Karen A. Lillycrop

Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition (2009)

Burdge, Graham C., Lillycrop, Karen A., Phillips, Emma S., Slater-Jefferies, Joanne L., Jackson, Alan A., Hanson, Mark A.

Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adulthood contingent on adult diet. In rats, folic acid supplementation of a protein-restricted (PR)...

Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale? (2009)

Burdge, Graham C., Lillycrop, Karen A., Jackson, Alan A.

There is substantial evidence which shows that constraints in the early life environment are an important determinant of risk of metabolic disease and CVD. There is emerging evidence that higher...

Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3 (2007)

Underwood, Timothy J., Amin, Jay, Lillycrop, Karen A., Blaydes, Jeremy P.

Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease (2007)

Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D., Hanson, Mark A.

There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that environmental influences acting during...

Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations (2007)

Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A., Lillycrop, Karen A.

Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent...

Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring (2005)

Lillycrop, Karen A., Phillips, Emma S., Jackson, Alan A., Hanson, Mark A., Burdge, Graham C.

Environmental constraints during early life result in phenotypic changes that can be associated with increased disease risk in later life. This suggests persistent alteration of gene transcription....

Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor g activation induced by 15-deoxyD(12),(14)-prostaglandin J(2) in neuroblastoma cells (2004)

Rodway, Helen A., Hunt, Alan N., Kohler, Janice A., Postle, Anthony D., Lillycrop, Karen A.

PPARg (peroxisome proliferator-activated receptor g) is a ligand-activated transcription factor that responds to 15dPGJ(2) (15-deoxy-D(12),(14)-prostglandin J(2)). 15dPGJ(2), in vitro, halts...

Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferator-activated receptors in the liver and adipose tissue of the offspring (2004)

Burdge, Graham C., Phillips, Emma S., Dunn, Rebecca L., Jackson, Alan A., Lillycrop, Karen A.

The effect of protein consumption during pregnancy on peroxisomal proliferator-activated receptor (PPAR) expression and plasma lipid concentrations in the offspring were determined in the rat. Rats...

The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc (2002)

Harris, Robert G., White, Edward, Phillips, Emma S., Lillycrop, Karen A.

N-Myc is a member of the Myc family of transcription factors that have been shown to play a pivotal role in cell proliferation and differentiation. In this report, we have investigated the...

The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter (1994)

Dawson, Sally J., Yoon, Sung Ok, Chikaraishi, Dona M., Lillycrop, Karen A., Latchman, David S.

The tyrosine hydroxylase (TH) gene promoter contains adjacent octamer and heptamer motifs which act as target sites for octamer binding transcription factors. Mutation of the heptamer motif but not...

Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor (1994)

Lillycrop, Karen A., Howard, M.Keith, Estridge, John K., Latchman, David S.

Herpes simplex virus (HSV) is capable of lytic replication in most cells, such replication in epithelial cells resulting in the mucocutaneous lesions observed following In vivo infection. In addition...

Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains (1993)

Morris, Peter J., Ring, Christopher J.A., Lillycrop, Karen A., Latchman, David S.

The upstream regulatory region (URR) of the human papillomaviruses HPV16 and 18 contains a sequence with a seven out of eight base match to the consensus binding site for octamer binding...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...