Schön, Margarete, Wienrich, B. Gregor, Kneitz, Susanne, Sennefelder, Helga, Amschler, Katharina, Vöhringer, Verena, ...
Background Increasing the efficacy of chemotherapeutics by reducing chemoresistance may be a useful strategy in cancer therapy. Constitutive activation of nuclear factor-kappa B (NF-κB) is a...
Bernd Hutter, Christoph Schaab, Sebastian Albrecht, Matthias Borgmann, Nina A. Brunner, Christoph Freiberg, ...
We have generated a database of expression profiles carrying the transcriptional responses of the model organism Bacillus subtilis following treatment with 37 well-characterized antibacterial...
Fischer, Hans Peter, Brunner, Nina A., Wieland, Bernd, Paquette, Jesse, Macko, Ludwig, Ziegelbauer, Karl, ...
As present antibiotics therapy becomes increasingly ineffectual, new technologies are required to identify and develop novel classes of antibacterial agents. An attractive alternative to the...
Leberer, Ekkehard, Harcus, Doreen, Broadbent, Ian D., Clark, Karen L., Dignard, Daniel, Ziegelbauer, Karl, ...
The CST20 gene of Candida albicans was cloned by functional complementation of a deletion of the STE20 gene in Saccharomyces cerevisiae. CST20 encodes a homolog of the Ste20p/p65PAK family of protein...
BAY 10-8888, a cyclic β-amino acid, exerts its antifungal activity by inhibition of isoleucyl-tRNA synthetase activity after accumulation to a millimolar concentration inside the cell. We have...
Molecular Mode of Action of the Antifungal β-Amino Acid BAY 10-8888
Ziegelbauer, Karl, Babczinski, Peter, Schönfeld, Wolfgang
BAY 10-8888 is a cyclic β-amino acid that is related to cispentacin and that has antifungal activity. Candida albicans cells accumulated BAY 10-8888 intracellularly to a concentration about 200 that...
Fischer, Hans Peter, Brunner, Nina A., Wieland, Bernd, Paquette, Jesse, Macko, Ludwig, Ziegelbauer, Karl, ...
As present antibiotics therapy becomes increasingly ineffectual, new technologies are required to identify and develop novel classes of antibacterial agents. An attractive alternative to the...
Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Schiffer, Guido, Siegel, Stephan, Bauser, Marcus, ...
Phenylalanyl (Phe)-tRNA synthetase (Phe-RS) is an essential enzyme which catalyzes the transfer of phenylalanine to the Phe-specific transfer RNA (tRNAPhe), a key step in protein biosynthesis....
Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling
Hutter, Bernd, Schaab, Christoph, Albrecht, Sebastian, Borgmann, Matthias, Brunner, Nina A., Freiberg, Christoph, ...
We have generated a database of expression profiles carrying the transcriptional responses of the model organism Bacillus subtilis following treatment with 37 well-characterized antibacterial...
Biological Characterization of Novel Inhibitors of the Gram-Positive DNA Polymerase IIIC Enzyme
Kuhl, Alexander, Svenstrup, Niels, Ladel, Christoph, Otteneder, Michael, Binas, Annegret, Schiffer, Guido, ...
Novel N-3-alkylated 6-anilinouracils have been identified as potent and selective inhibitors of bacterial DNA polymerase IIIC, the enzyme essential for the replication of chromosomal DNA in...
Leberer, Ekkehard, Harcus, Doreen, Broadbent, Ian D., Clark, Karen L., Dignard, Daniel, Ziegelbauer, Karl, ...
The CST20 gene of Candida albicans was cloned by functional complementation of a deletion of the STE20 gene in Saccharomyces cerevisiae. CST20 encodes a homolog of the Ste20p/p65PAK family of protein...
BAY 10-8888, a cyclic β-amino acid, exerts its antifungal activity by inhibition of isoleucyl-tRNA synthetase activity after accumulation to a millimolar concentration inside the cell. We have...
Molecular Mode of Action of the Antifungal β-Amino Acid BAY 10-8888
Ziegelbauer, Karl, Babczinski, Peter, Schönfeld, Wolfgang
BAY 10-8888 is a cyclic β-amino acid that is related to cispentacin and that has antifungal activity. Candida albicans cells accumulated BAY 10-8888 intracellularly to a concentration about 200 that...
Fischer, Hans Peter, Brunner, Nina A., Wieland, Bernd, Paquette, Jesse, Macko, Ludwig, Ziegelbauer, Karl, ...
As present antibiotics therapy becomes increasingly ineffectual, new technologies are required to identify and develop novel classes of antibacterial agents. An attractive alternative to the...
Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Schiffer, Guido, Siegel, Stephan, Bauser, Marcus, ...
Phenylalanyl (Phe)-tRNA synthetase (Phe-RS) is an essential enzyme which catalyzes the transfer of phenylalanine to the Phe-specific transfer RNA (tRNAPhe), a key step in protein biosynthesis....
Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling
Hutter, Bernd, Schaab, Christoph, Albrecht, Sebastian, Borgmann, Matthias, Brunner, Nina A., Freiberg, Christoph, ...
We have generated a database of expression profiles carrying the transcriptional responses of the model organism Bacillus subtilis following treatment with 37 well-characterized antibacterial...
Biological Characterization of Novel Inhibitors of the Gram-Positive DNA Polymerase IIIC Enzyme
Kuhl, Alexander, Svenstrup, Niels, Ladel, Christoph, Otteneder, Michael, Binas, Annegret, Schiffer, Guido, ...
Novel N-3-alkylated 6-anilinouracils have been identified as potent and selective inhibitors of bacterial DNA polymerase IIIC, the enzyme essential for the replication of chromosomal DNA in...
Ziegelbauer, Karl, Gantner, Florian, Lukacs, Nicholas W, Berlin, Aaron, Fuchikami, Kinji, Niki, Toshiro, ...
Pulmonary inflammatory diseases such as asthma are characterized by chronic, cell-mediated inflammation of the bronchial mucosa.Recruitment and activation of inflammatory cells is orchestrated by a...
Novel Whole-Cell Antibiotic Biosensors for Compound Discovery▿
Urban, Andreas, Eckermann, Stefan, Fast, Beate, Metzger, Susanne, Gehling, Matthias, Ziegelbauer, Karl, ...
Cells containing reporters which are specifically induced via selected promoters are used in pharmaceutical drug discovery and in environmental biology. They are used in screening for novel drug...