Karl-Anders Karlsson

Helicobacter pylori binding to new glycans based on N-acetyllactosamine (2009)

Miller-Podraza, Halina, Weikkolainen, Krista, Larsson, Thomas, Linde, Petra, Helin, Jari, Natunen, Jari, ...

Previously we reported binding of Helicobacter pylori to various nonacid and sialylated neolacto carbohydrate structures using a wide range of natural and chemically modified sequences. A novel...

Default biosynthesis pathway for blood group-related glycolipids in human small intestine as defined by structural identification of linear and branched glycosylceramides in a group O Le(a-b-) nonsecretor (2004)

Ångström, Jonas, Larsson, Thomas, Hansson, Gunnar C., Karlsson, Karl-Anders, Henry, Stephen

Glycoconjugates of the GI tract are important for microbial interactions. The expression of histo-blood group glycosyltransferases governs both the expression of blood group determinants and in part...

Studies on gangliosides with affinity for Helicobacter pylori: binding to natural and chemically modified structures (2004)

Miller-Podraza, Halina, Johansson, Petra, Ångström, Jonas, Larsson, Thomas, Longard, Marianne, Karlsson, Karl-Anders

Helicobacter pylori, like many other microbes, has the ability to bind to carbohydrate epitopes. Several sugar sequences have been reported as active for the bacterium, including some neutral,...

Default biosynthesis pathway for blood-group related glycolipids in human small intestine as defined by structural identification of linear and branched glycosylceramides in a group O Le(a-b-) nonsecretor (2003)

Ångström, Jonas, Larsson, Thomas, Hansson, Gunnar C., Karlsson, Karl-Anders, Henry, Stephen

Glycoconjugates of the gastrointestinal tract are important for microbial interactions. The expression of histo-blood group glycosyltransferases both governs the expression of blood group...

Studies on gangliosides with affinity for Helicobacter pylori: binding to natural and chemically modified structures (2003)

Miller-Podraza, Halina, Johansson, Petra, Ångström, Jonas, Larsson, Thomas, Longard, Marianne, Karlsson, Karl-Anders

Helicobacter pylori, like many other microbes has the ability to bind to carbohydrate epitopes and several sugar sequences have been reported as active for the bacterium including some neutral,...

Default biosynthesis pathway for blood-group related glycolipids in human small intestine as defined by structural identification of linear and branched glycosylceramides in a group O Le(a-b-) nonsecretor (2003)

Ångström, Jonas, Larsson, Thomas, Hansson, Gunnar C., Karlsson, Karl-Anders, Henry, Stephen

Glycoconjugates of the gastrointestinal tract are important for microbial interactions. The expression of histo-blood group glycosyltransferases both governs the expression of blood group...

Studies on gangliosides with affinity for Helicobacter pylori: binding to natural and chemically modified structures (2003)

Miller-Podraza, Halina, Johansson, Petra, Ångström, Jonas, Larsson, Thomas, Longard, Marianne, Karlsson, Karl-Anders

Helicobacter pylori, like many other microbes has the ability to bind to carbohydrate epitopes and several sugar sequences have been reported as active for the bacterium including some neutral,...

Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation (2002)

Mahdavi, Jafar, Sondén, Berit, Hurtig, Marina, Olfat, Farzad O., Forsberg, Lina, Roche, Niamh, ...

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for...

Lactotetraosylceramide, a novel glycosphingolipid receptor for Helicobacter pylori, present in human gastric epithelium (2002)

Teneberg, Susann, Leonardsson, Iréne, Karlsson, Hasse, Jovall, Per-Åke, Ångström, Jonas, Danielsson, Dan, ...

The binding of Helicobacter pylori to glycosphingolipids was examined by binding of 35S-labeled bacteria to glycosphingolipids on thin-layer chromatograms. In addition to previously reported binding...

The human gastric colonizer Helicobacter pylori: a challenge for host-parasite glycobiology (2000)

Karlsson, Karl-Anders

The Gram-negative bacterium Helicobacter pylori was first described in 1983 and currently represents one of the most active single research topics in biomedicine. It is specific for the human stomach...

Inhibition of nonopsonic Helicobacter pylori-induced activation of human neutrophils by sialylated oligosaccharides (2000)

Teneberg, Susann, Jurstrand, Margaretha, Karlsson, Karl-Anders, Danielsson, Dan

Certain strains of Helicobacter pylori have nonopsonic neutrophil-activating capacity. Some H.pylori strains and the neutrophil-activating protein of H.pylori (HPNAP) bind selectively to gangliosides...

