Colot, Hildur V, Park, Gyungsoon, Turner, Gloria E, Ringelberg, Carol, Crew, Christopher M, Litvinkova, Liubov, ...
The low rate of homologous recombination exhibited by wild-type strains of filamentous fungi has hindered development of high-throughput gene knockout procedures for this group of organisms. In this...
Hyphal development in Neurospora crassa: Involvement of a two-component histidine kinase (1996)
Alex, Lisa A., Borkovich, Katherine A., Simon, Melvin I.
Two-component signal transduction systems are most often found in prokaryotic organisms where they are responsible for mediating the cellular responses to many environmental stimuli. These systems...
Attenuation of Sensory Receptor Signaling by Covalent Modification (1992)
Borkovich, Katherine A., Alex, Lisa A., Simon, Melvin I.
The Tar receptor is a transmembrane protein that regulates bacterial chemotaxis in response to changes in the level of aspartic acid in the medium. The extracellular portion of the protein can bind...
Borkovich, Katherine A., Kaplan, Nachum, Hess, J. Fred, Simon, Melvin I.
Signal transduction in Escherichia coli involves the interaction of transmembrane receptor proteins such as the aspartate receptor, Tar, and the products of four chemotaxis genes, cheA, cheY, cheW,...
Bieszke, Jennifer A., Braun, Edward L., Bean, Laura E., Kang, Seogchan, Natvig, Donald O., Borkovich, Katherine A.
Opsins are a class of retinal-binding, seven transmembrane helix proteins that function as light-responsive ion pumps or sensory receptors. Previously, genes encoding opsins had been identified in...
Regulation of Conidiation and Adenylyl Cyclase Levels by the Gα Protein GNA-3 in Neurospora crassa
Kays, Ann M., Rowley, Patricia S., Baasiri, Rudeina A., Borkovich, Katherine A.
We have identified a new gene encoding the G protein α subunit, gna-3, from the filamentous fungus Neurospora crassa. The predicted amino acid sequence of GNA-3 is most similar to the Gα proteins...
Ivey, F. Douglas, Kays, Ann M., Borkovich, Katherine A.
Growth and development are regulated using cyclic AMP (cAMP)-dependent and -independent pathways in Neurospora crassa. The cr-1 adenylyl cyclase mutant lacks detectable cAMP and exhibits numerous...
Yang, Qi, Poole, Sheven I., Borkovich, Katherine A.
The genome of the filamentous fungus Neurospora crassa contains a single gene encoding a heterotrimeric G-protein β subunit, gnb-1. The predicted GNB-1 protein sequence is most identical to Gβ...
Borkovich, Katherine A., Alex, Lisa A., Yarden, Oded, Freitag, Michael, Turner, Gloria E., Read, Nick D., ...
We present an analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics and...
Krystofova, Svetlana, Borkovich, Katherine A.
We have identified a gene encoding a heterotrimeric G protein γ subunit, gng-1, from the filamentous fungus Neurospora crassa. gng-1 possesses a gene structure similar to that of mammalian Gγ...
Kim, Hyojeong, Borkovich, Katherine A.
Neurospora crassa is a self-sterile filamentous fungus with two mating types, mat A and mat a. Its mating involves chemotropic polarized growth of female-specific hyphae (trichogynes) toward male...
Kays, Ann M, Borkovich, Katherine A
Heterotrimeric G alpha proteins play a critical role in regulating growth and differentiation in filamentous fungi. No systematic analysis of functional relationships between subunits has been...
Li, Liande, Borkovich, Katherine A.
The filamentous fungus Neurospora crassa is able to utilize a wide variety of carbon sources. Here, we examine the involvement of a predicted G-protein-coupled receptor (GPCR), GPR-4, during growth...
Bieszke, Jennifer A., Braun, Edward L., Bean, Laura E., Kang, Seogchan, Natvig, Donald O., Borkovich, Katherine A.
Opsins are a class of retinal-binding, seven transmembrane helix proteins that function as light-responsive ion pumps or sensory receptors. Previously, genes encoding opsins had been identified in...
Regulation of Conidiation and Adenylyl Cyclase Levels by the Gα Protein GNA-3 in Neurospora crassa
Kays, Ann M., Rowley, Patricia S., Baasiri, Rudeina A., Borkovich, Katherine A.
We have identified a new gene encoding the G protein α subunit, gna-3, from the filamentous fungus Neurospora crassa. The predicted amino acid sequence of GNA-3 is most similar to the Gα proteins...
Ivey, F. Douglas, Kays, Ann M., Borkovich, Katherine A.
Growth and development are regulated using cyclic AMP (cAMP)-dependent and -independent pathways in Neurospora crassa. The cr-1 adenylyl cyclase mutant lacks detectable cAMP and exhibits numerous...
Yang, Qi, Poole, Sheven I., Borkovich, Katherine A.
The genome of the filamentous fungus Neurospora crassa contains a single gene encoding a heterotrimeric G-protein β subunit, gnb-1. The predicted GNB-1 protein sequence is most identical to Gβ...
Borkovich, Katherine A., Alex, Lisa A., Yarden, Oded, Freitag, Michael, Turner, Gloria E., Read, Nick D., ...
We present an analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics and...
Krystofova, Svetlana, Borkovich, Katherine A.
We have identified a gene encoding a heterotrimeric G protein γ subunit, gng-1, from the filamentous fungus Neurospora crassa. gng-1 possesses a gene structure similar to that of mammalian Gγ...
Kim, Hyojeong, Borkovich, Katherine A.
Neurospora crassa is a self-sterile filamentous fungus with two mating types, mat A and mat a. Its mating involves chemotropic polarized growth of female-specific hyphae (trichogynes) toward male...
Kays, Ann M, Borkovich, Katherine A
Heterotrimeric G alpha proteins play a critical role in regulating growth and differentiation in filamentous fungi. No systematic analysis of functional relationships between subunits has been...
Li, Liande, Borkovich, Katherine A.
The filamentous fungus Neurospora crassa is able to utilize a wide variety of carbon sources. Here, we examine the involvement of a predicted G-protein-coupled receptor (GPCR), GPR-4, during growth...
Krystofova, Svetlana, Borkovich, Katherine A.
G-protein-coupled receptors (GPCRs) control important aspects of asexual and sexual development in eukaryotic organisms. We have identified a predicted GPCR in the filamentous fungus Neurospora...
Colot, Hildur V., Park, Gyungsoon, Turner, Gloria E., Ringelberg, Carol, Crew, Christopher M., Litvinkova, Liubov, ...
The low rate of homologous recombination exhibited by wild-type strains of filamentous fungi has hindered development of high-throughput gene knockout procedures for this group of organisms. In this...
Jones, Carol A., Greer-Phillips, Suzanne E., Borkovich, Katherine A.
Two-component systems, consisting of proteins with histidine kinase and/or response regulator domains, regulate environmental responses in bacteria, Archaea, fungi, slime molds, and plants. Here, we...
Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK
Vitalini, Michael W., De Paula, Renato M., Goldsmith, Charles S., Jones, Carol A., Borkovich, Katherine A., Bell-Pedersen, Deborah
Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate...
Park, Gyungsoon, Pan, Songqin, Borkovich, Katherine A.
Mitogen-activated protein kinase (MAPK) signaling cascades are composed of MAPK kinase kinases (MAPKKKs), MAPK kinases (MAPKKs), and MAPKs. In this study, we characterize components of a MAPK cascade...