Tamez, Pamela A., Bhattacharjee, Souvik, Van Ooij, Christiaan, Hiller, N. Luisa, Llin S, Manuel, Balu, Bharath, ...
Plasmodium falciparum is the protozoan parasite that causes the most virulent of human malarias. The blood stage parasites export several hundred proteins into their host erythrocyte that underlie...
The malaria secretome: from algorithms to essential function in blood stage infection. (2008)
Van Ooij, Christiaan, Tamez, Pamela, Bhattacharjee, Souvik, Hiller, N. Luisa, Harrison, Travis, Liolios, Konstantinos, ...
The malaria agent Plasmodium falciparum is predicted to export a "secretome" of several hundred proteins to remodel the host erythrocyte. Prediction of protein export is based on the presence of an...
Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy (2006)
Sean C. Murphy, Travis Harrison, Heidi E. Hamm, Jon W. Lomasney, Narla Mohandas, Kasturi Haldar
BackgroundMalaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to...
The Malarial Host-Targeting Signal Is Conserved in the Irish Potato Famine Pathogen (2006)
Souvik Bhattacharjee, N. Luisa Hiller, Konstantinos Liolios, Joe Win, Thirumala-Devi Kanneganti, Carolyn Young, ...
Animal and plant eukaryotic pathogens, such as the human malaria parasite Plasmodium falciparum and the potato late blight agent Phytophthora infestans, are widely divergent eukaryotic microbes. Yet...
Wang, Qian, Fujioka, Hisashi, Nussenzweig, Victor, Haldar, Kasturi
Plasmodium sporozoites develop within oocysts residing in the mosquito midgut. Mature sporozoites exit the oocysts, enter the hemolymph, and invade the salivary glands. The circumsporozoite (CS)...
Proton translocation and quinone reduction catalysed by D-amino acid dehydrogenase / (1982)
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1982.
In Vitro Activity of Riboflavin against the Human Malaria Parasite Plasmodium falciparum
Akompong, Thomas, Ghori, Nafisa, Haldar, Kasturi
The human malaria parasite Plasmodium falciparum digests hemoglobin and polymerizes the released free heme into hemozoin. This activity occurs in an acidic organelle called the food vacuole and is...
Kadekoppala, Madhusudan, Kline, Kimberly, Akompong, Thomas, Haldar, Kasturi
Stable transfection of a new, chimeric reporter in the human malaria parasite Plasmodium falciparum confers green fluorescence and methotrexate resistance that can be quantitated by Western blotting...
Akompong, Thomas, Eksi, Saliha, Williamson, Kim, Haldar, Kasturi
Our previous studies have shown that riboflavin has activity against Plasmodium falciparum asexual-stage parasites in vitro. In the present study we examine the gametocytocidal activity of riboflavin...
Lopez-Estraño, Carlos, Bhattacharjee, Souvik, Harrison, Travis, Haldar, Kasturi
When the malaria parasite Plasmodium falciparum infects an erythrocyte, it resides in a parasitophorous vacuole and remarkably exports proteins into the periphery of its host cell. Two of these...
Nawabi, Parwez, Lykidis, Athanasios, Ji, Darder, Haldar, Kasturi
Here we show that blood-stage Plasmodium falciparum organisms accumulate a high mass of triacylglycerol and diacylglycerol. However, we failed to detect cholesterol esters, a second neutral lipid...
Lauer, Sabine, VanWye, Jeffrey, Harrison, Travis, McManus, Heather, Samuel, Benjamin U., Hiller, N.Luisa, ...
Erythrocytes, which are incapable of endocytosis or phagocytosis, can be infected by the malaria parasite Plasmodium falciparum. We find that a transmembrane protein (Duffy),...
Catron, Drew M., Lange, Yvonne, Borensztajn, Jayme, Sylvester, Matthew D., Jones, Bradley D., Haldar, Kasturi
We have previously shown that Salmonella enterica serovar Typhimurium infection perturbs the host cholesterol biosynthetic pathway. Here we show that inhibiting the first step of this pathway...
The Malarial Host-Targeting Signal Is Conserved in the Irish Potato Famine Pathogen
Bhattacharjee, Souvik, Hiller, N. Luisa, Liolios, Konstantinos, Win, Joe, Kanneganti, Thirumala-Devi, Young, Carolyn, ...
Animal and plant eukaryotic pathogens, such as the human malaria parasite Plasmodium falciparum and the potato late blight agent Phytophthora infestans, are widely divergent eukaryotic microbes. Yet...
In Vitro Activity of Riboflavin against the Human Malaria Parasite Plasmodium falciparum
Akompong, Thomas, Ghori, Nafisa, Haldar, Kasturi
The human malaria parasite Plasmodium falciparum digests hemoglobin and polymerizes the released free heme into hemozoin. This activity occurs in an acidic organelle called the food vacuole and is...
Kadekoppala, Madhusudan, Kline, Kimberly, Akompong, Thomas, Haldar, Kasturi
Stable transfection of a new, chimeric reporter in the human malaria parasite Plasmodium falciparum confers green fluorescence and methotrexate resistance that can be quantitated by Western blotting...
Akompong, Thomas, Eksi, Saliha, Williamson, Kim, Haldar, Kasturi
Our previous studies have shown that riboflavin has activity against Plasmodium falciparum asexual-stage parasites in vitro. In the present study we examine the gametocytocidal activity of riboflavin...
