Karl Bacos

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion (2009)

Smith, Ruben, Bacos, Karl, Fedele, Valentina, Soulet, Denis, Walz, Helena A., Obermüller, Stefanie, ...

Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and...

Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes. (2007)

Anderson, Kristina, Rusterholz, Corinne, Mansson, Robert, Jensen, Christina T, Bacos, Karl, Zandi, Sasan, ...

Abstract is not available

Increased metabolism in the R6/2 mouse model of Huntington's disease. (2007)

Bacos, Karl, Wood, Nigel I, Lindqvist, Andreas, Wierup, Nils, Woodman, Ben, ...

Abstract is not available

Progressive Alterations in the Hypothalamic-Pituitary-Adrenal Axis in the R6/2 Transgenic Mouse Model of Huntington's disease (2006)

Björkqvist, Maria, Petersén, Åsa, Bacos, Karl, Isaacs, Jeremy, Norlén, Per, Gil, Joana, ...

Huntington's disease (HD) is characterised by a triad of motor, psychiatric, and cognitive symptoms. While many of these symptoms are likely to be related to central nervous system pathology, others...

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease (2006)

Björkqvist, Maria, Petersén, Åsa, Bacos, Karl, Isaacs, Jeremy, Norlén, Per, Gil, Joana, ...

Huntington's disease (HD) is characterized by a triad of motor, psychiatric and cognitive symptoms. Although many of these symptoms are likely to be related to central nervous system pathology,...

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis. (2005)

Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Asa, Gil, Joana, ...

Abstract is not available

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis (2005)

Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Åsa, Gil, Joana, ...

Diabetes frequently develops in Huntington's disease (HD) patients and in transgenic mouse models of HD such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the...

Hormone-sensitive Lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact. (2004)

Fex, Malin, Olofsson, Charlotta S., Fransson, Ulrika, Bacos, Karl, Lindvall, Håkan, Sörhede-Winzell, Maria, ...

Abstract is not available