Lactobacillus johnsonii La1 shares carbohydrate-binding specificities with several enteropathogenic bacteria (2000)

Neeser, Jean-Richard, Granato, Dominique, Rouvet, Martine, Servin, Alain, Teneberg, Susann, Karlsson, Karl-Anders

The carbohydrate-binding specificities of the probiotic lactic acid bacterium Lactobacillus johnsonii La1 (a health-beneficial bacterial strain able to be incorporated into the human intestinal...

Polyglycosylceramides recognized by Helicobacter pylori: analysis by matrix-assisted laser desorption/ionization mass spectrometry after degradation with endo-{beta}-galactosidase and by fast atom bombardment mass spectrometry of permethylated undegraded material (2000)

Karlsson, Hasse, Larsson, Thomas, Karlsson, Karl-Anders, Miller-Podraza, Halina

Human erythrocyte polyglycosylceramides (PGCs) are recognized by the gastric pathogen Helicobacter pylori and are based on a successively extended and highly branched N-acetyllactosamine core linked...

A strain of human influenza A virus binds to extended but not short gangliosides as assayed by thin-layer chromatography overlay (2000)

Miller-Podraza, Halina, Johansson, Lena, Johansson, Petra, Larsson, Thomas, Matrosovich, Mikhail, Karlsson, Karl-Anders

A human strain of influenza virus (A, H1N1) was shown to bind in an unexpected way to leukocyte and other gangliosides when compared with avian virus (A, H4N6) as assayed on TLC plates. The human...

Gal{alpha}4Gal-binding antibodies: specificity and use for the mapping of glycolipids of Burkitt lymphoma and other human tumors (1996)

Lanne, Boel, Jondal, Mikael, Karlsson, Karl-Anders

The binding of four different Galα4Gal-speciflc antibodies was examined using several natural and synthetic Galα4Gal-containing glycolipids on thin-layer chromatograms. One of the antibodies,...

Molecular mimicry in the recognition of glycosphingolipids by Gal{alpha}3Gal{beta}4GlcNAc{beta}-binding Clostridium difficile toxin A, human natural anti {alpha}-galactosyl IgG and the monoclonal antibody Gal-13: characterization of a binding-active human glycosphingolipid, non-identical with the animal receptor (1996)

Teneberg, Susann, Lönnroth, Ivar, López, Javier F. Torres, Galili, Uri, Halvarsson, Maria Ölwegård, Ångström, Jonas, ...

Glycoconjugates with terminal Galα3Galβ4GlcNAcβ sequences have been shown to be recognized by three carbohydrate-binding proteins: toxin A of Clostridium difficile, human natural anti...

Characterization of Gangliosides of Epithelial Cells of Calf Small Intestine, with Special Reference to Receptor-Active Sequences for Enteropathogenic Escherichia coli K99 (1994)

Teneberg, Susann, Willemsen, Peter T.J., De Graaf, Frits K., Stenhagen, Gunnar, Pimlott, Weston, Jovall, Per-Åke, ...

Glycolipids were prepared from epithelial cells of the small intestine of a newborn calf and assayed for Escherichia coli K99 binding activity on thin-layer chromatograms and in microtiter wells. The...

On the Role of the Carboxyl Group of Sialic Acid in Binding of Cholera Toxin to the Receptor Glycosphingolipid, GM1 (1994)

Lanne, Boel, Schierbeck, Birgitta, Karlsson, Karl-Anders

The earboxyl group of the natural cholera toxin receptor, the ganglioside GM1, Galβl-3GalNAcβl-4(NeuAcα2-3)Galβl-4Glcβl-Cer, has been converted to a number of C(l)-amides of NeuAc. The binding...

The Preparative Separation of Sialic Acid-Containing Lipids from Sulphate Group-Containing Glycolipids from Small Intestine of Different Animals. Analysis by Thin-Layer Chromatography and Detection of Novel Species (1983)

BREIMER, Michael E., HANSSON, Gunnar C., KARLSSON, Karl-Anders, LEFFLER, Hakon

Acidic glycolipids (gangliosides and glycolipid sulphates) were purified from nonglycolipid contaminants by silicic acid chromatography of their acetylated derivatives. Acetylation converted...

