K. Weber

Publication List Details

Period

1971 - 2009

Number

613

Co-Authors

Die Rissendknolle und ihre mechanische Bedeutung. (2009)

Weber, K., Mattheck, C., Bethge, K.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

Der untere Schubdurchriss: ein Qualitätssprung! (2009)

Mattheck, C., Tesari, I., Bethge, K., Weber, K.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

Astgeschichten: Vom grünen zum devitalisierten und zum toten Ast. (2009)

Mattheck, C., Bethge, K., Weber, K.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

Astbruch-Risiko: Bei welchem Schlankheitsgrad L/D brechen grüne Äste am häufigsten? (2009)

Weber, K., Bethge, K., Mattheck, C.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

Zur Charakterisierung und Bewertung von Totästen in der Baumkrone. (2009)

Weber, K., Bethge, K., Sörensen, J., Mattheck, C.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

Angriff der Schlauchpilze. Ascomyceten auf dem Vormarsch? (2009)

Weber, K., Mattheck, C.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

VTA-Totholzsymptome (a+b) (2009)

Weber, K., Bethge, K., Mattheck, C.

15.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 12.-13.Mai 2009

Fabric Development, Electrical Conductivity and Graphite Formation in graphite-bearing Marbles from the Central Damara (2008)

Belt Namibia, Jens Martin Walter, Referent Prof, K. Weber, Korreferent Dr. B. Leiss

Graphite-bearing marbles occur in crustal-scale dome structures of the central parts of the Damara Belt in north-western Namibia. They have been reported to show significant anomalies of high...

Organising accountabilities for data quality management - a data governance case study (2008)

Weber, K., Cheong, Lai, Otto, B., Chang, Vanessa

Enterprises need corporate data quality management (DQM) that combines business-driven and technical perspectives to respond to strategic and operational challenges that demand high-quality corporate...

Zur mechanischen Wirkung der Holzstrahlen im Druckzwiesel. (2008)

Weber, K., Mattheck, C.

14.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 22.-23.April 2008

Die Reaktion der Wurzelplatte auf Staunässe. (2008)

Mattheck, C., Bethge, K., Weber, K.

14.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 22.-23.April 2008

Zur Biologie von Bäumen in Staunässe. (2008)

Weber, K.

14.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 22.-23.April 2008

Selbstsabotage beim Bruch von Nadelbaumästen. (2008)

Weber, K., Mattheck, C.

14.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 22.-23.April 2008

Strategische Gemeinsamkeit von Erregern der 'Massaria-Krankheit' und wurzelbürtiger Fäulen. (2008)

Weber, K., Mattheck, C.

14.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 22.-23.April 2008

Der Hohlweg - stilles Biotop oder Verkehrsfalle und die Wirkung von Erosionsstoppern. (2008)

Mattheck, C., Bethge, K., Weber, K.

14.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 22.-23.April 2008

Erhaltungsstrategien für Naturdenkmale. (2008)

Mattheck, C., Bethge, K., Weber, K.

11.Kommunales Baumpflegeseminar, Waiblingen, 8.April 2008

Holzzersetzende Pilze an alten Bäumen. (2008)

Weber, K., Mattheck, C.

11.Kommunales Baumpflegeseminar, Waiblingen, 8.April 2008

2 (2007)

J. Chahl, K. Weber, M. V. Srinivasan, S. Venkatesh

In this paper it is shown that simple, low-level motion cues, inspired by the visual navigation of flying insects, can be used to provide a mobile robot with the ability to traverse various corridor...

Landmark Based Corridor Discrimination (2007)

K. Weber, S. Venkatesh, M. V. Srinivasany

For a mobile robot to perform some sort of useful function it usually must have some sort of global understanding of its environment. This is usually expressed in the form of map. Through real-world...

Ochratoxin A: 13-Week Oral Toxicity and Cell Proliferation in Male F344/N Rats (2007)

Rached, E, Hard, GC, Blumbach, K, Weber, K, Draheim, R, Özden, S, ...

Ochratoxin A (OTA) is nephrotoxic and a potent renal carcinogen. Male rats are most susceptible to OTA toxicity and chronic administration of OTA (70 and 210 μg/kg b.w.) for two years has been shown...

Zwieselbruch durch Moderfäule. Brandkrustenpilz in 10 Metern Höhe. (2007)

Weber, K., Mattheck, C.

13.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 8.-9.Mai 2007

Kritischer Ast- und Stämmlingswinkel für Rindeneinschluss. (2007)

Weber, K., Mattheck, C.

13.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 8.-9.Mai 2007

Neue Erkenntnisse zum Sommerbruch grüner Äste. (2007)

Weber, K., Mattheck, C.

13.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 8.-9.Mai 2007

Die Mechanik des Massaria-Astbruches. (2007)

Mattheck, C., Bethge, K., Weber, K.

13.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 8.-9.Mai 2007

Kritische Astschlankheiten L/D und das Astbruchrisiko. (2007)

Mattheck, C., Bethge, K., Weber, K., Sauer, A., Sörensen, J., Kappel, R., ...

13.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 8.-9.Mai 2007

Schlankheitsgrad und Kronensatz bei Bäumen. (2007)

Mattheck, C., Bethge, K., Weber, K., Kappel, R., Tesari, I., Sörensen, J., ...

13.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 8.-9.Mai 2007

Whom to treat? The contribution of vertebral X-rays to risk-based algorithms for fracture prediction. Results from the European Prospective Osteoporosis Study (2006)

Armbrecht, G, Felsenberg, D, Lunt, M, Weber, K, ...

INTRODUCTION: Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5-20% of subjects with a spine fracture are identified in primary care....

Whom to treat? The contribution of vertebral X-rays to risk-based algorithms for fracture prediction; results from the European Prospective Osteoporosis Study (2006)

Kaptoge, S., Armbrecht, G., Felsenberg, D., Lunt, M., Weber, K., Boonen, S., ...

INTRODUCTION: Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5-20% of subjects with a spine fracture are identified in primary care....

Untersuchungen zur Anatomie der Blattnerven und der Nervenanbindung bei Laubbäumen. (2006)

Weber, K., Mattheck, C.

12.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 4.-5.Mai 2006

Der Kiefern-Feuerschwamm. Phellinus pini (Brot.: Fr.) L.M. Ames. (2006)

Weber, K., Klöhn, N.A., Mattheck, C.

12.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 4.-5.Mai 2006

Bedeutender Stammfäuleerreger. (2006)

Weber, K., Klöhn, N.A., Mattheck, C.

bi GaLaBau: Garten- und Landschaftsbau, (2006) Nr.8-9, S.108-11

Abductive Case Based Reasoning (2005)

Sun, Z., Finnie, G., Weber, K.

This article will introduce abductive case-based reasoning (CBR) and attempt to show that abductive CBR and deductive CBR can be integrated in clinical process and problem solving. Then it provides a...

Abductive Case Based Reasoning (2005)

Sun, Z., Finnie, G., Weber, K.

This article will introduce abductive case-based reasoning (CBR) and attempt to show that abductive CBR and deductive CBR can be integrated in clinical process and problem solving. Then it provides a...

Low BMD is less predictive than reported falls for future limb fractures in women across Europe: results from the European Prospective Osteoporosis Study (2005)

Benevolenskaya, L I, Bhalla, A K, Cannata, J B, Falch, J A, ...

We have previously shown that center- and sex-specific fall rates explained one-third of between-center variation in upper limb fractures across Europe. In this current analysis, our aim was to...

ON THE LUMINESCENCE OF LUMINOLS VIII: A VERY EFFECTIVE INHIBITION OF THE LUMINOL REACTION (2005)

Weber, K., Kostelac, R.

The chemoluminescence of Luminol caused by the oxydizing influence of potassium-ferro-cyanide may be controlled in such a manner that either a non- catalytic or a catalytic reaction will result. Both...

THE LUMINESCENCE OF LUMINOL IX (2005)

Weber, K., Huic, Lj., Mrazovic, M.

Quantitative photoelectric measurements of the intensity of emitted light were used to investigate the catalytic action of istopestox on the chemiluminescence of luminol in the presence of hydrogen...

INHIBITIVE PROPERTIES OF OXIMES. II. THE QUENCHING OF THE FLUORESCENCE OF LUMINOL BY OXIMES (2005)

Matkovic, Jelka, Weber, K., Palla, Ljerka

In connection with the inhibitive properties of oximes with respect to the luminol reaction in the presence of organophosphoric poisons, measurements are made of the quenching of luminol fluorescence...

THE LUMINESCENCE OF LUMINOL XI (2005)

Weber, K., Mikulovic, V.

The luminol reaction may serve very well for the detection of blood spots and traces of blood on various objects in judicial-medical and criminological practice. There are various recipes for...

ON THE LUMINESCENCE OF LUMINOLS. 7. THE EFFECT OF FOREIGN MATTER ADDITION ON THE LUMINOL REACTION (2005)

Weber, K.

An investigation was conducted to determine the effect of foreign matter additions on the chemoluminescence of luminol, using various complex ferruginous compounds as catalysts. Foreign additions...

Abductive Case Based Reasoning (2005)

Sun, Z., Finnie, G., Weber, K.

This article will introduce abductive case-based reasoning (CBR) and attempt to show that abductive CBR and deductive CBR can be integrated in clinical process and problem solving. Then it provides a...

Abductive Case Based Reasoning (2005)

Sun, Z., Finnie, G., Weber, K.

This article will introduce abductive case-based reasoning (CBR) and attempt to show that abductive CBR and deductive CBR can be integrated in clinical process and problem solving. Then it provides a...

Holzfäulen. Holzzersetzungsmuster und biomechanische Ersatzmodelle. Eine Bildergalerie. (2005)

Weber, K., Mattheck, C.

Pilzausstellung der Pilzkundlichen Arbeitsgemeinschaft Berlin-Brandenburg (PABB) und der Stiftung Naturschutz Berlin (SNB), Berlin, Oktober 2004 - März 2005 (Poster)

Die Astanbindung - eine schraubenartige Verzahnung? (2005)

Weber, K., Mattheck, C.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Die Körpersprache der Astanbindung. (2005)

Weber, K., Mattheck, C.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Die Mechanik des Astbruchs bei Schlagregen. (2005)

Mattheck, C., Weber, K., Bethge, K., Ritzhaupt-Kleissl, B.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Neue Scherbomben im Kronenbereich. (2005)

Mattheck, C., Weber, K., Bethge, K.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Ein neues Anschauungsmodell zum tieferen Verständnis der Biomechanik der Wurzelplatte. (2005)

Mattheck, C., Weber, K., Müller, P., Bethge, K.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Untersuchungen zur Holzanatomie von Löwenschwanzästen. (2005)

Weber, K., Mattheck, C.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Die Anbindung der Seitenwurzel. Eine gespiegelte Astanbindung? (2005)

Weber, K., Mattheck, C.

