de Novo Structure Prediction (2008)
K. V. Holmes, In Fields Virology, P. M. Howley, X. Xiao, S. Chakraborti, ...
(2001). 13. W. Li et al., Nature 426, 450 (2003). 14. H. Hofmann et al., Proc. Natl. Acad. Sci. U.S.A. 102, 7988 (2005).
Bats: Important reservoir hosts of emerging viruses (2006)
Calisher, C.H., Childs, J.E., Field, H.E., Holmes, K.V., Schountz, T.
Bats (order Chiroptera, suborders Megachiroptera and Microchiroptera) are abundant, diverse, and geographically widespread. These mammals provide us with resources, but their importance is minimized...
Bats: Important reservoir hosts of emerging viruses (2006)
Calisher, C.H., Childs, J.E., Field, H.E., Holmes, K.V., Schountz, T.
Bats (order Chiroptera, suborders Megachiroptera and Microchiroptera) are abundant, diverse, and geographically widespread. These mammals provide us with resources, but their importance is minimized...
Bats: Important reservoir hosts of emerging viruses (2006)
Calisher, C.H., Childs, J.E., Field, H.E., Holmes, K.V., Schountz, T.
Bats (order Chiroptera, suborders Megachiroptera and Microchiroptera) are abundant, diverse, and geographically widespread. These mammals provide us with resources, but their importance is minimized...
Dveksler, G S, Pensiero, M N, Dieffenbach, C W, Cardellichio, C B, Basile, A A, Elia, P E, ...
Mouse hepatitis virus (MHV) strain A59 uses as cellular receptors members of the carcinoembryonic antigen family in the immunoglobulin superfamily. Recombinant receptor proteins with deletions of...
Williams, R K, Jiang, G S, Holmes, K V
The receptor for mouse hepatitis virus (MHV), a murine coronavirus, is a 110- to 120-kDa glycoprotein on intestinal brush border membranes and hepatocyte membranes. The N-terminal 25-amino acid...
Dveksler, G S, Basile, A A, Cardellichio, C B, Holmes, K V
Mouse hepatitis virus binds to the N-terminal domain of its receptor, MHVR, a murine biliary glycoprotein with four immunoglobulin-like domains (G.S. Dveksler, M. N. Pensiero, C. W. Dieffenbach, C....
Gagneten, S, Gout, O, Dubois-Dalcq, M, Rottier, P, Rossen, J, Holmes, K V
In addition to the spike (S) glycoprotein that binds to carcinoembryonic antigen-related receptors on the host cell membrane, some strains of mouse coronavirus (mouse hepatitis virus [MHV]) express a...
Sawicki, S G, Lu, J H, Holmes, K V
The A59 strain of murine coronavirus mouse hepatitis virus (MHV) can cause persistent infection of 17C1-1 cells and other murine cell lines. Persistently infected cultures released large amounts of...
Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice.
Godfraind, C, Holmes, K V, Coutelier, J P
Mouse hepatitis virus A59 (MHV-A59) infection of adult BALB/c mice induced a severe, transient atrophy of the thymus. The effect was maximal at 1 week after infection, and thymuses returned to normal...
Dveksler, G S, Gagneten, S E, Scanga, C A, Cardellichio, C B, Holmes, K V
Mouse hepatitis virus (MHV) receptor, the receptor for the murine coronavirus MHV, was expressed in MHV-resistant hamster and human cells as a series of mutant, recombinant glycoproteins with...
Tresnan, D B, Levis, R, Holmes, K V
Two members of coronavirus serogroup I, human respiratory coronavirus HCV-229E and porcine transmissible gastroenteritis virus (TGEV), use aminopeptidase N (APN) as their cellular receptors. These...
Elaboration of cellulose fibrils by Agrobacterium tumefaciens during attachment to carrot cells.
Matthysse, A G, Holmes, K V, Gurlitz, R H
The attachment of virulent strains of Agrobacterium tumefaciens to plant cells is the first step in the bacterial induction of tumors. Binding of A. tumefaciens to carrot tissue culture cells...
Schickli, J H, Zelus, B D, Wentworth, D E, Sawicki, S G, Holmes, K V
In murine 17 Cl 1 cells persistently infected with murine coronavirus mouse hepatitis virus strain A59 (MHV-A59), expression of the virus receptor glycoprotein MHVR was markedly reduced (S. G....
Nédellec, P, Dveksler, G S, Daniels, E, Turbide, C, Chow, B, Basile, A A, ...
Murine coronaviruses such as mouse hepatitis virus (MHV) infect mouse cells via cellular receptors that are isoforms of biliary glycoprotein (Bgp) of the carcinoembryonic antigen gene family (G. S....
Dveksler, G S, Dieffenbach, C W, Cardellichio, C B, McCuaig, K, Pensiero, M N, Jiang, G S, ...
