GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells
Ling, Kam-Wing, Ottersbach, Katrin, Van Hamburg, Jan Piet, Oziemlak, Aneta, Tsai, Fong-Ying, Orkin, Stuart H., ...
GATA-2 is an essential transcription factor in the hematopoietic system that is expressed in hematopoietic stem cells (HSCs) and progenitors. Complete deficiency of GATA-2 in the mouse leads to...
Pimanda, John E., Ottersbach, Katrin, Knezevic, Kathy, Kinston, Sarah, Chan, Wan Y. I., Wilson, Nicola K., ...
Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1...
Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells
Durand, Charles, Robin, Catherine, Bollerot, Karine, Baron, Margaret H., Ottersbach, Katrin, Dzierzak, Elaine
Hematopoietic stem cell (HSC) self-renewal and differentiation is regulated by cellular and molecular interactions with the surrounding microenvironment. During ontogeny, the...