M Centlivre, X Zhou, S M Pouw, K Weijer, W Kleibeuker, A T Das, ...
O Ter Brake, N Legrand, M Centlivre, H Spits, K Weijer, ...
Cupedo, T., Crellin, N.K., Papazian, N., Rombouts, E.J., Weijer, K., Grogan, J.L., ...
The human body contains over 500 individual lymph nodes, yet the biology of their formation is poorly understood. Here we identify human lymphoid tissue-inducer cells (LTi cells) as lineage-negative...
Scheeren, F.A., Nagasawa, M., Weijer, K., Cupedo, T., Kirberg, J., Legrand, N., ...
IgM+IgD+CD27+ B cells from peripheral blood have been described as circulating marginal zone B cells. It is still unknown when and where these cells develop. These IgM+IgD +CD27+ B cells exhibit...
Experimental models to study development and function of the human immune system in vivo (2006)
Legrand, N., Weijer, K., Spits, H.
The study of development and function of the immune system in vivo has made intensive use ofanimal models, but performing such work in humans is difflcultfor experimental, practical and ethical...
Legrand, N., Cupedo, T., Lent, A.U. Van, Ebeli, M.J., Weijer, K., Hanke, T., ...
Efficient and quick reconstitution of T-cell compartments in lymphopenic patients is of great importance to prevent opportunistic infections, but remains difficult to achieve. Human T-cell...
Deurholt, T., Bloemendaal, L. Ten, Chhatta, A.A., Weijer, K., Seppen, J., ...
Mature human hepatocytes are not suitable for large-scale in vitro applications that rely on hepatocyte function, due to their limited availability and insufficient proliferation capacity in vitro....
Location of B cell epitopes on the core protein p24 of feline immunodeficency virus. (1995)
Weijer, K., Langedijk, H., Herwijnen, R. Van, Pfauth, A., Siebelink, K., ...
Rimmelzwaan, G.F., Siebelink, K.H.J., Broos, H., Drost, G.A., Weijer, K., Herwijnen, R. Van, ...
In order to monitor the antibody response to feline immunodeficiency virus (FIV) in cats, following experimental and natural infection, enzyme-linked immunosorbent assays (ELISAs) were developed...
Weijer, K., Pfauth, A., Herwijnen, R. Van, Jarrett, O., Meloen, R.H., Tomee, C., ...
The surface glycoprotein, gp70, of feline leukaemia virus (FeLV) contains sites which are important in inducing neutralizing antibodies. Using synthetic peptides corresponding to nucleotide sequence...
Siebelink, K.H.J., Chu, I-H., Rimmelzwaan, G.F., Weijer, K., Bosch, M.L.
Replication-competent molecular clones of feline immunodeficiency virus (FIV) were isolated directly from the DNA of bone marrow cells of a naturally FIV-infected cat. After transfection in a feline...
Siebelink, C.H.J., Chu, I-H., Rimmelzwaan, G.F., Weijer, K., Herwijnen, R. Van, Knell, P., ...
To assess the value of feline immunodeficiency virus (FIV) infection as a model for human immunodeficiency virus (HIV) infection in man, we studied the impairment of certain immunological functions...
Siebelink, C.H.J., Windrich, R.W., Chu, I., Groen, J., Weijer, K., ...
Recently, a newly discovered lentivirus--Feline Immunodeficiency Virus (FIV)--was identified as the cause of an AIDS-like syndrome in the cat. For the detection of FIV antigen in cell culture, an...
Control of feline leukaemia virus. (1989)
Feline leukaemia virus (FeLV) usually occurs in its natural species, the domestic cat. FeLV is also important to human individuals as a comparative model, as it may cause a variety of diseases, some...
Serological responses in cats vaccinated with FeLV ISCOM and an inactivated FeLV vaccine. (1989)
Weijer, K., UytdeHaag, F., Knell, P., Jarrett, O., Morein, B.
Various approaches have been considered for generation of effective and safe vaccines against retroviruses, including HIV, with limited success. In the present vaccination study, encompassing 137...
Syngeneic monoclonal anti-idiotypic antibodies were raised against idiotopes on neutralizing monoclonal antibodies with specificity for feline leukemia virus and canine parvovirus. The anti-idiotypic...
Weijer, K., Herwijnen, R. Van, Siebelink, K., UytdeHaag, F.
The prevalence in the Netherlands and the Free Republic of Germany (FRG) of the newly discovered retrovirus of cats, which causes an immunodeficiency syndrome in this species and is termed feline...
Feline leukemia virus (FeLV) and FeLV-associated diseases in cats: a review (1987)
Feline leukaemia virus (FeLV) usually occurs in its natural species, the domestic cat. FeLV is also important to human individuals as a comparative model, as FeLV may cause a variety of diseases...
Weijer, K., Jarrett, O., Lutz, H.
We have attempted to protect kittens against oronasal infection with FeLV (strain A/Glasgow-1) by treatment with a mixture of two virus-neutralizing (VN) MAbs (IgGl, K) directed against the same...
Weijer, K., UytdeHaag, F., Jarrett, O., Sundquist, B., Morein, B.
An effective candidate subunit vaccine consisting of the gp 70/85 of feline leukemia virus (FeLV) was prepared by using the immunostimulating complex (iscom) method for the presentation of membrane...
Siebelink, K H, Chu, I H, Rimmelzwaan, G F, Weijer, K, Osterhaus, A D, Bosch, M L
Replication-competent molecular clones of feline immunodeficiency virus (FIV) were isolated directly from the DNA of bone marrow cells of a naturally FIV-infected cat. After transfection in a feline...
Eichinger, L, Köppel, B, Noegel, A A, Schleicher, M, Schliwa, M, Weijer, K, ...
To determine the specific contribution of cytoskeletal proteins to cellular viscoelasticity we performed rheological experiments with Dictyostelium discoideum wild-type cells (AX2) and mutant cells...
Siebelink, K H, Chu, I H, Rimmelzwaan, G F, Weijer, K, Osterhaus, A D, Bosch, M L
Replication-competent molecular clones of feline immunodeficiency virus (FIV) were isolated directly from the DNA of bone marrow cells of a naturally FIV-infected cat. After transfection in a feline...
Eichinger, L, Köppel, B, Noegel, A A, Schleicher, M, Schliwa, M, Weijer, K, ...
To determine the specific contribution of cytoskeletal proteins to cellular viscoelasticity we performed rheological experiments with Dictyostelium discoideum wild-type cells (AX2) and mutant cells...
Weimar, I S, Weijer, K, Muller, E J, Miranda, N, Bakker, A Q, ...
The MET protooncogene, c-MET, encodes a cell surface tyrosine kinase receptor. The ligand for c-MET is hepatocyte growth factor (HGF), also known as scatter factor (SF), which is known to affect...