Mouse hepatitis virus-A59 (MHV-A59), a murine coronavirus, can utilize as a cellular receptor MHVR, a murine glycoprotein in the biliary glycoprotein (BGP) subfamily of the carcinoembryonic antigen...
Compton, S R, Stephensen, C B, Snyder, S W, Weismiller, D G, Holmes, K V
Like most coronaviruses, the coronavirus mouse hepatitis virus (MHV) exhibits strong species specificity, causing natural infection only in mice. MHV-A59 virions use as a receptor a 110- to 120-kDa...
Pensiero, M N, Dveksler, G S, Cardellichio, C B, Jiang, G S, Elia, P E, Dieffenbach, C W, ...
Recently, we showed that a murine member of the carcinoembryonic antigen family of glycoproteins serves as a cellular receptor (MHVR) for the coronavirus mouse hepatitis virus A59 (MHV-A59) (G. S....
Stephensen, C B, Montali, R J, Ramsay, E C, Holmes, K V
Callitrichid hepatitis (CH) is an acute, frequently fatal viral hepatitis which affects members of the primate family Callitrichidae (R. J. Montali, E. C. Ramsay, C. B. Stephensen, M. Worley, J. A....
Stephensen, C B, Jacob, J R, Montali, R J, Holmes, K V, Muchmore, E, Compans, R W, ...
Callitrichid hepatitis (CH) is an acute, often fatal viral infection of New World primates from the family Callitrichidae. The etiologic agent of CH is unknown. We report here the isolation of an...
Sturman, L S, Ricard, C S, Holmes, K V
We have obtained biochemical and electron microscopic evidence of conformational changes at pH 8.0 and 37 degrees C in the coronavirus spike glycoprotein E2 (S). The importance of these changes is...
Weismiller, D G, Sturman, L S, Buchmeier, M J, Fleming, J O, Holmes, K V
Monoclonal antibodies (MAbs) directed against the E2 glycoprotein of mouse hepatitis virus (MHV) have been classified according to their ability to bind to either of the two purified...
Williams, R K, Jiang, G S, Snyder, S W, Frana, M F, Holmes, K V
The receptor for mouse hepatitis virus strain A59 (MHV-A59) is a 110- to 120-kilodalton (kDa) glycoprotein which is expressed in MHV-susceptible mouse strains on the membranes of hepatocytes,...
Dveksler, G S, Pensiero, M N, Cardellichio, C B, Williams, R K, Jiang, G S, Holmes, K V, ...
The cellular receptor for murine coronavirus mouse hepatitis virus (MHV)-A59 is a member of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin superfamily. We isolated a...
Sturman, L S, Ricard, C S, Holmes, K V
In the murine coronavirus mouse hepatitis virus, a single glycoprotein, E2, is required both for attachment to cells and for cell fusion. Cell fusion induced by infection with mouse hepatitis virus...
Frana, M F, Behnke, J N, Sturman, L S, Holmes, K V
Cell fusion induced by infection with mouse hepatitis virus strain A59 (MHV-A59) varied markedly in extent and time course in four different murine cell lines. When inoculated at a multiplicity of 3...
RNA-binding proteins of bovine rotavirus.
Two major bovine rotavirus proteins have RNA-binding activity as shown by an RNA overlay-protein blot assay. Of the six proteins in purified virions, only one showed RNA-binding activity. This...
In vitro replication of mouse hepatitis virus strain A59.
Compton, S R, Rogers, D B, Holmes, K V, Fertsch, D, Remenick, J, McGowan, J J
An in vitro replication system for mouse hepatitis virus (MHV) strain A59 was developed using lysolecithin to produce cell extracts. In extracts of MHV-infected cells, radiolabeled UMP was...
Boyle, J F, Weismiller, D G, Holmes, K V
The molecular mechanism of genetic resistance of inbred mouse strains to mouse hepatitis virus, a murine coronavirus, was studied by comparing virus binding to plasma membranes of intestinal...
Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid.
Sturman, L S, Holmes, K V, Behnke, J
The two envelope glycoproteins and the viral nucleocapsid of the coronavirus A59 were isolated by solubilization of the viral membrane with Nonidet P-40 at 4 degrees C followed by sucrose density...
L2 cells infected with vesicular stomatitis virus under single-cycle conditions have been studied by scanning electron microscopy after preparation by the critical point drying technique. Three...
Comparative ultrastructural study of four reticuloendothelias viruses.
Kang, C Y, Wong, T C, Holmes, K V
The morphology and development of four members of the reticuloendotheliosis virus group were studied by transmission electron microscopy. Virions of duck spleen necrosis virus, duck infectious anemia...