11.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 19.-20.April 2005

Die Doppelnatur der Wurzelplatte. (2005)

Weber, K., Mattheck, C.

Allgemeine Forst- und Jagdzeitung, 176(2005) S.77-85

Wurzelschäden erkennen und abschätzen. Pilze im Wurzelbereich. (2005)

Weber, K.

8.Kommunales Baumpflegeseminar, Waiblingen, 15.Juni 2005

Die Körpersprache der Astanbindung. (2005)

Weber, K., Mattheck, C.

bi GaLaBau: Garten- und Landschaftsbau, (2005) Nr.10-11, S.24-27

Characterisation of the thermal response of Silver® cells and modules (2004)

Everett, V., Babaei, J., Deenapanray, P., Weber, K., Blakers, A., Stocks, M.

Sliver cells, invented and developed at The Australian National University, are long, thin, narrow, and bifacial. They are constructed from high-grade mono-crystalline silicon. Solar modules that...

Characterisation of the thermal response of Silver® cells and modules (2004)

Everett, V., Babaei, J., Deenapanray, P., Weber, K., Blakers, A., Stocks, M.

Sliver cells, invented and developed at The Australian National University, are long, thin, narrow, and bifacial. They are constructed from high-grade mono-crystalline silicon. Solar modules that...

Characterisation of the thermal response of Silver® cells and modules (2004)

Everett, V., Babaei, J., Deenapanray, P., Weber, K., Blakers, A., Stocks, M.

Sliver cells, invented and developed at The Australian National University, are long, thin, narrow, and bifacial. They are constructed from high-grade mono-crystalline silicon. Solar modules that...

Characterisation of the thermal response of Silver® cells and modules (2004)

Everett, V., Babaei, J., Deenapanray, P., Weber, K., Blakers, A., Stocks, M.

Sliver cells, invented and developed at The Australian National University, are long, thin, narrow, and bifacial. They are constructed from high-grade mono-crystalline silicon. Solar modules that...

Characterisation of the thermal response of Silver® cells and modules (2004)

Everett, V., Babaei, J., Deenapanray, P., Weber, K., Blakers, A., Stocks, M.

Sliver cells, invented and developed at The Australian National University, are long, thin, narrow, and bifacial. They are constructed from high-grade mono-crystalline silicon. Solar modules that...

Die Doppelnatur der Wurzelplatte. Teil 2. Holzanatomie in Abhängigkeit des Wurzelplatten-Radius. (2004)

Weber, K., Mattheck, C.

10.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 4.-5.Mai 2004

Die Körpersprache der Überwallungswülste beim Eichen-Feuerschwamm an Roteiche. (2004)

Weber, K., Mattheck, C.

10.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 4.-5.Mai 2004

Der Flächenkallus. Erfahrungen bei der Wundbehandlung mit Folie. (2004)

Weber, K., Mattheck, C.

10.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 4.-5.Mai 2004

VTA-Schadsymptome und Versagenmechanismen bei Bäumen. (2004)

Weber, K., Mattheck, C.

7. Kommunales Baumpflegeseminar, Waiblingen, 12. Mai 2004

Der Flächenkallus. Erfahrungen bei der Wundbehandlung mit Folie. (2004)

Weber, K., Mattheck, C.

bi-GaLaBau : Garten- und Landschaftsbau, (2004) Nr.8-9, S.118-24

Event Management Education in Finland (2003)

Slaughter, Lee-Jaye, Reid, Sacha Louise, Arcodia, Charles W., Weber, K.

As event management emerges to become a key sector of the tourism and leisure industries worldwide there is increasing need for tertiary educated event managers, and for evaluations of event...

Professionalising Event Practitioners: The Educational Role of Event Management Associations (2003)

Arcodia, Charles V., Reid, Sacha Louise, Weber, K.

The proliferation of events in recent decades has resulted in a burgeoning of the event management industry. As the event management industry grows and consolidates worldwide, associations play an...

The Cultural Dimension of Event Management: The Case for Understanding Confucianism (2003)

Arcodia, Charles V., Weber, K.

There is much evidence that event management is being recognised as a significant sector of the international tourism and leisure industries. While event management research is increasingly...

Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS) (2003)

Roy, D.K., O'Neill, T.W., Finn, J.D., Lunt, M., Silman, A.J., Felsenberg, D., ...

The aim of this analysis was to determine the influence of lifestyle, anthropometric and reproductive factors on the subsequent risk of incident vertebral fracture in men and women aged 50-79 years....

Robust Speech Recognition and Feature Extraction Using HMM2 (2003)

Weber, K., Ikbal, S., Bengio, S., Bourlard, H.

This paper presents the theoretical basis and preliminary experimental results of a new HMM model, referred to as HMM2, which can be considered as a mixture of HMMs. In this new model, the emission...

Die Barrierezone (CODIT-Wall IV): Holzanatomische Besonderheiten erklären den Bohrwiderstand. (2003)

Weber, K., Mattheck, C.

9.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 1.-2.April 2003

Fäulediagnose an Holzspielgeräten - Risiko auf Spielplätzen. (2003)

Weber, K., Mattheck, C.

9.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 1.-2.April 2003

Bohrwiderstände im Veredlungsbereich - eine neue Interpretation. (2003)

Bethge, K., Weber, K., Mattheck, C.

9.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 1.-2.April 2003

Gibt es Besonderheiten der Holzanatomie im Schubmaximum am Stammfuss der Bäume? (2003)

Weber, K., Mattheck, C.

9.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 1.-2.April 2003

Die Folgen exzessiven Bohrens auf Holzfäulen im Baum. (2003)

Weber, K., Mattheck, C.

9.VTA Spezialseminar 'Messen und Beurteilen am Baum' Karlsruhe, 1.-2.April 2003

Fundamental noise limitations to supercontinuum generation in microstructure fiber (2002)

Corwin, K. L., Newbury, N. R., Dudley, J. M., Coen, S., Diddams, S. A., Weber, K., ...

Broadband noise on supercontinuum spectra generated in microstructure fiber is shown to lead to amplitude fluctuations as large as 50 % for certain input laser pulse parameters. We study this noise...

The relationship between bone density and incident vertebral fracture in men and women (2002)

O'Neill, T.W., Cooper, C., Lunt, M., Silman, A.J., Felsenberg, D., Benevolenskaya, L.I., ...

Bone mineral density (BMD) is an important predictor of future fracture risk in women; however, there are few prospective data in men. The aim of this analysis was to determine whether there are...

Incidence of limb fracture across Europe: results from the European Prospective Osteoporosis Study (EPOS) (2002)

Ismail, A.A., Pye, S.R., Cockerill, W.C., Lunt, M., Silman, A.J., Reeve, J., ...

The aim of this population-based prospective study was to determine the incidence of limb fracture by site and gender in different regions of Europe. Men and women aged 50-79 years were recruited...

Analysis of gene function in somatic mammalian cells using small interfering RNAs (2002)

Elbashir, S. M., Harborth, J., Weber, K., Tuschl, T.

RNA interference (RNAi) is a highly conserved gene silencing mechanism that uses double-stranded RNA (dsRNA) as a signal to trigger the degradation of homologous mRNA. The mediators of...

The gene for a cytoplasmic intermediate filament (IF) protein of the hemichordate Saccoglossus kowalevskii; definition of the unique features of chordate IF proteins (2002)

Zimek, A., Weber, K.

We have isolated full length cDNAs encoding a cytoplasmic intermediate filament (IF) protein of a priapulid (Priapulus caudatus) and of a hemichordate (Saccoglossus kowalevskii) and determined the...

Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans (2002)

Karabinos, A., Schulze, E., Klisch, T., Wang, J., Weber, K.

The multigene family of intermediate filament (IF) proteins in Caenorhabditis elegans covers 11 members of which four (A1-3, B1) are essential for development. Suppression of a fifth gene (C2)...

The mitotic-spindle-associated protein astrin is essential for progression through mitosis (2002)

Gruber, J., Harborth, J., Schnabel, J., Weber, K., Hatzfeld, M.

Astrin is a mitotic-spindle-associated protein expressed in most human cell lines and tissues. However, its functions in spindle organization and mitosis have not yet been determined. Sequence...

Cytoplasmic intermediate filament protein expression in tunicate development: a specific marker for the test cells (2002)

Wang, J., Karabinos, A., Zimek, A., Meyer, M., Riemer, D., Hudson, C., ...

The urochordate Ciona intestinalis is a well established system for embryological studies, and large scale EST sequences begin to emerge. We cloned five cytoplasmic intermediate filament (IF) cDNAs...

Tissue-specific co-expression and in vitro heteropolymer formation of the two small Branchiostoma intermediate filament proteins A3 and B2 (2002)

Karabinos, A., Schuenemann, J., Parry, D. A. D., Weber, K.

The two small intermediate filament (IF) proteins A3 and B2 of the cephalochordate Amphioxus were investigated. Blot overlays indicated a heterotypic interaction pattern of the recombinant proteins....

Conservation of the gene structure and membrane-targeting signals of germ cell-specific lamin LIII in amphibians and fish (2002)

Hofemeister, H., Kuhn, C., Franke, W. W., Weber, K., Stick, R.

Targeting of nuclear lamins to the inner nuclear membrane requires CaaX motif-dependent posttranslational isoprenylation and carboxyl methylation. We previously have shown that two variants of lamin...

Increasing Speech Recognition Noise Robustness with HMM2 (2002)

Weber, K., Bengio, S., Bourlard, H.

The purpose of this paper is to investigate the behavior of HMM2 models for the recognition of noisy speech. It has previously been shown that HMM2 is able to model dynamically important structural...

Evaluation of Formant-Like Features for ASR (2002)

Weber, K., De Wet, F., Cranen, B., Boves, L., Bengio, S., Bourlard, H.

This paper investigates possibilities to automatically find a low-dimensional, formant-related physical representation of the speech signal, which is suitable for automatic speech recognition (ASR)....

Speaker Normalization using HMM2 (2002)

Ikbal, S., Weber, K., Bourlard, H.

In this paper, we present an HMM2 based method for speaker normalization. Introduced as an extension of Hidden Markov Model (HMM), HMM2 differentiates itself from the regular HMM in terms of the...

Speaker Normalization using HMM2 (2002)

Ikbal, S., Weber, K., Bourlard, H.

In this paper, we present an HMM2 based method for speaker normalization. Introduced as an extension of Hidden Markov Model (HMM), HMM2 differentiates itself from the regular HMM in terms of the...

