K. Yoshida

Publication List Details

Period

1967 - 9999

Number

462

Co-Authors

Winding of Optical Fiber Cable onto Existing Ground Wire, (9999)

Yoshida,K., Ikeya,T., Kamata,Y., Miyajima,Y.

A compact optical fiber cable with 4mm outer diameter and 25kg/km weight has been developed and wounded around existing ground wire using currently developed automatic winding machine. Suitable...

Relationship Between Sediment Pollution and Macrobenthic Communities in Hiroshima Bay, Japan, (9999)

Yoshida, K.

Distribution of sediment, macrobenthos, and the anoxic water mass in Hiroshima Bay was investigated. The accumulation of organic matter in the sediment was considerable in the semi-closed bays, such...

Sustainable society based on diverse family structure : Future Society In Japan Compared to Foreign Countries (2009)

Yoshida, K., Motoyama, C., Shigematsu, H., Otsuji, T.

Grand Prix Award in the following 3 categories, Breakthrough Research: Technological Innovation, Social Change, Breakthrough Research: Education, Communication, and Breakthrough Research: Human...

Matrix Model and beta-deformed N=4 SYM (2009)

Rossi, G. C., Siccardi, M., Stanev, Ya. S., Yoshida, K.

This work is the result of the ideas developed by Ken Yoshida about the possibility of extending the range of applications of the matrix model approach to the computation of the holomorphic...

Spectroscopy of 32Ne and the Island of Inversion (2009)

Doornenbal, P., Scheit, H., Aoi, N., Takeuchi, S., Li, K., Takeshita, E., ...

We report on the first spectroscopic study of the N=22 nucleus 32Ne at the newly completed RIKEN Radioactive Ion Beam Factory. A single gamma-ray line with an energy of 722(9) keV was observed in...

Time-of-flight observation of electron swarm in methane (2009)

Hasegawa, H., Date, H., Yoshida, K., Shimozuma, M.

This paper reports on the evolution of an isolated electron swarm, which is experimentally observed as spatial distributions at every moment. This observation is assumed to directly correspond to the...

Production of Neutron-Rich Lambda Hypernuclei at J-PARC (2009)

Sakaguchi, A., Ajimura, S., Bhang, H., Busso, L., Endo, M., Faso, D., ...

We discuss the usefulness of the double charge-exchange reactions (DCX) for the production of the neutron-rich Lambda-hypernuclei. We believe the (pi-,K+) reaction is one of the most promising DCX...

ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC) (2009)

Witta, S. E., Dziadziuszko, R., Yoshida, K., Hedman, K., Varella-Garcia, M., Bunn, P. A., ...

Background: Epidermal growth factor receptor (EGFR) inhibitors are effective in a subset of patients with non-small-cell lung cancer (NSCLC). We previously showed that E-cadherin expression...

Fabrication of graphene nanoribbon by local anodic oxidation lithography using atomic force microscope (2008)

Masubuchi, S., Ono, M., Yoshida, K., Hirakawa, K., Machida, T.

We conducted local anodic oxidation (LAO) lithography in single-layer, bilayer, and multilayer graphene using tapping-mode atomic force microscope. The width of insulating oxidized area depends...

High-energy electron observations by PPB-BETS flight in Antarctica (2008)

Torii, S., Yamagami, T., Tamura, T., Yoshida, K., Kitamura, H., Anraku, K., ...

We have observed cosmic-ray electrons from 10 GeV to 800 GeV by a long duration balloon flight using Polar Patrol Balloon (PPB) in Antarctica. The observation was carried out for 13 days at an...

Impedance Matching Circuit for Wireless Transceiver Amplifier Based on Transmission Line Theory (2008)

H. Kanaya, F. Koga, K. Seki, K. Yoshida

Abstract—This paper presents a new design theory of impedance matching circuits for single-chip SiGe BiCMOS low noise amplifier (LNA), power amplifier (PA) and T/R switch for 5GHz-band wireless LAN...

Electrically driven single electron spin resonance in a slanting Zeeman field (2008)

Pioro-Ladriere, M., Obata, T., Tokura, Y., Kubo, T., Yoshida, K., ...

The rapidly rising fields of spintronics and quantum information science have led to a strong interest in developing the ability to coherently manipulate electron spins. Electron spin resonance (ESR)...

Multichannel thin-film electrode for intramuscular electromyographic recordings (2008)

Farina, D., Yoshida, K., Stieglitz, T., Koch, K.P.

It is currently not possible to record electromyographic (EMG) signals from many locations concurrently inside the muscle in a single wire electrode system. We developed a thin-film wire electrode...

Identification of new isotopes $^{125}$Pd and $^{126}$Pd produced by in-flight fission of 345 MeV/nucleon $^{238}$U: first results from the RIKEN RI beam factory (2008)

Ohnishi, T., Kubo, T., Kusaka, K., Yoshida, A., Yoshida, K., Fukuda, N., ...

A search for new isotopes using in-flight fission of a 345 MeV/nucleon $^{238}$U beam has been carried out in the commissioning experiment of the next-generation in-flight radioactive beam separator...

Identification of new isotopes $^{125}$Pd and $^{126}$Pd produced by in-flight fission of 345 MeV/nucleon $^{238}$U: first results from the RIKEN RI beam factory (2008)

Ohnishi, T., Kubo, T., Kusaka, K., Yoshida, A., Yoshida, K., Fukuda, N., ...

A search for new isotopes using in-flight fission of a 345 MeV/nucleon $^{238}$U beam has been carried out in the commissioning experiment of the next-generation in-flight radioactive beam separator...

Identification of new isotopes $^{125}$Pd and $^{126}$Pd produced by in-flight fission of 345 MeV/nucleon $^{238}$U: first results from the RIKEN RI beam factory (2008)

Ohnishi, T., Kubo, T., Kusaka, K., Yoshida, A., Yoshida, K., Fukuda, N., ...

A search for new isotopes using in-flight fission of a 345 MeV/nucleon $^{238}$U beam has been carried out in the commissioning experiment of the next-generation in-flight radioactive beam separator...

On the use of longitudinal intrafascicular peripheral interfaces for the control of cybernetic hand prostheses in amputees (2008)

Micera, S., Navarro, X., Carpaneto, J., Citi, L., Tonet, O., Rossini, P.M., ...

Significant strides have been recently made to develop highly sensorized cybernetic prostheses aimed at restoring sensorimotor limb functions to those who have lost them because of a traumatic event...

JT-60SA toroidal field magnet system. (2008)

Pizzuto, A., Semeraro, L., Zani, L., Bayetti, P., Cucchiaro, A., Decool, P., ...

IEEE Transactions on Applied Superconductivity, 18(2008) S.505-08

Performance of the prototype detector for the LHCf experiment (2007)

Sako, T., Adriani, O., Bonechi, L., Bongi, M., Faus, Ángeles, Haguenauer, M., ...

14 pages, 11 figures.-- PACS nrs.: 13.85.Tp; 95.30.Cq; 95.55.Vj; 95.85.Ry.-- ISI Article Identifier: 000248784500012

N=1* model superpotential revisited (IR behaviour of N=4 limit) (2007)

Arnone, S., Di Segni, G., Siccardi, M., Yoshida, K.

The one-loop contribution to the superpotential, in particular the Veneziano-Yankielowicz potential in N=1 supersymmetric Yang-Mills model is discussed from an elementary field theory method and the...

Search for low lying dipole strength in the neutron rich nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Coulomb excitation of the exotic neutron-rich nucleus $^{26}$Ne on a $^{nat}$Pb target was measured at 58 A.MeV in order to search for low-lying E1 strength above the neutron emission threshold. Data...

LHCf: A LHC detector for astroparticle physics (2007)

D'Alessandro, Raffaello, Adriani, O., Bonechi, L., Bongi, M., Papini, P., Castellini, G., ...

10 pages, 10 figures.-- PACS nrs.: 13.85.Tp, 13.85.Ni, 13.85.Qk.-- ISI Article Identifier: 000245672900017.-- Presented at the "Physics at LHC" Conference, Kraków, Poland, July 3–8, 2006.

Measurement of the B(E2, $0^+_1 \rightarrow 2^+_1$) in the N = 16 nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Differential cross section of the inelastic scattering of a 54 MeV/u 26Ne beam on a lead target has been measured by detecting the de-excitation $\gamma$-rays. Analysis of the first 2+ state angular...

Search for low lying dipole strength in the neutron rich nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Coulomb excitation of the exotic neutron-rich nucleus $^{26}$Ne on a $^{nat}$Pb target was measured at 58 A.MeV in order to search for low-lying E1 strength above the neutron emission threshold. Data...

Assessment of biocompatibility of chronically implanted polyimide and platinum intrafascicular electrodes (2007)

Lago, N., Yoshida, K., Koch, K.P., Navarro, X.

Longitudinal intrafascicular electrodes (LIFEs) are electrodes designed to be placed inside the peripheral nerve to improve stimulation selectivity and to increase the recording signal-to-noise...

Shape memory alloy microactuation of tf-LIFEs: Preliminary results (2007)

Bossi, S., Menciassi, A., Koch, K.P., Yoshida, K., Dario, P., ...

In this paper, a new approach aimed at improving the performance of intraneural longitudinal interfaces (tf-LIFEs) with the peripheral nervous system (PNS) is presented. Our goal is to develop a...

Measurement of the B(E2, $0^+_1 \rightarrow 2^+_1$) in the N = 16 nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Differential cross section of the inelastic scattering of a 54 MeV/u 26Ne beam on a lead target has been measured by detecting the de-excitation $\gamma$-rays. Analysis of the first 2+ state angular...

Search for low lying dipole strength in the neutron rich nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Coulomb excitation of the exotic neutron-rich nucleus $^{26}$Ne on a $^{nat}$Pb target was measured at 58 A.MeV in order to search for low-lying E1 strength above the neutron emission threshold. Data...

Measurement of the B(E2, $0^+_1 \rightarrow 2^+_1$) in the N = 16 nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Differential cross section of the inelastic scattering of a 54 MeV/u 26Ne beam on a lead target has been measured by detecting the de-excitation $\gamma$-rays. Analysis of the first 2+ state angular...

Search for low lying dipole strength in the neutron rich nucleus $^{26}$Ne (2007)

Gibelin, J., Beaumel, D., Motobayashi, T., Aoi, N., Baba, H., Blumenfeld, Y., ...

Coulomb excitation of the exotic neutron-rich nucleus $^{26}$Ne on a $^{nat}$Pb target was measured at 58 A.MeV in order to search for low-lying E1 strength above the neutron emission threshold. Data...

JT-60SA toroidal field magnet system. (2007)

Pizzuto, A., Bayetti, P., Cucchiaro, A., Decool, P., Della Corte, A., Di Zenobio, A., ...

20th Bi-Annual Conf.on Magnet Technology (MT-20), Philadelphia, Pa., August 27- 31, 2007

Cosmic-ray spectra of primary protons and high altitude muons deconvolved from observed atmospheric gamma rays (2006)

Yoshida, K., Ohmori, R., Kobayashi, T., Komori, Y., Sato, Y., Nishimura, J.

We have observed atmospheric gamma rays from 30GeV to 8TeV, using emulsion chambers at balloon altitudes, accumulating the largest total exposure in this energy range to date, SOT ~ 6.66m^2.sr.day....

Increased expression of mucinous glycoprotein KL-6 in human pterygium (2006)

Kase, S., Kitaichi, N., Furudate, N., Yoshida, K.

Pterygia represent growth onto the cornea of fibrovascular tissue continuous with the conjunctiva.1 KL-6 (Krebs von den Lunge-6) is a high molecular weight mucinous glycoprotein, and the monoclonal...

Increased expression of mucinous glycoprotein KL-6 in human pterygium. (2006)

Kase, S., Kitaichi, N., Furudate, N., Yoshida, K.

Pterygia represent growth onto the cornea of fibrovascular tissue continuous with the conjunctiva.1 KL-6 (Krebs von den Lunge-6) is a high molecular weight mucinous glycoprotein, and the monoclonal...

Increased expression of mucinous glycoprotein KL-6 in human pterygium. (2006)

Kase, S., Kitaichi, N., Furudate, N., Yoshida, K.

Pterygia represent growth onto the cornea of fibrovascular tissue continuous with the conjunctiva.1 KL-6 (Krebs von den Lunge-6) is a high molecular weight mucinous glycoprotein, and the monoclonal...

Measurement of the spin and magnetic moment of 23Al (2006)

Ozawa, A., Matsuta, K., Nagatomo, T., Mihara, M., Yamada, K., Yamaguchi, T., ...

For the first time, we obtained the g factor for the ground state of 23Al by use of a -NMR measurement. 23Al has a small proton separation energy and is a potential proton-halo candidate. The...

Pairing and continuum effects on low-frequency quadrupole vibrations in deformed Mg isotopes close to the neutron drip line (2006)

Yoshida, K., Yamagami, M., Matsuyanagi, K.

Low-frequency quadrupole vibrational modes in deformed $^{36,38,40}$Mg close to the neutron drip line are studied by means of the quasiparticle-random-phase approximation based on the...

Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer (2006)

Aung, P. P., Oue, N., Mitani, Y., Nakayama, H., Yoshida, K., Noguchi, T., ...

Gastric cancer (GC) is one of the most common malignancies worldwide. Genes expressed only in cancer tissue will be useful molecular markers for diagnosis and may also be good therapeutic targets....

Expression of glutamine synthetase and cell proliferation in human idiopathic epiretinal membrane (2006)

Kase, S, Saito, W, Yokoi, M, Yoshida, K, Furudate, N, Muramatsu, M, ...

Background/aim: The mechanisms of the cellular origin and cell proliferation in the idiopathic epiretinal membrane (ERM) are unsolved. The aim of this study was to examine the expression of cell...

Expression of glutamine synthetase and cell proliferation in human idiopathic epiretinal membrane (2006)

Kase, S, Saito, W, Yokoi, M, Yoshida, K, Furudate, N, Muramatsu, M, ...

Background/aim: The mechanisms of the cellular origin and cell proliferation in the idiopathic epiretinal membrane (ERM) are unsolved. The aim of this study was to examine the expression of cell...

Expression of glutamine synthetase and cell proliferation in human idiopathic epiretinal membrane (2006)

Kase, S, Saito, W, Yokoi, M, Yoshida, K, Furudate, N, Muramatsu, M, ...

Background/aim: The mechanisms of the cellular origin and cell proliferation in the idiopathic epiretinal membrane (ERM) are unsolved. The aim of this study was to examine the expression of cell...

Experimental study of positron production from a 2.55-mm-thick silicon crystal target using 8-GeV channeling electron beams with high-bunch charges (2006)

Suwada, T., Furukawa, K., Kamitania, T., Satoh, M., Sugimura, T., Umemori, K., ...

