Karl Köhrer

The full-ORF clone resource of the German cDNA Consortium (2007)

Bechtel, Stephanie, Rosenfelder, Heiko, Duda, Anny, Schmidt, Christian, Ernst, Ute, Wellenreuther, Ruth, ...

Abstract Background With the completion of the human genome sequence the functional analysis and characterization of the encoded proteins has become the next urging challenge in the post-genome era....

BMC Genomics Methodology article The full-ORF clone resource of the German cDNA Consortium (2007)

Stephanie Bechtel, Heiko Rosenfelder, Anny Duda, Christian Peter Schmidt, Ute Ernst, Ruth Wellenreuther, ...

© 2007 Bechtel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License

Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals (2000)

Schmitz, Franz-Josef, Sadurski, Ralf, Kray, Angela, Boos, Mechthild, Geisel, Roland, Köhrer, Karl, ...

The polymerase chain reaction (PCR) was used to study the prevalence of the macrolide resistance genes ermA, ermB, ermC, msrA/msrB, ereA and ereB, in 851 clinical isolates of Staphylococcus aureus...

Multiple mutations conferring ciprofloxacin resistance in Staphylococcus aureus demonstrate long-term stability in an antibiotic-free environment (2000)

Jones, Mark E., Boenink, Nienke M., Verhoef, Jan, Köhrer, Karl, Schmitz, Franz-Josef

Two unrelated strains of Staphylococcus aureus, one with a single mutation in grlA, the other with multiple mutations in gyrA, gyrB, grlA, grlB, norA and the norA promoter region, encoding low-level...

Splicing and spliceosome formation of the yeast MATa1 transcript require a minimum distance from the 5' splice site to the internal branch acceptor site (1988)

Köhrer, Karl, Domdey, Horst

Small deletions of 6, 7, and 12 nucleotides introduced between the 5' splice site and the internal branch acceptor site of the first intron of the yeast MATaI gene completely abolish accurate...

Functional RNA polymerase II promoters in solitary retroviral long terminal repeats (LTR-IS elements) (1985)

Köhrer, Karl, Grummt, Ingrid, Horak, Ivan

LTR-IS elements are middle repetitive sequences in the mouse genome with structural features of solitary retroviral LTRs. In order to get some insight in the possible functional role of these...

Increased Prevalence of Class I Integrons in Escherichia coli, Klebsiella Species, and Enterobacter Species Isolates over a 7-Year Period in a German University Hospital

Schmitz, Franz-Josef, Hafner, Dieter, Geisel, Roland, Follmann, Patrick, Kirschke, Christian, Verhoef, Jan, ...

The prevalence of integrons in five enterobacterial species was analyzed in 900 blood culture isolates from 1993, 1996, and 1999. Remarkably, the prevalence increased from 4.7% in 1993 to 9.7% in...

Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones

Brisse, Sylvain, Fluit, Ad C., Wagner, Ulrich, Heisig, Peter, Milatovic, Dana, Verhoef, Jan, ...

The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in...

In Vitro Development of Resistance to Six Quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus

Boos, Mechthild, Mayer, Susanne, Fischer, Ansgar, Köhrer, Karl, Scheuring, Sibylle, Heisig, Peter, ...

Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs of ciprofloxacin, sparfloxacin, gatifloxacin, moxifloxacin, clinafloxacin, and...

Development of Resistance to Ciprofloxacin, Rifampin, and Mupirocin in Methicillin-Susceptible and -Resistant Staphylococcus aureus Isolates

Schmitz, Franz-Josef, Fluit, Ad C., Hafner, Dieter, Beeck, Andreas, Perdikouli, Mirella, Boos, Mechthild, ...

A relationship between resistance to methicillin and resistance to fluoroquinolones, rifampin, and mupirocin has been described for Staphylococcus aureus. Differences in resistance rates may be...