Evaluation of Formant-Like Features for ASR (2002)

Weber, K., De Wet, F., Cranen, B., Boves, L., Bengio, S., Bourlard, H.

This paper investigates possibilities to automatically find a low-dimensional, formant-related physical representation of the speech signal, which is suitable for automatic speech recognition (ASR)....

Towards Robust and Adaptive Speech Recognition Models (2002)

Bourlard, H., Bengio, S., Weber, K.

In this paper, we discuss a family of new Automatic Speech Recognition (ASR) approaches, which somewhat deviate from the usual ASR approaches but which have recently been shown to be more robust to...

Der Pilzfruchtkörper als Zeuge beim Baumunfall. (2002)

Mattheck, C., Weber, K.

8.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 16.-17.April 2002

'Schwimmringe' an Buchen - Ringwulst durch Fäule oder Faserknicken? (2002)

Weber, K., Mattheck, C.

8.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 16.-17.April 2002

Der Platanenunfall in Strasbourg. Eine Schadensanalyse. (2002)

Mattheck, C., Weber, K.

8.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 16.-17.April 2002

Warum fällt der Pilzfruchtkörper nicht vom Stamm? Die Biomechanik einer mehrjährigen Verbindung. (2002)

Mattheck, C., Weber, K.

8.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 16.-17.April 2002

Wenn saprophytische Pilze für lebende Bäume gefährlich werden. (2002)

Weber, K., Mattheck, C.

8.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 16.-17.April 2002

Der Nasskern als Abschottungsersatz. (2002)

Weber, K., Mattheck, C.

8.VTA Spezialseminar 'Messen und Beurteilen am Baum', Karlsruhe, 16.-17.April 2002

Fäulediagnose an Holzspielgeräten. (2002)

Weber, K., Mattheck, C.

GaLaBau 2002 : 15.Internat.Fachmesse Urbanes Grün und Freiräume, Nürnberg, 18.-21.September 2002

Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study (2001)

Ismail, A.A., Cockerill, W., Cooper, C., Finn, J.D., Abendroth, K., Parisi, G., ...

The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip...

Identification of essential genes in cultured mammalian cells using small interfering RNAs (2001)

Harborth, J., Elbashir, S. M., Bechert, K., Tuschl, T., Weber, K.

We report the first RNAi-induced phenotypes in mammalian cultured cells using RNA interference mediated by duplexes of 21-nt RNAs. The 21 gene products studied have different functions and...

HMM2- Extraction of Formant Features and their Use for Robust ASR (2001)

Weber, K., Bengio, S., Bourlard, H.

As recently introduced, an HMM2 can be considered as a particular case of an HMM mixture in which the HMM emission probabilities (usually estimated through Gaussian mixtures or an artificial neural...

Speech Recognition Using Advanced HMM2 Features (2001)

Weber, K., Bengio, S., Bourlard, H.

HMM2 is a particular hidden Markov model where state emission probabilities of the temporal (primary) HMM are modeled through (secondary) state-dependent frequency-based HMMs [12]. As shown in [13],...

A Pragmatic View of the Application of HMM2 for ASR (2001)

Weber, K., Bengio, S., Bourlard, H.

This report investigates the HMM2 approach recently introduced in the framework of automatic speech recognition. HMM2 can be seen as a mixture of HMMs, where a conventional primary HMM (processing a...

Speech Recognition Using Advanced HMM2 Features (2001)

Weber, K., Bengio, S., Bourlard, H.

HMM2 is a particular hidden Markov model where state emission probabilities of the temporal (primary) HMM are modeled through (secondary) state-dependent frequency-based HMMs [12]. As shown in [13],...

IDIAP HMM/HMM2 System: Theoretical Basis and Software Specifications (2001)

Ikbal, S., Bourlard, H., Bengio, S., Weber, K.

State-of-the-art Automatic Speech Recognition (ASR) systems make extensive use of Hidden Markov Models (HMMs), characterized by flexible statistical modeling, powerful optimization (training)...

Increasing Speech Recognition Noise Robustness with HMM2 (2001)

Weber, K., Bengio, S., Bourlard, H.

The purpose of this paper is to investigate the behavior of HMM2 models for the recognition of noisy speech. It has previously been shown that HMM2 is able to model dynamically important structural...

Robust Speech Recognition and Feature Extraction Using HMM2 (2001)

Weber, K., Ikbal, S., Bengio, S., Bourlard, H.

This paper presents the theoretical basis and preliminary experimental results of a new HMM model, referred to as HMM2, which can be considered as a mixture of HMMs. In this new model, the emission...

The effects of lifestyle, dietary dairy intake and diabetes on bone density and vertebral deformity prevalence: The EVOS study (2001)

Masaryk, P, Scheidt-Nave, C, Poor, G, Pois, H, ...

The risk of low and moderate energy fracture is related to bone mineral density (BMD). Yet it is uncertain whether the epidemiologic determinants of fracture risk are the same as for low bone...

Taschenbuch der Holzfäulen im Baum. (2001)

Weber, K., Mattheck, C.

Karlsruhe : Forschungszentrum Karlsruhe GmbH, 2001

Rindeneinschlüsse in Zwieseln. Entschärfte Risse. (2001)

Tesari, I., Weber, K., Süberkrüb, S., Mattheck, C.

7.VTA Spezialseminar Messen und Beurteilen am Baum, Karlsruhe, 27.-28.März 2001 Poster

Gibt es Selbstsabotage der Bäume an Veredelungsstellen? (2001)

Weber, K., Mattheck, C.

7.VTA Spezialseminar Messen und Beurteilen am Baum, Karlsruhe, 27.-28.März 2001 Tagungsband

Verfahren zur Kontrolle eines Saegeprozesses (2000)

Schwirtlich, I., Weber, K., Froehlich, K., Stephan, M., Pridoehl, E.

DE 19859291 A UPAB: 20000823 NOVELTY - The control is carried out during cutting or sawing of discs of brittle material, such as glass, ceramics, semiconductor materials, etc., by wire saw and the...

HMM2- A Novel Approach to HMM Emission Probability Estimation (2000)

Weber, K., Bengio, S., Bourlard, H.

In this paper, we discuss and investigate a new method to estimate local emission probabilities in the framework of hidden Markov models (HMM). Each feature vector is considered to be a sequence and...

HMM2- A Novel Approach to HMM Emission Probability Estimation (2000)

Weber, K., Bengio, S., Bourlard, H.

In this paper, we discuss and investigate a new method to estimate local emission probabilities in the framework of hidden Markov models (HMM). Each feature vector is considered to be a sequence and...

HMM2- Extraction of Formant Features and their Use for Robust ASR (2000)

Weber, K., Bengio, S., Bourlard, H.

As recently introduced, an HMM2 can be considered as a particular case of an HMM mixture in which the HMM emission probabilities (usually estimated through Gaussian mixtures or an artificial neural...

Die Bohrwiderstandsmessung am Stamm der Eiche. (2000)

Weber, K., Mattheck, C.

6.VTA Spezialseminar Messen und Beurteilen am Baum, Karlsruhe, 11.-12.April 2000 Tagungsband

Die Holzanatomie des Druckzwiesels und das Aufsplitten der Holzstrahlen als Rißstopper. (2000)

Weber, K., Mattheck, C.

6.VTA Spezialseminar Messen und Beurteilen am Baum, Karlsruhe, 11.-12.April 2000 Tagungsband

Texture asymmetries as shear sense indicators in naturally deformed mono- and polyphase carbonate rocks (1999)

Leiss, B., Siegesmund, S., Weber, K.

The microstructural and quantitative texture analyses of a naturally deformed calcite mylonite, a dolomite mylonite and a dolomitic calcite mylonite reveal different texture asymmetries for...

Lattice preferred orientation as an indicator of a complex deformation history of rocks (1999)

Ullemeyer, K., Weber, K.

The deconvolution of the deformation history of rocks is one of the main goals of texture analysis in geology. The frequent observation that the macroscopic structures are obliquely oriented with...

Lattice Preferred Orientation as an Indicator of a Complex Deformation History of Rocks (1999)

K. Ullemeyer, K. Weber

The deconvolution of the deformation history of rocks is one of the main goals of texture analysis in geology. The frequent observation that the macroscopic structures are obliquely oriented with...

Texture Asymmetries as Shear Sense Indicators in Naturally Deformed Mono- and Polyphase Carbonate Rocks (1999)

B. Leiss, S. Siegesmund, K. Weber

The microstructural and quantitative texture analyses of a naturally deformed calcite mylonite, a dolomite mylonite and a dolomitic calcite mylonite reveal different texture asymmetries for...

ON THE LUMINESCENCE OF LUMINOL V. MECHANISM OF THE CATALYTIC ACTION OF IRON COMPLEXES, (1998)

Weber, K.

A study was made of the effect of temperature on the chemiluminescence of luminol in the presence of the following catalysts: hemin chloride, salicylaldehyde ethylenene diamine-ferric chloride,...

Behavior of Materials in a Dynamic Environment: Summary of Phase II Results (1998)

El-Raheb, M., Weber, K., Hohler, V.

A theoretical and experimental study was conducted on stress waves and ballistic performance of weakly coupled stacks of AlN tiles bonded by thin polyurethane films. The cylindrical projectile was...

Insect-Inspired Robotic Homing (1998)

K. Weber, S. Venkatesh, M. V. Srinivasany

Many animals, including insects, successfully engage in visual homing. We describe a system that allows a mobile robot to home. Specifically, we propose a simple, yet robust, homing scheme that only...

How trees oppose the lateral forces acting nearby the root-stem junction. (1998)

Götz, K.O., Tesari, I., Weber, K., Mattheck, C.

Meeting'Supporting Roots: Structure and Function', Bordeaux, F, 20.-24.Juli 1998 (Poster)

Annexin II modulates volume-activated chloride currents in vascular endothelial cells (1997)

Gerke, V, Prenen, Jean; U0027905, Szücs, G, Heinke, S, Weber, K, ...

The membrane-associated, microfilament-binding protein annexin II is abundantly expressed in endothelial cells from calf pulmonary artery (CPAE cells). We have analyzed its role in the regulation of...

Hypervelocity Penetration of Tungsten Alloy Rods into Ceramic Tiles: Experiments and 2-D Simulations (1997)

Rosenberg, Z., Dekel, E., Hohler, V., Stilp, A.J., Weber, K.

A series of terminal ballistics experiments and 2-D simulations, with small scale tungsten alloy penetrators, was performed in order to quantify the ballistic efficiency of confined ceramic tiles....

Debris Clouds Behind Double-Layer Targets (1997)

Stilp, A.J., Weber, K.