Proia, R L, Hart, D A, Holmes, R K, Holmes, K V, Eidels, L
125I-Labeled membrane glycoproteins that specifically interact with diphtheria toxin and CRM197 protein--but not with diphtheria toxoid, fragment A of diphtheria toxin, or cholera toxin--were...
Plasmid-dependent attachment of Agrobacterium tumefaciens to plant tissue culture cells.
Matthysse, A G, Wyman, P M, Holmes, K V
Kinetic, microscopic, and biochemical studies show that virulent Ti (tumor inducing)-plasmid-containing strains of Agrobacterium attach to normal tobacco and carrot tissue culture cells. Kinetic...
Dveksler, G S, Pensiero, M N, Dieffenbach, C W, Cardellichio, C B, Basile, A A, Elia, P E, ...
Mouse hepatitis virus (MHV) strain A59 uses as cellular receptors members of the carcinoembryonic antigen family in the immunoglobulin superfamily. Recombinant receptor proteins with deletions of...
Williams, R K, Jiang, G S, Holmes, K V
The receptor for mouse hepatitis virus (MHV), a murine coronavirus, is a 110- to 120-kDa glycoprotein on intestinal brush border membranes and hepatocyte membranes. The N-terminal 25-amino acid...
Dveksler, G S, Basile, A A, Cardellichio, C B, Holmes, K V
Mouse hepatitis virus binds to the N-terminal domain of its receptor, MHVR, a murine biliary glycoprotein with four immunoglobulin-like domains (G.S. Dveksler, M. N. Pensiero, C. W. Dieffenbach, C....
Gagneten, S, Gout, O, Dubois-Dalcq, M, Rottier, P, Rossen, J, Holmes, K V
In addition to the spike (S) glycoprotein that binds to carcinoembryonic antigen-related receptors on the host cell membrane, some strains of mouse coronavirus (mouse hepatitis virus [MHV]) express a...
Sawicki, S G, Lu, J H, Holmes, K V
The A59 strain of murine coronavirus mouse hepatitis virus (MHV) can cause persistent infection of 17C1-1 cells and other murine cell lines. Persistently infected cultures released large amounts of...
Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice.
Godfraind, C, Holmes, K V, Coutelier, J P
Mouse hepatitis virus A59 (MHV-A59) infection of adult BALB/c mice induced a severe, transient atrophy of the thymus. The effect was maximal at 1 week after infection, and thymuses returned to normal...
Dveksler, G S, Gagneten, S E, Scanga, C A, Cardellichio, C B, Holmes, K V
Mouse hepatitis virus (MHV) receptor, the receptor for the murine coronavirus MHV, was expressed in MHV-resistant hamster and human cells as a series of mutant, recombinant glycoproteins with...
Tresnan, D B, Levis, R, Holmes, K V
Two members of coronavirus serogroup I, human respiratory coronavirus HCV-229E and porcine transmissible gastroenteritis virus (TGEV), use aminopeptidase N (APN) as their cellular receptors. These...
Elaboration of cellulose fibrils by Agrobacterium tumefaciens during attachment to carrot cells.
Matthysse, A G, Holmes, K V, Gurlitz, R H
The attachment of virulent strains of Agrobacterium tumefaciens to plant cells is the first step in the bacterial induction of tumors. Binding of A. tumefaciens to carrot tissue culture cells...
Schickli, J H, Zelus, B D, Wentworth, D E, Sawicki, S G, Holmes, K V
In murine 17 Cl 1 cells persistently infected with murine coronavirus mouse hepatitis virus strain A59 (MHV-A59), expression of the virus receptor glycoprotein MHVR was markedly reduced (S. G....
Nédellec, P, Dveksler, G S, Daniels, E, Turbide, C, Chow, B, Basile, A A, ...
Murine coronaviruses such as mouse hepatitis virus (MHV) infect mouse cells via cellular receptors that are isoforms of biliary glycoprotein (Bgp) of the carcinoembryonic antigen gene family (G. S....
Dveksler, G S, Dieffenbach, C W, Cardellichio, C B, McCuaig, K, Pensiero, M N, Jiang, G S, ...
Mouse hepatitis virus-A59 (MHV-A59), a murine coronavirus, can utilize as a cellular receptor MHVR, a murine glycoprotein in the biliary glycoprotein (BGP) subfamily of the carcinoembryonic antigen...
Compton, S R, Stephensen, C B, Snyder, S W, Weismiller, D G, Holmes, K V
Like most coronaviruses, the coronavirus mouse hepatitis virus (MHV) exhibits strong species specificity, causing natural infection only in mice. MHV-A59 virions use as a receptor a 110- to 120-kDa...
Pensiero, M N, Dveksler, G S, Cardellichio, C B, Jiang, G S, Elia, P E, Dieffenbach, C W, ...