Blood Group Type Glycosphingolipids from the Small Intestine of Different Animals Analysed by Mass Spectrometry and Thin-Layer Chromatography. A Note on Species Diversity (1981)

BREIMER, Michael E., HANSSON, Gunnar C., KARLSSON, Karl-Anders, LEFFLER, Hakon

The total non-acid glycosphingolipids were isolated from the small intestine of cat, cod-fish, guinea-pig, hen, mouse, rabbit, and two strains of rat. The samples were analyzed by thin-layer...

Separation and Characterization of Hematosides with Different Sialic Acids and Ceramides from Rat Small Intestine. Different Composition of Epithelial Cells versus Non-Epithelial Tissue and of Duodenum versus Jejunum-Ileum (1981)

ÅNGSTRÖM, Jonas, BREIMER, Michael E., FALK, Karl-Anders, GRIPH, Inga, HANSSON, Gunnar C., KARLSSON, Karl-Anders, ...

The hematosides (sialyl-lactosylceramides) of rat small intestine were separated as their acetylated derivatives. The isolated fractions were characterized by mass spectrometry and degradative...

The Identification of Sulphatides in Human Erythrocyte Membrance and Their Relation to Sodium-Potassium Dependent Adenosine Triphosphatase (1978)

HANSSON, C. Gunnar, KARLSSON, Karl-Anders, SAMUELSSON, Bo E.

Sulphatides (ceramide galactose-3-sulphate) were isolated from human erythrocyte membranes. The amount obtained was 3.3 mg from 6.7 kg of wet cells, or 1.5�10−9 mol per g dry cells. The polar...

Adhesion of Type 1-Fimbriated Escherichia coli to Abiotic Surfaces Leads to Altered Composition of Outer Membrane Proteins

Otto, Karen, Norbeck, Joakim, Larsson, Thomas, Karlsson, Karl-Anders, Hermansson, Malte

Phenotypic differences between planktonic bacteria and those attached to abiotic surfaces exist, but the mechanisms involved in the adhesion response of bacteria are not well understood. By the use...

Helicobacter pylori and Neutrophils: Sialic Acid-Dependent Binding to Various Isolated Glycoconjugates

Miller-Podraza, Halina, Bergström, Jörgen, Teneberg, Susann, Milh, Maan Abul, Longard, Marianne, Olsson, Britt-Marie, ...

Helicobacter pylori has been shown to agglutinate erythrocytes in a sialic acid-dependent manner. However, very few studies have examined relevant target cells in the human stomach. Neutrophils are...

Glycosphingolipid Binding Specificities of Rotavirus: Identification of a Sialic Acid-Binding Epitope

Delorme, Cécile, Brüssow, Harald, Sidoti, Josette, Roche, Niamh, Karlsson, Karl-Anders, Neeser, Jean-Richard, ...

The glycosphingolipid binding specificities of neuraminidase-sensitive (simian SA11 and bovine NCDV) and neuraminidase-insensitive (bovine UK) rotavirus strains were investigated using the thin-layer...

Adhesion of Type 1-Fimbriated Escherichia coli to Abiotic Surfaces Leads to Altered Composition of Outer Membrane Proteins

Otto, Karen, Norbeck, Joakim, Larsson, Thomas, Karlsson, Karl-Anders, Hermansson, Malte

Phenotypic differences between planktonic bacteria and those attached to abiotic surfaces exist, but the mechanisms involved in the adhesion response of bacteria are not well understood. By the use...

Helicobacter pylori and Neutrophils: Sialic Acid-Dependent Binding to Various Isolated Glycoconjugates

Miller-Podraza, Halina, Bergström, Jörgen, Teneberg, Susann, Milh, Maan Abul, Longard, Marianne, Olsson, Britt-Marie, ...

Helicobacter pylori has been shown to agglutinate erythrocytes in a sialic acid-dependent manner. However, very few studies have examined relevant target cells in the human stomach. Neutrophils are...

Glycosphingolipid Binding Specificities of Rotavirus: Identification of a Sialic Acid-Binding Epitope

Delorme, Cécile, Brüssow, Harald, Sidoti, Josette, Roche, Niamh, Karlsson, Karl-Anders, Neeser, Jean-Richard, ...

The glycosphingolipid binding specificities of neuraminidase-sensitive (simian SA11 and bovine NCDV) and neuraminidase-insensitive (bovine UK) rotavirus strains were investigated using the thin-layer...