It is demonstrated that the impedance mismatch and the order of the layers in two-layer sandwiches strongly influences the crater hole size formed in the target, the downrange debris cloud peak...

Insect inspired behaviours for the autonomous control of mobile robots (1997)

K. Weber, S. Venkatesh, M. V. Srinivasan

Animals navigate through various uncontrolled environments with seemingly little effort. Flying insects, especially, are quite adept at manoeuvring in complex, unpredictable and possibly hostile...

Insect Inspired Behaviours for the Autonomous Control of Mobile Robots (1997)

K. Weber, S. Venkatesh, M.V. Srinivasan

Giving robots the ability to move around autonomously in various real-world environments has long been a major challenge in the field of Artificial Intelligence. To this end, it is vital for robots...

Molecular changes of titin in left ventricular dysfunction as a result of chronic hibernation (1995)

Fürst, D, Thoné, F, Weber, K, ...

Cardiomyocytes of chronic hibernating myocardium are affected by partial to complete loss of sarcomeres, accumulation of glycogen, adaptations in size and shape of mitochondria, reorganisation of...

Cytoskeletal modulation of the response to mechanical stimulation in human vascular endothelial cells (1995)

Schwarz, G, Sehrer, J, Jost, M, Gerke, V, Weber, K, ...

Possible interactions of cytoskeletal elements with mechanically induced membrane currents and Ca2+ signals were studied in human endothelial cells by using a combined patch-clamp and Fura II...

Ranking Methods of Ceramics and Experimental Optimization of a Laminated Target with Ceramics (1995)

Hohler, V., Stilp, A.J., Weber, K.

The use of non-metallic materials in armor has become more and more of interest during the last years. The optimal application of such materials supposes the understanding of the interaction process...

High Obliquity Impact of Soft and Hard Spheres on Thin Plates (1995)

Kivity, Y., Mayseless, M., Luttwak, G., Stilp, A.J., Hohler, V., Weber, K., ...

This paper presents a combined experimental-computational study of the impact of steel spheres on thin armor plates at an oblique angle of 70 deg. The plates were nominally 6 mm thick, rolled...

High speed superconducting flywheel system for energy storage. (1995)

Bornemann, H.J., Urban, C., Boegler, P., Ritter, T., Zaitsev, O., Weber, K., ...

Proc.of the 4th Internat.Conf.on Materials and Mechanisms of Superconductivity and High Temperature Superconductors, Grenoble, F, July 4-9, 1994

Energiespeicher mit HTSL-Magnetlagern. (1995)

Bornemann, H.J., Urban, C., Boegler, P., Ritter, T., Zaitsev, O., Weber, K., ...

Supraleitung und Tieftemperaturtechnik : zum Statusseminar, Weimar, 13.-14.Juni 1994

Intron positions in actin genes seem unrelated to the secondary structure of the protein (1994)

Weber,K., Kabsch,Wolfgang

A catalogue of intron positions along the coding sequence was assembled from the large number of actin genes known for different eukaryotes. 36 positions in the amino acid sequence were compared with...

Intron positions in actin genes seem unrelated to the secondary structure of the protein (1994)

Weber, K., Kabsch, Wolfgang

A catalogue of intron positions along the coding sequence was assembled from the large number of actin genes known for different eukaryotes. 36 positions in the amino acid sequence were compared with...

Hypervelocity Penetration of Tungsten Sinter-Alloy Rods into Alumina (1994)

Hohler, V., Stilp, A.J., Weber, K.

Es wurde das Penetrationsverhalten von Penetratoren aus Wolfram-Sinter-Legierung mit L/D von 10 und 12,5 in Al2O3 im Geschwindigkeitsbereich von 1,25 km/s bis 3 km/s untersucht. Es wurden die...

Insect Based Navigation and its Application to the Autonomous Control of Mobile Robots. (1994)

K. Weber, S. Venkatesh, D. Kieronska

Giving robots the ability to autonomously move around in various real-world environments has been a major goal of AI (artificial intelligence) for quite some time. To this end it is vital for robots...

Terminal Ballistic Behavior of Tungsten-Rhenium Rod Projectiles (1993)

Hohler, V., Stilp, A.J., Weber, K.

The terminal ballistic performance of tungsten-rhenium alloy rods has been compared with the behavior of standard tungsten-sinter alloy penetrators. The Re-content is x = 3, 5, 10 and 26% with the...

Impact flash and debris cloud expansion of high-pure metal foils (1993)

Weber, K., Hohler, V., Stilp, A.J.

Results of 2 mm aluminium spheres perforating Al, Cu, Mo, Ag, Au, Sn, and Zn metal foils of a purity bigger than 99.9 percent with thicknesses between 0.1 mm and 2.0 mm, densities of up to 20 g/ccm,...

Experimental and numerical simulation of high velocity impact on steel targets (1993)

Hohler, V., Nahme, H., Tham, R., Stilp, A.J., Weber, K., ...

The perforation process of steel plates at normal impact by cylindrical steel fragments together with the debris cloud expansion have been studied in the velocity range 2-3 km/s. The fragments have a...

Debris cloud expansion around a residual rod behind a perforated plate target (1992)

Hohler, V., Kleinschnitger, K., Schmolinske, E., Stilp, A.J., Weber, K., Mayseless, M., ...

The debris cloud expansion around a residual rod behind a perforated plate target has been studied by means of the laser stroboscope and the flash X-ray observation technique. Especially the bulging...

Simulation of armor perforation by long rod projectiles at normal incidence. (1991)

Weber, K., Mayseless, M., Chazan, G., Kivity, Y., Hohler, V., Stilp, A.J.

This work presents an analysis of the penetration process of long rod projectiles into finite thickness targets. The study is based on detailed computations using a two-dimensional hydrocode, and...

Description of test setups for behind armor debris studies. (1991)

Kleinschnitger, K., Schmolinske, E., Weber, K., Mayseless, M., Hohler, V., Stilp, A.J.

In the case of armor perforation by a rod shaped projectile there is a residual rod surrounded by a debris cloud. Beside the residual rod also the debris cloud can produce considerable damage on...

Versatile controlling system for cryopreparation techniques in electron microscopy (1991)

Humbel, B. M., Weber, K., Merkl, Rainer

A new setup for freeze-substitution and a versatile controlling system has been developed. Our goal was to build a simple system allowing precise control of the physical parameters of...

The Texas LoanSTAR Program: Acquiring and Archiving LoanSTAR Data (1990)

Haberl, J. S., Katipamula, S., Willis, D., Weber, K., Matson, J., Rayaprolu, M., ...

This paper discusses the acquisition and archiving of data for the Texas LoanSTAR monitoring program, an eight year, $98 million revolving loan program for energy conservation retrofits in Texas...

Micrometeorid impacts on silver bus bar targets at elevated voltages. (1989)

Schneider, E., Weber, K., Bogus, K., Robben, A., Krüger, F.R., Maas, D., ...

Micrometeoroid impacts on silver bus bars at elevated positive voltages were performed for different particle sizes. For small particles (smaller than 10 mym) the possibility of short circuit...

Debris cloud expansion studies (1989)

Schneider, E., Weber, K., Hohler, V., Stilp, A.

Properties of fragment clouds produced by hypervelocity perforation of metal plates have been experimentally investigated. Replica model techniques have been applied. Targets consisted of steel...

Haemodynamic studies with a phasic release nitroglycerin patch system (1989)

Bergbauer, M., Weber, K.

The use of transdermal nitroglycerin (GTN) patches in patients with coronary artery disease is of uncertain value as numerous investigators have failed to confirm clinical efficacy for more than 8 h....

Dynamic testing of innovative solutions to child occupant protection problems. Final report (1984)

Weber, K.

Notes: Report covers the period Sept 1982-Sept 1984. Contract amount $63,809

Dynamic testing of child occupant protection concepts. Final report (1982)

Weber, K.

Notes: Report covers the period March 1982-May 1982. Contract amount $9,999

FIELD EFFECT STUDIES ON a-Si:H FILMS (1981)

Grünewald, M., Weber, K., Fuhs, W., Thomas, P.

The density of localized gap states N(E) is calculated using a new scheme, which computes the charge density ρ (V) without explicit solution of Poisson's equation directly from the experimental...

Infant restraint usability follow-up (1981)

Weber, K.

Insurance Institute for Highway Safety, Washington, D.C.

FIELD EFFECT STUDIES ON a-Si:H FILMS (1981)

Grünewald, M., Weber, K., Fuhs, W., Thomas, P.

The density of localized gap states N(E) is calculated using a new scheme, which computes the charge density ρ (V) without explicit solution of Poisson's equation directly from the experimental...

FIELD EFFECT STUDIES ON a-Si:H FILMS (1981)

Grünewald, M., Weber, K., Fuhs, W., Thomas, P.

The density of localized gap states N(E) is calculated using a new scheme, which computes the charge density ρ (V) without explicit solution of Poisson's equation directly from the experimental...

Development of instruments. (1979)

Crecelius, G., Fink, J., Geibel, G., Johnen, P., Manzke, R., Schmidt, F., ...

In: Progress Report. Teilinstitut Nukleare Festkoerperphysik des Instituts fuer Angewandte Kernphysik. 1.6.1978 - 31.5.1979 KfK-2881 (Oktober 79) S.146-50

Development of measuring devices and techniques. (1978)

Conrad, M., Ernst, A., Haase, E.L., Hanak, H., Nadasdy, J., Nuecker, N., ...

In: Progress Report. Teilinstitut Nukleare Festkoerperphysik. 1.6.1977-31.5.1978

Development of measuring devices and techniques. (1977)

Geerk, J., Nuecker, N., Scheerer, B., Weber, K.

In: Progress Report of the Teilinstitut Nukleare Festkoerperphysik. 1.6.1976 - 31.5.1977. KFK-2538 (Oktober 77) S.140-48

Development of measuring devices and techniques. (1976)

Blanckenhagen, P.von, Czjzek, G., Ehret, G., Fink, J., Hanak, H., Krisch, J., ...

In: Progress Report of the Teilinstitut Nukleare Festkoerperphysik. 1.6.1975 - 31.5.1976

MAGNETOCHEMICAL AND MAGNETIC PROPERTIES OF AB2S4 TYPE COMPOUNDS (1971)

Lugscheider, W., Pink, H., Weber, K., Zinn, W.

Relations between electric properties, cation distances, valencies (controlled by 151Eu isomer shifts) and the magnetic properties of AB2S4-type compounds (A = Eu2+, B = Rare Earth (R3+) Y, Sc)...

MAGNETOCHEMICAL AND MAGNETIC PROPERTIES OF AB2S4 TYPE COMPOUNDS (1971)

Lugscheider, W., Pink, H., Weber, K., Zinn, W.