Recently, we showed that a murine member of the carcinoembryonic antigen family of glycoproteins serves as a cellular receptor (MHVR) for the coronavirus mouse hepatitis virus A59 (MHV-A59) (G. S....
Stephensen, C B, Montali, R J, Ramsay, E C, Holmes, K V
Callitrichid hepatitis (CH) is an acute, frequently fatal viral hepatitis which affects members of the primate family Callitrichidae (R. J. Montali, E. C. Ramsay, C. B. Stephensen, M. Worley, J. A....
Stephensen, C B, Jacob, J R, Montali, R J, Holmes, K V, Muchmore, E, Compans, R W, ...
Callitrichid hepatitis (CH) is an acute, often fatal viral infection of New World primates from the family Callitrichidae. The etiologic agent of CH is unknown. We report here the isolation of an...
Sturman, L S, Ricard, C S, Holmes, K V
We have obtained biochemical and electron microscopic evidence of conformational changes at pH 8.0 and 37 degrees C in the coronavirus spike glycoprotein E2 (S). The importance of these changes is...
Weismiller, D G, Sturman, L S, Buchmeier, M J, Fleming, J O, Holmes, K V
Monoclonal antibodies (MAbs) directed against the E2 glycoprotein of mouse hepatitis virus (MHV) have been classified according to their ability to bind to either of the two purified...
Williams, R K, Jiang, G S, Snyder, S W, Frana, M F, Holmes, K V
The receptor for mouse hepatitis virus strain A59 (MHV-A59) is a 110- to 120-kilodalton (kDa) glycoprotein which is expressed in MHV-susceptible mouse strains on the membranes of hepatocytes,...
Dveksler, G S, Pensiero, M N, Cardellichio, C B, Williams, R K, Jiang, G S, Holmes, K V, ...
The cellular receptor for murine coronavirus mouse hepatitis virus (MHV)-A59 is a member of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin superfamily. We isolated a...
Sturman, L S, Ricard, C S, Holmes, K V
In the murine coronavirus mouse hepatitis virus, a single glycoprotein, E2, is required both for attachment to cells and for cell fusion. Cell fusion induced by infection with mouse hepatitis virus...
Frana, M F, Behnke, J N, Sturman, L S, Holmes, K V
Cell fusion induced by infection with mouse hepatitis virus strain A59 (MHV-A59) varied markedly in extent and time course in four different murine cell lines. When inoculated at a multiplicity of 3...
RNA-binding proteins of bovine rotavirus.
Two major bovine rotavirus proteins have RNA-binding activity as shown by an RNA overlay-protein blot assay. Of the six proteins in purified virions, only one showed RNA-binding activity. This...
In vitro replication of mouse hepatitis virus strain A59.
Compton, S R, Rogers, D B, Holmes, K V, Fertsch, D, Remenick, J, McGowan, J J
An in vitro replication system for mouse hepatitis virus (MHV) strain A59 was developed using lysolecithin to produce cell extracts. In extracts of MHV-infected cells, radiolabeled UMP was...
Boyle, J F, Weismiller, D G, Holmes, K V
The molecular mechanism of genetic resistance of inbred mouse strains to mouse hepatitis virus, a murine coronavirus, was studied by comparing virus binding to plasma membranes of intestinal...
Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid.
Sturman, L S, Holmes, K V, Behnke, J
The two envelope glycoproteins and the viral nucleocapsid of the coronavirus A59 were isolated by solubilization of the viral membrane with Nonidet P-40 at 4 degrees C followed by sucrose density...
L2 cells infected with vesicular stomatitis virus under single-cycle conditions have been studied by scanning electron microscopy after preparation by the critical point drying technique. Three...
Comparative ultrastructural study of four reticuloendothelias viruses.
Kang, C Y, Wong, T C, Holmes, K V
The morphology and development of four members of the reticuloendotheliosis virus group were studied by transmission electron microscopy. Virions of duck spleen necrosis virus, duck infectious anemia...
Proia, R L, Hart, D A, Holmes, R K, Holmes, K V, Eidels, L
125I-Labeled membrane glycoproteins that specifically interact with diphtheria toxin and CRM197 protein--but not with diphtheria toxoid, fragment A of diphtheria toxin, or cholera toxin--were...
Plasmid-dependent attachment of Agrobacterium tumefaciens to plant tissue culture cells.
Matthysse, A G, Wyman, P M, Holmes, K V
Kinetic, microscopic, and biochemical studies show that virulent Ti (tumor inducing)-plasmid-containing strains of Agrobacterium attach to normal tobacco and carrot tissue culture cells. Kinetic...
Montali, R. J., Connolly, B. M., Armstrong, D. L., Scanga, C. A., Holmes, K. V.
Callitrichid hepatitis is an arenavirus infection that recently emerged as a highly fatal disease of New World primates in the Callitrichidae family. As we previously reported, these primates develop...