We have investigated quenching phenomena of channeling radiation through positron production from a silicon crystal hit by a single-bunch electron beam with high-bunch charge at the 8-GeV...

Experimental study of positron production from a 2.55-mm-thick silicon crystal target using 8-GeV channeling electron beams with high-bunch charges (2006)

Suwada, T., Furukawa, K., Kamitania, T., Satoh, M., Sugimura, T., Umemori, K., ...

We have investigated quenching phenomena of channeling radiation through positron production from a silicon crystal hit by a single-bunch electron beam with high-bunch charge at the 8-GeV...

Determination of strontium segregation in modified hypoeutectic Al-Si alloy by micro X-ray fluorescence analysis (2006)

Nogita, K, Yasuda, H, Yoshida, K, Uesugi, K, Takeuchi, A, Suzuki, Y, ...

Analysis of intra- and inter-phase distribution of modifying elements in aluminium-silicon alloys is difficult due to the low concentrations used. This research utilises a mu-XRF (X-ray fluorescence)...

Experimental study of positron production from a 2.55-mm-thick silicon crystal target using 8-GeV channeling electron beams with high-bunch charges (2006)

Suwada, T., Furukawa, K., Kamitania, T., Satoh, M., Sugimura, T., Umemori, K., ...

We have investigated quenching phenomena of channeling radiation through positron production from a silicon crystal hit by a single-bunch electron beam with high-bunch charge at the 8-GeV...

Determination of strontium segregation in modified hypoeutectic Al-Si alloy by micro X-ray fluorescence analysis (2006)

Nogita, K, Yasuda, H, Yoshida, K, Uesugi, K, Takeuchi, A, Suzuki, Y, ...

Analysis of intra- and inter-phase distribution of modifying elements in aluminium-silicon alloys is difficult due to the low concentrations used. This research utilises a mu-XRF (X-ray fluorescence)...

A preliminary study of the sedimentary petrography of coarse clastic deposits in the Da Nang-Khe Sanh shear zone, central Vietnam(Geology) (2005)

Yoshida, K, Sugawara, M

The ductile deformation belt in the Da Nang-Khe Sanh shear zone is the one of the NW-trending fault zone developing in the central Vietnam. This belt mainly comprises undeformed Jurassic sedimentary...

Measurement of the Xi-p Scattering Cross Sections at Low Energy (2005)

Ahn, J. K., Aoki, S., Chung, K. S., Chung, M. S., Enyo, H., Fukuda, T., ...

In this paper we report cross-section measurements for $\Xi^-p$ elastic and inelastic scatterings at low energy using a scintillating fiber active target. Upper limit on the total cross-section for...

Isolation of Bovine Arboviruses from Culicoides Biting Midges (Diptera: Ceratopogonidae) in Southern Japan: 1985–2002 (2005)

T. Yanase, T. Kato, T. Kubo, K. Yoshida, S. Ohashi, M. Yamakawa, ...

In 1985–2002, surveillance for bovine arboviruses was conducted in Kagoshima, located in the most southern part of the main islands of Japan and known to be an area where bovine arboviral diseases...

Excited states in neutron rich boron isotopes (2005)

Kanungo, R., Elekes, Z., Baba, H., Dombrádi, Zs., Fülöp, Zs., Gibelin, J., ...

New experimental results on in-beam gamma spectroscopy of neutron rich boron isotopes are presented for 17B and its neutron removal fragments 14,15B, after scattering with a H2 target. A gamma...

Search for an isomeric state in $^{19}$C (2005)

Kanungo, R., Elekes, Z., Baba, H., Dombrádi, Zs., Fülö, Zs., Gibelin, J., ...

A search for an isomeric state in the neutron-rich nucleus $^{19}$C is reported. The existence of an isomer in the nucleus is predicted by shell model calculations which also predicts the...

Low-lying excited states in $^{17,19}$C (2005)

Elekes, Z., Dombrádi, Zs., Kanungo, R., Baba, H., Fülöp, Zs., Gibelin, J., ...

$^{17,19}$C nuclei have been investigated by proton inelastic scattering on a liquid hydrogen target at intermediate energies. Two peaks were observed in the Doppler-corrected $\gamma$-ray spectra...

Excited states in neutron rich boron isotopes (2005)

Kanungo, R., Elekes, Z., Baba, H., Dombrádi, Zs., Fülöp, Zs., Gibelin, J., ...

New experimental results on in-beam gamma spectroscopy of neutron rich boron isotopes are presented for 17B and its neutron removal fragments 14,15B, after scattering with a H2 target. A gamma...

Search for an isomeric state in $^{19}$C (2005)

Kanungo, R., Elekes, Z., Baba, H., Dombrádi, Zs., Fülö, Zs., Gibelin, J., ...

A search for an isomeric state in the neutron-rich nucleus $^{19}$C is reported. The existence of an isomer in the nucleus is predicted by shell model calculations which also predicts the...

Low-lying excited states in $^{17,19}$C (2005)

Elekes, Z., Dombrádi, Zs., Kanungo, R., Baba, H., Fülöp, Zs., Gibelin, J., ...

$^{17,19}$C nuclei have been investigated by proton inelastic scattering on a liquid hydrogen target at intermediate energies. Two peaks were observed in the Doppler-corrected $\gamma$-ray spectra...

Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay (2005)

Darakhshan, F., Badie, C., Moody, J., Coster, M., Finnon, R., Finnon, P., ...

The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse...

Postnatal depression across countries and cultures : a qualitative study (2004)

Oates, M. R., Cox, J. L., Neema, S., Asten, P., Glangeaud-Freudenthal, N., Figueiredo, Bárbara, ...

Background: Postnatal depression seems to be a universal condition with similar rates in different countries. However, anthropologists question the cross-cultural equivalence of depression,...

DEVELOPMENT OF A KNOWLEDGE BASED SYSTEM LINKED TO A MATERIALS DATABASE (2004)

Y Kaji, H Tsuji, M Fujita, Y Xu, K Yoshida, S Mashiko, ...

The distributed materials database system named ‘Data-Free-Way ’ has been developed by four

The Most Likely Sources of High Energy Cosmic-Ray Electrons in Supernova Remnants (2003)

Kobayashi, T., Komori, Y., Yoshida, K., Nishimura, J.

Evidences of non-thermal X-ray emission and TeV gamma-rays from the supernova remnants (SNRs) has strengthened the hypothesis that primary Galactic cosmic-ray electrons are accelerated in SNRs. High...

Scanning tunneling spectroscopic studies of the pairing state of cuprate superconductors (2003)

Vasquez, R. P., Jung, C. U., Yoshida, K., ...

Quasiparticle tunneling spectra of both hole-doped (p-type) and electron-doped (n-type) cuprates are studied using a low-temperature scanning tunneling microscope. The results reveal that neither the...

Measurement of Intrafascicular Insertion Force of a Tungsten Needle into Peripheral Nerve (2003)

Jensen, W., Yoshida, K., Malina, T., Hofmann, U.

Microfabricated silicon array structures, such as those being developed by the VSAMUEL consortium may one day provide inexpensive yet highly selective chronically implanted interfaces to the...

Detecting Skin Burns Induced by Surface Electrodes (2003)

Patriciu, A., Yoshida, K., DeMonte, T. P., Joy, M. L.

The origin of electrical burns under gel-type surface electrodes is a controversial topic that is not well understood. To investigate the phenomenon, we have developed an excised porcine skin+gel...

On the IR/UV mixing and experimental limits on the parameters of canonical noncommutative spacetimes (2002)

Amelino-Camelia, G, Mandanici, G, Yoshida, K

We investigate some issues that are relevant for the derivation of experimental limits on the parameters of canonical noncommutative spacetimes. By analyzing a simple Wess-Zumino-type model in...

Scanning Tunneling Spectroscopic Studies of Cuprate Superconductors (2002)

Vasquez, R. P., Jung, C. U., Yoshida, K., ...

Quasiparticle tunneling spectra of both hole-doped (p-type) and electron-doped (n-type) cuprates are studied using a low-temperature scanning tunneling microscope. The results reveal that neither the...

Atmospheric gamma-ray observation with the BETS detectorfor calibrating atmospheric neutrino flux calculations (2002)

Kasahara, K., Mochizuki, E., Torii, S., Tamura, T., Tateyama, N., Yoshida, K., ...

We observed atmospheric gamma-rays around 10 GeV at balloon altitudes (15~25 km) and at a mountain (2770 m a.s.l). The observed results were compared with Monte Carlo calculations to find that an...

Cyclic changes of granulocyte colony-stimulating factor (G-CSF) mRNA in the human follicle during the normal menstrual cycle and immunolocalization of G-CSF protein (2002)

Yanagi, K., Makinoda, S., Fujii, R., Miyazaki, S., Fujita, S., Tomizawa, H., ...

BACKGROUND: Ovulation has several similarities with inflammation and is closely connected to the activity of leukocytes and inflammatory cytokines. Since granulocytes are one of the major leukocytes,...

Spatial homogeneity and doping dependence of quasiparticle tunneling spectra in cuprate superconductors (2001)

Hammerl, G., Mannhart, J., Tajima, S., Yoshida, K., ...

Scanning tunneling spectroscopy (STS) studies reveal long-range (similar to 100 nm) spatial homogeneity in optimally and underdoped superconducting YBa2Cu3O7-delta (YBCO) single crystals and thin...

Exact renormalization group equation in presence of rescaling anomaly II - The local potential approximation (2001)

Arnone, S., Francia, D., Yoshida, K.

Exact renormalization group techniques are applied to mass deformed N=4 supersymmetric Yang-Mills theory, viewed as a regularised N=2 model. The solution of the flow equation, in the local potential...

Relativistic Electron Facility for Education and Research at Hiroshima University (2001)

Ohgaki, T., Endo, I., Andreyashikin, M., Chouffani, K., Goto, K., Masuda, S., ...

The Relativistic Electron Facility for Education and Research (REFER) at Hiroshima University accepts a 150 MeV electron beam from a microtron, the injector to the 700 MeV storage ring of the...

Evidence of doping-dependent pairing symmetry in cuprate superconductors (2001)

Hammerl, G., Mannhart, J., Schmehl, A., Schneider, C. W., ...

Scanning tunneling spectroscopy studies reveal long-range spatial homogeneity and predominantly d(x2)-(y2)-pairing spectral characteristics in under- and optimally doped YBa2Cu3O7-delta...

Evidence of Doping-Dependent Pairing Symmetry in Cuprate Superconductors (2001)

Hammerl, G., Mannhart, J., Schmehl, A., Schneider, C. W., ...

Scanning tunneling spectroscopy (STS) studies reveal long-range spatial homogeneity and predominantly $d_{x^2-y^2}$-pairing spectral characteristics in under- and optimally doped $\rm...

Spatial homogeneity and doping dependence of quasiparticle tunneling spectra in cuprate superconductors (2001)

Hammerl, G., Mannhart, J., Tajima, S., Yoshida, K., ...

Scanning tunneling spectroscopy (STS) studies reveal long-range (~100 nm) spatial homogeneity in optimally and underdoped superconducting YBa_2Cu_3O_{7-\delta} (YBCO) single crystals and thin films,...

Coronary flow reserve in angiographically normal coronary arteries with one-vessel coronary artery disease without traditional risk factors (2001)

Fujiwara, M, Tamura, T, Yoshida, K, Nakagawa, K, Nakao, M, Yamanouchi, M, ...

Aims Reduced coronary flow reserve has been reported in patients with traditional risk factors, in particular hyperlipidaemia, despite angiographically normal coronary arteries. However, it is...

Applications of Exact Renormalization Group techniques to the non-perturbative study of supersymmetric gauge field theory (2000)

Arnone, S., Chiantese, S., Yoshida, K.

Exact Renormalization Group techniques are applied to supersymmetric models in order to get some insights into the low energy effective actions of such theories. Starting from the ultra-violet finite...

Angle-resolved photoemission study of insulating and metallic Cu-O chains in PrBa$_2$Cu$_3$O$_7$ and PrBa$_2$Cu$_4$O$_8$ (2000)

Mizokawa, T., Kim, C., Ino, A., Yoshida, T., Fujimori, A., ...

We compare the angle-resolved photoemission spectra of the hole-doped Cu-O chains in PrBa$_2$Cu$_3$O$_7$ (Pr123) and in PrBa$_2$Cu$_4$O$_8$ (Pr124). While, in Pr123, a dispersive feature from the...

Barrier penetration and rotational damping of thermally excited superdeformed nuclei (2000)

Yoshida, K., Matsuo, M., Shimizu, Y. R.

We construct a microscopic model of thermally excited superdeformed states that describes both the barrier penetration mechanism, leading to the decay-out transitions to normal deformed states, and...

Theoretical study of the decay-out spin of superdeformed bands in the Dy and Hg regions (2000)

Shimizu, Y. R., Matsuo, M., Yoshida, K.

Decay of the superdeformed bands have been studied mainly concentrating upon the decay-out spin, which is sensitive to the tunneling probability between the super- and normal-deformed wells. Although...

On the behaviour of solutions to discrete time Lotka-Volterra equation (2000)

Narita, Y., Saito, S., Saitoh, N., Yoshida, K.

The time evolution of a class of completely integrable discrete Lotka-Volterra s ystem is shown not unique but have two different ways chosen randomly at every s tep of generation. This uncertainty...

U_A(1) Symmetry Breaking and eta, eta prime mesons in the Bethe-Salpeter Approach (1999)

Naito, K., Nemoto, Y., Takizawa, M., Yoshida, K., Oka, M.

U_A(1) symmetry breaking is studied by introducing the flavor mixing interaction proposed by Kobayashi, Maskawa and 't Hooft. Combining the one gluon exchange interaction, the rainbow like...

Angle-resolved photoemission study of untwinned PrBa$_2$Cu$_3$O$_7$: undoped CuO$_2$ plane and doped CuO$_3$ chain (1999)

Mizokawa, T., Kim, C., Ino, A., Fujimori, A., Goto, M., ...

We have performed an angle-resolved photoemission study on untwinned PrBa$_2$Cu$_3$O$_7$, which has low resistivity but does not show superconductivity. We have observed a dispersive feature with a...

Finite Quark Mass Effects in the Improved Ladder Bethe-Salpeter Amplitudes (1998)

Naito, K., Yoshida, K., Nemoto, Y., Oka, M., Takizawa, M.

We study the finite quark mass effects of the low-energy QCD using the improved ladder Schwinger-Dyson and Bethe-Salpeter equations which are derived in the manner consistent with the vector and...

