Karin Broberg

Association between polymorphisms in RMI1, TOP3A, and BLMand risk of cancer, a case-control study (2009)

Broberg, Karin, Huynh, Elizabeth, Engström, Karin, Björk, Jonas, Albin, Maria, Ingvar, Christian, ...

Abstract Background Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome). Thus, genetic variants of BLM and proteins that form complexes with...

Ranking of genome-wide association scan signals by different measures (2009)

Strömberg, Ulf, Björk, Jonas, Vineis, Paolo, Broberg, Karin, Zeggini, Eleftheria

Background The P-value approach has been employed to prioritizing genome-wide association (GWA) scan signals, with a genome-wide significance defined by a prior P-value threshold, although this is...

Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study (2008)

Broberg, Karin, Tinnerberg, Håkan, Axmon, Anna, Warholm, Margareta, Rannug, Agneta, Littorin, Margareta

Abstract Background Toluene diisocyanate (TDI) is a highly reactive compound used in the production of, e.g., polyurethane foams and paints. TDI is known to cause respiratory symptoms and diseases....

Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review (2007)

Kellen, Eliane, Hemelt, Marjolein, Broberg, Karin, Golka, Klaus, Kristensen, Vessela Nedelcheva, Hung, Rayjean J., ...

The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To...

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer (2005)

Broberg, Karin, Björk, Jonas, Paulsson, Karin, Höglund, Mattias, Albin, Maria

Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal...

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer (2005)

Broberg, Karin, Björk, Jonas, Paulsson, Karin, Höglund, Mattias, Albin, Maria

Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal...

Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. (2002)

Broberg, Karin, Zhang, Miao, Strombeck, Bodil, Isaksson, Margareth, Nilsson, Malin, Mertens, Fredrik, ...

Rearrangements of chromosome bands 12q13-15 are frequent in various benign mesenchymal and epithelial tumors, and the gene HMGA2 seems to be the most common target within this chromosome region. In...

Proteoglycan production in disomic and trisomy 7-carrying human synovial cells. (2002)

Eklund, Erik, Broberg, Karin, Westergren-Thorsson, Gunilla, Bjärdahlen, Anette, Hedlund, Maria, Malmström, Anders

To gain further insight into the synthesis and structure of the synovial matrix of joints, we have established cell cultures from synovial specimens and elaborated their production of hyaluronan and...

Characterization of somatic mutations in nonneoplastic cells (2001)

Broberg, Karin

Acquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent...

Characterization of somatic mutations in nonneoplastic cells (2001)

Broberg, Karin

Acquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent...

Genetic Polymorphisms Influencing Arsenic Metabolism: Evidence from Argentina

Engström, Karin Schläwicke, Broberg, Karin, Concha, Gabriela, Nermell, Barbro, Warholm, Margareta, Vahter, Marie

The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to interindividual variations in As metabolism that affect retention and distribution of toxic...