Katsuya Okawa

Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor (2003)

Shimojima, Tsukasa, Okada, Masahiro, Nakayama, Takahiro, Ueda, Hitoshi, Okawa, Katsuya, Iwamatsu, Akihiro, ...

Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates...

Nitric Oxide Inactivates Glyoxalase I in Cooperation with Glutathione (2000)

Mitsumoto, Atsushi, Kim, Kwi-Ryeon, Oshima, Genichiro, Kunimoto, Manabu, Okawa, Katsuya, Iwamatsu, Akihiro, ...

We previously found that glyoxalase I (Glo I) is inactivated upon exposure of human endothelial cells to extracellular nitric oxide (NO), and this event correlates with an increase in its pI on...

Cloning of chlorophyllase, the key enzyme in chlorophyll degradation: Finding of a lipase motif and the induction by methyl jasmonate

Tsuchiya, Tohru, Ohta, Hiroyuki, Okawa, Katsuya, Iwamatsu, Akihiro, Shimada, Hiroshi, Masuda, Tatsuru, ...

Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyzes the hydrolysis of ester bond to yield chlorophyllide and phytol. In the present study, we isolated...

An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization

Mazaki, Yuichi, Hashimoto, Shigeru, Okawa, Katsuya, Tsubouchi, Asako, Nakamura, Kuniaki, Yagi, Ryohei, ...

Paxillin acts as an adaptor protein in integrin signaling. We have shown that paxillin exists in a relatively large cytoplasmic pool, including perinuclear areas, in addition to focal complexes...

Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor

Shimojima, Tsukasa, Okada, Masahiro, Nakayama, Takahiro, Ueda, Hitoshi, Okawa, Katsuya, Iwamatsu, Akihiro, ...

Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates...

A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells

Kato, Takeo, Heike, Toshio, Okawa, Katsuya, Haruyama, Munetada, Shiraishi, Kazuhiro, Yoshimoto, Momoko, ...

Although embryonic stem (ES) cells are capable of unlimited proliferation and pluripotent differentiation, effective preparation of neural stem cells from ES cells are not achieved. Here, we have...

Cloning of chlorophyllase, the key enzyme in chlorophyll degradation: Finding of a lipase motif and the induction by methyl jasmonate

Tsuchiya, Tohru, Ohta, Hiroyuki, Okawa, Katsuya, Iwamatsu, Akihiro, Shimada, Hiroshi, Masuda, Tatsuru, ...

Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyzes the hydrolysis of ester bond to yield chlorophyllide and phytol. In the present study, we isolated...

An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization

Mazaki, Yuichi, Hashimoto, Shigeru, Okawa, Katsuya, Tsubouchi, Asako, Nakamura, Kuniaki, Yagi, Ryohei, ...

Paxillin acts as an adaptor protein in integrin signaling. We have shown that paxillin exists in a relatively large cytoplasmic pool, including perinuclear areas, in addition to focal complexes...

Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor

Shimojima, Tsukasa, Okada, Masahiro, Nakayama, Takahiro, Ueda, Hitoshi, Okawa, Katsuya, Iwamatsu, Akihiro, ...

Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates...

A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells

Kato, Takeo, Heike, Toshio, Okawa, Katsuya, Haruyama, Munetada, Shiraishi, Kazuhiro, Yoshimoto, Momoko, ...

Although embryonic stem (ES) cells are capable of unlimited proliferation and pluripotent differentiation, effective preparation of neural stem cells from ES cells are not achieved. Here, we have...

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling

Nakaoka, Yoshikazu, Nishida, Keigo, Narimatsu, Masahiro, Kamiya, Atsunori, Minami, Takashi, Sawa, Hirofumi, ...

Grb2-associated binder (Gab) family of scaffolding adaptor proteins coordinate signaling cascades downstream of growth factor and cytokine receptors. In the heart, among EGF family members,...

Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo

Hirai, Maretoshi, Ohbayashi, Tetsuya, Horiguchi, Masahito, Okawa, Katsuya, Hagiwara, Akari, Chien, Kenneth R., ...

Elastic fibers are required for the elasticity and integrity of various organs. We and others previously showed that fibulin-5 (also called developing arteries and neural crest EGF-like [DANCE] or...

A novel histone exchange factor, protein phosphatase 2Cγ, mediates the exchange and dephosphorylation of H2A–H2B

Kimura, Hiroshi, Takizawa, Nanako, Allemand, Eric, Hori, Tetsuya, Iborra, Francisco J., Nozaki, Naohito, ...

In eukaryotic nuclei, DNA is wrapped around a protein octamer composed of the core histones H2A, H2B, H3, and H4, forming nucleosomes as the fundamental units of chromatin. The modification and...

MKKS Is a Centrosome-shuttling Protein Degraded by Disease-causing Mutations via CHIP-mediated Ubiquitination

Hirayama, Shoshiro, Yamazaki, Yuji, Kitamura, Akira, Oda, Yukako, Morito, Daisuke, Okawa, Katsuya, ...

McKusick–Kaufman syndrome (MKKS) is a recessively inherited human genetic disease characterized by several developmental anomalies. Mutations in the MKKS gene also cause Bardet–Biedl syndrome...

In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans

Aoki, Kazuma, Moriguchi, Hiromi, Yoshioka, Tomoko, Okawa, Katsuya, Tabara, Hiroaki

In the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) play important roles as intermediates. Primary siRNAs are produced from trigger dsRNAs by an RNaseIII-related enzyme called...

Isolation and characterization of post-splicing lariat–intron complexes

Yoshimoto, Rei, Kataoka, Naoyuki, Okawa, Katsuya, Ohno, Mutsuhito

Pre-mRNA splicing occurs in a large complex spliceosome. The steps of both spliceosome assembly and splicing reaction have been extensively analyzed, and many of the factors involved have been...