Exact renormalization group equation in presence of rescaling anomaly (1998)

Arnone, S., Fusi, C., Yoshida, K.

Wilson's approach to renormalization group is reanalyzed for supersymmetric Yang-Mills theory. Usual demonstration of exact renormalization group equation must be modified due to the presence of the...

Effect of Inhibitor on SCC of A533B CL.1 and Sensitized Type 304 Stainless Steels in Pressurized High-Temperature Waters. (1998)

Shoji, T., Yoshida, K.

Effects of n-hexylamine acting as an inhibitor in stress corrosion cracking in pressurized high-temperature waters have been investigated with and without n-hexylamine at a strain rate of 0.0000021...

Corrosion Potential Measurements on Type 304 SS and Alloy 182 in Simulated BWR Environments. (1998)

Macdonald, D. D., Song, H., Makela, K., Yoshida, K.

The effects of dissolved oxygen, hydrogen, and hydrogen peroxide on the corrosion (electrochemical) potentials (ECPs) of type 304 SS and alloy 182 in simulated boiling water reactor (BWR) coolant...

The Charpy Impact Test as an Evaluation of 4 K Fracture Toughness. (1998)

Nakajima, H., Yoshida, K., Tsuji, H., Tobler, R. L., Hwang, I. S.

A 4 K Charpy test is defined as a Charpy test in which the initial temperature of a specimen is 4 K. Two methods, a glass Dewar method and a flow method, are compared in this study to demonstrate...

Pressure-Pulsed CVI of SiC Into 2D-TYRANNO/C Preforms. (1998)

Sugiyama, K., Yoshida, K.

Preforms of two-dimensional Tyranno fiber of 7x20x1.3 mm were infiltrated with SiC in the temperature range of 850-1050 C and with pressure pulse between below 2 Tor and 760 Torr using a gas mixture...

Investigation of Bulk Laser Damage Threshold of Lithium Niobate Single Crystals by Q-Switched Pulse Laser. (1998)

Furukawa, Y., Yokotani, A., Sasaki, T., Yoshida, H., Yoshida, K.

A Q-switched Nd(3+):LiYF(4) laser has been used to measure the bulk laser damage threshold of 2-in.-diam. MgO-doped LiNbOsub3 crystals grown using the Czochralski technique. Dependence on the crystal...

Dependence of Damage Threshold of Anti-Reflection Coatings on Substrate Surface Roughness. (1998)

Nose, Y., Kato, Y., Yoshida, K., Yamanaka, C.

Geometrical shapes of the damage sites in the 5-layer anti-reflection (AR) coatings generated by 1 micron laser irradiation have been accurately determined. Deep damage and shallow damage are the two...

Super-Polished Single Crystal Molybdenum Mirror for XUV Gamma X-Ray Radiation. (1998)

Yoshida, K., Takeuchi, K., Kato, Y., Fujiwara, E., Yamanaka, C.

A new polishing technique has been used to polish a high quality single crystal molybdenum (Mo) fabricated by secondary recrystallization method. This super-polished single crystal Mo has been used...

Laser Induced Mo Mirror Damage for High Power CO(2) Laser. (1998)

Okamoto, H., Matsusue, N., Kityazima, K., Yoshida, K., Ichikawa, Y.

We have developed a high-purity molybdenum (Mo) mirror by electron-beam melting method (e.b.m. Mo mirror). Its high laser-damage threshold has been demonstrated for the high-power TEA CO2 laser...

Highly Damage Resistant Porous Dielectric Coating for High Power Lasers in the Ultraviolet to Near-Infrared Wavelength Region. (1998)

Yoshida, K., Yoshida, H., Kato, Y., Yamanaka, C.

Mechanically hard and broadband gradient refractive index antireflection coating was developed. It has a high damage threshold in the visible to near-infrared region. It will be applicable to high...

Dependence of Damage Threshold of Anti-Reflection Coatings on Substrate Surface Roughness. (1998)

Nose, Y., Kato, Y., Yoshida, K., Yamanaka, C.

Geometrical shapes of the damage sites in the 5-layer SiO2/ZrO2 anti-reflection (AR) coatings generated by 1 micron laser irradiation have been accurately determined. The damages can be classified...

Microscopic Structure of Rotational Damping (1998)

Matsuo, M., Yoshida, K., Døssing, T., Vigezzi, E., Broglia, R. A.

The damping of collective rotational motion is studied microscopically, making use of shell model calculations based on the cranked Nilsson deformed mean-field and on residual two-body interactions,...

Longitudinal and Transverse Spin Responses in Relativistic Many Body Theory (1998)

Yoshida, K., Toki, H.

Spin longitudinal and transverse response function are studied by means of the relativistic many-body theory. The spin response functions in the relativistic theory are largely reduced from those in...

Dynamical Chiral Symmetry Breaking in Effective Models of QCD in the Bethe-Salpeter Approach (1998)

Naito, K., Yoshida, K., Nemoto, Y., Oka, M., Takizawa, M.

Dynamical breaking of chiral symmetry in effective models of QCD is studied. Introducing a cut-off function or a non-local interaction, the Noether current must be modified and thus the...

Shell Effects on Rotational Damping in Superdeformed Nuclei (1998)

Yoshida, K., Matsuo, M.

Damping of rotational motion in superdeformed Hg and Dy-region nuclei is studied by means of cranked shell model diagonalization. It is shown that a shell oscillation in single-particle alignments...

Angular momentum dependence of the prescission time of medium mass hot nuclei (1998)

Yuasa Nakagawa, K., Nakagawa, T., Furutaka, K., Matsuda, K., Futami, Y., Yoshida, K., ...

We have deduced the prescission time of hot nuclei as a function of the angular momentum from the light charged particle- and gamma ray-multiplicities measured simultaneously in coincidence with...

Angular momentum dependence of the prescission time of medium mass hot nuclei (1998)

Yuasa Nakagawa, K., Nakagawa, T., Furutaka, K., Matsuda, K., Futami, Y., Yoshida, K., ...

We have deduced the prescission time of hot nuclei as a function of the angular momentum from the light charged particle- and gamma ray-multiplicities measured simultaneously in coincidence with...

Complete nose coverage to prevent airborne contamination via nostrils is unnecessary (1997)

Yoshida, K, Papaioannou, W, Bollen, C M

Besides an atraumatic procedure, aseptic techniques during surgery have been suggested to have a positive impact on the predictability of osseointegration. To avoid an infection of the surgical...

Simple Photoelectric Absorption during Dipping in the ASCA Observation of XB1916-053 (1997)

Church, M. J., Dotani, T., Balucinska-Church, M., Mitsuda, K., Takahashi, T., Inoue, H., ...

We report results of analysis of the ASCA observation of the Low Mass X-ray Binary dipping source XB1916-053 made on 1993, May 2nd. We have shown that the spectra can be well fitted by the same...

Three-dimensional deposition of TiN film using low frequency (50 Hz) plasma chemical vapor deposition (1997)

Shimozuma, M., Date, H., Iwasaki, T., Tagashira, H., Yoshino, M., Yoshida, K., ...

本編とその訂正箇所(Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, 1997.Nov, 15(6), p3170に掲載)

Three-dimensional deposition of TiN film using low frequency (50 Hz) plasma chemical vapor deposition (1997)

Shimozuma, M., Date, H., Iwasaki, T., Tagashira, H., Yoshino, M., Yoshida, K.

Titanium nitride (TiN) films have been deposited on three-dimensional substrates by low frequency (50 Hz) plasma chemical vapor deposition method using a TiCl4 + N2 + H2 mixture at a substrate...

Three-dimensional deposition of TiN film using low frequency (50 Hz) plasma chemical vapor deposition (1997)

Shimozuma, M., Date, H., Iwasaki, T., Tagashira, H., Yoshino, M., Yoshida, K.

Titanium nitride (TiN) films have been deposited on three-dimensional substrates by low frequency (50 Hz) plasma chemical vapor deposition method using a TiCl4 + N2 + H2 mixture at a substrate...

Shell Model for Warm Rotating Nuclei (1997)

Matsuo, M., Døssing, T., Vigezzi, E., Broglia, R. A., Yoshida, K.

In order to provide a microscopic description of levels and E2 transitions in rapidly rotating nuclei with internal excitation energy up to a few MeV, use is made of a shell model which combines the...

Magnetic and Magneto-Optical Properties of Nano-Size Bi-YIG Particles Dispersed in a Plastic Binder (1997)

Yamazaki, Y., Namimawa, T., Hirano, T., Yoshida, K.

Magneto-optical films were prepared by coating nano-size Bi-YIG particles, the Faraday rotation of the films were measured. The particle size was changed by milling with a planetary milling machine...

The complete genome sequence of the Gram-positive bacterium Bacillus subtilis (1997)

Kunst, F., Ogasawara, N., Moszer, I., Albertini, A.M., Alloni, G., Azevedo, V., ...

Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are...

Magnetic and Magneto-Optical Properties of Nano-Size Bi-YIG Particles Dispersed in a Plastic Binder (1997)

Yamazaki, Y., Namimawa, T., Hirano, T., Yoshida, K.

Magneto-optical films were prepared by coating nano-size Bi-YIG particles, the Faraday rotation of the films were measured. The particle size was changed by milling with a planetary milling machine...

Magnetic and Magneto-Optical Properties of Nano-Size Bi-YIG Particles Dispersed in a Plastic Binder (1997)

Yamazaki, Y., Namimawa, T., Hirano, T., Yoshida, K.

Magneto-optical films were prepared by coating nano-size Bi-YIG particles, the Faraday rotation of the films were measured. The particle size was changed by milling with a planetary milling machine...

Nuclear G-Matrix Elements from Nonlocal Potentials (1996)

Yoshida, K., Hosaka, A., Oka, M.

We study effects of nonlocality in the nuclear force on the G-matrix elements for finite nuclei. Nuclear G-matrix elements for $\O16$ are calculated in the harmonic oscillator basis from a nonlocal...

Onset of Rotational Damping in Superdeformed Nuclei (1996)

Yoshida, K., Matsuo, M.

We discuss damping of the collective rotational motion in $A\sim 150$ superdeformed nuclei by means of a shell model combining the cranked Nilsson mean-filed and the surface-delta two-body residual...

The Quantization of Anomalous Gauge Field Theory and BRST-invariant Models of Two Dimensional Quantum Gravity (1996)

Martellini, M., Yoshida, K., Spreafico, M.

We analyze the problems with the so called gauge invariant quantization of the anomalous gauge field theories originary due to Faddeev and Shatashvili (FS). Our analysis bring to a generalization of...

Study of the levels in $^{17}$C above the $^{16}$C + neutron threshold (1995)

Raimann, G., Ozawa, A., Boyd, R. N., Chloupek, F. R., Fujimaki, M., Kimura, K., ...

The $\beta$-delayed neutron decay of $^{17}$B was studied using a radioactive ion beam. The neutron energies, measured via time-of-flight, give information on states in $^{17}$C above the $^{16}$C +...

The Quantization of Anomalous Gauge Field Theory (1995)

Martellini, M., Spreafico, M., Yoshida, K.

We discuss the so called gauge invariant quantization of anomalous gauge field theory, originally due to Faddeev and Shatashvili. It is pointed out that the further non invariance of relevant path...

A generalized model for two dimensional quantum gravity and dynamics of random surfaces for d>1 (1994)

Martellini, M., Spreafico, M., Yoshida, K.

The possible interpretations of a new continuum model for the two-dimensional quantum gravity for $d>1$ ($d$=matter central charge), obtained by carefully treating both diffeomorphism and Weyl...

A continuum approach to 2D-Quantum Gravity for c$>$1 (1993)

Martellini, M., Spreafico, M., Yoshida, K.

Two dimensional induced quantum gravity with matter central charge $c>1$ is studied taking a careful consideration of both diffeomorphism and Weyl symmetries . It is shown that, for the gauge fixing...

Finite-Temperature and -Density QED: Schwinger-Dyson Equation in the Real-Time Formalism (1993)

Yoshida, K.

Based on the real-time formalism, especially, on Thermo Field Dynamics, we derive the Schwinger-Dyson gap equation for the fermion propagator in QED and Four-Fermion model at finite-temperature and...

(D+1)-Dimensional Formulation for D-Dimensional Constrained Systems (1992)

Mochizuki, R., Yoshida, K.

D-dimensional constrained systems are studied with stochastic Lagrangian and\break Hamiltonian. It is shown that stochastic consistency conditions are second class constraints and Lagrange multiplier...

Large N Limit on Langevin Equation: Two-Dimensional Nonlinear Sigma Model (1992)

Mochizuki, R., Yoshida, K.

We study the stochastic quantization of two-dimensional nonlinear sigma model in the large $N$ limit. Our main tool is the {\it effective} Langevin equation with which we investigate nonperturbative...

Dynamical Symmetry Breaking on Langevin Equation : Nambu $\cdot$ Jona-Lasinio Model (1992)

Ikegami, K., Mochizuki, R., Yoshida, K.

In order to investigate dynamical symmetry breaking, we study Nambu$\cdot$Jona-Lasinio model in the large-N limit in the stochastic quantization method. Here in order to solve Langevin equation, we...

A Continuum Approach to 2D-Quantum Gravity for C>1 (1992)

Martellini, M., Spreafico, M., Yoshida, K.

A Lagrangian continuum model for a string theory with central charge $c>1$ is formulated by incorporating Weyl and diffeomorphism gauge fixing. In particular the tachyon scattering amplitudes are...

On the Black-Hole Conformal Field Theory Coupled to the Polyakov's String Theory. A Non Perturbative Analysis (1992)

Martellini, M., Spreafico, M., Yoshida, K.

We couple the 2D black-hole conformal field theory discovered by Witten to a $D-1$ dimensional Euclidean bosonic string. We demonstrate that the resulting planar (=zero genus) string susceptibility...

A continuum string model for $D>1$ (1992)

Martellini, M., Spreafico, M., Yoshida, K.

The non critical string (2D gravity coupled to the matter with central charge $D$) is quantized taking care of both diffeomorphism and Weyl symmetries. In incorporating the gauge fixing with respect...

A novel sulfated structure in the carbohydrate-protein linkage region isolated from porcine intestinal heparin (1992)

Vliegenthart, J.F.G., Sugahara, K., Yamada, S., Yoshida, K., Waard, P. De

A preparation of porcine stage 14 intestinal heparin, which contains Ser as a predominant amino acid, was used for isolation of the carbohydrate-protein linkage region of heparin. Two glycoserines...

ELECTRON MICROSCOPY STUDY ON GROWTH PROCESS OF VACUUM DEPOSITED Co-Cr THIN FILMS (1988)

Futamoto, M., Honda, Y., Yoshida, K.