Characterization of grlA, grlB, gyrA, and gyrB Mutations in 116 Unrelated Isolates of Staphylococcus aureus and Effects of Mutations on Ciprofloxacin MIC

Schmitz, Franz-Josef, Jones, Mark E., Hofmann, Basia, Hansen, Birgit, Scheuring, Sibylle, Lückefahr, Marc, ...

One hundred sixteen unrelated clinical isolates of Staphylococcus aureus (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations...

Production of BRO β-Lactamases and Resistance to Complement in European Moraxella catarrhalis Isolates

Schmitz, Franz-Josef, Beeck, Andreas, Perdikouli, Mirella, Boos, Mechthild, Mayer, Susanne, Scheuring, Sybille, ...

Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were β-lactamase positive. Twenty-two (5.7%) produced BRO-2 β-lactamase....

Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs

Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...

With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs, both sequences...

In yeast, loss of Hog1 leads to osmosensitivity of autophagy

Prick, Tanja, Thumm, Michael, Köhrer, Karl, Häussinger, Dieter, Vom Dahl, Stephan

In mammalian liver, proteolysis is regulated by the cellular hydration state in a microtubule- and p38MAPK (p38 mitogen-activated protein kinase)-dependent fashion. Osmosensing in liver cells towards...

Increased Prevalence of Class I Integrons in Escherichia coli, Klebsiella Species, and Enterobacter Species Isolates over a 7-Year Period in a German University Hospital

Schmitz, Franz-Josef, Hafner, Dieter, Geisel, Roland, Follmann, Patrick, Kirschke, Christian, Verhoef, Jan, ...

The prevalence of integrons in five enterobacterial species was analyzed in 900 blood culture isolates from 1993, 1996, and 1999. Remarkably, the prevalence increased from 4.7% in 1993 to 9.7% in...

Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones

Brisse, Sylvain, Fluit, Ad C., Wagner, Ulrich, Heisig, Peter, Milatovic, Dana, Verhoef, Jan, ...

The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in...

In Vitro Development of Resistance to Six Quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus

Boos, Mechthild, Mayer, Susanne, Fischer, Ansgar, Köhrer, Karl, Scheuring, Sibylle, Heisig, Peter, ...

Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs of ciprofloxacin, sparfloxacin, gatifloxacin, moxifloxacin, clinafloxacin, and...

Development of Resistance to Ciprofloxacin, Rifampin, and Mupirocin in Methicillin-Susceptible and -Resistant Staphylococcus aureus Isolates

Schmitz, Franz-Josef, Fluit, Ad C., Hafner, Dieter, Beeck, Andreas, Perdikouli, Mirella, Boos, Mechthild, ...

A relationship between resistance to methicillin and resistance to fluoroquinolones, rifampin, and mupirocin has been described for Staphylococcus aureus. Differences in resistance rates may be...

Characterization of grlA, grlB, gyrA, and gyrB Mutations in 116 Unrelated Isolates of Staphylococcus aureus and Effects of Mutations on Ciprofloxacin MIC

Schmitz, Franz-Josef, Jones, Mark E., Hofmann, Basia, Hansen, Birgit, Scheuring, Sibylle, Lückefahr, Marc, ...

One hundred sixteen unrelated clinical isolates of Staphylococcus aureus (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations...

Production of BRO β-Lactamases and Resistance to Complement in European Moraxella catarrhalis Isolates

Schmitz, Franz-Josef, Beeck, Andreas, Perdikouli, Mirella, Boos, Mechthild, Mayer, Susanne, Scheuring, Sybille, ...

Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were β-lactamase positive. Twenty-two (5.7%) produced BRO-2 β-lactamase....

Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs

Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...

With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs, both sequences...

In yeast, loss of Hog1 leads to osmosensitivity of autophagy

Prick, Tanja, Thumm, Michael, Köhrer, Karl, Häussinger, Dieter, Vom Dahl, Stephan

In mammalian liver, proteolysis is regulated by the cellular hydration state in a microtubule- and p38MAPK (p38 mitogen-activated protein kinase)-dependent fashion. Osmosensing in liver cells towards...