Katsuhiko Nosho

Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma (2008)

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...

Abstract Background Cyclooxygenase-2 (COX-2, PTGS2 ) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite...

A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer (2008)

Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Kawasaki, Takako, Chan, Andrew T., Schernhammer, Eva S., ...

Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome...

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer (2007)

Ogino, Shuji, Hazra, Aditi, Tranah, Gregory J., Kirkner, Gregory J., Kawasaki, Takako, Nosho, Katsuhiko, ...

O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may...

Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma (2007)

Imsumran, Arisa, Adachi, Yasushi, Yamamoto, Hiroyuki, Li, Rong, Wang, Yu, Min, Yongfen, ...

Insulin-like growth factor (IGF)-I receptor (IGF-Ir) signaling is required for tumorigenicity and progression of many tumors but this pathway has not been well studied as a prognostic factor or...

Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers: Genetic and epigenetic profiling in early colorectal tumors (2006)

Nosho, Katsuhiko, Yamamoto, Hiroyuki, Takahashi, Taiga, Mikami, Masashi, Taniguchi, Hiroaki, Miyamoto, Nobuki, ...

Morphologically, early colorectal tumors are divided into two groups, protruded-type tumors and flat-type tumors. Although some studies have shown genetic alterations in protruded-type tumors, little...

Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers (2006)

Nosho, Katsuhiko, Yamamoto, Hiroyuki, Takahashi, Taiga, Mikami, Masashi, Taniguchi, Hiroaki, Miyamoto, Nobuki, ...

Morphologically, early colorectal tumors are divided into two groups, protruded-type tumors and flat-type tumors. Although some studies have shown genetic alterations in protruded-type tumors, little...

Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers (2006)

Nosho, Katsuhiko, Yamamoto, Hiroyuki, Takahashi, Taiga, Mikami, Masashi, Taniguchi, Hiroaki, Miyamoto, Nobuki, ...

Morphologically, early colorectal tumors are divided into two groups, protruded-type tumors and flat-type tumors. Although some studies have shown genetic alterations in protruded-type tumors, little...

Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma (2006)

Imsumran, Arisa, Adachi, Yasushi, Yamamoto, Hiroyuki, Li, Rong, Wang, Yu, Min, Yongfen, ...

Insulin-like growth factor (IGF)-I receptor (IGF-Ir) signaling is required for tumorigenicity and progression of many tumors but this pathway has not been well studied as a prognostic factor or...

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis (2005)

Nosho, Katsuhiko, Yoshida, Mio, Yamamoto, Hiroyuki, Taniguchi, Hiroaki, Adachi, Yasushi, Mikami, Masashi, ...

It is now becoming clear that matrix metalloproteinases (MMPs) also play a key role in tumor development and growth. MMPs are overexpressed in a variety of premalignant tumor tissues, including...

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis (2005)

Nosho, Katsuhiko, Yoshida, Mio, Yamamoto, Hiroyuki, Taniguchi, Hiroaki, Adachi, Yasushi, Mikami, Masashi, ...

It is now becoming clear that matrix metalloproteinases (MMPs) play a key role in tumor development and growth. MMPs are overexpressed in a variety of premalignant tumor tissues, including colorectal...

Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma (2004)

Yamamoto, Hiroyuki, Vinitketkumnuen, Akravit, Adachi, Yasushi, Taniguchi, Hiroaki, Hirata, Tamaki, Miyamoto, Nobuki, ...

Expression of matrilysin-2, matrix metalloproteinase (MMP)-26, has been implicated in the progression of several types of human cancer. Matrilysin-2 has been reported to be a physiological and...

Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer (2004)

Yamamoto, Hiroyuki, Horiuchi, Shina, Adachi, Yasushi, Taniguchi, Hiroaki, Nosho, Katsuhiko, Min, Yongfen, ...

Expression of E1AF/PEA3 (ETV4), an ets family transcriptional factor, has been implicated in tumor progression through induction of matrix metalloproteinase (MMP) expression. The aim of this...

Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma (2004)

Yamamoto, Hiroyuki, Vinitketkumnuen, Akravit, Adachi, Yasushi, Taniguchi, Hiroaki, Hirata, Tamaki, Miyamoto, Nobuki, ...

Expression of matrilysin-2, matrix metalloproteinase (MMP)-26, has been implicated in the progression of several types of human cancer. Matrilysin-2 has been reported to be a physiological and...

Expression of ets-related transcriptional factor E1AF is associated with tumor progression and overexpression of matrilysin in human gastric cancer (2003)

Yamamoto, Hiroyuki, Horiuchi, Shina, Adachi, Yasushi, Taniguchi, Hiroaki, Nosho, Katsuhiko, Min, Yongfen, ...

Expression of E1AF/PEA3 (ETV4), an ets family transcriptional factor, has been implicated in tumor progression through induction of matrix metalloproteinase (MMP) expression. The aim of this study...

Expression of ets-related transcriptional factor E1AF is associated with tumor progression and overexpression of matrilysin in human gastric cancer (2003)

Yamamoto, Hiroyuki, Horiuchi, Shina, Adachi, Yasushi, Taniguchi, Hiroaki, Nosho, Katsuhiko, Min, Yongfen, ...

Expression of E1AF/PEA3 (ETV4), an ets family transcriptional factor, has been implicated in tumor progression through induction of matrix metalloproteinase (MMP) expression. The aim of this study...

Correlation of β-Catenin Localization with Cyclooxygenase-2 Expression and CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer1

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Dehari, Reiko, ...

The WNT/β-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested....

IGFBP3 Promoter Methylation in Colorectal Cancer: Relationship with Microsatellite Instability, CpG Island Methylator Phenotype, and p531

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Fuchs, Charles S, ...

Insulin-like growth factor binding protein 3 (IGFBP3), which is induced by wild-type p53, regulates IGF and interacts with the TGF-β pathway. IGFBP3 promoter methylation may occur in colorectal...

Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...

PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations1

Nosho, Katsuhiko, Kawasaki, Takako, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Zepf, Dimity, ...

Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island...

Comprehensive Biostatistical Analysis of CpG Island Methylator Phenotype in Colorectal Cancer Using a Large Population-Based Sample

Nosho, Katsuhiko, Irahara, Natsumi, Shima, Kaori, Kure, Shoko, Kirkner, Gregory J., Schernhammer, Eva S., ...

JC Virus T-Antigen in Colorectal Cancer Is Associated with p53 Expression and Chromosomal Instability, Independent of CpG Island Methylator Phenotype1

Nosho, Katsuhiko, Shima, Kaori, Kure, Shoko, Irahara, Natsumi, Baba, Yoshifumi, Chen, Li, ...

JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG...

Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal Cancer1

Baba, Yoshifumi, Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Toyoda, Saori, ...

AURKA (the official symbol for Aurora-A, STK15, or BTAK) regulates the function of centrosomes, spindles, and kinetochores for proper mitotic progression. AURKA overexpression is observed in various...

Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer

Maehata, Tadateru, Taniguchi, Hiroaki, Yamamoto, Hiroyuki, Nosho, Katsuhiko, Adachi, Yasushi, Miyamoto, Nobuki, ...

AIM: To clarify alterations of Dickkopfs (Dkks) and Kremen2 (Krm2) in gastrointestinal cancer.