Morphology and crystallographic structure of polycrystalline Co-Cr films are investigated as a function of thickness by scanning and transmission electron microscopy. A method of controlling the...

RECORDED MAGNETIZATION PATTERNS OF HIGHLY c-AXIS ORIENTED Co-Cr FILM OBSERVED BY ELECTRON HOLOGRAPHY (1988)

Honda, Y., Futamoto, M., Kugiya, F., Koizuwi, M., ...

Magnetization structures of leakage flux of a Co-Cr perpendicular magnetic recording medium recorded at 200 and 300 kFCI are successfully visualized by electron holography. The magnetic field...

ELECTRON MICROSCOPY STUDY ON GROWTH PROCESS OF VACUUM DEPOSITED Co-Cr THIN FILMS (1988)

Futamoto, M., Honda, Y., Yoshida, K.

Morphology and crystallographic structure of polycrystalline Co-Cr films are investigated as a function of thickness by scanning and transmission electron microscopy. A method of controlling the...

RECORDED MAGNETIZATION PATTERNS OF HIGHLY c-AXIS ORIENTED Co-Cr FILM OBSERVED BY ELECTRON HOLOGRAPHY (1988)

Honda, Y., Futamoto, M., Kugiya, F., Koizuwi, M., ...

Magnetization structures of leakage flux of a Co-Cr perpendicular magnetic recording medium recorded at 200 and 300 kFCI are successfully visualized by electron holography. The magnetic field...

ELECTRON MICROSCOPY STUDY ON GROWTH PROCESS OF VACUUM DEPOSITED Co-Cr THIN FILMS (1988)

Futamoto, M., Honda, Y., Yoshida, K.

Morphology and crystallographic structure of polycrystalline Co-Cr films are investigated as a function of thickness by scanning and transmission electron microscopy. A method of controlling the...

RECORDED MAGNETIZATION PATTERNS OF HIGHLY c-AXIS ORIENTED Co-Cr FILM OBSERVED BY ELECTRON HOLOGRAPHY (1988)

Honda, Y., Futamoto, M., Kugiya, F., Koizuwi, M., ...

Magnetization structures of leakage flux of a Co-Cr perpendicular magnetic recording medium recorded at 200 and 300 kFCI are successfully visualized by electron holography. The magnetic field...

PRESENT STATUS OF UVSOR (1986)

Watanabe, M, Kasuga, T, Yonehara, H, Uchida, A, Sakai, K, Matsudo, O, ...

In *Tsukuba 1984, Proceedings, Accelerator Science and Technology*, 15-17

Alberta Occupational Medicine Newsletter: Summer 1986 (1986)

Johnson, Mary, Russell, Margaret L., Yoshida, K., Barber, Kirk, Corbet, Kenneth, Bell, G. Douglas, ...

Editorial Comments -- Publications on Guidelines From Alberta Community and Occupational Health -- Upcoming Conference Announcement (Calgary, November '86) -- Infection Control Apsects of...

Alberta Occupational Medicine Newsletter: Summer 1986 (1986)

Johnson, Mary, Russell, Margaret L., Yoshida, K., Barber, Kirk, Corbet, Kenneth, Bell, G. Douglas, ...

Editorial Comments -- Publications on Guidelines From Alberta Community and Occupational Health -- Upcoming Conference Announcement (Calgary, November '86) -- Infection Control Apsects of...

STABILITY TEST RESULT OF THE JAPANESE TEST COIL FOR THE LARGE COIL TASK AT THE DOMESTIC TEST (1984)

Nishi, M., Ando, T., Hiyama, T., Tsuji, H., Takahashi, Y., Okuno, K., ...

The designing work of the Japanese LCT coil was begun based on the cold end recovery criterion. But, as the result of research and development work on the conductor's cooling surface, the completed...

TEST RESULTS OF 60-cm BORE Nb3Sn TEST MODULE COIL (TMC-I) IN THE CLUSTER TEST FACILITY (1984)

Ando, T., Shimamoto, S., Hiyama, T., Tsuji, H., Takahashi, Y., Nishi, M., ...

An extended test of a 60-cm-bore Nb3Sn coil (TMC-I), constructed as a development of superconducting toroidal coil in tokamak machine, has been carried out in the cluster test facility. A...

TEST RESULTS OF 60-cm BORE Nb3Sn TEST MODULE COIL (TMC-I) IN THE CLUSTER TEST FACILITY (1984)

Ando, T., Shimamoto, S., Hiyama, T., Tsuji, H., Takahashi, Y., Nishi, M., ...

An extended test of a 60-cm-bore Nb3Sn coil (TMC-I), constructed as a development of superconducting toroidal coil in tokamak machine, has been carried out in the cluster test facility. A...

STABILITY TEST RESULT OF THE JAPANESE TEST COIL FOR THE LARGE COIL TASK AT THE DOMESTIC TEST (1984)

Nishi, M., Ando, T., Hiyama, T., Tsuji, H., Takahashi, Y., Okuno, K., ...

The designing work of the Japanese LCT coil was begun based on the cold end recovery criterion. But, as the result of research and development work on the conductor's cooling surface, the completed...

TEST RESULTS OF 60-cm BORE Nb3Sn TEST MODULE COIL (TMC-I) IN THE CLUSTER TEST FACILITY (1984)

Ando, T., Shimamoto, S., Hiyama, T., Tsuji, H., Takahashi, Y., Nishi, M., ...

An extended test of a 60-cm-bore Nb3Sn coil (TMC-I), constructed as a development of superconducting toroidal coil in tokamak machine, has been carried out in the cluster test facility. A...

TEST RESULTS OF 60-cm BORE Nb3Sn TEST MODULE COIL (TMC-I) IN THE CLUSTER TEST FACILITY (1984)

Ando, T., Shimamoto, S., Hiyama, T., Tsuji, H., Takahashi, Y., Nishi, M., ...

An extended test of a 60-cm-bore Nb3Sn coil (TMC-I), constructed as a development of superconducting toroidal coil in tokamak machine, has been carried out in the cluster test facility. A...

STABILITY TEST RESULT OF THE JAPANESE TEST COIL FOR THE LARGE COIL TASK AT THE DOMESTIC TEST (1984)

Nishi, M., Ando, T., Hiyama, T., Tsuji, H., Takahashi, Y., Okuno, K., ...

The designing work of the Japanese LCT coil was begun based on the cold end recovery criterion. But, as the result of research and development work on the conductor's cooling surface, the completed...

TEST RESULTS OF 60-cm BORE Nb3Sn TEST MODULE COIL (TMC-I) IN THE CLUSTER TEST FACILITY (1984)

Ando, T., Shimamoto, S., Hiyama, T., Tsuji, H., Takahashi, Y., Nishi, M., ...

An extended test of a 60-cm-bore Nb3Sn coil (TMC-I), constructed as a development of superconducting toroidal coil in tokamak machine, has been carried out in the cluster test facility. A...

TEST RESULTS OF 60-cm BORE Nb3Sn TEST MODULE COIL (TMC-I) IN THE CLUSTER TEST FACILITY (1984)

Ando, T., Shimamoto, S., Hiyama, T., Tsuji, H., Takahashi, Y., Nishi, M., ...

An extended test of a 60-cm-bore Nb3Sn coil (TMC-I), constructed as a development of superconducting toroidal coil in tokamak machine, has been carried out in the cluster test facility. A...

Measurements of superconducting niobium cavities at 700 MHz. (1979)

Yoshida, K., Yoshioka, M., Halbritter, J.

Particle Accelerator Conf., San Francisco, Calif., March 12-14, 1979

CURRENT-STEPS IN LARGE JOSEPHSON TUNNEL JUNCTIONS (1978)

Irie, F., Hamasaki, K., Yoshida, K.

A new type of current-steps corresponding to a relation ∂ω0/∂β0 = [MATH]/n (n = 2, 3 et 4) has been observed in dc current-voltage characteristics of a large Josephson tunnel...

CURRENT-STEPS IN LARGE JOSEPHSON TUNNEL JUNCTIONS (1978)

Irie, F., Hamasaki, K., Yoshida, K.

A new type of current-steps corresponding to a relation ∂ω0/∂β0 = [MATH]/n (n = 2, 3 et 4) has been observed in dc current-voltage characteristics of a large Josephson tunnel...

CURRENT-STEPS IN LARGE JOSEPHSON TUNNEL JUNCTIONS (1978)

Irie, F., Hamasaki, K., Yoshida, K.

A new type of current-steps corresponding to a relation ∂ω0/∂β0 = [MATH]/n (n = 2, 3 et 4) has been observed in dc current-voltage characteristics of a large Josephson tunnel...

Physiological detection of a binding substance for the agglutinability-inducing pheromone, {alpha} substance-I in Saccharomyces cerevisiae (1977)

Yanagishima, N., Shimizu, T., Hagiya, M., Yoshida, K., Sakurai, A., Tamura, S.

We found a substance which binds to α substance-I to inactivate the biological activity of the pheromone to induce sexual agglutinability of a mating type cells. Both living and boiled cells of the...

Regulation of sexual agglutinability in Saccharomyces cerevisiae of {alpha} and {alpha} types by sex-specific factors produced by their respective opposite mating types (1976)

Yanagishima, N., Yoshida, K., Hamada, K., Hagiya, M., Kawanabe, Y., Sakurai, A., ...

The sexual agglutinability of haploid cells of heterothallic Saccharomyces cerevisiae was repressed when they were cultured in the absence of easily fermentable sugars, such as glucose and mannose....

SPECIFIC RNA FROM PHOTOPERIODICALLY INDUCED COTYLEDONS OF PHARBITIS NIL (1967)

YOSHIDA, K., UMEMURA, K., YOSHINAGA, K., OOTA, Y.

The nucleotide ratio of several RNA species from cotyledons of Pharbitis nil subjected to a single 16 hr night with or without a 15 min light-break, or to continuous light was investigated. RNA...

Mammalian phospholipase D: phosphatidylethanolamine as an essential component.

Nakamura, S, Kiyohara, Y, Jinnai, H, Hitomi, T, Ogino, C, Yoshida, K, ...

Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine...

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

Yoshida, K, Taga, T, Saito, M, Suematsu, S, Kumanogoh, A, Tanaka, T, ...

gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and...

Mammalian phospholipase D: activation by ammonium sulfate and nucleotides.

Nakamura, S, Shimooku, K, Akisue, T, Jinnai, H, Hitomi, T, Kiyohara, Y, ...

Phospholipase D (PLD) associated with the rat kidney membrane was activated by guanine 5'-[gamma-thio]triphosphate and a cytosol fraction that contained ADP-ribosylation factor. When assayed by...

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

Hirota, H, Yoshida, K, Kishimoto, T, Taga, T

To investigate the physiological roles of gp130 in detail and to determine the pathological consequence of abnormal activation of gp130, transgenic mice having continuously activated gp130 were...

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

Narazaki, M, Witthuhn, B A, Yoshida, K, Silvennoinen, O, Yasukawa, K, Ihle, J N, ...

The interleukin 6 receptor-associated signal transducer, gp130, is shared by receptor complexes for leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and interleukin 11. We show...

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.

Fujiwara, H, Kikutani, H, Suematsu, S, Naka, T, Yoshida, K, Yoshida, K, ...

The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been...

Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.

Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y, Murakami, M, Kudo, I, ...

Both 2-lysophosphatidylcholine and cis-unsaturated fatty acids were previously shown to intensify agonist-induced cellular responses by enhancing the diacylglycerol-dependent activation of protein...

Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.

Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y

2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC...

Phytochrome-regulated expression of the genes encoding the small GTP-binding proteins in peas.

Yoshida, K, Nagano, Y, Murai, N, Sasaki, Y

We examined the effect of light on the mRNA levels of 11 genes (pra1-pra9A, pra9B, and pra9C) encoding the small GTP-binding proteins that belong to the ras superfamily in Pisum sativum. When the...

Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids.

Yoshida, K, Asaoka, Y, Nishizuka, Y

Several cis-unsaturated fatty acids such as oleic, linoleic, linolenic, eicosapentaenoic, and docosahexaenoic acids added directly to intact human platelets greatly enhance protein kinase C...

Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.

Asaoka, Y, Oka, M, Yoshida, K, Sasaki, Y, Nishizuka, Y

2-Lysophosphatidylcholine (lysoPtdCho), a product of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2, greatly potentiates the activation of human resting T lymphocytes that is...

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

Shinomura, T, Asaoka, Y, Oka, M, Yoshida, K, Nishizuka, Y

Kinetic properties of the purified alpha, beta, and gamma subspecies of protein kinase C (PKC) to respond to diacylglycerol, phosphatidylserine (PtdSer), and Ca2+ were reinvestigated in the presence...

Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.

Asaoka, Y, Oka, M, Yoshida, K, Nishizuka, Y

DL-1,2-Dioctanoylglycerol (1,2-DiC8) added to human peripheral resting T lymphocytes was rapidly metabolized to produce octanoic acid and further to small molecules, probably by the action of...

Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

Aihara, H, Asaoka, Y, Yoshida, K, Nishizuka, Y

Although a single dose of phorbol 12-myristate 13-acetate (PMA) allowed HL-60 cells to differentiate to macrophages, a single dose of membrane-permeant diacylglycerol (DAG), 1,2-dioctanoylglycerol...

Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.

Yoshida, K, Matsuoka, M, Usuda, S, Mori, A, Ishizaka, K, Sakano, H

We have characterized immunoglobulin switch circular DNA in mice infected with the nematode parasite Nippostrongylus brasiliensis. Two kinds of circular DNA were identified in the lymph nodes as...

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.

Yagi, T, Ikawa, Y, Yoshida, K, Shigetani, Y, Takeda, N, Mabuchi, I, ...

In attempting to produce a mutant mouse with embryonic stem cells, the critical step is the efficient isolation of homologous recombinants; the frequency of the homologous recombination is usually...

Essential Bacillus subtilis genes

Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., ...

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the...

Correlated Changes in the Activity, Amount of Protein, and Abundance of Transcript of NADPH:Protochlorophyllide Oxidoreductase and Chlorophyll Accumulation during Greening of Cucumber Cotyledons.

Yoshida, K., Chen, R. M., Tanaka, A., Teramoto, H., Tanaka, R., Timko, M. P., ...

Changes in the activity and abundance of NADPH:protochlorophyllide oxidoreductase (NPR) and the abundance of mRNA encoding it were examined during the greening of 5-d-old etiolated cucumber...

Differential expression of two hemA mRNAs encoding glutamyl-tRNA reductase proteins in greening cucumber seedlings.

Tanaka, R, Yoshida, K, Nakayashiki, T, Masuda, T, Tsuji, H, Inokuchi, H, ...

