Karl Dreja

Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery. (2002)

Swärd, Karl, Dreja, Karl, Lindqvist, Anders, Persson, Erik, Hellstrand, Per

Inhibition of oxidative metabolism is often found to decrease contractility of systemic vascular smooth muscle, but not to reduce global [Ca(2+)](i). In the present study, we probe the hypothesis...

Effects of oxygen tension on energetics of cultured vascular smooth muscle. (2002)

Lindqvist, Anders, Dreja, Karl, Swärd, Karl, Hellstrand, Per

Chronic hypoxia is a clinically important condition known to cause vascular abnormalities. To investigate the cellular mechanisms involved, we kept rings of a rat tail artery for 4 days in hypoxic...

Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction. (2002)

Dreja, Karl, Voldstedlund, Marianne, Vinten, Jørgen, Tranum-Jensen, Jørgen, Hellstrand, Per, Swärd, Karl

OBJECTIVE: This study assessed the role of cholesterol-rich membrane regions, including caveolae, in the regulation of arterial contractility. Methods and Results- Rat tail artery devoid of...

Dynamics of Ca2+ handling in vascular smooth muscle. (2001)

Dreja, Karl

Intracellular Ca2+ is a key regulator of vascular contractility, and thereby of blood perfusion and pressure. Ca2+ signals are essential also for cell migration, proliferation and regulation of...

Dynamics of Ca2+ handling in vascular smooth muscle (2001)

Dreja, Karl

Intracellular Ca 2+ is a key regulator of vascular contractility, and thereby of blood perfusion and pressure. Ca 2+ signals are essential also for cell migration, proliferation and regulation of...

Rat arterial smooth muscle devoid of ryanodine receptor function: effects on cellular Ca2+ handling (2001)

Dreja, Karl, Nordström, Ina, Hellstrand, Per

The roles of intracellular Ca2+ stores and ryanodine (Ry) receptors for vascular Ca2+ homeostasis and viability were investigated in rat tail arterial segments kept in organ culture with Ry (10 100...

Rat arterial smooth muscle devoid of ryanodine receptor function: effects on cellular Ca2+ handling

Dreja, Karl, Nordström, Ina, Hellstrand, Per

The roles of intracellular Ca2+ stores and ryanodine (Ry) receptors for vascular Ca2+ homeostasis and viability were investigated in rat tail arterial segments kept in organ culture with Ry...

Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum

Swärd, Karl, Dreja, Karl, Susnjar, Marija, Hellstrand, Per, Hartshorne, David J, Walsh, Michael P

Ca2+ sensitization of smooth muscle contraction involves the small GTPase RhoA, inhibition of myosin light chain phosphatase (MLCP) and enhanced myosin regulatory light chain (LC20) phosphorylation....