Efficacy of Ravuconazole in Treatment of Systemic Murine Histoplasmosis
Clemons, K. V., Martinez, M., Calderon, L., Stevens, D. A.
Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis. All regimens tested prolonged survival (P <...
Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis.
The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole. All regimens of D0870 (1 or 10 mg/kg of body weight given daily or 1, 10, or...
Activities of the triazole SCH 51048 against Coccidioides immitis in vitro and in vivo.
Clemons, K V, Homola, M E, Stevens, D A
The activity of the novel triazole SCH 51048 was tested against Coccidioides immitis. SCH 51048 inhibited C. immitis in vitro; MICs for 13 isolates ranged from < or = 0.39 to 0.78 micrograms/ml, and...
UR-9746 and UR-9751 are novel azole derivatives each containing a morpholine ring. They were examined for both in vitro and in vivo activities against Coccidioides immitis. In vitro, UR-9746 and...
Activity of the triazole SCH 56592 against disseminated murine coccidioidomycosis.
Lutz, J E, Clemons, K V, Aristizabal, B H, Stevens, D A
SCH 56592 (SCH) is a new triazole antifungal with a broad spectrum of activity. In vitro susceptibility testing against five strains of Coccidioides immitis revealed MICs from 0.39 to 3.13 microg/ml...
Efficacy of nikkomycin Z against experimental pulmonary blastomycosis.
Nikkomycin Z is a chitin synthetase inhibitor. In vitro, nikkomycin Z had good activity against Blastomyces dermatitidis, with an MIC of 0.78 microg/ml and a minimal fungicidal concentration of 3.1...
Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis.
Clemons, K V, Hanson, L H, Perlman, A M, Stevens, D A
The efficacies of SCH39304 (SCH) and fluconazole (FLU) were tested in a murine model of coccidioidomycosis. CD-1 mice were infected with Coccidioides immitis and dosed with SCH at 2, 10, 25, or 50...
Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice.
Byron, J K, Clemons, K V, McCusker, J H, Davis, R W, Stevens, D A
We have previously determined the relative virulence of isolates of Saccharomyces cerevisiae on the basis of differences in proliferation and resistance to clearance in CD-1 mice. These infections...
Activities of the triazole D0870 in vitro and against murine blastomycosis.
Clemons, K V, Hanson, L H, Stevens, D A
The novel triazole D0870 was tested for in vitro activity, as well as in vivo in a murine model of pulmonary blastomycosis. In vitro, D0870 had inhibitory and fungicidal activity against Blastomyces...
Hostetler, J S, Heykants, J, Clemons, K V, Woestenborghs, R, Hanson, L H, Stevens, D A
Pharmacologic studies of itraconazole (IZ), a triazole antifungal, indicated unexplained differences between bioassay and chromatographic determinations and large variations in steady-state blood...
Deresinski, S C, Clemons, K V, Kemper, C A, Roesch, K, Walton, B, Stevens, D A
A cluster of isolates of Candida parapsilosis recovered from clinical specimens was demonstrated, by both classical and molecular epidemiological techniques, to have resulted from contamination in...
Clemons, K V, Feroze, F, Holmberg, K, Stevens, D A
The objective of the present study was to conduct a comparative genotypic analysis of Candida albicans isolates from the United States, Europe, and Southeast Asia to determine whether differences...
Clemons, K V, Park, P, McCusker, J H, McCullough, M J, Davis, R W, Stevens, D A
We have previously described differences in phenotype and virulence among clinical and nonclinical isolates of Saccharomyces. To further characterize these isolates, a comparison of restriction...
Synergy between cilofungin and amphotericin B in a murine model of candidiasis.
Hanson, L H, Perlman, A M, Clemons, K V, Stevens, D A
The efficacies of cilofungin and amphotericin B separately and together in mice with disseminated candidiasis were studied. Male CD-1 mice (age, 5 weeks) were infected intravenously with 3 X 10(5)...
The efficacy of a novel sterol-complexed preparation of amphotericin B, amphotericin B colloidal dispersion, was compared with that of deoxycholate-complexed amphotericin B in an acute murine model...
Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001)....
Hostetler, J S, Clemons, K V, Hanson, L H, Stevens, D A
The efficacy and safety of amphotericin B colloidal dispersion (ABCD) were compared with those of amphotericin B deoxycholate suspension (ABDS) (Fungizone) in a murine model of disseminated...
Progesterone binding and inhibition of growth in Trichophyton mentagrophytes.
Schär, G, Stover, E P, Clemons, K V, Feldman, D, Stevens, D A
Specific binding of [3H]progesterone to cytosol of Trichophyton mentagrophytes was demonstrated. Scatchard analysis of [3H]progesterone binding showed a single class of binding sites with a...
Estradiol-binding proteins from mycelial and yeast-form cultures of Paracoccidioides brasiliensis.