Relations between electric properties, cation distances, valencies (controlled by 151Eu isomer shifts) and the magnetic properties of AB2S4-type compounds (A = Eu2+, B = Rare Earth (R3+) Y, Sc)...

MAGNETOCHEMICAL AND MAGNETIC PROPERTIES OF AB2S4 TYPE COMPOUNDS (1971)

Lugscheider, W., Pink, H., Weber, K., Zinn, W.

Relations between electric properties, cation distances, valencies (controlled by 151Eu isomer shifts) and the magnetic properties of AB2S4-type compounds (A = Eu2+, B = Rare Earth (R3+) Y, Sc)...

Systemic Infection of an Immunocompromised Patient with Methylobacterium zatmanii

Hornei, B., Lüneberg, E., Schmidt-Rotte, H., Maaß, M., Weber, K., Heits, F., ...

We describe the identification of Methylobacterium zatmanii as the causative agent of bacteremia and fever in an immunocompromised patient. The patient, a 60-year-old man, had a 5-month history of...

Characterization of intracellular and extracellular vaccinia virus variants: N1-isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine interferes with cytoplasmic virus dissemination and release.

Hiller, G, Eibl, H, Weber, K

Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and...

Golgi-derived membranes that contain an acylated viral polypeptide are used for vaccinia virus envelopment.

Hiller, G, Weber, K

A 37,000-dalton polypeptide (p37K) present on purified extracellular vaccinia virus but absent from intracellular virus particles of classical morphology (G. Hiller et al., J. Virol. 39:903-913,...

A phosphorylated basic vaccinia virion polypeptide of molecular weight 11,000 is exposed on the surface of mature particles and interacts with actin-containing cytoskeletal elements.

Hiller, G, Weber, K

A phosphorylated vaccinia virus structural polypeptide of an apparent molecular weight of 11,000 (p11K) was isolated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis and used...

The association of annexin I with early endosomes is regulated by Ca2+ and requires an intact N-terminal domain.

Seemann, J, Weber, K, Osborn, M, Parton, R G, Gerke, V

Annexin I is a member of a multigene family of Ca2+/phospholipid-binding proteins and a major substrate for the epidermal growth factor (EGF) receptor kinase, which has been implicated in...

Binding of two desmin derivatives to the plasma membrane and the nuclear envelope of avian erythrocytes: evidence for a conserved site-specificity in intermediate filament-membrane interactions.

Georgatos, S D, Weber, K, Geisler, N, Blobel, G

Using solution binding assays, we found that a 45-kDa fragment of desmin, lacking 67 residues from the N terminus, could specifically associate with avian erythrocyte nuclear envelopes but not with...

A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.

Melchior, F, Weber, K, Gerke, V

The RNA1 gene from Saccharomyces cerevisiae is defined by the temperature-sensitive rna1-1 mutation that interferes with the maturation and/or nucleocytoplasmic transport of RNA. We describe the...

Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin.

Gabbiani, G, Schmid, E, Winter, S, Chaponnier, C, De Ckhastonay, C, Vandekerckhove, J, ...

Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-size filament constituent and also show a predominance of...

Calcium control of microfilaments: uncoupling of the F-actin-severing and -bundling activity of villin by limited proteolysis in vitro.

Glenney, J R, Weber, K

Villin is a major F-actin-bundling protein present in the microfilament bundle underlying the plasma membrane of the microvilli present on intestinal epithelial cells. Mild in vitro proteolysis...

Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin.

Geisler, N, Weber, K

Although all intermediate-size filaments (10-nm filaments) seem to show similar morphology and share a number of biochemical properties, different cell- and tissue-specific subclasses have been...

Cytoplasmic microtubules in tissue culture cells appear to grow from an organizing structure towards the plasma membrane.

Osborn, M, Weber, K

A structure which appears to organize cytoplasmic microtubules in interphase mouse 3T3 cells can be visualized by immunofluorescence microscopy. Purified monospecific antibody against homogeneous...

Different intermediate-sized filaments distinguished by immunofluorescence microscopy.

Franke, W W, Schmid, E, Osborn, M, Weber, K

The major protein of intermediate-sized filaments in mouse 3T3 cells, for which the name vimentin is proposed, has a molecular weight of 57,000. Antibodies against vimentin and antibodies against...

Erythroid spectrin, brain fodrin, and intestinal brush border proteins (TW-260/240) are related molecules containing a common calmodulin-binding subunit bound to a variant cell type-specific subunit.

Glenney, J R, Glenney, P, Weber, K

Spectrin, fodrin, and TW-260/240 form a group of structurally and functionally similar but not identical high molecular weight actin-binding proteins from chicken erythrocytes, brain tissue, or...

Calcium control of the intestinal microvillus cytoskeleton: its implications for the regulation of microfilament organizations.

Glenney, J R, Bretscher, A, Weber, K

The microvillus core-filament bundle from intestinal epithelial cells is a highly ordered structure containing actin and four major associated proteins. Two of these, villin and calmodulin, bind...

Simian virus 40 gene A function and maintenance of transformation.

Osborn, M, Weber, K

Transformants have been isolated after infection of rat embryo cells at 33 C with either wild-type simian virus 40 or with the temperature-sensitive gene A mutants, tsA7 and tsA28. Examination of...

Three-dimensional electron microscopical visualization of the cytoskeleton of animal cells: immunoferritin identification of actin- and tubulin-containing structures.

Webster, R E, Henderson, D, Osborn, M, Weber, K

Cytoskeletons prepared by Triton X-100 treatment of tissue culture cells appear in stereo electron microscopy as a highly organized and interconnected three-dimensional matrix of different fibrous...

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

Saftig, P, Hetman, M, Schmahl, W, Weber, K, Heine, L, Mossmann, H, ...

Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in a state of...

Intron positions in actin genes seem unrelated to the secondary structure of the protein.

Weber, K, Kabsch, W

A catalogue of intron positions along the coding sequence was assembled from the large number of actin genes known for different eukaryotes. 36 positions in the amino acid sequence were compared with...

Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.

Dodemont, H, Riemer, D, Ledger, N, Weber, K

Cytoplasmic intermediate filament (IF) proteins of Caenorhabditis elegans are encoded by a dispersed multigene family comprising at least eight genes which map to three linkage groups. Exon sequences...

Epitope mapping and direct visualization of the parallel, in-register arrangement of the double-stranded coiled-coil in the NuMA protein.

Harborth, J, Weber, K, Osborn, M

NuMA, a 238 kDa protein present in the nucleus during interphase, translocates to the spindle poles in mitosis. NuMA plays an essential role in mitosis, since microinjection of the NuMA SPN-3...

Cytoplasmic intermediate filament proteins of invertebrates are closer to nuclear lamins than are vertebrate intermediate filament proteins; sequence characterization of two muscle proteins of a nematode.

Weber, K, Plessmann, U, Ulrich, W

The giant body muscle cells of the nematode Ascaris lumbricoides show a complex three dimensional array of intermediate filaments (IFs). They contain two proteins, A (71 kd) and B (63 kd), which we...

Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site.

Morris, S A, Schröder, S, Plessmann, U, Weber, K, Ungewickell, E

Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats. The largest rat brain cDNA clone isolated predicts a molecular weight of 91,430 for AP180. Two cDNA clones have an...

Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.

Gabbiani, G, Kocher, O, Bloom, W S, Vandekerckhove, J, Weber, K

Actin of smooth muscle cells of rat and human aortic media shows a predominance of the alpha-isoform. In experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured...

Isolation of a set of hybrid lac repressors made in vitro between normal lac repressor and its homogeneous tryptic core.

Geisler, N, Weber, K

Lactose repressor can be renatured from 8 M guanidine-HCl solution. The renatured repressor is tetrameric and shows DNA binding activity. Thus it becomes possible to obtain hybrid tetramers in vitro...

In vitro assembly of pure tubulin into microtubules in the absence of microtubule-associated proteins and glycerol.

Herzog, W, Weber, K

Microtubule protein from porcine cerebrum was fractionate into pure tubulin and microtubule-associated proteins by chromatography on phosphocellulose. In agreement with previous studies, pure tubulin...

Visualization of a system of filaments 7-10 nm thick in cultured cells of an epithelioid line (Pt K2) by immunofluorescence microscopy.

Osborn, M, Franke, W W, Weber, K

During our studies with antibodies against structural proteins of the cytoskeleton of eukaryotic cells we have observed that sera from many normal rabbits decorate a fiber system in cells of the...

Antibody against tuberlin: the specific visualization of cytoplasmic microtubules in tissue culture cells.

Weber, K, Pollack, R, Bibring, T

Cytoplasmic microtubules in tissue culture cells can be directly visualized by immunofluorescence microscopy. Antibody against tubulin from the outer doublets of sea urchin sperm flagella decorates a...

Patterns of organization of actin and myosin in normal and transformed cultured cells.

Pollack, R, Osborn, M, Weber, K

The patterns of distribution of intracellular actin and myosin were examined by specific immunofluorescence in a series of normal, simian-virus-40-transformed, and revertant cell lines of rat and...

A 210 kDa nuclear matrix protein is a functional part of the mitotic spindle; a microinjection study using SPN monoclonal antibodies.

Kallajoki, M, Weber, K, Osborn, M

Six monoclonal antibodies identify a 210 kDa polypeptide which shows a cell cycle specific redistribution from the nucleus to the mitotic spindle. In interphase cells this polypeptide was localized...

Phosphorylation of desmin in vitro inhibits formation of intermediate filaments; identification of three kinase A sites in the aminoterminal head domain.

Geisler, N, Weber, K

The in vitro phosphorylation of chicken desmin by the catalytic subunit of cAMP-dependent protein kinase was analysed. Phosphorylated desmin loses the ability to form intermediate filaments (IFs)....

Amino acid sequences and homopolymer-forming ability of the intermediate filament proteins from an invertebrate epithelium.

Weber, K, Plessmann, U, Dodemont, H, Kossmagk-Stephan, K

Intermediate filaments (IF) isolated from the oesophagus epithelium of the snail Helix pomatia contain two polypeptides of mol. wt 66,000 (A) and 52,000 (B), which we have now characterized by in...

p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix.

Johnsson, N, Marriott, G, Weber, K

Protein I is a hetero-tetramer which contains two copies each of p11 and p36. p36 (calpactin I, lipocortin II) is a major substrate of retrovirally encoded tyrosine protein kinases, while p11...

Structure of an invertebrate gene encoding cytoplasmic intermediate filament (IF) proteins: implications for the origin and the diversification of IF proteins.

Dodemont, H, Riemer, D, Weber, K

The structure of the single gene encoding the cytoplasmic intermediate filament (IF) proteins in non-neuronal cells of the gastropod Helix aspersa is described. Genomic and cDNA sequences show that...