The first committed step of porphyrin synthesis in higher plants is the reduction of glutamyl-tRNA to glutamate 1-semialdehyde. This reaction is catalyzed by glutamyl-tRNA reductase, which is encoded...

Bacillus subtilis gnt repressor mutants that diminish gluconate-binding ability.

Yoshida, K, Ohmori, H, Miwa, Y, Fujita, Y

The Bacillus subtilis gnt operon is negatively regulated by GntR, which is antagonized by gluconate. Three GntR mutants with diminished gluconate-binding ability were obtained. Two were missense...

Cloning and characterization of a region of Enterococcus faecalis plasmid pPD1 encoding pheromone inhibitor (ipd), pheromone sensitivity (traC), and pheromone shutdown (traB) genes.

Nakayama, J, Yoshida, K, Kobayashi, H, Isogai, A, Clewell, D B, Suzuki, A

Bacteriocin plasmid pPD1 in Enterococcus faecalis encodes a mating response to recipient-produced sex pheromone cPD1. Once a recipient acquires pPD1, transconjugants apparently shut off cPD1 activity...

Disposition of carumonam (AMA-1080/Ro 17-2301), a new N-sulfonated monocyclic beta-lactam, in rats and dogs.

Yoshida, K, Mitani, M, Naeshiro, I, Torii, H, Tanayama, S

Rats and dogs were given a single 20-mg/kg dose of [14C]carumonam intramuscularly or intravenously. In rats, the level in plasma of [14C]carumonam administered intramuscularly peaked (29.1...

The yeast Saccharomyces kluyveri as a recipient eukaryote in transkingdom conjugation: behavior of transmitted plasmids in transconjugants.

Inomata, K, Nishikawa, M, Yoshida, K

The prokaryote Escherichia coli successfully conjugated with the eukaryote Saccharomyces kluyveri, which is relatively distant from the species S. cerevisiae. To achieve this transkingdom...

Outermost-cell-surface changes in an encapsulated strain of Staphylococcus aureus after preservation by freeze-drying.

Ohtomo, T, Yamada, T, Yoshida, K

The effects of drying time during freeze-drying on the outermost cell surface of an encapsulated strain of Staphylococcus aureus S-7 (Smith, diffuse) were investigated, with special attention paid to...

Transcriptional regulation of Bacillus thuringiensis subsp. israelensis mosquito larvicidal crystal protein gene cryIVA.

Yoshisue, H, Fukada, T, Yoshida, K, Sen, K, Kurosawa, S, Sakai, H, ...

The cryIVA gene encodes a component of the delta-endotoxin of Bacillus thuringiensis subsp. israelensis. By S1 nuclease mapping and primer extension analysis, we have identified the transcriptional...

Characterization of a porcine kidney cell line resistant to influenza virus infection.

Kimura, Y, Yokochi, T, Miyadai, T, Yoshida, K, Yokoo, J, Matsumoto, K

A mutant cell line of porcine kidney cells that resists the cytopathic effect of influenza virus has been obtained and characterized. These cells, designated ESK-R, were originally obtained by...

In vivo effects of bacterial lipopolysaccharide on proliferation of macrophage colony-forming cells in bone marrow and peripheral lymphoid tissues.

Yokochi, T, Nakashima, I, Kato, N, Miyadai, T, Yoshida, K, Kimura, Y

Changes in the number of macrophage colony-forming cells in various tissues of mice injected with lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli, or Salmonella enteritidis were...

Positive reaction in mouse ligated intestinal loop assay with nonenterotoxigenic and nonhemolytic strains of Staphylococcus aureus.

Sakaguchi, T, Sakaguchi, S, Nakamura, I, Kudo, Y, Ichiman, Y, Yoshida, K

Nonenterotoxigenic and nonhemolytic strains of Staphylococcus aureus exhibited a positive reaction in the mouse intestinal loop assay except for a strain negative for the egg yolk reaction. Edema and...

Possible common biological and immunological properties for detecting encapsulated strains of Staphylococcus epidermidis.

Yamada, T, Ichiman, Y, Yoshida, K

Twenty strains of capsular type II Staphylococcus epidermidis, determined by the method of Ichiman, were obtained from clinical specimens. Among them, 5, 5, and 10 strains were 4+, 3+, and 2+ in the...

Pseudodiffuse-type growth of a Staphylococcus aureus strain in serum-soft agar.

Chomarat, M, Ichiman, Y, Yoshida, K

Strain MC31 of Staphylococcus aureus showed diffuse-type growth in regular serum-soft agar (SSA) (pH 7.2), but in alkaline SSA (pH 8.4) the type of growth was compact. The organisms were of extra low...

Cell surface antigen of encapsulated Staphylococcus epidermidis ATCC 31432.

Ohshima, Y, Ichiman, Y, Usui, Y, Ko, H L, Beuth, J, Pulverer, G, ...

The cell surface antigen (CSA) from encapsulated Staphylococcus epidermidis ATCC 31432 was isolated and fractionated by DEAE-Sephadex ion-exchange chromatography. It yielded a single precipitin line...

Successive extraction of specific protective immunoglobulins from pooled human sera.

Yoshida, K, Ichiman, Y

By use of pooled human sera, specific protective immunoglobulins against the Smith-diffuse strain of Staphylococcus aureus, strains SS-620 and SS-619 of types III and II group B streptococci, and...

Comparison of three blood-clotting substances in Staphylococcus aureus strains.

Yoshida, K, Takahashi, M, Haga, K, Kono, E, Kushiro, H, Ito, S

Besides the two well-known blood-clotting substances, coagulase and clumping factor, a third one has been identified from the staphylococci which is a cell surface polysaccharide, is alkali stable,...

Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide.

Yoshida, K, Akaike, T, Doi, T, Sato, K, Ijiri, S, Suga, M, ...

The antimicrobial action of .NO against Cryptococcus neoformans was investigated by using imidazolineoxyl N-oxide, which we recently reported removes .NO via oxidation (T. Akaike, M. Yoshida, Y....

Metabolic fate of SCE-1365, a new broad-spectrum cephalosporin, after parenteral administration to rats and dogs.

Tanayama, S, Yoshida, K, Adachi, K, Kondo, T

Disposition of [14C]SCE-1365 was studied in rats and dogs after intramuscular or intravenous injection. The plasma level of [14C]SCE-1365 peaked at 15 min after intramuscular administration and...

Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.

Higashino, F, Yoshida, K, Fujinaga, Y, Kamio, K, Fujinaga, K

The cDNA encoding adenovirus E1A enhancer-binding protein E1A-F was isolated by screening a HeLa cell lambda gt11 expression library for E1A-F site-specific DNA binding. One cDNA clone produced...

A simple and efficient method for constructing high resolution physical maps.

Yoshida, K, Strathmann, M P, Mayeda, C A, Martin, C H, Palazzolo, M J

This paper describes a simple and efficient walking method for constructing high resolution physical maps and discusses its applications to genome analysis. The method is an integration of three...

Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene.

Yoshida, K, Narita, M, Fujinaga, K

Twenty one binding sites of HeLa cell nuclear proteins were identified on the upstream region of adenovirus type 5 E1A gene using DNase I footprint assay. The proximal promoter region contained five...

Effect of bile acid derivatives on taurine biosynthesis and extracellular slime production in encapsulated Staphylococcus aureus S-7.

Ohtomo, T, Yoshida, K, San Clemente, C L

Various bile acids were added to cultures of encapsulated strains of Staphylococcus aureus growing in serum-soft agar medium of brain heart infusion broth. We examined effects of these compounds on...

Mappings of adenovirus type 7 cytoplasmic RNA species synthesized early in lytically infected cells and synthesized in transformed cells.

Yoshida, K, Sekikawa, K, Fujinaga, K

Early virus-specific RNA synthesized in KB cells infected with adenovirus type 7 and virus-specific RNA synthesized in rat embryo cells (71JY1-2) transformed by the adenovirus type 7 HindIII-I.J...

Unique species of mRNA from adenovirus type 7 early region 1 in cells transformed by adenovirus type 7 DNA fragment.

Yoshida, K, Fujinaga, K

Adenovirus type 7 (Ad7) early region 1 mRNA species transcribed in rat cell lines transformed by the HindIII-I . J fragment (the left 7.8% of the viral genome) and in human KB cells infected with Ad7...

HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes.

Shirakata, M, Hüppi, K, Usuda, S, Okazaki, K, Yoshida, K, Sakano, H

In order to isolate cDNA clones for DNA-binding components of the V-(D)-J recombinase, phage libraries from a pre-B-cell line were screened with a radiolabeled probe containing recombination signal...

Demonstration of CD44 gene expression in cells from fine needle aspirates of breast lesions by the polymerase chain reaction

Bolodeoku, J, Yoshida, K, Yeomans, P, Wells, C A, Tarin, D

Aim—To demonstrate the feasibility of studying specific gene expression in fine needle aspirates from clinical lesions. The reverse transcription/polymerase chain reaction (RT-PCR) technique was...

Distribution of CD44 messenger RNA in archival paraffin wax embedded tumours and normal tissues viewed by in situ hybridisation

Gorham, H, Sugino, T, Bolodeoku, J, Yoshida, K, Goodison, S, Tarin, D

Aims—We have previously demonstrated the abnormal localisation of expression of the CD44 gene in carcinoma cells in cryostat sections of fresh frozen tumour tissues, using radioactive in situ...

Induction of resistance with heat-killed compact-type strains of Staphylococcus aureus against challenge with the diffuse variant of the Smith strain of Staphylococcus aureus.

Yoshida, K, Ichiman, Y, Otomo, T

Active immunization of mice with high doses of heat-killed and autoclaved vaccine of unencapsulated strains of Staphylococcus aureus, which was grown in brain heart infusion media, protected against...

Relationship of capsular type to biochemical and immunological properties of teichoic acid preparations from unencapsulated strains of Staphylococcus aureus.

Ohtomo, T, Yoshida, K, Clemente, C L

We investigated the biochemical and immunological characteristics of teichoic acid preparations (TAP) obtained from four unencapsulated strains of Staphylococcus aureus which nonetheless, according...

Telomerase activity in human gynaecological malignancies.

Gorham, H, Yoshida, K, Sugino, T, Marsh, G, Manek, S, Charnock, M, ...

AIM: To evaluate whether increased telomerase activity can be clinically useful for detecting malignant cells in a variety of gynaecological specimens. METHODS: Telomerase activity was examined in...

Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene.

Yoshida, K, Sugino, T, Bolodeoku, J, Warren, B F, Goodison, S, Woodman, A, ...

AIMS: To investigate whether colonic cancer cells exfoliated into the lumen of the organ can be detected by identification of their abnormal CD44 gene products. METHODS: Exfoliated cells were...

Serum albumin as an auxiliary factor enhancing compact-colony formation by Staphylococcus aureus in serum-soft agar.

Usui, Y, Yoshida, K, San Clemente, C L

Serum albumin was identified as an auxiliary factor enhancing the substance active in compact-colony formation by strains of S. aureus when cultivated in serum-soft agar.

Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.

Usuda, S, Takemori, T, Matsuoka, M, Shirasawa, T, Yoshida, K, Mori, A, ...

Circular DNA resulting from V gene replacement was studied with an A-MuLV transformed cell line containing ablts. This cell line undergoes V gene replacement at elevated temperatures in the...

Structural differences between heparan sulphates of proteoglycan involved in the formation of basement membranes in vivo by Lewis-lung-carcinoma-derived cloned cells with different metastatic potentials.

Nakanishi, H, Oguri, K, Yoshida, K, Itano, N, Takenaga, K, Kazama, T, ...

This study addresses the characterization of heparan sulphates of the basement-membrane proteoglycans in tumour formed after the subcutaneous implantation of Lewis-lung-carcinoma-derived different...

Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor.

Habuchi, H, Suzuki, S, Saito, T, Tamura, T, Harada, T, Yoshida, K, ...

Binding of basic fibroblast growth factor (bFGF) to the extracellular matrix of cultured bovine aorta smooth muscle cells is likely to be mediated via heparan sulphate, since not only exogenous...

Comparison of the effects of phorbol 12-myristate 13-acetate and prostaglandin E1 on calcium regulation in human platelets.

Yoshida, K, Stark, F, Nachmias, V T

We compared the effects of phorbol 12-myristate 13-acetate (PMA) with those of prostaglandin E1 (PGE1) on the calcium transient in intact platelets and on 45Ca2+ uptake in saponin-treated platelets...

Solution structure of midkine, a new heparin-binding growth factor.

Iwasaki, W, Nagata, K, Hatanaka, H, Inui, T, Kimura, T, Muramatsu, T, ...

Midkine (MK) is a 13 kDa heparin-binding polypeptide which enhances neurite outgrowth, neuronal cell survival and plasminogen activator activity. MK is structurally divided into two domains, and most...

Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.

Kamiya, A, Kinoshita, T, Ito, Y, Matsui, T, Morikawa, Y, Senba, E, ...

Fetal liver, the major site of hematopoiesis during embryonic development, acquires additional various metabolic functions near birth. Although liver development has been characterized biologically...

Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia.

Aki, T, Mizukami, Y, Oka, Y, Yamaguchi, K, Uemura, K, Fujimiya, T, ...

Using H9c2 cells derived from rat cardiomyocytes, we investigated the mechanism of cell death during hypoxia in the presence of serum and glucose. Hypoxic cell death is by necrosis and is accompanied...

Fabrication of a new substrate for atomic force microscopic observation of DNA molecules from an ultrasmooth sapphire plate.

Yoshida, K, Yoshimoto, M, Sasaki, K, Ohnishi, T, Ushiki, T, Hitomi, J, ...

A new stable substrate applicable to the observation of DNA molecules by atomic force microscopy (AFM) was fabricated from a ultrasmooth sapphire (alpha-Al2O3 single crystal) plate. The atomically...

Population Sizes and Growth Pressure Responses of Intestinal Microfloras of Deep-Sea Fish Retrieved from the Abyssal Zone

Yano, Y., Nakayama, A., Yoshida, K.

The intestinal floras of seven deep-sea fish retrieved at depths of from 3,200 to 5,900 m were examined for population sizes and growth responses to pressure. Large populations of culturable...

Distribution of Polyunsaturated Fatty Acids in Bacteria Present in Intestines of Deep-Sea Fish and Shallow-Sea Poikilothermic Animals

Yano, Y., Nakayama, A., Yoshida, K.

The lipid and fatty acid compositions in nine obligate and facultative barophilic bacteria isolated from the intestinal contents of seven deep-sea fish were determined. Phospholipid compositions were...

Is postoperative radiotherapy for thymoma effective?

Haniuda, M, Miyazawa, M, Yoshida, K, Oguchi, M, Sakai, F, Izuno, I, ...