Stover, E P, Schär, G, Clemons, K V, Stevens, D A, Feldman, D
Paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis, causes disease much more frequently in men than it does in women, suggesting that the hormonal milieu of the host might...
Systemic Coccidioides immitis infection in nude and beige mice.
Clemons, K V, Leathers, C R, Lee, K W
The course of experimental systemic Coccidioides immitis infection was assessed quantitatively and histologically in beige mice, congenitally athymic nude mice, and their respective normal...
Clemons, K V, Schär, G, Stover, E P, Feldman, D, Stevens, D A
We reported previously that Trichophyton mentagrophytes contains a cytoplasmic macromolecule which specifically binds progesterone. Progesterone is also an effective inhibitor of growth of the...
Epidemiologic study by DNA typing of a Candida albicans outbreak in heroin addicts.
Clemons, K V, Shankland, G S, Richardson, M D, Stevens, D A
The epidemiology of an outbreak of Candida endophthalmitis in heroin addicts was studied by DNA typing. Although one biotype was prevalent, the 13 isolates of Candida albicans from seven of the...
Increased indole detection for Pasteurella multocida.
A supplemented 2% peptone broth is described for the detection of indole production by Pasteurella multocida. The 96 isolates of P. multocida that were utilized in this evaluation were indole...
Clemons, K V, Brummer, E, Stevens, D A
Cell-mediated immune responses appear to be critical in the outcome of cryptococcosis. Interleukin-12 (IL-12) was studied for its potential use as a therapeutic agent because of its stimulation of...
McCusker, J H, Clemons, K V, Stevens, D A, Davis, R W
Saccharomyces cerevisiae isolates have been shown previously to exhibit a high degree of variation in their ability to proliferate and persist in CD-1 mice (K.V. Clemons, J.H. McCusker, R. W. Davis,...
Genetic Characterization of Pathogenic Saccharomyces Cerevisiae Isolates
McCusker, J. H., Clemons, K. V., Stevens, D. A., Davis, R. W.
Saccharomyces cerevisiae isolates from human patients have been genetically analyzed. Some of the characteristics of these isolates are very different from laboratory and industrial strains of S....
Efficacy of Ravuconazole in Treatment of Systemic Murine Histoplasmosis
Clemons, K. V., Martinez, M., Calderon, L., Stevens, D. A.
Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis. All regimens tested prolonged survival (P <...
Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis.
The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole. All regimens of D0870 (1 or 10 mg/kg of body weight given daily or 1, 10, or...
Activities of the triazole SCH 51048 against Coccidioides immitis in vitro and in vivo.
Clemons, K V, Homola, M E, Stevens, D A
The activity of the novel triazole SCH 51048 was tested against Coccidioides immitis. SCH 51048 inhibited C. immitis in vitro; MICs for 13 isolates ranged from < or = 0.39 to 0.78 micrograms/ml, and...
UR-9746 and UR-9751 are novel azole derivatives each containing a morpholine ring. They were examined for both in vitro and in vivo activities against Coccidioides immitis. In vitro, UR-9746 and...
Activity of the triazole SCH 56592 against disseminated murine coccidioidomycosis.
Lutz, J E, Clemons, K V, Aristizabal, B H, Stevens, D A
SCH 56592 (SCH) is a new triazole antifungal with a broad spectrum of activity. In vitro susceptibility testing against five strains of Coccidioides immitis revealed MICs from 0.39 to 3.13 microg/ml...
Efficacy of nikkomycin Z against experimental pulmonary blastomycosis.
Nikkomycin Z is a chitin synthetase inhibitor. In vitro, nikkomycin Z had good activity against Blastomyces dermatitidis, with an MIC of 0.78 microg/ml and a minimal fungicidal concentration of 3.1...
Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis.
Clemons, K V, Hanson, L H, Perlman, A M, Stevens, D A
The efficacies of SCH39304 (SCH) and fluconazole (FLU) were tested in a murine model of coccidioidomycosis. CD-1 mice were infected with Coccidioides immitis and dosed with SCH at 2, 10, 25, or 50...
Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice.
Byron, J K, Clemons, K V, McCusker, J H, Davis, R W, Stevens, D A
We have previously determined the relative virulence of isolates of Saccharomyces cerevisiae on the basis of differences in proliferation and resistance to clearance in CD-1 mice. These infections...
Activities of the triazole D0870 in vitro and against murine blastomycosis.
Clemons, K V, Hanson, L H, Stevens, D A
The novel triazole D0870 was tested for in vitro activity, as well as in vivo in a murine model of pulmonary blastomycosis. In vitro, D0870 had inhibitory and fungicidal activity against Blastomyces...
Hostetler, J S, Heykants, J, Clemons, K V, Woestenborghs, R, Hanson, L H, Stevens, D A
Pharmacologic studies of itraconazole (IZ), a triazole antifungal, indicated unexplained differences between bioassay and chromatographic determinations and large variations in steady-state blood...