Protein-protein recognition via short amphiphilic helices; a mutational analysis of the binding site of annexin II for p11.

Becker, T, Weber, K, Johnsson, N

Annexin II (p36) interacts with its ligand p11 via the short stretch of 12 amino acids (Ac-S-T-V-H-E-I-L-C-K-L-S-L) situated at the N-terminus. We have now synthesized some 37 tetradecapeptides,...

A monoclonal antibody specific for the 200 K polypeptide of the neurofilament triplet.

Debus, E, Flügge, G, Weber, K, Osborn, M

A mouse monoclonal antibody, designated NF1, was obtained from a cloned hybridoma isolated from a fusion of mouse myeloma Sp2 cells with spleen cells from a BALB/c mouse immunized with a crude...

The structural relation between intermediate filament proteins in living cells and the alpha-keratins of sheep wool.

Weber, K, Geisler, N

Although not complete, the available sequence data on smooth muscle desmin, a prototype of 10 nm filaments present in living vertebrate cells, and two wool alpha-keratin components indicate a common...

Monoclonal cytokeratin antibodies that distinguish simple from stratified squamous epithelia: characterization on human tissues.

Debus, E, Weber, K, Osborn, M

Four monoclonal antibodies designated CK1 - CK4 were obtained from fusions of mouse myeloma F0 cells with spleen cells from BALB/c mice immunized with cytoskeletal preparations made by treatment of...

The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins.

Geisler, N, Weber, K

The complete amino acid sequence of muscle desmin reported here is the first for an intermediate filament protein. Alignment with partial data available for vimentin, glial fibrillary acid protein,...

The amino acid sequence of protein II and its phosphorylation site for protein kinase C; the domain structure Ca2+-modulated lipid binding proteins.

Weber, K, Johnsson, N, Plessmann, U, Van, P N, Söling, H D, Ampe, C, ...

Protein II isolated from porcine intestinal epithelium is a Ca2+-modulated lipid-binding protein. The amino acid sequence of porcine protein II reported here sheds new light on the properties of a...

Protein-chemical characterization of NF-H, the largest mammalian neurofilament component; intermediate filament-type sequences followed by a unique carboxy-terminal extension

Geisler, N., Fischer, S., Vandekerckhove, J., Damme, J. Van, Plessmann, U., Weber, K.

NF-H has the highest mol. wt. of the three mammalian neurofilament components (NF-L, NF-M, NF-H). In spite of its unusually large mol. wt., estimated to be 200 K by gel electrophoresis, NF-H contains...

The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells.

Gerke, V, Weber, K

The major cytoplasmic target of various tyrosine-specific protein kinases is a 36-kd protein (p36). This protein can exist as a monomer or as a complex with a small subunit which seems to have a...

Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between triplet proteins.

Geisler, N, Kaufmann, E, Fischer, S, Plessmann, U, Weber, K

Mammalian neurofilament triplet proteins (68 K, 160 K and 200 K) have been correlated by a biochemical, immunological and protein chemical study. The 160 K and 200 K triplet proteins are intermediate...

Amino acid sequence data on glial fibrillary acidic protein (GFA); implications for the subdivision of intermediate filaments into epithelial and non-epithelial members.

Geisler, N, Weber, K

Determination of 50% of the sequence of the astrocyte-specific intermediate filament (IF) protein documents the hypervariable regions as well as parts of the coiled-coil array of glial fibrillary...

Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein.

Debus, E, Weber, K, Osborn, M

A set of monoclonal antibodies to desmin has been isolated from a fusion of mouse myeloma cells with spleen cells from mice immunized with purified porcine desmin. Eleven group I antibodies...

Identity of p36K phosphorylated upon Rous sarcoma virus transformation with a protein purified from brush borders; calcium-dependent binding to non-erythroid spectrin and F-actin.

Gerke, V, Weber, K

Membrane vesicles derived from the apical side of procine intestinal epithelial cells retain, after demembranation in the presence of calcium, two major proteins (I, II) which are released by the...

Amino acid sequence requirements in the epitope recognized by the alpha-tubulin-specific rat monoclonal antibody YL 1/2.

Wehland, J, Schröder, H C, Weber, K

We have characterized the epitope of the rat monoclonal antibody YL 1/2 in detail using synthetic peptides and several alpha-tubulin derivatives. The epitope seems to be provided by the linear...

Hybrid character of a large neurofilament protein (NF-M): intermediate filament type sequence followed by a long and acidic carboxy-terminal extension.

Geisler, N, Fischer, S, Vandekerckhove, J, Plessmann, U, Weber, K

The sequence of the amino-terminal 436 residues of porcine neurofilament component NF-M (apparent mol. wt. in gel electrophoresis 160 kd), one of the two high mol. wt. components of mammalian...

Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker.

Weber, K, Osborn, M, Moll, R, Wiklund, B, Lüning, B

Because of the broad clinical interest which tissue polypeptide antigen (TPA) has attracted as a tumor marker, human cell lines and human tissues have been analyzed for TPA expression using...

Annexin II contains two types of Ca(2+)-binding sites.

Jost, M, Weber, K, Gerke, V

The annexins are a multigene family of Ca(2+)-dependent phospholipid-binding proteins which contain novel types of Ca2+ sites. Using site-directed mutagenesis, we generated mutant proteins that show...

Functionally distinct serine phosphorylation sites of p36, the cellular substrate of retroviral protein kinase; differential inhibition of reassociation with p11.

Johnsson, N, Nguyen Van, P, Söling, H D, Weber, K

P36 was originally defined as the major cytoplasmic target of retrovirally coded tyrosine-kinases. While recently much has been learned about its biochemistry, the functional importance of its...

Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin.

Obermann, W M, Gautel, M, Weber, K, Fürst, D O

The M band of sarcomeric muscle is a highly complex structure which contributes to the maintenance of the regular lattice of thick filaments. We propose that the spatial coordination of this assembly...

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice.

Harborth, J, Wang, J, Gueth-Hallonet, C, Weber, K, Osborn, M

NuMA is a nuclear matrix protein in interphase and relocates to the spindle poles in mitotis. Different NuMA constructs, in which either N- or C-terminal domains were deleted, and the full-length...

Structural requirements for annexin I-S100C complex-formation.

Seemann, J, Weber, K, Gerke, V

S100C is a member of the S100 family of EF-hand-type Ca(2+)-binding proteins which are thought to bind to and thereby regulate the activity of cellular target proteins in a Ca(2+)-dependent manner....

An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster.

Weber, K, Eisman, R, Morey, L, Patty, A, Sparks, J, Tausek, M, ...

Loci on the third chromosome of Drosophila melanogaster that affect an index of wing shape were mapped, using recombinant isogenic lines, with transposable elements as markers. Many genes with small...

An analysis of polygenes affecting wing shape on chromosome 2 in Drosophila melanogaster.

Weber, K, Eisman, R, Higgins, S, Morey, L, Patty, A, Tausek, M, ...

Genetic effects on an index of wing shape on chromosome 2 of Drosophila melanogaster were mapped using isogenic recombinants with transposable element markers. At least 10 genes with small additive...

Systemic Infection of an Immunocompromised Patient with Methylobacterium zatmanii

Hornei, B., Lüneberg, E., Schmidt-Rotte, H., Maaß, M., Weber, K., Heits, F., ...

We describe the identification of Methylobacterium zatmanii as the causative agent of bacteremia and fever in an immunocompromised patient. The patient, a 60-year-old man, had a 5-month history of...

Characterization of intracellular and extracellular vaccinia virus variants: N1-isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine interferes with cytoplasmic virus dissemination and release.

Hiller, G, Eibl, H, Weber, K

Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and...

Golgi-derived membranes that contain an acylated viral polypeptide are used for vaccinia virus envelopment.

Hiller, G, Weber, K

A 37,000-dalton polypeptide (p37K) present on purified extracellular vaccinia virus but absent from intracellular virus particles of classical morphology (G. Hiller et al., J. Virol. 39:903-913,...

A phosphorylated basic vaccinia virion polypeptide of molecular weight 11,000 is exposed on the surface of mature particles and interacts with actin-containing cytoskeletal elements.

Hiller, G, Weber, K

A phosphorylated vaccinia virus structural polypeptide of an apparent molecular weight of 11,000 (p11K) was isolated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis and used...

The association of annexin I with early endosomes is regulated by Ca2+ and requires an intact N-terminal domain.

Seemann, J, Weber, K, Osborn, M, Parton, R G, Gerke, V

Annexin I is a member of a multigene family of Ca2+/phospholipid-binding proteins and a major substrate for the epidermal growth factor (EGF) receptor kinase, which has been implicated in...

Binding of two desmin derivatives to the plasma membrane and the nuclear envelope of avian erythrocytes: evidence for a conserved site-specificity in intermediate filament-membrane interactions.

Georgatos, S D, Weber, K, Geisler, N, Blobel, G

Using solution binding assays, we found that a 45-kDa fragment of desmin, lacking 67 residues from the N terminus, could specifically associate with avian erythrocyte nuclear envelopes but not with...

A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.

Melchior, F, Weber, K, Gerke, V

The RNA1 gene from Saccharomyces cerevisiae is defined by the temperature-sensitive rna1-1 mutation that interferes with the maturation and/or nucleocytoplasmic transport of RNA. We describe the...

Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin.

Gabbiani, G, Schmid, E, Winter, S, Chaponnier, C, De Ckhastonay, C, Vandekerckhove, J, ...

Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-size filament constituent and also show a predominance of...

Calcium control of microfilaments: uncoupling of the F-actin-severing and -bundling activity of villin by limited proteolysis in vitro.

Glenney, J R, Weber, K

Villin is a major F-actin-bundling protein present in the microfilament bundle underlying the plasma membrane of the microvilli present on intestinal epithelial cells. Mild in vitro proteolysis...

Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin.

Geisler, N, Weber, K

Although all intermediate-size filaments (10-nm filaments) seem to show similar morphology and share a number of biochemical properties, different cell- and tissue-specific subclasses have been...

Cytoplasmic microtubules in tissue culture cells appear to grow from an organizing structure towards the plasma membrane.

Osborn, M, Weber, K

A structure which appears to organize cytoplasmic microtubules in interphase mouse 3T3 cells can be visualized by immunofluorescence microscopy. Purified monospecific antibody against homogeneous...

Different intermediate-sized filaments distinguished by immunofluorescence microscopy.

Franke, W W, Schmid, E, Osborn, M, Weber, K

The major protein of intermediate-sized filaments in mouse 3T3 cells, for which the name vimentin is proposed, has a molecular weight of 57,000. Antibodies against vimentin and antibodies against...

