A functional Notch-survivin gene signature in basal breast cancer (2008)
Lee, Connie Wing-Ching, Simin, Karl, Liu, Qin, Plescia, Janet, Guha, Minakshi, Khan, Ashraf, ...
INTRODUCTION: Basal-type, or triple-negative, breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression) is a high-risk disease for...
A functional Notch–survivingene signature in basal breast cancer (2008)
Lee, Connie W, Simin, Karl, Liu, Qin, Plescia, Janet, Guha, Minakshi, Khan, Ashraf, ...
Abstract Introduction Basal-type, or triple-negative, breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression) is a high-risk disease...
Lu, Shaolei, Simin, Karl, Khan, Ashraf, Mercurio, Arthur M.
PURPOSE: The beta4 integrin has been implicated in functions associated with the genesis and progression of carcinomas based on data obtained from cell lines and mouse models. Data on its expression...
Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...
Abstract Background Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To...
Karl Simin, Hua Wu, Lucy Lu, Dan Pinkel, Donna Albertson, Robert D. Cardiff, ...
Inactivation of the three retinoblastoma genes in the mouse mammary gland provides a new animal model for human breast cancer.
Karl Simin, Hua Wu, Lucy Lu, Dan Pinkel, Donna Albertson, Robert D. Cardiff, ...
Retinoblastoma 1 (pRb) and the related pocket proteins, retinoblastoma-like 1 (p107) and retinoblastoma-like 2 (p130) (pRbf, collectively), play a pivotal role in regulating eukaryotic cell cycle...
Profiling Patterned Transcripts in Drosophila Embryos (2002)
Simin, Karl, Scuderi, Anne, Reamey, James, Dunn, Diane, Weiss, Robert, Metherall, James E., ...
Barrow, Lon L., Simin, Karl, Jones, Julie M., Lee, David C., Meisler, Miriam H.
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on...
Insertional mutation of the hairless locus on mouse Chromosome 14 (1993)
Jones, Julie M., Keller, Scott A., Elder, James T., Simin, Karl, Meisler, Miriam H.
Crosses between heterozygous transgenic mice from line 5053 produced offspring with progressive irreversible hair loss beginning at day 10. With increasing age, the skin of these animals became...
mnd2: A New Mouse Model of Inherited Motor Neuron Disease (1993)
Jones, Julie M., Albin, Roger L., Feldman, Eva L., Simin, Karl, Schuster, Timothy G., Dunnick, Wesley A., ...
The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days...
Conserved linkage of neurotrophin-3 and von Willebrand factor on mouse Chromosome 6 (1993)
Barrow, Lon L., Ginsburg, David, Mohlke, Karen L., Simin, Karl, Nichols, William C., Meisler, Miriam H.
Peer Reviewed
Ivanov, Ivaylo P., Simin, Karl, Letsou, Anthea, Atkins, John F., Gesteland, Raymond F.
Previously, a Drosophila melanogaster sequence with high homology to the sequence for mammalian antizyme (ornithine decarboxylase antizyme) was reported. The present study shows that homology of this...
Profiling Patterned Transcripts in Drosophila Embryos
Simin, Karl, Scuderi, Anne, Reamey, James, Dunn, Diane, Weiss, Robert, Metherall, James E., ...
Here we describe a high-throughput screen to isolate transcripts with spatially restricted patterns of expression in early embryos. Our approach utilizes robotic automation for rapid analysis of...
Simin, Karl, Wu, Hua, Lu, Lucy, Pinkel, Dan, Albertson, Donna, Cardiff, Robert D, ...
Retinoblastoma 1 (pRb) and the related pocket proteins, retinoblastoma-like 1 (p107) and retinoblastoma-like 2 (p130) (pRbf, collectively), play a pivotal role in regulating eukaryotic cell cycle...
Ivanov, Ivaylo P., Simin, Karl, Letsou, Anthea, Atkins, John F., Gesteland, Raymond F.
Previously, a Drosophila melanogaster sequence with high homology to the sequence for mammalian antizyme (ornithine decarboxylase antizyme) was reported. The present study shows that homology of this...
Profiling Patterned Transcripts in Drosophila Embryos
Simin, Karl, Scuderi, Anne, Reamey, James, Dunn, Diane, Weiss, Robert, Metherall, James E., ...
Here we describe a high-throughput screen to isolate transcripts with spatially restricted patterns of expression in early embryos. Our approach utilizes robotic automation for rapid analysis of...
Simin, Karl, Wu, Hua, Lu, Lucy, Pinkel, Dan, Albertson, Donna, Cardiff, Robert D, ...
Retinoblastoma 1 (pRb) and the related pocket proteins, retinoblastoma-like 1 (p107) and retinoblastoma-like 2 (p130) (pRbf, collectively), play a pivotal role in regulating eukaryotic cell cycle...
Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...
Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human...