Deresinski, S C, Clemons, K V, Kemper, C A, Roesch, K, Walton, B, Stevens, D A
A cluster of isolates of Candida parapsilosis recovered from clinical specimens was demonstrated, by both classical and molecular epidemiological techniques, to have resulted from contamination in...
Clemons, K V, Feroze, F, Holmberg, K, Stevens, D A
The objective of the present study was to conduct a comparative genotypic analysis of Candida albicans isolates from the United States, Europe, and Southeast Asia to determine whether differences...
Clemons, K V, Park, P, McCusker, J H, McCullough, M J, Davis, R W, Stevens, D A
We have previously described differences in phenotype and virulence among clinical and nonclinical isolates of Saccharomyces. To further characterize these isolates, a comparison of restriction...
Synergy between cilofungin and amphotericin B in a murine model of candidiasis.
Hanson, L H, Perlman, A M, Clemons, K V, Stevens, D A
The efficacies of cilofungin and amphotericin B separately and together in mice with disseminated candidiasis were studied. Male CD-1 mice (age, 5 weeks) were infected intravenously with 3 X 10(5)...
The efficacy of a novel sterol-complexed preparation of amphotericin B, amphotericin B colloidal dispersion, was compared with that of deoxycholate-complexed amphotericin B in an acute murine model...
Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001)....
Hostetler, J S, Clemons, K V, Hanson, L H, Stevens, D A
The efficacy and safety of amphotericin B colloidal dispersion (ABCD) were compared with those of amphotericin B deoxycholate suspension (ABDS) (Fungizone) in a murine model of disseminated...
Progesterone binding and inhibition of growth in Trichophyton mentagrophytes.
Schär, G, Stover, E P, Clemons, K V, Feldman, D, Stevens, D A
Specific binding of [3H]progesterone to cytosol of Trichophyton mentagrophytes was demonstrated. Scatchard analysis of [3H]progesterone binding showed a single class of binding sites with a...
Estradiol-binding proteins from mycelial and yeast-form cultures of Paracoccidioides brasiliensis.
Stover, E P, Schär, G, Clemons, K V, Stevens, D A, Feldman, D
Paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis, causes disease much more frequently in men than it does in women, suggesting that the hormonal milieu of the host might...
Systemic Coccidioides immitis infection in nude and beige mice.
Clemons, K V, Leathers, C R, Lee, K W
The course of experimental systemic Coccidioides immitis infection was assessed quantitatively and histologically in beige mice, congenitally athymic nude mice, and their respective normal...
Clemons, K V, Schär, G, Stover, E P, Feldman, D, Stevens, D A
We reported previously that Trichophyton mentagrophytes contains a cytoplasmic macromolecule which specifically binds progesterone. Progesterone is also an effective inhibitor of growth of the...
Epidemiologic study by DNA typing of a Candida albicans outbreak in heroin addicts.
Clemons, K V, Shankland, G S, Richardson, M D, Stevens, D A
The epidemiology of an outbreak of Candida endophthalmitis in heroin addicts was studied by DNA typing. Although one biotype was prevalent, the 13 isolates of Candida albicans from seven of the...
Increased indole detection for Pasteurella multocida.
A supplemented 2% peptone broth is described for the detection of indole production by Pasteurella multocida. The 96 isolates of P. multocida that were utilized in this evaluation were indole...
Clemons, K V, Brummer, E, Stevens, D A
Cell-mediated immune responses appear to be critical in the outcome of cryptococcosis. Interleukin-12 (IL-12) was studied for its potential use as a therapeutic agent because of its stimulation of...
McCusker, J H, Clemons, K V, Stevens, D A, Davis, R W
Saccharomyces cerevisiae isolates have been shown previously to exhibit a high degree of variation in their ability to proliferate and persist in CD-1 mice (K.V. Clemons, J.H. McCusker, R. W. Davis,...
Genetic Characterization of Pathogenic Saccharomyces Cerevisiae Isolates
McCusker, J. H., Clemons, K. V., Stevens, D. A., Davis, R. W.
Saccharomyces cerevisiae isolates from human patients have been genetically analyzed. Some of the characteristics of these isolates are very different from laboratory and industrial strains of S....
Zucker, K E, Kamberi, P, Sobel, R A, Cloud, G, Meli, D N, Clemons, K V, ...
Strokes due to transmural vasculitis associated with coccidioidal meningitis result in significant morbidity and mortality. The immunological and inflammatory processes responsible are poorly...
Clemons, K V, Grunig, G, Sobel, R A, Mirels, L F, Rennick, D M, Stevens, D A
IL-10 is associated with a Th2 response, down-regulation of a Th1 response and macrophage activation. We assessed the role of IL-10 during systemic infection with Aspergillus fumigatus. Systemic...