Erythroid spectrin, brain fodrin, and intestinal brush border proteins (TW-260/240) are related molecules containing a common calmodulin-binding subunit bound to a variant cell type-specific subunit.

Glenney, J R, Glenney, P, Weber, K

Spectrin, fodrin, and TW-260/240 form a group of structurally and functionally similar but not identical high molecular weight actin-binding proteins from chicken erythrocytes, brain tissue, or...

Calcium control of the intestinal microvillus cytoskeleton: its implications for the regulation of microfilament organizations.

Glenney, J R, Bretscher, A, Weber, K

The microvillus core-filament bundle from intestinal epithelial cells is a highly ordered structure containing actin and four major associated proteins. Two of these, villin and calmodulin, bind...

Simian virus 40 gene A function and maintenance of transformation.

Osborn, M, Weber, K

Transformants have been isolated after infection of rat embryo cells at 33 C with either wild-type simian virus 40 or with the temperature-sensitive gene A mutants, tsA7 and tsA28. Examination of...

Three-dimensional electron microscopical visualization of the cytoskeleton of animal cells: immunoferritin identification of actin- and tubulin-containing structures.

Webster, R E, Henderson, D, Osborn, M, Weber, K

Cytoskeletons prepared by Triton X-100 treatment of tissue culture cells appear in stereo electron microscopy as a highly organized and interconnected three-dimensional matrix of different fibrous...

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

Saftig, P, Hetman, M, Schmahl, W, Weber, K, Heine, L, Mossmann, H, ...

Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in a state of...

Intron positions in actin genes seem unrelated to the secondary structure of the protein.

Weber, K, Kabsch, W

A catalogue of intron positions along the coding sequence was assembled from the large number of actin genes known for different eukaryotes. 36 positions in the amino acid sequence were compared with...

Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.

Dodemont, H, Riemer, D, Ledger, N, Weber, K

Cytoplasmic intermediate filament (IF) proteins of Caenorhabditis elegans are encoded by a dispersed multigene family comprising at least eight genes which map to three linkage groups. Exon sequences...

Epitope mapping and direct visualization of the parallel, in-register arrangement of the double-stranded coiled-coil in the NuMA protein.

Harborth, J, Weber, K, Osborn, M

NuMA, a 238 kDa protein present in the nucleus during interphase, translocates to the spindle poles in mitosis. NuMA plays an essential role in mitosis, since microinjection of the NuMA SPN-3...

Cytoplasmic intermediate filament proteins of invertebrates are closer to nuclear lamins than are vertebrate intermediate filament proteins; sequence characterization of two muscle proteins of a nematode.

Weber, K, Plessmann, U, Ulrich, W

The giant body muscle cells of the nematode Ascaris lumbricoides show a complex three dimensional array of intermediate filaments (IFs). They contain two proteins, A (71 kd) and B (63 kd), which we...

Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site.

Morris, S A, Schröder, S, Plessmann, U, Weber, K, Ungewickell, E

Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats. The largest rat brain cDNA clone isolated predicts a molecular weight of 91,430 for AP180. Two cDNA clones have an...

Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.

Gabbiani, G, Kocher, O, Bloom, W S, Vandekerckhove, J, Weber, K

Actin of smooth muscle cells of rat and human aortic media shows a predominance of the alpha-isoform. In experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured...

Isolation of a set of hybrid lac repressors made in vitro between normal lac repressor and its homogeneous tryptic core.

Geisler, N, Weber, K

Lactose repressor can be renatured from 8 M guanidine-HCl solution. The renatured repressor is tetrameric and shows DNA binding activity. Thus it becomes possible to obtain hybrid tetramers in vitro...

In vitro assembly of pure tubulin into microtubules in the absence of microtubule-associated proteins and glycerol.

Herzog, W, Weber, K

Microtubule protein from porcine cerebrum was fractionate into pure tubulin and microtubule-associated proteins by chromatography on phosphocellulose. In agreement with previous studies, pure tubulin...

Visualization of a system of filaments 7-10 nm thick in cultured cells of an epithelioid line (Pt K2) by immunofluorescence microscopy.

Osborn, M, Franke, W W, Weber, K

During our studies with antibodies against structural proteins of the cytoskeleton of eukaryotic cells we have observed that sera from many normal rabbits decorate a fiber system in cells of the...

Antibody against tuberlin: the specific visualization of cytoplasmic microtubules in tissue culture cells.

Weber, K, Pollack, R, Bibring, T

Cytoplasmic microtubules in tissue culture cells can be directly visualized by immunofluorescence microscopy. Antibody against tubulin from the outer doublets of sea urchin sperm flagella decorates a...

Patterns of organization of actin and myosin in normal and transformed cultured cells.

Pollack, R, Osborn, M, Weber, K

The patterns of distribution of intracellular actin and myosin were examined by specific immunofluorescence in a series of normal, simian-virus-40-transformed, and revertant cell lines of rat and...

A 210 kDa nuclear matrix protein is a functional part of the mitotic spindle; a microinjection study using SPN monoclonal antibodies.

Kallajoki, M, Weber, K, Osborn, M

Six monoclonal antibodies identify a 210 kDa polypeptide which shows a cell cycle specific redistribution from the nucleus to the mitotic spindle. In interphase cells this polypeptide was localized...

Phosphorylation of desmin in vitro inhibits formation of intermediate filaments; identification of three kinase A sites in the aminoterminal head domain.

Geisler, N, Weber, K

The in vitro phosphorylation of chicken desmin by the catalytic subunit of cAMP-dependent protein kinase was analysed. Phosphorylated desmin loses the ability to form intermediate filaments (IFs)....

Amino acid sequences and homopolymer-forming ability of the intermediate filament proteins from an invertebrate epithelium.

Weber, K, Plessmann, U, Dodemont, H, Kossmagk-Stephan, K

Intermediate filaments (IF) isolated from the oesophagus epithelium of the snail Helix pomatia contain two polypeptides of mol. wt 66,000 (A) and 52,000 (B), which we have now characterized by in...

p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix.

Johnsson, N, Marriott, G, Weber, K

Protein I is a hetero-tetramer which contains two copies each of p11 and p36. p36 (calpactin I, lipocortin II) is a major substrate of retrovirally encoded tyrosine protein kinases, while p11...

Structure of an invertebrate gene encoding cytoplasmic intermediate filament (IF) proteins: implications for the origin and the diversification of IF proteins.

Dodemont, H, Riemer, D, Weber, K

The structure of the single gene encoding the cytoplasmic intermediate filament (IF) proteins in non-neuronal cells of the gastropod Helix aspersa is described. Genomic and cDNA sequences show that...

Protein-protein recognition via short amphiphilic helices; a mutational analysis of the binding site of annexin II for p11.

Becker, T, Weber, K, Johnsson, N

Annexin II (p36) interacts with its ligand p11 via the short stretch of 12 amino acids (Ac-S-T-V-H-E-I-L-C-K-L-S-L) situated at the N-terminus. We have now synthesized some 37 tetradecapeptides,...

A monoclonal antibody specific for the 200 K polypeptide of the neurofilament triplet.

Debus, E, Flügge, G, Weber, K, Osborn, M

A mouse monoclonal antibody, designated NF1, was obtained from a cloned hybridoma isolated from a fusion of mouse myeloma Sp2 cells with spleen cells from a BALB/c mouse immunized with a crude...

The structural relation between intermediate filament proteins in living cells and the alpha-keratins of sheep wool.

Weber, K, Geisler, N

Although not complete, the available sequence data on smooth muscle desmin, a prototype of 10 nm filaments present in living vertebrate cells, and two wool alpha-keratin components indicate a common...

Monoclonal cytokeratin antibodies that distinguish simple from stratified squamous epithelia: characterization on human tissues.

Debus, E, Weber, K, Osborn, M

Four monoclonal antibodies designated CK1 - CK4 were obtained from fusions of mouse myeloma F0 cells with spleen cells from BALB/c mice immunized with cytoskeletal preparations made by treatment of...

The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins.

Geisler, N, Weber, K

The complete amino acid sequence of muscle desmin reported here is the first for an intermediate filament protein. Alignment with partial data available for vimentin, glial fibrillary acid protein,...

The amino acid sequence of protein II and its phosphorylation site for protein kinase C; the domain structure Ca2+-modulated lipid binding proteins.

Weber, K, Johnsson, N, Plessmann, U, Van, P N, Söling, H D, Ampe, C, ...

Protein II isolated from porcine intestinal epithelium is a Ca2+-modulated lipid-binding protein. The amino acid sequence of porcine protein II reported here sheds new light on the properties of a...

Protein-chemical characterization of NF-H, the largest mammalian neurofilament component; intermediate filament-type sequences followed by a unique carboxy-terminal extension

Geisler, N., Fischer, S., Vandekerckhove, J., Damme, J. Van, Plessmann, U., Weber, K.

NF-H has the highest mol. wt. of the three mammalian neurofilament components (NF-L, NF-M, NF-H). In spite of its unusually large mol. wt., estimated to be 200 K by gel electrophoresis, NF-H contains...

The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells.

Gerke, V, Weber, K

The major cytoplasmic target of various tyrosine-specific protein kinases is a 36-kd protein (p36). This protein can exist as a monomer or as a complex with a small subunit which seems to have a...

Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between triplet proteins.

Geisler, N, Kaufmann, E, Fischer, S, Plessmann, U, Weber, K

Mammalian neurofilament triplet proteins (68 K, 160 K and 200 K) have been correlated by a biochemical, immunological and protein chemical study. The 160 K and 200 K triplet proteins are intermediate...

Amino acid sequence data on glial fibrillary acidic protein (GFA); implications for the subdivision of intermediate filaments into epithelial and non-epithelial members.

Geisler, N, Weber, K

Determination of 50% of the sequence of the astrocyte-specific intermediate filament (IF) protein documents the hypervariable regions as well as parts of the coiled-coil array of glial fibrillary...

Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein.

Debus, E, Weber, K, Osborn, M

A set of monoclonal antibodies to desmin has been isolated from a fusion of mouse myeloma cells with spleen cells from mice immunized with purified porcine desmin. Eleven group I antibodies...

Identity of p36K phosphorylated upon Rous sarcoma virus transformation with a protein purified from brush borders; calcium-dependent binding to non-erythroid spectrin and F-actin.

Gerke, V, Weber, K

Membrane vesicles derived from the apical side of procine intestinal epithelial cells retain, after demembranation in the presence of calcium, two major proteins (I, II) which are released by the...

Amino acid sequence requirements in the epitope recognized by the alpha-tubulin-specific rat monoclonal antibody YL 1/2.