OBJECTIVE: The authors determined the effect of postoperative mediastinal irradiation in preventing local and pleural recurrence of thymoma. SUMMARY BACKGROUND DATA: The role of mediastinal...

Inapparent carcinoma of the gallbladder. An appraisal of a radical second operation after simple cholecystectomy.

Shirai, Y, Yoshida, K, Tsukada, K, Muto, T

This study was designed to investigate issues concerning "inapparent carcinoma" of the gallbladder and the effectiveness of a radical second operation in the treatment of inapparent carcinoma....

Radical surgery for gallbladder carcinoma. Long-term results.

Shirai, Y, Yoshida, K, Tsukada, K, Muto, T, Watanabe, H

The authors' objective was to evaluate the effectiveness of radical surgery with lymph node dissection for gallbladder carcinoma. Long-term results were analyzed in 40 patients in a 5-year study. The...

Neural correlates of horizontal vestibulo-ocular reflex cancellation during rapid eye movements in the cat.

Berthoz, A, Droulez, J, Vidal, P P, Yoshida, K

1. The aim of the present study is to describe the behaviour of identified second-order vestibular neurones in the alert cat during eye saccades. A selection of neurones which are involved in...

Spatial patterns of reflex evoked by pressure stimulation of the foot pads in cats.

Hongo, T, Kudo, N, Oguni, E, Yoshida, K

1. The spatial patterns of reflexes elicited by localized pressure stimulation of the foot skin were analysed by recording electromyographic activities of various hindlimb muscles or muscle nerve...

Inhibition of dorsal spinocerebellar tract cells by interneurones in upper and lower lumbar segments in the cat.

Hongo, T, Jankowska, E, Ohno, T, Sasaki, S, Yamashita, M, Yoshida, K

The topographical distribution of interneurones mediating disynaptic inhibition of dorsal spinocerebellar tract (d.s.c.t.) cells from group I muscle afferents in the cat was investigated using both...

The same interneurones mediate inhibition of dorsal spinocerebellar tract cells and lumbar motoneurones in the cat.

Hongo, T, Jankowska, E, Ohno, T, Sasaki, S, Yamashita, M, Yoshida, K

The aim of the study was to investigate whether inhibition of dorsal spinocerebellar tract (d.s.c.t.) cells evoked from group I afferents is mediated by the same interneurones which mediate the...

Biotransformation of nitric oxide.

Yoshida, K, Kasama, K

Previous investigations into the health effects of nitrogen oxides (NOx) have mostly been conducted with special reference to nitrogen dioxide (NO2) and its direct effects on the respiratory system,...

Retrotransposon-Induced Ectopic Expression of Cut Causes the Om(1a) Mutant in Drosophila Ananassae

Awasaki, T., Juni, N., Hamabata, T., Yoshida, K., Matsuda, M., Tobari, Y. N., ...

Optic morphology (Om) mutations in Drosophila ananassae map to at least 22 loci scattered throughout the genome. They are semidominant, neomorphic, nonpleiotropic, and are associated with the...

The Om(1e) Mutation in Drosophila Ananassae Causes Compound Eye Overgrowth Due to Tom Retrotransposon-Driven Overexpression of a Novel Gene

Juni, N., Awasaki, T., Yoshida, K., Hori, S. H.

Optic morphology (Om) mutations in Drosophila ananassae are a group of retrotransposon (tom)-induced gain-of-function mutations that map to at least 22 independent loci and exclusively affect the...

Human beta-galactosidase gene mutations in morquio B disease.

Oshima, A, Yoshida, K, Shimmoto, M, Fukuhara, Y, Sakuraba, H, Suzuki, Y

Three different beta-galactosidase gene mutations--a 273Trp----Leu (mutation F) in both families, 482Arg----His (mutation G) in one family, and 509Trp----Cys (mutation H) in the other family--were...

Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases.

Yoshida, K, Oshima, A, Shimmoto, M, Fukuhara, Y, Sakuraba, H, Yanagisawa, N, ...

Molecular analysis of the human beta-galactosidase gene revealed six different mutations in 10 of 11 Japanese GM1-gangliosidosis patients. They were the only abnormalities in each allele examined in...

Mammalian phospholipase D: phosphatidylethanolamine as an essential component.

Nakamura, S, Kiyohara, Y, Jinnai, H, Hitomi, T, Ogino, C, Yoshida, K, ...

Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine...

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

Yoshida, K, Taga, T, Saito, M, Suematsu, S, Kumanogoh, A, Tanaka, T, ...

gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and...

Mammalian phospholipase D: activation by ammonium sulfate and nucleotides.

Nakamura, S, Shimooku, K, Akisue, T, Jinnai, H, Hitomi, T, Kiyohara, Y, ...

Phospholipase D (PLD) associated with the rat kidney membrane was activated by guanine 5'-[gamma-thio]triphosphate and a cytosol fraction that contained ADP-ribosylation factor. When assayed by...

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

Hirota, H, Yoshida, K, Kishimoto, T, Taga, T

To investigate the physiological roles of gp130 in detail and to determine the pathological consequence of abnormal activation of gp130, transgenic mice having continuously activated gp130 were...

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

Narazaki, M, Witthuhn, B A, Yoshida, K, Silvennoinen, O, Yasukawa, K, Ihle, J N, ...

The interleukin 6 receptor-associated signal transducer, gp130, is shared by receptor complexes for leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and interleukin 11. We show...

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.

Fujiwara, H, Kikutani, H, Suematsu, S, Naka, T, Yoshida, K, Yoshida, K, ...

The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been...

Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.

Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y, Murakami, M, Kudo, I, ...

Both 2-lysophosphatidylcholine and cis-unsaturated fatty acids were previously shown to intensify agonist-induced cellular responses by enhancing the diacylglycerol-dependent activation of protein...

Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.

Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y

2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC...

Phytochrome-regulated expression of the genes encoding the small GTP-binding proteins in peas.

Yoshida, K, Nagano, Y, Murai, N, Sasaki, Y

We examined the effect of light on the mRNA levels of 11 genes (pra1-pra9A, pra9B, and pra9C) encoding the small GTP-binding proteins that belong to the ras superfamily in Pisum sativum. When the...

Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids.

Yoshida, K, Asaoka, Y, Nishizuka, Y

Several cis-unsaturated fatty acids such as oleic, linoleic, linolenic, eicosapentaenoic, and docosahexaenoic acids added directly to intact human platelets greatly enhance protein kinase C...

Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.

Asaoka, Y, Oka, M, Yoshida, K, Sasaki, Y, Nishizuka, Y

2-Lysophosphatidylcholine (lysoPtdCho), a product of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2, greatly potentiates the activation of human resting T lymphocytes that is...

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

Shinomura, T, Asaoka, Y, Oka, M, Yoshida, K, Nishizuka, Y

Kinetic properties of the purified alpha, beta, and gamma subspecies of protein kinase C (PKC) to respond to diacylglycerol, phosphatidylserine (PtdSer), and Ca2+ were reinvestigated in the presence...

Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.

Asaoka, Y, Oka, M, Yoshida, K, Nishizuka, Y

DL-1,2-Dioctanoylglycerol (1,2-DiC8) added to human peripheral resting T lymphocytes was rapidly metabolized to produce octanoic acid and further to small molecules, probably by the action of...

Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

Aihara, H, Asaoka, Y, Yoshida, K, Nishizuka, Y

Although a single dose of phorbol 12-myristate 13-acetate (PMA) allowed HL-60 cells to differentiate to macrophages, a single dose of membrane-permeant diacylglycerol (DAG), 1,2-dioctanoylglycerol...

Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.

Yoshida, K, Matsuoka, M, Usuda, S, Mori, A, Ishizaka, K, Sakano, H

We have characterized immunoglobulin switch circular DNA in mice infected with the nematode parasite Nippostrongylus brasiliensis. Two kinds of circular DNA were identified in the lymph nodes as...

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.

Yagi, T, Ikawa, Y, Yoshida, K, Shigetani, Y, Takeda, N, Mabuchi, I, ...

In attempting to produce a mutant mouse with embryonic stem cells, the critical step is the efficient isolation of homologous recombinants; the frequency of the homologous recombination is usually...

Essential Bacillus subtilis genes

Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., ...

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the...

Correlated Changes in the Activity, Amount of Protein, and Abundance of Transcript of NADPH:Protochlorophyllide Oxidoreductase and Chlorophyll Accumulation during Greening of Cucumber Cotyledons.

Yoshida, K., Chen, R. M., Tanaka, A., Teramoto, H., Tanaka, R., Timko, M. P., ...

Changes in the activity and abundance of NADPH:protochlorophyllide oxidoreductase (NPR) and the abundance of mRNA encoding it were examined during the greening of 5-d-old etiolated cucumber...

Differential expression of two hemA mRNAs encoding glutamyl-tRNA reductase proteins in greening cucumber seedlings.

Tanaka, R, Yoshida, K, Nakayashiki, T, Masuda, T, Tsuji, H, Inokuchi, H, ...

The first committed step of porphyrin synthesis in higher plants is the reduction of glutamyl-tRNA to glutamate 1-semialdehyde. This reaction is catalyzed by glutamyl-tRNA reductase, which is encoded...

Bacillus subtilis gnt repressor mutants that diminish gluconate-binding ability.

Yoshida, K, Ohmori, H, Miwa, Y, Fujita, Y

The Bacillus subtilis gnt operon is negatively regulated by GntR, which is antagonized by gluconate. Three GntR mutants with diminished gluconate-binding ability were obtained. Two were missense...

Cloning and characterization of a region of Enterococcus faecalis plasmid pPD1 encoding pheromone inhibitor (ipd), pheromone sensitivity (traC), and pheromone shutdown (traB) genes.

Nakayama, J, Yoshida, K, Kobayashi, H, Isogai, A, Clewell, D B, Suzuki, A

Bacteriocin plasmid pPD1 in Enterococcus faecalis encodes a mating response to recipient-produced sex pheromone cPD1. Once a recipient acquires pPD1, transconjugants apparently shut off cPD1 activity...

Disposition of carumonam (AMA-1080/Ro 17-2301), a new N-sulfonated monocyclic beta-lactam, in rats and dogs.

Yoshida, K, Mitani, M, Naeshiro, I, Torii, H, Tanayama, S

Rats and dogs were given a single 20-mg/kg dose of [14C]carumonam intramuscularly or intravenously. In rats, the level in plasma of [14C]carumonam administered intramuscularly peaked (29.1...

The yeast Saccharomyces kluyveri as a recipient eukaryote in transkingdom conjugation: behavior of transmitted plasmids in transconjugants.

Inomata, K, Nishikawa, M, Yoshida, K

The prokaryote Escherichia coli successfully conjugated with the eukaryote Saccharomyces kluyveri, which is relatively distant from the species S. cerevisiae. To achieve this transkingdom...

Outermost-cell-surface changes in an encapsulated strain of Staphylococcus aureus after preservation by freeze-drying.

Ohtomo, T, Yamada, T, Yoshida, K

The effects of drying time during freeze-drying on the outermost cell surface of an encapsulated strain of Staphylococcus aureus S-7 (Smith, diffuse) were investigated, with special attention paid to...

Transcriptional regulation of Bacillus thuringiensis subsp. israelensis mosquito larvicidal crystal protein gene cryIVA.

Yoshisue, H, Fukada, T, Yoshida, K, Sen, K, Kurosawa, S, Sakai, H, ...

The cryIVA gene encodes a component of the delta-endotoxin of Bacillus thuringiensis subsp. israelensis. By S1 nuclease mapping and primer extension analysis, we have identified the transcriptional...

Characterization of a porcine kidney cell line resistant to influenza virus infection.

Kimura, Y, Yokochi, T, Miyadai, T, Yoshida, K, Yokoo, J, Matsumoto, K

A mutant cell line of porcine kidney cells that resists the cytopathic effect of influenza virus has been obtained and characterized. These cells, designated ESK-R, were originally obtained by...

In vivo effects of bacterial lipopolysaccharide on proliferation of macrophage colony-forming cells in bone marrow and peripheral lymphoid tissues.

Yokochi, T, Nakashima, I, Kato, N, Miyadai, T, Yoshida, K, Kimura, Y

Changes in the number of macrophage colony-forming cells in various tissues of mice injected with lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli, or Salmonella enteritidis were...

Positive reaction in mouse ligated intestinal loop assay with nonenterotoxigenic and nonhemolytic strains of Staphylococcus aureus.

Sakaguchi, T, Sakaguchi, S, Nakamura, I, Kudo, Y, Ichiman, Y, Yoshida, K

Nonenterotoxigenic and nonhemolytic strains of Staphylococcus aureus exhibited a positive reaction in the mouse intestinal loop assay except for a strain negative for the egg yolk reaction. Edema and...

Possible common biological and immunological properties for detecting encapsulated strains of Staphylococcus epidermidis.

Yamada, T, Ichiman, Y, Yoshida, K

Twenty strains of capsular type II Staphylococcus epidermidis, determined by the method of Ichiman, were obtained from clinical specimens. Among them, 5, 5, and 10 strains were 4+, 3+, and 2+ in the...

Pseudodiffuse-type growth of a Staphylococcus aureus strain in serum-soft agar.

Chomarat, M, Ichiman, Y, Yoshida, K

Strain MC31 of Staphylococcus aureus showed diffuse-type growth in regular serum-soft agar (SSA) (pH 7.2), but in alkaline SSA (pH 8.4) the type of growth was compact. The organisms were of extra low...

Cell surface antigen of encapsulated Staphylococcus epidermidis ATCC 31432.

Ohshima, Y, Ichiman, Y, Usui, Y, Ko, H L, Beuth, J, Pulverer, G, ...

The cell surface antigen (CSA) from encapsulated Staphylococcus epidermidis ATCC 31432 was isolated and fractionated by DEAE-Sephadex ion-exchange chromatography. It yielded a single precipitin line...

Successive extraction of specific protective immunoglobulins from pooled human sera.

Yoshida, K, Ichiman, Y

By use of pooled human sera, specific protective immunoglobulins against the Smith-diffuse strain of Staphylococcus aureus, strains SS-620 and SS-619 of types III and II group B streptococci, and...

Comparison of three blood-clotting substances in Staphylococcus aureus strains.

Yoshida, K, Takahashi, M, Haga, K, Kono, E, Kushiro, H, Ito, S

Besides the two well-known blood-clotting substances, coagulase and clumping factor, a third one has been identified from the staphylococci which is a cell surface polysaccharide, is alkali stable,...

Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide.

Yoshida, K, Akaike, T, Doi, T, Sato, K, Ijiri, S, Suga, M, ...