Lopez-Estraño, Carlos, Bhattacharjee, Souvik, Harrison, Travis, Haldar, Kasturi
When the malaria parasite Plasmodium falciparum infects an erythrocyte, it resides in a parasitophorous vacuole and remarkably exports proteins into the periphery of its host cell. Two of these...
Nawabi, Parwez, Lykidis, Athanasios, Ji, Darder, Haldar, Kasturi
Here we show that blood-stage Plasmodium falciparum organisms accumulate a high mass of triacylglycerol and diacylglycerol. However, we failed to detect cholesterol esters, a second neutral lipid...
Lauer, Sabine, VanWye, Jeffrey, Harrison, Travis, McManus, Heather, Samuel, Benjamin U., Hiller, N.Luisa, ...
Erythrocytes, which are incapable of endocytosis or phagocytosis, can be infected by the malaria parasite Plasmodium falciparum. We find that a transmembrane protein (Duffy),...
Catron, Drew M., Lange, Yvonne, Borensztajn, Jayme, Sylvester, Matthew D., Jones, Bradley D., Haldar, Kasturi
We have previously shown that Salmonella enterica serovar Typhimurium infection perturbs the host cholesterol biosynthetic pathway. Here we show that inhibiting the first step of this pathway...
The Malarial Host-Targeting Signal Is Conserved in the Irish Potato Famine Pathogen
Bhattacharjee, Souvik, Hiller, N. Luisa, Liolios, Konstantinos, Win, Joe, Kanneganti, Thirumala-Devi, Young, Carolyn, ...
Animal and plant eukaryotic pathogens, such as the human malaria parasite Plasmodium falciparum and the potato late blight agent Phytophthora infestans, are widely divergent eukaryotic microbes. Yet...
Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy
Murphy, Sean C, Harrison, Travis, Hamm, Heidi E, Lomasney, Jon W, Mohandas, Narla, Haldar, Kasturi
Erythrocyte G protein signaling is needed for intracellular malarial parasite proliferation and thus may present a novel antimalarial target.
Pollard, Angela M., Onatolu, Krystal N., Hiller, Luisa, Haldar, Kasturi, Knoll, Laura J.
The life cycle of the apicomplexan parasite Toxoplasma gondii requires that an infectious cyst develop and be maintained throughout the life of the host. The molecules displayed on the parasite...
Partitioning of the Golgi Apparatus during Mitosis in Living HeLa Cells
Shima, David T., Haldar, Kasturi, Pepperkok, Rainer, Watson, Rose, Warren, Graham
The Golgi apparatus of HeLa cells was fluorescently tagged with a green fluorescent protein (GFP), localized by attachment to the NH2-terminal retention signal of N-acetylglucosaminyltransferase I...
MacKenzie, Julia J., Gómez, Noé D., Bhattacharjee, Souvik, Mann, Shaina, Haldar, Kasturi
Plasmodium falciparum (P. falciparum) secretes hundreds of proteins—including major virulence proteins—into the host erythrocyte. In order to reach the host cytoplasm, most P. falciparum proteins...
The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection
Van Ooij, Christiaan, Tamez, Pamela, Bhattacharjee, Souvik, Hiller, N. Luisa, Harrison, Travis, Liolios, Konstantinos, ...
The malaria agent Plasmodium falciparum is predicted to export a “secretome” of several hundred proteins to remodel the host erythrocyte. Prediction of protein export is based on the presence of...
Pei, Xinhong, Guo, Xinhua, Coppel, Ross, Bhattacharjee, Souvik, Haldar, Kasturi, Gratzer, Walter, ...
The malaria parasite Plasmodium falciparum releases the ring-infected erythrocyte surface antigen (RESA) inside the red cell on entry. The protein migrates to the host cell membrane, where it binds...
Tamez, Pamela A., Bhattacharjee, Souvik, Van Ooij, Christiaan, Hiller, N. Luisa, Llinás, Manuel, Balu, Bharath, ...
Plasmodium falciparum is the protozoan parasite that causes the most virulent of human malarias. The blood stage parasites export several hundred proteins into their host erythrocyte that underlie...
Murphy, Sean C., Fernandez-Pol, Sebastian, Chung, Paul H., Prasanna Murthy, S. N., Milne, Stephen B., Salomao, Marcela, ...
Studies of detergent-resistant membrane (DRM) rafts in mature erythrocytes have facilitated identification of proteins that regulate formation of endovacuolar structures such as the parasitophorous...
Effects of Lysosomal Membrane Protein Depletion on the Salmonella-Containing Vacuole
Roark, Everett A., Haldar, Kasturi
Salmonella is an intracellular bacterial pathogen that replicates within a membrane-bound vacuole in host cells. The major lysosomal membrane proteins 1 and 2 (LAMP-1 and LAMP-2) are recruited to the...
Bhattacharjee, Souvik, Van Ooij, Christiaan, Balu, Bharath, Adams, John H., Haldar, Kasturi
In blood-stage infection by the human malaria parasite Plasmodium falciparum, export of proteins from the intracellular parasite to the erythrocyte is key to virulence. This export is mediated by a...
Correction: The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection
Van Ooij, Christiaan, Tamez, Pamela, Bhattacharjee, Souvik, Hiller, N. Luisa, Harrison, Travis, Liolios, Konstantinos, ...
The Salmonella virulence protein SifA is a G protein antagonist
Jackson, Laurie K., Nawabi, Parwez, Hentea, Cristiana, Roark, Everett A., Haldar, Kasturi
Salmonella's success at proliferating intracellularly and causing disease depends on the translocation of a major virulence protein, SifA, into the host cell. SifA recruits membranes enriched in...