Wehland, J, Schröder, H C, Weber, K

We have characterized the epitope of the rat monoclonal antibody YL 1/2 in detail using synthetic peptides and several alpha-tubulin derivatives. The epitope seems to be provided by the linear...

Hybrid character of a large neurofilament protein (NF-M): intermediate filament type sequence followed by a long and acidic carboxy-terminal extension.

Geisler, N, Fischer, S, Vandekerckhove, J, Plessmann, U, Weber, K

The sequence of the amino-terminal 436 residues of porcine neurofilament component NF-M (apparent mol. wt. in gel electrophoresis 160 kd), one of the two high mol. wt. components of mammalian...

Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker.

Weber, K, Osborn, M, Moll, R, Wiklund, B, Lüning, B

Because of the broad clinical interest which tissue polypeptide antigen (TPA) has attracted as a tumor marker, human cell lines and human tissues have been analyzed for TPA expression using...

Annexin II contains two types of Ca(2+)-binding sites.

Jost, M, Weber, K, Gerke, V

The annexins are a multigene family of Ca(2+)-dependent phospholipid-binding proteins which contain novel types of Ca2+ sites. Using site-directed mutagenesis, we generated mutant proteins that show...

Functionally distinct serine phosphorylation sites of p36, the cellular substrate of retroviral protein kinase; differential inhibition of reassociation with p11.

Johnsson, N, Nguyen Van, P, Söling, H D, Weber, K

P36 was originally defined as the major cytoplasmic target of retrovirally coded tyrosine-kinases. While recently much has been learned about its biochemistry, the functional importance of its...

Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin.

Obermann, W M, Gautel, M, Weber, K, Fürst, D O

The M band of sarcomeric muscle is a highly complex structure which contributes to the maintenance of the regular lattice of thick filaments. We propose that the spatial coordination of this assembly...

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice.

Harborth, J, Wang, J, Gueth-Hallonet, C, Weber, K, Osborn, M

NuMA is a nuclear matrix protein in interphase and relocates to the spindle poles in mitotis. Different NuMA constructs, in which either N- or C-terminal domains were deleted, and the full-length...

Structural requirements for annexin I-S100C complex-formation.

Seemann, J, Weber, K, Gerke, V

S100C is a member of the S100 family of EF-hand-type Ca(2+)-binding proteins which are thought to bind to and thereby regulate the activity of cellular target proteins in a Ca(2+)-dependent manner....

An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster.

Weber, K, Eisman, R, Morey, L, Patty, A, Sparks, J, Tausek, M, ...

Loci on the third chromosome of Drosophila melanogaster that affect an index of wing shape were mapped, using recombinant isogenic lines, with transposable elements as markers. Many genes with small...

An analysis of polygenes affecting wing shape on chromosome 2 in Drosophila melanogaster.

Weber, K, Eisman, R, Higgins, S, Morey, L, Patty, A, Tausek, M, ...

Genetic effects on an index of wing shape on chromosome 2 of Drosophila melanogaster were mapped using isogenic recombinants with transposable element markers. At least 10 genes with small additive...

A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle.

Weber, K, Wilson, J N, Taylor, L, Brierley, E, Johnson, M A, Turnbull, D M, ...

We have identified a new mutation in mtDNA, involving tRNALeu(CUN) in a patient manifesting an isolated skeletal myopathy. This heteroplasmic A-->G transition at position 12320 affects the T psi C...

Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction.

Domagala, W., Lasota, J., Bartkowiak, J., Weber, K., Osborn, M.

Vimentin expression, growth fractions (GF), and estrogen receptor (ER) levels were determined for 90 untreated primary breast carcinomas. Coexpression of keratin and vimentin was found in...

Vimentin is preferentially expressed in high-grade ductal and medullary, but not in lobular breast carcinomas.

Domagala, W., Woźniak, L., Lasota, J., Weber, K., Osborn, M.

Two hundred sixty-two invasive breast carcinomas dating from 1979 to 1984 were tested for vimentin and keratin on formaldehyde-fixed paraffin-embedded sections. None of 26 lobular carcinomas...

Vimentin expression appears to be associated with poor prognosis in node-negative ductal NOS breast carcinomas.

Domagala, W., Lasota, J., Dukowicz, A., Markiewski, M., Striker, G., Weber, K., ...

Vimentin expression in tumors from 83 node-negative and 112 node-positive patients with infiltrative ductal not otherwise specified (NOS) breast carcinomas has been compared with 5-year survival. For...

Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders

Eherer, A J, Schwetz, I, Hammer, H F, Petnehazy, T, Scheidl, S J, Weber, K, ...

Background and aims: Sildenafil blocks phosphodiesterase type 5 which degrades nitric oxide (NO) stimulated 3`5`-cyclic monophosphate (cGMP), thereby relaxing smooth muscle cells in various organs....

A shared epitope in the acetylcholine receptor-alpha subunit and fast troponin I of skeletal muscle. Is it important for myasthenia gravis?

Osborn, M., Marx, A., Kirchner, T., Tzartos, S. J., Plessman, U., Weber, K.

The monoclonal antibody MAb 155, isolated by Tzartos et al, recognizes the alpha subunit of acetylcholine receptor (AChR) and stains type II skeletal muscle fibers but does not decorate heart muscle....

Nuclear p53 protein accumulates preferentially in medullary and high-grade ductal but rarely in lobular breast carcinomas.

Domagala, W., Harezga, B., Szadowska, A., Markiewski, M., Weber, K., Osborn, M.

Striking differences were found between different histological types of breast cancer when 263 invasive breast carcinomas were tested for nuclear p53 accumulation in formaldehyde-fixed paraffin...

Desmin is a specific marker for rhabdomyosarcomas of human and rat origin.

Altmannsberger, M., Weber, K., Droste, R., Osborn, M.

Putative human rhabdomyosarcoma (RMS) has been divided into two groups according to desmin content. Twenty-five tumors with histologic features consistent with but not necessarily sufficient to prove...

Immunohistochemical localization of neurofilaments and neuron-specific enolase in 29 cases of neuroblastoma.

Osborn, M., Dirk, T., Käser, H., Weber, K., Altmannsberger, M.

Twenty-nine neuroblastomas have been examined with the use of rabbit antibodies specific for each of the three neurofilament polypeptides, with a monoclonal antibody specific for the NF-L...

Villin--a marker of brush border differentiation and cellular origin in human renal cell carcinoma.

Gröne, H. J., Weber, K., Helmchen, U., Osborn, M.

Expression of villin, a 95-kd F-actin bundling and severing protein, is restricted in animal tissues to epithelial cells with a brush border. Thus, the enterocytes of the intestine and epithelial...

Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.

Domagala, W., Striker, G., Szadowska, A., Dukowicz, A., Weber, K., Osborn, M.

Cathepsin D expression was assessed by immunohistochemistry in 59 node-negative and 77 node-positive infiltrative ductal not otherwise specified (NOS) breast carcinomas and compared with overall...

Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney.

Gröne, H. J., Weber, K., Gröne, E., Helmchen, U., Osborn, M.

Most renal cell carcinomas coexpress vimentin and keratin, while renal tubular epithelia express only keratin. Investigation of the intermediate filament composition of tubular epithelia in diseased...

Keratin polypeptides in malignant epithelial liver tumors. Differential diagnostic and histogenetic aspects.

Fischer, H. P., Altmannsberger, M., Weber, K., Osborn, M.

Five monoclonal antibodies recognizing different keratin polypeptides in immunoblotting or different epithelial cell types in complex tissues were studied for their suitability as reagents for the...

Immunohistochemical distinction of human carcinomas by cytokeratin typing with monoclonal antibodies.

Debus, E., Moll, R., Franke, W. W., Weber, K., Osborn, M.

Carcinomas of different origin have been tested in immunofluorescence microscopy with the monoclonal murine antibodies CK1-CK4, which recognize a single cytokeratin polypeptide (human cytokeratin No....

Amino acid metabolism in tennis and its possible influence on the neuroendocrine system.

Strüder, H K, Hollmann, W, Duperly, J, Weber, K

To investigate amino acid metabolism during endurance exercise as well as its influence on plasma prolactin (PRL) we subjected eight nationally ranked tennis players (mean(s.d.) age 25.6(2.8) years,...

Effects of tennis training on lipid metabolism and lipoproteins in recreational players.

Ferrauti, A, Weber, K, Strüder, H K

OBJECTIVE: To investigate the short term effects of tennis training on lipid metabolism and to find out if a typical tennis training programme has positive longitudinal effects on cardiovascular risk...

A hydrostatic weighing method using total lung capacity and a small tank.

Warner, J G, Yeater, R, Sherwood, L, Weber, K

The purpose of this study was to establish the validity and reliability of a hydrostatic weighing method using total lung capacity (measuring vital capacity with a respirometer at the time of...

Individual microtubules viewed by immunofluorescence and electron microscopy in the same PtK2 cell

Osborn, M., Webster, R. E., Weber, K.

PtK2 cells were grown on gold grids and treated with Triton X-100 in a microtubule stabilizing buffer. The resulting cytoskeletons were fixed with glutaraldehyde and subjected to the indirect...

Evidence for rapid structural and functional changes of the melanophore microtubule-organizing center upon pigment movements

Schliwa, M, Euteneuer, U, Herzog, W, Weber, K

Melanophores of the angelfish, pterophyllum scalare, have previously been shown to display approximately 2,400 microtubules in cells wih pigment dispersed; these microtubules radiate from a...

Secretion of E,E-Farnesol and Biofilm Formation in Eight Different Candida Species▿

Weber, K., Sohr, R., Schulz, B., Fleischhacker, M., Ruhnke, M.

Production of E,E-farnesol (FOH) and biofilm formation were studied under various conditions in 56 strains of eight Candida spp. FOH production differed significantly not only between Candida spp....

European erythema migrans disease and related disorders.

Weber, K., Schierz, G., Wilske, B., Preac-Mursic, V.

European erythema migrans disease, lymphocytoma, and acrodermatitis chronica are a group of disorders associated with the bite of ixodid ticks. These disorders are now thought to be due to a single,...

Spatial Price Integration in U.S. and Mexican Rice Markets

Weber, K., Lee, D.

Agricultural trade between the U.S. and Mexico has become progressively liberalized over the past 20 years, with significant increases in bilateral trade in many sectors. The rice sector in both...

Reproducibility of measurements of potential doubling time of tumour cells in the multicentre National Cancer Institute protocol T92-0045

Wilson, G D, Paschoud, N, Pavy, J-J, Weber, K, Weber, P, Dubray, B, ...

We compared the flow cytometric measurement and analysis of the potential doubling time (Tpot) between three centres involved in the National Cancer Institute (NCI) protocol T92-0045. The primary...