The antimicrobial action of .NO against Cryptococcus neoformans was investigated by using imidazolineoxyl N-oxide, which we recently reported removes .NO via oxidation (T. Akaike, M. Yoshida, Y....

Metabolic fate of SCE-1365, a new broad-spectrum cephalosporin, after parenteral administration to rats and dogs.

Tanayama, S, Yoshida, K, Adachi, K, Kondo, T

Disposition of [14C]SCE-1365 was studied in rats and dogs after intramuscular or intravenous injection. The plasma level of [14C]SCE-1365 peaked at 15 min after intramuscular administration and...

Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.

Higashino, F, Yoshida, K, Fujinaga, Y, Kamio, K, Fujinaga, K

The cDNA encoding adenovirus E1A enhancer-binding protein E1A-F was isolated by screening a HeLa cell lambda gt11 expression library for E1A-F site-specific DNA binding. One cDNA clone produced...

A simple and efficient method for constructing high resolution physical maps.

Yoshida, K, Strathmann, M P, Mayeda, C A, Martin, C H, Palazzolo, M J

This paper describes a simple and efficient walking method for constructing high resolution physical maps and discusses its applications to genome analysis. The method is an integration of three...

Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene.

Yoshida, K, Narita, M, Fujinaga, K

Twenty one binding sites of HeLa cell nuclear proteins were identified on the upstream region of adenovirus type 5 E1A gene using DNase I footprint assay. The proximal promoter region contained five...

Effect of bile acid derivatives on taurine biosynthesis and extracellular slime production in encapsulated Staphylococcus aureus S-7.

Ohtomo, T, Yoshida, K, San Clemente, C L

Various bile acids were added to cultures of encapsulated strains of Staphylococcus aureus growing in serum-soft agar medium of brain heart infusion broth. We examined effects of these compounds on...

Mappings of adenovirus type 7 cytoplasmic RNA species synthesized early in lytically infected cells and synthesized in transformed cells.

Yoshida, K, Sekikawa, K, Fujinaga, K

Early virus-specific RNA synthesized in KB cells infected with adenovirus type 7 and virus-specific RNA synthesized in rat embryo cells (71JY1-2) transformed by the adenovirus type 7 HindIII-I.J...

Unique species of mRNA from adenovirus type 7 early region 1 in cells transformed by adenovirus type 7 DNA fragment.

Yoshida, K, Fujinaga, K

Adenovirus type 7 (Ad7) early region 1 mRNA species transcribed in rat cell lines transformed by the HindIII-I . J fragment (the left 7.8% of the viral genome) and in human KB cells infected with Ad7...

HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes.

Shirakata, M, Hüppi, K, Usuda, S, Okazaki, K, Yoshida, K, Sakano, H

In order to isolate cDNA clones for DNA-binding components of the V-(D)-J recombinase, phage libraries from a pre-B-cell line were screened with a radiolabeled probe containing recombination signal...

Demonstration of CD44 gene expression in cells from fine needle aspirates of breast lesions by the polymerase chain reaction

Bolodeoku, J, Yoshida, K, Yeomans, P, Wells, C A, Tarin, D

Aim—To demonstrate the feasibility of studying specific gene expression in fine needle aspirates from clinical lesions. The reverse transcription/polymerase chain reaction (RT-PCR) technique was...

Distribution of CD44 messenger RNA in archival paraffin wax embedded tumours and normal tissues viewed by in situ hybridisation

Gorham, H, Sugino, T, Bolodeoku, J, Yoshida, K, Goodison, S, Tarin, D

Aims—We have previously demonstrated the abnormal localisation of expression of the CD44 gene in carcinoma cells in cryostat sections of fresh frozen tumour tissues, using radioactive in situ...

Induction of resistance with heat-killed compact-type strains of Staphylococcus aureus against challenge with the diffuse variant of the Smith strain of Staphylococcus aureus.

Yoshida, K, Ichiman, Y, Otomo, T

Active immunization of mice with high doses of heat-killed and autoclaved vaccine of unencapsulated strains of Staphylococcus aureus, which was grown in brain heart infusion media, protected against...

Relationship of capsular type to biochemical and immunological properties of teichoic acid preparations from unencapsulated strains of Staphylococcus aureus.

Ohtomo, T, Yoshida, K, Clemente, C L

We investigated the biochemical and immunological characteristics of teichoic acid preparations (TAP) obtained from four unencapsulated strains of Staphylococcus aureus which nonetheless, according...

Telomerase activity in human gynaecological malignancies.

Gorham, H, Yoshida, K, Sugino, T, Marsh, G, Manek, S, Charnock, M, ...

AIM: To evaluate whether increased telomerase activity can be clinically useful for detecting malignant cells in a variety of gynaecological specimens. METHODS: Telomerase activity was examined in...

Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene.

Yoshida, K, Sugino, T, Bolodeoku, J, Warren, B F, Goodison, S, Woodman, A, ...

AIMS: To investigate whether colonic cancer cells exfoliated into the lumen of the organ can be detected by identification of their abnormal CD44 gene products. METHODS: Exfoliated cells were...

Serum albumin as an auxiliary factor enhancing compact-colony formation by Staphylococcus aureus in serum-soft agar.

Usui, Y, Yoshida, K, San Clemente, C L

Serum albumin was identified as an auxiliary factor enhancing the substance active in compact-colony formation by strains of S. aureus when cultivated in serum-soft agar.

Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.

Usuda, S, Takemori, T, Matsuoka, M, Shirasawa, T, Yoshida, K, Mori, A, ...

Circular DNA resulting from V gene replacement was studied with an A-MuLV transformed cell line containing ablts. This cell line undergoes V gene replacement at elevated temperatures in the...

Structural differences between heparan sulphates of proteoglycan involved in the formation of basement membranes in vivo by Lewis-lung-carcinoma-derived cloned cells with different metastatic potentials.

Nakanishi, H, Oguri, K, Yoshida, K, Itano, N, Takenaga, K, Kazama, T, ...

This study addresses the characterization of heparan sulphates of the basement-membrane proteoglycans in tumour formed after the subcutaneous implantation of Lewis-lung-carcinoma-derived different...

Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor.

Habuchi, H, Suzuki, S, Saito, T, Tamura, T, Harada, T, Yoshida, K, ...

Binding of basic fibroblast growth factor (bFGF) to the extracellular matrix of cultured bovine aorta smooth muscle cells is likely to be mediated via heparan sulphate, since not only exogenous...

Comparison of the effects of phorbol 12-myristate 13-acetate and prostaglandin E1 on calcium regulation in human platelets.

Yoshida, K, Stark, F, Nachmias, V T

We compared the effects of phorbol 12-myristate 13-acetate (PMA) with those of prostaglandin E1 (PGE1) on the calcium transient in intact platelets and on 45Ca2+ uptake in saponin-treated platelets...

Solution structure of midkine, a new heparin-binding growth factor.

Iwasaki, W, Nagata, K, Hatanaka, H, Inui, T, Kimura, T, Muramatsu, T, ...

Midkine (MK) is a 13 kDa heparin-binding polypeptide which enhances neurite outgrowth, neuronal cell survival and plasminogen activator activity. MK is structurally divided into two domains, and most...

Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.

Kamiya, A, Kinoshita, T, Ito, Y, Matsui, T, Morikawa, Y, Senba, E, ...

Fetal liver, the major site of hematopoiesis during embryonic development, acquires additional various metabolic functions near birth. Although liver development has been characterized biologically...

Neural correlates of horizontal vestibulo-ocular reflex cancellation during rapid eye movements in the cat.

Berthoz, A, Droulez, J, Vidal, P P, Yoshida, K

1. The aim of the present study is to describe the behaviour of identified second-order vestibular neurones in the alert cat during eye saccades. A selection of neurones which are involved in...

Spatial patterns of reflex evoked by pressure stimulation of the foot pads in cats.

Hongo, T, Kudo, N, Oguni, E, Yoshida, K

1. The spatial patterns of reflexes elicited by localized pressure stimulation of the foot skin were analysed by recording electromyographic activities of various hindlimb muscles or muscle nerve...

Inhibition of dorsal spinocerebellar tract cells by interneurones in upper and lower lumbar segments in the cat.

Hongo, T, Jankowska, E, Ohno, T, Sasaki, S, Yamashita, M, Yoshida, K

The topographical distribution of interneurones mediating disynaptic inhibition of dorsal spinocerebellar tract (d.s.c.t.) cells from group I muscle afferents in the cat was investigated using both...

The same interneurones mediate inhibition of dorsal spinocerebellar tract cells and lumbar motoneurones in the cat.

Hongo, T, Jankowska, E, Ohno, T, Sasaki, S, Yamashita, M, Yoshida, K

The aim of the study was to investigate whether inhibition of dorsal spinocerebellar tract (d.s.c.t.) cells evoked from group I afferents is mediated by the same interneurones which mediate the...

Retrotransposon-Induced Ectopic Expression of Cut Causes the Om(1a) Mutant in Drosophila Ananassae

Awasaki, T., Juni, N., Hamabata, T., Yoshida, K., Matsuda, M., Tobari, Y. N., ...

Optic morphology (Om) mutations in Drosophila ananassae map to at least 22 loci scattered throughout the genome. They are semidominant, neomorphic, nonpleiotropic, and are associated with the...

The Om(1e) Mutation in Drosophila Ananassae Causes Compound Eye Overgrowth Due to Tom Retrotransposon-Driven Overexpression of a Novel Gene

Juni, N., Awasaki, T., Yoshida, K., Hori, S. H.

Optic morphology (Om) mutations in Drosophila ananassae are a group of retrotransposon (tom)-induced gain-of-function mutations that map to at least 22 independent loci and exclusively affect the...

Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia.

Aki, T, Mizukami, Y, Oka, Y, Yamaguchi, K, Uemura, K, Fujimiya, T, ...

Using H9c2 cells derived from rat cardiomyocytes, we investigated the mechanism of cell death during hypoxia in the presence of serum and glucose. Hypoxic cell death is by necrosis and is accompanied...

Is postoperative radiotherapy for thymoma effective?

Haniuda, M, Miyazawa, M, Yoshida, K, Oguchi, M, Sakai, F, Izuno, I, ...

OBJECTIVE: The authors determined the effect of postoperative mediastinal irradiation in preventing local and pleural recurrence of thymoma. SUMMARY BACKGROUND DATA: The role of mediastinal...

Inapparent carcinoma of the gallbladder. An appraisal of a radical second operation after simple cholecystectomy.

Shirai, Y, Yoshida, K, Tsukada, K, Muto, T

This study was designed to investigate issues concerning "inapparent carcinoma" of the gallbladder and the effectiveness of a radical second operation in the treatment of inapparent carcinoma....

Radical surgery for gallbladder carcinoma. Long-term results.

Shirai, Y, Yoshida, K, Tsukada, K, Muto, T, Watanabe, H

The authors' objective was to evaluate the effectiveness of radical surgery with lymph node dissection for gallbladder carcinoma. Long-term results were analyzed in 40 patients in a 5-year study. The...

Fabrication of a new substrate for atomic force microscopic observation of DNA molecules from an ultrasmooth sapphire plate.

Yoshida, K, Yoshimoto, M, Sasaki, K, Ohnishi, T, Ushiki, T, Hitomi, J, ...

A new stable substrate applicable to the observation of DNA molecules by atomic force microscopy (AFM) was fabricated from a ultrasmooth sapphire (alpha-Al2O3 single crystal) plate. The atomically...

Population Sizes and Growth Pressure Responses of Intestinal Microfloras of Deep-Sea Fish Retrieved from the Abyssal Zone

Yano, Y., Nakayama, A., Yoshida, K.

The intestinal floras of seven deep-sea fish retrieved at depths of from 3,200 to 5,900 m were examined for population sizes and growth responses to pressure. Large populations of culturable...

Distribution of Polyunsaturated Fatty Acids in Bacteria Present in Intestines of Deep-Sea Fish and Shallow-Sea Poikilothermic Animals

Yano, Y., Nakayama, A., Yoshida, K.

The lipid and fatty acid compositions in nine obligate and facultative barophilic bacteria isolated from the intestinal contents of seven deep-sea fish were determined. Phospholipid compositions were...

Biotransformation of nitric oxide.

Yoshida, K, Kasama, K

Previous investigations into the health effects of nitrogen oxides (NOx) have mostly been conducted with special reference to nitrogen dioxide (NO2) and its direct effects on the respiratory system,...

Human beta-galactosidase gene mutations in morquio B disease.

Oshima, A, Yoshida, K, Shimmoto, M, Fukuhara, Y, Sakuraba, H, Suzuki, Y

Three different beta-galactosidase gene mutations--a 273Trp----Leu (mutation F) in both families, 482Arg----His (mutation G) in one family, and 509Trp----Cys (mutation H) in the other family--were...

Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases.

Yoshida, K, Oshima, A, Shimmoto, M, Fukuhara, Y, Sakuraba, H, Yanagisawa, N, ...

Molecular analysis of the human beta-galactosidase gene revealed six different mutations in 10 of 11 Japanese GM1-gangliosidosis patients. They were the only abnormalities in each allele examined in...

Host origin of follicular dendritic cells induced in the spleen of SCID mice after transfer of allogeneic lymphocytes.

Yoshida, K, Kaji, M, Takahashi, T, Van Den Berg, T K, Dijkstra, C D

Follicular dendritic cells (FDC) are uniquely characterized by the ability to trap immune complexes. In a previous report, it was shown that functional FDC with the capacity to trap immune complexes...

Activation of extrathymic T cells in the liver during liver regeneration following partial hepatectomy.

Sato, Y, Tsukada, K, Iiai, T, Ohmori, K, Yoshida, K, Muto, T, ...

Partial hepatectomy was performed in C57BL/6 mice to investigate whether extrathymic T cells in the liver are activated during liver regeneration. This study is based on the finding that in mice with...

Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcR gamma II-mediated immune-complex trapping.

Yoshida, K, Van Den Berg, T K, Dijkstra, C D

The capacity to trap immune complexes (IC) was examined using purified peroxidase-antiperoxidase IgG on frozen sections of mouse spleen. In the absence of serum, binding of IC was confined to...

Accessory cell functions of dendritic cells and macrophages in the thymic T-cell response to Con A.

Hirayama, Y, Inaba, K, Komatsubara, S, Yoshida, K, Kawai, J, Naito, K, ...

Accessory cell (A cell) functions of splenic dendritic cells (DC) and peritoneal macrophages (M phi) were investigated in the Con A-stimulated proliferative response of thymic T cells. DC were more...

Complement titration by rectilinear attenuance and attempts at its automatization

Satoh, P. S., Yoshida, T. O., Fukusima, Y., Ono, N., Yoshida, K., Ito, Y.

