The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events (2009)
Bhaskar, Kiran, Miller, Megan, Chludzinski, Alexandra, Herrup, Karl, Zagorski, Michael, Lamb, Bruce T
Abstract Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently...
The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. (2009)
Bhaskar, Kiran, Miller, Megan, Chludzinski, Alexandra, Herrup, Karl, Zagorski, Michael, Lamb, Bruce T
ABSTRACT: Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently...
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons. (2008)
Zhang, Jie, Cicero, Samantha A., Wang, Li, Romito-DiGiacomo, Rita R., Yang, Yan, Herrup, Karl
Cyclin-dependent kinase 5 (Cdk5) is a nontraditional Cdk that is primarily active in postmitotic neurons. Its best known substrates are cytoskeletal proteins. Less appreciated is its role in the...
Cell number in the Inferior Olive of nervous and leaner mutant mice. (2004)
Zanjani, Hadi, Herrup, Karl, Mariani, Jean
Naturally occurring cell death is an important feature of neuronal network development: the absence of adequate postsynaptic target neurons during a critical period may result in the death of...
Yin, Zhan, Haynie, Jennifer, Yang, Xiaoming, Han, Baoguang, Kiatchoosakun, Songsak, Restivo, Joseph, ...
Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its...
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. (2000)
Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...
We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient (Atm-/-)...
Walther, Ernst U., Dichgans, Martin, Maricich, Stephen M., Romito, Rita R., Yang, Fei, Dziennis, Suzan, ...
Aldolase C is regarded as the brain-specific form of fructose-1, 6-bisphosphate aldolase whereas aldolase A is regarded as muscle-specific. In situ hybridization of mouse central nervous system using...
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...
We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient...
Walther, Ernst U., Dichgans, Martin, Maricich, Stephen M., Romito, Rita R., Yang, Fei, Dziennis, Suzan, ...
Aldolase C is regarded as the brain-specific form of fructose-1,6-bisphosphate aldolase whereas aldolase A is regarded as muscle-specific. In situ hybridization of mouse central nervous system using...
The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation
Yin, Zhan, Haynie, Jennifer, Yang, Xiaoming, Han, Baoguang, Kiatchoosakun, Songsak, Restivo, Joseph, ...
Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitive...
Properties of the β Nerve Growth Factor Receptor of Avian Dorsal Root Ganglia
Iodination of the β nerve growth factor protein up to 4.1 iodines per mole of nerve growth factor was achieved with no loss of biological activity. At this level of incorporation no native or...
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...
We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient...
Walther, Ernst U., Dichgans, Martin, Maricich, Stephen M., Romito, Rita R., Yang, Fei, Dziennis, Suzan, ...
Aldolase C is regarded as the brain-specific form of fructose-1,6-bisphosphate aldolase whereas aldolase A is regarded as muscle-specific. In situ hybridization of mouse central nervous system using...
The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation
Yin, Zhan, Haynie, Jennifer, Yang, Xiaoming, Han, Baoguang, Kiatchoosakun, Songsak, Restivo, Joseph, ...
Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitive...
Properties of the β Nerve Growth Factor Receptor of Avian Dorsal Root Ganglia
Iodination of the β nerve growth factor protein up to 4.1 iodines per mole of nerve growth factor was achieved with no loss of biological activity. At this level of incorporation no native or...
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons
Zhang, Jie, Cicero, Samantha A., Wang, Li, Romito-DiGiacomo, Rita R., Yang, Yan, Herrup, Karl
Cyclin-dependent kinase 5 (Cdk5) is a nontraditional Cdk that is primarily active in postmitotic neurons. Its best known substrates are cytoskeletal proteins. Less appreciated is its role in the...
The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
Bhaskar, Kiran, Miller, Megan, Chludzinski, Alexandra, Herrup, Karl, Zagorski, Michael, Lamb, Bruce T
Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently demonstrated...