono, K, Evans, R M
Reactivation of latent virus is believed to result from a signal transduction event that induces immediate-early (IE) gene transcription. Evidence is presented that the major IE promoter (MIEP) of...
Osawa, S, Ohama, T, Yamao, F, Muto, A, Jukes, T H, Ozeki, H, ...
Bacterial species have diverged into a series of families, some with high G + C content in their DNA, and other with high A + T content, resulting, respectively, from G.C- and A.T-directional...
Umesono, K, Inokuchi, H, Ohyama, K, Ozeki, H
The nucleotide sequence of a region of Marchantia polymorpha chloroplast DNA was determined. On this DNA sequence (3.38kb), three open reading frames (ORFs) and three putative tRNA genes were...
A nicked group II intron and trans-splicing in liverwort, Marchantia polymorpha, chloroplasts.
Kohchi, T, Umesono, K, Ogura, Y, Komine, Y, Nakahigashi, K, Komano, T, ...
The chloroplast gene rps12 for ribosomal protein S12 in a liverwort, Marchantia polymorpha, is split into three exons by two introns, one of which (intron 1) is discontinuous. Exon 1 of rps12 for the...
Makino, Y, Okamoto, K, Yoshikawa, N, Aoshima, M, Hirota, K, Yodoi, J, ...
Adaptation to stress evokes a variety of biological responses, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and synthesis of a panel of stress-response proteins at cellular...
Okuno, A, Tamemoto, H, Tobe, K, Ueki, K, Mori, Y, Iwamoto, K, ...
Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma (PPARgamma), which is expressed primarily in adipose tissues. To elucidate...
Kitabayashi, I, Kawakami, Z, Chiu, R, Ozawa, K, Matsuoka, T, Toyoshima, S, ...
Differentiation of mouse F9 embryonal carcinoma (EC) cells can be induced by exposure to retinoic acid (RA) or by expression of adenovirus E1A. The transcription of the c-jun gene is stimulated by...