Immune haemolysis was determined by rectilinear attenuance at 625 mμ (l = 1.3 mm, 1.25 mm), and the data obtained treated by von Krogh's empirical equation. The C′H50/ml values obtained by the...

Contents and compositions of glycosaminoglycans in different sites of the human hip joint cartilage.

Yoshida, K, Azuma, H

The distribution of glycosaminoglycans (GAGs) in different functional regions (weight-bearing and nonweight-bearing portions) of the human hip joint cartilage was studied. The results obtained were...

Inhibition of arthritis by systemic administration of endostatin in passive murine collagen induced arthritis

Kurosaka, D, Yoshida, K, Yasuda, J, Yokoyama, T, Kingetsu, I, Yamaguchi, N, ...

Methods: Four kinds of monoclonal anti-type II collagen antibody followed by lipopolysaccharide (LPS) three days later were given to 6 week old, female Balb/c mice to induce arthritis. Three groups...

Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.

Hida, K., Shindoh, M., Yasuda, M., Hanzawa, M., Funaoka, K., Kohgo, T., ...

E1AF is a newly identified human ets-family transcription factor. We have reported that E1AF can up-regulate transcription of matrix metalloproteinase (MMP) genes and confers invasive phenotype on...

Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.

Shindoh, M., Higashino, F., Kaya, M., Yasuda, M., Funaoka, K., Hanzawa, M., ...

Matrix metalloproteinases (MMPs) have been implicated in invasion and metastasis of tumor cells. Transcription regulatory regions of MMP genes often contain binding sites for ets transcription...

Progressive loss of CD44 gene expression in invasive bladder cancer.

Sugino, T., Gorham, H., Yoshida, K., Bolodeoku, J., Nargund, V., Cranston, D., ...

This study investigated CD44 gene expression at both the RNA and protein level in well differentiated superficial and in deeply invasive bladder carcinomas. Proteins were studied by...

Analysis of anomalous CD44 gene expression in human breast, bladder, and colon cancer and correlation of observed mRNA and protein isoforms.

Woodman, A. C., Sugiyama, M., Yoshida, K., Sugino, T., Borgya, A., Goodison, S., ...

Many studies have now demonstrated disorganized overexpression of the CD44 gene in various types of human malignant tumors, and this abnormality has emerged as an interesting candidate marker for...

Cellular distribution of 92-kd type IV collagenase/gelatinase B in human hepatocellular carcinoma.

Ashida, K., Nakatsukasa, H., Higashi, T., Ohguchi, S., Hino, N., Nouso, K., ...

To examine the possible involvement of gelatinase B in human hepatocellular carcinoma (HCC), cellular localization of transcripts and protein of gelatinase B were studied by using in situ...

Use of intravascular ultrasound for in vivo assessment of changes in intimal thickness of angiographically normal saphenous vein grafts one year after aortocoronary bypass surgery.

Hozumi, T., Yoshikawa, J., Yoshida, K., Akasaka, T., Takagi, T., Honda, Y., ...

OBJECTIVE: To use intravascular ultrasound in vivo to evaluate changes in the intimal thickness of angiographically normal saphenous vein grafts one year after implantation. DESIGN: Fifteen saphenous...

Non-invasive automated assessment of the ratio of pulmonary to systemic flow in patients with atrial septal defects by the colour Doppler velocity profile integration method

Ueda, Y, Hozumi, T, Yoshida, K, Watanabe, H, Akasaka, T, Takagi, T, ...

Background: The recent introduction of the automated cardiac flow measurement (ACM) method, using spatiotemporal integration of the Doppler velocity profile, provides a quick and accurate automated...

Automated quantification of aortic regurgitant volume and regurgitant fraction using the digital colour Doppler velocity profile integration method in patients with aortic regurgitation

Miyake, Y, Hozumi, T, Mori, I, Sugioka, K, Yamamuro, A, Akasaka, T, ...

Background: The recently introduced automated cardiac flow measurement (ACM) technique provides a quick and an accurate automated calculation of stroke volume and cardiac output. This is obtained by...

Coronary flow velocity analysis during short term follow up after coronary reperfusion: use of transthoracic Doppler echocardiography to predict regional wall motion recovery in patients with acute myocardial infarction

Hozumi, T, Kanzaki, Y, Ueda, Y, Yamamuro, A, Takagi, T, Akasaka, T, ...

Background: A recent study using a Doppler guide wire showed that coronary flow velocity measurements immediately after coronary reperfusion were useful in predicting recovery of regional left...

Activation of nuclear factor-kappa B in the conjunctiva with the epithelial scraping of the mouse cornea and human epidemic keratoconjunctivitis

Kase, S, Aoki, K, Harada, T, Harada, C, Ohgami, K, Shiratori, K, ...

Aim: To examine the expression of p65, one of nuclear factor-kappa B (NF-κB), in the conjunctival epithelium of the C57Bl6 mouse and a patient with epidemic keratoconjunctivitis (EKC).

Seroepidemiology of Chlamydia pneumoniae in Japan between 1991 and 2000

Miyashita, N, Fukano, H, Yoshida, K, Niki, Y, Matsushima, T

Aim: To clarify the endemic and epidemic status of Chlamydia pneumoniae in Japan, the incidence of anti-C pneumoniae antibody was evaluated over a period of 10 years.

Sudden death of a patient with primary hypereosinophilia, colon tumours, and pulmonary emboli

Uemura, K, Nakajima, M, Yamauchi, N, Fukayama, M, Yoshida, K

A 33 year old man was admitted to hospital six days after the onset of abdominal pain. There was hypereosinophilia, but the cause could not be identified (primary hypereosinophilia). The...

Lymphokine activity production in graft-versus-host reactions across minor histocompatibility antigen barriers.

Hirokawa, M, Takatsu, H, Ohshima, A, Chubachi, A, Kudo, K, Niitsu, H, ...

Activated T cells responding to murine minor histocompatibility antigens (HA) were characterized according to the patterns of lymphokine activity production. Although B10.D2/nSN and BALB/c are...

The change in C3b receptors on erythrocytes from patients with systemic lupus erythematosus.

Yoshida, K, Yukiyama, Y, Hirose, S, Miyamoto, T

A deficiency of C3b receptors (CR1) on erythrocytes from patients with systemic lupus erythematosus (SLE) has already been reported and assumed to be one of the causes of the impaired immune complex...

The perforin mediated apoptotic pathway in lung injury and fibrosis

Miyazaki, H, Kuwano, K, Yoshida, K, Maeyama, T, Yoshimi, M, Fujita, M, ...

Aims: The perforin mediated pathway is the major pathway of cytotoxicity induced by activated T cells and natural killer cells, and may be involved in the development of pulmonary fibrosis.

Close correlation of the cardioprotective effect of FK409, a spontaneous NO releaser, with an increase in plasma cyclic GMP level.

Kita, Y, Sugimoto, T, Hirasawa, Y, Yoshida, K, Maeda, K

FK409 ((+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide) , which has been reported by us to be a new spontaneous nitric oxide (NO) releaser, prevented myocardial infarction following...

Antiplatelet activities of FK409, a new spontaneous NO releaser.

Kita, Y, Hirasawa, Y, Yoshida, K, Maeda, K

1. We reported that (+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide (FK409) released nitric oxide (NO) spontaneously with a chemiluminescence analyzer. The aim of this study was to compare...

Antianginal effects of FK409, a new spontaneous NO releaser.

Kita, Y, Ozaki, R, Sakai, S, Sugimoto, T, Hirasawa, Y, Ohtsuka, M, ...

1. The aim of this study was to compare antianginal effects of (+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide (FK409), a new spontaneous nitric oxide releaser, with those of isosorbide...

Exocytotic release of catecholamines and dopamine-beta-hydroxylase from the perfused adrenal gland of the rabbit and cat.

Sorimachi, M, Yoshida, K

1 Secretion of catecholamines (CA) and dopamine-beta-hydroxylase (DBH) activity from the perfused rabbit and cat adrenal gland was studied following stimulation by a number of substances, including...

Intraoperative spasm of coronary and peripheral artery--a case occurring after tourniquet deflation during sevoflurane anesthesia.

Yoshida, K., Murata, Y., Takano, H., Furuya, M., Ohsawa, A.

A 68-yr-old man with a 9-yr history of hypertension presented for hemiglossectomy, segmental resection of the mandible, and the radial forearm free flap grafting. Intraoperatively, facial artery...

Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions.

Mizuguchi, M, Abe, J, Mikkaichi, K, Noma, S, Yoshida, K, Yamanaka, T, ...

The clinicopathological features of a previously unrecognised type of acute encephalopathy prevalent among Japanese children is described by reviewing the records of 13 consecutive patients treated...

Dynamics of cerebral blood flow and metabolism in patients with cranioplasty as evaluated by 133Xe CT and 31P magnetic resonance spectroscopy.

Yoshida, K, Furuse, M, Izawa, A, Iizima, N, Kuchiwaki, H, Inao, S

OBJECTIVE--Prolonged improvement in neurological and mental disorders has been seen after only cranioplasty in patients initially treated with external decompression for high intracranial pressure....

Hypersensitivity pneumonitis induced by a smut fungus Ustilago esculenta.

Yoshida, K, Suga, M, Yamasaki, H, Nakamura, K, Sato, T, Kakishima, M, ...

A case of hypersensitivity pneumonitis caused by a smut fungus Ustilago esculenta is presented.

Occupational hypersensitivity pneumonitis in Japan: data on a nationwide epidemiological study.

Yoshida, K, Suga, M, Nishiura, Y, Arima, K, Yoneda, R, Tamura, M, ...

OBJECTIVES--Diagnostic criteria were prepared for hypersensitivity pneumonitis (HP) and a nationwide survey was conducted to investigate epidemiological and clinical characteristics of HP in Japan....

Effect of one or more co-morbid conditions on diagnostic accuracy of coronary flow velocity reserve for detecting significant left anterior descending coronary stenosis

Yoshitani, H, Takeuchi, M, Sakamoto, K, Akasaka, T, Yoshida, K, Yoshikawa, J

Objective: To determine the effect of one or multiple co-morbid conditions on the diagnostic accuracy of coronary flow velocity reserve (CFVR) in a heterogeneous patient population.

Does informed consent exempt Japanese doctors from reporting therapeutic deaths?

Ikegaya, H, Kawai, K, Kikuchi, Y, Yoshida, K

The Japanese Medical Act section 21 states that doctors must report unnatural deaths to the police, even though the term “unnatural death” is not defined by law. However, many doctors are...

眼球内臟反射の實驗的研究補遺(第1編) : 健康家兎に於ける眼球肺臟,眼球心臟,特に眼球血管反射に就て

吉田, 喜司, Yoshida, K.

In der vorliegenden Mitteilung wurden die drei genannten Reflexe am Kaninchen bei gleichzeitiger Registrierung der Blutdruck und Atemkurve beobachtet. Einerseits geschah dies, um die erhaltenen...

眼球内臟反射の實驗的研究補遺(第2編) : 眼球肺臟,眼球心臟,眼球血管反射の求心脚に就て

吉田, 喜司, Yoshida, K.

家兎に於ける三叉神經切斷後眼球内臟反射(眼球肺臟,眼球心臟,眼球血管反射)は甚だしく?退するも全く消失するに至らない。同様に視神經切斷も之を...

Alterations of oncogenes in metastatic tumours of human gastric carcinomas.

Tsujino, T., Yoshida, K., Nakayama, H., Ito, H., Shimosato, T., Tahara, E.

To determine whether alterations in oncogenes are associated with tumour progression and metastasis, DNAs from 32 metastatic tumour samples of different sites in 12 autopsy cases of gastric...

Immunohistochemical characterisation of extracellular matrix components of salivary gland tumours.

Nara, Y., Takeuchi, J., Yoshida, K., Fukatsu, T., Nagasaka, T., Kawaguchi, T., ...

Proteoglycans (PGs) were localised immunohistochemically in 52 salivary gland tumours including pleomorphic adenoma, adenoid cystic carcinoma, acinic cell carcinoma, oncocytoma, mucoepidermoid...

Detection of telomerase activity in exfoliated cancer cells in colonic luminal washings and its related clinical implications.

Yoshida, K., Sugino, T., Goodison, S., Warren, B. F., Nolan, D., Wadsworth, S., ...

Telomerase is a ribonucleoprotein capable of replacing telomeric DNA sequences that are lost at each cell division. Under normal circumstances, it is active in rapidly dividing embryonic cells and in...

Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.

Yoneda, S., Fujisawa, M., Watanabe, J., Okabe, T., Takaku, F., Homma, T., ...

Monoclonal antibody TFS-4 has previously been shown to react selectively with human small cell lung cancer (SCLC). We evaluated the use of 131I-labelled TFS-4 for the treatment of established human...

Adenovirus-mediated interferon α gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer

Ohashi, M, Yoshida, K, Kushida, M, Miura, Y, Ohnami, S, Ikarashi, Y, ...

We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-α) gene transfer, which induced a more prominent growth suppression and cell...

The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target

Kuroda, M, Kiyono, T, Oikawa, K, Yoshida, K, Mukai, K

Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa...

MN/CA IX/G250 as a potential target for immunotherapy of renal cell carcinomas

Uemura, H, Nakagawa, Y, Yoshida, K, Saga, S, Yoshikawa, K, Hirao, Y, ...

The monoclonal antibody G250 (mAbG250) raised against a human renal cell carcinoma (RCC) has been shown to react with a large number of RCCs. Recently, G250 antigen was isolated and found to be...

Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer

Shou, Y, Hirano, T, Gong, Y, Kato, Y, Yoshida, K, Ohira, T, ...

We attempted to investigate immunohistochemical expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor (PD-ECGF), c-erbB-2,...

Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma

Cho, M, Uemura, H, Kim, S-C, Kawada, Y, Yoshida, K, Hirao, Y, ...

MN/CA9 is a cancer-related gene, frequently activated in human renal cell carcinomas (RCCs). To reveal the activation mechanism, we investigated the relationship between methylation status of the...

Phosphorylated tyrosine-containing proteins in primary lung cancer correlates with proliferation and prognosis

Gong, Y, Hirano, T, Kato, Y, Yoshida, K, Shou, Y, Ohira, T, ...

To determine the usefulness of tyrosine phosphorylation in evaluating biological characteristics, we attempted to evaluate the relationship between the amount of phosphorylated tyrosine-containing...

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan

Nakajima, M, Kojima, H, Takazawa, Y, Yahagi, N, Harada, K, Takahashi, K, ...

A 60-year old man with a 10-year history of multiple system atrophy (MSA) was found in respiratory arrest. After 4 months of respiratory support with two episodes of septic shock, he died. Autopsy...