Kathrine J. Smith

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species (2003)

Smith, Kathrine J., Petit, Chantal M., Aubart, Kelly, Smyth, Martin, McManus, Edward, Jones, Jo, ...

Polypeptide deformylase (PDF) catalyzes the deformylation of polypeptide chains in bacteria. It is essential for bacterial cell viability and is a potential antibacterial drug target. Here, we report...

Antagonist HIV-1 Gag peptides induce structural changes in HLA B8 (1996)

W. Reid, Steve Mcadam, Kathrine J. Smith, Paul Klenerman, Chris A. O’callaghan, Karl Harlos, ...

In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend,

Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

Gauthier, Laurent, Smith, Kathrine J., Pyrdol, Jason, Kalandadze, Avtandil, Strominger, Jack L., Wiley, Don C., ...

HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85–99) was previously found to bind to purified HLA-DR2 (DRA,...

Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+ T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure

Bourcier, Katarzyna D., Lim, Dong-Gyun, Ding, Yuan-Hua, Smith, Kathrine J., Wucherpfennig, Kai, Hafler, David A.

We investigated the T-cell receptor (TCR) repertoire of CD8+ T cells that recognize the Tax11-19 immunodominant epitope of Tax protein expressed by human T-cell leukemia virus (HTLV-1) that is...

Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

Gauthier, Laurent, Smith, Kathrine J., Pyrdol, Jason, Kalandadze, Avtandil, Strominger, Jack L., Wiley, Don C., ...

HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85–99) was previously found to bind to purified HLA-DR2 (DRA,...

Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+ T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure

Bourcier, Katarzyna D., Lim, Dong-Gyun, Ding, Yuan-Hua, Smith, Kathrine J., Wucherpfennig, Kai, Hafler, David A.

We investigated the T-cell receptor (TCR) repertoire of CD8+ T cells that recognize the Tax11-19 immunodominant epitope of Tax protein expressed by human T-cell leukemia virus (HTLV-1) that is...

Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function

Lim, Dong-Gyun, Slavik, Jacqueline M., Bourcier, Katarzyna, Smith, Kathrine J., Hafler, David A.

T cell receptors recognize small changes in peptide ligands leading to different T cell responses. Here, we analyzed a panel of HLA-A2–Tax11-19 reactive T cell clones to examine how small allelic...

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

Reid, Scott W., McAdam, Steve, Smith, Kathrine J., Klenerman, Paul, O'Callaghan, Chris A., Harlos, Karl, ...

In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J....

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

Smith, Kathrine J., Pyrdol, Jason, Gauthier, Laurent, Wiley, Don C., Wucherpfennig, Kai W.

Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 (DRB1*1501) haplotype. The structure of HLA-DR2 was determined with a bound peptide...

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

Smith, Kathrine J., Petit, Chantal M., Aubart, Kelly, Smyth, Martin, McManus, Edward, Jones, Jo, ...

Polypeptide deformylase (PDF) catalyzes the deformylation of polypeptide chains in bacteria. It is essential for bacterial cell viability and is a potential antibacterial drug target. Here, we report...