Kausik Chakraborty

Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies (2006)

Chakraborty, Kausik, Durani, Venuka, Roshan Miranda, Edward, Citron, Michael, Liang, Xiaoping, Schleif, William, ...

gp120 is a subunit of the envelope glycoprotein of HIV-1. The third variable loop region of gp120 (V3 loop) contains multiple immunodominant epitopes and is also functionally important for deciding...

NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water (2005)

Chakraborty, Kausik, Shivakumar, P, Raghothama, S, Varadarajan, Raghavan

gp120 is a subunit of the Env (viral envelope protein) of HIV-1. The protein consists of inner and outer domains linked by a bridging sheet. Several gp120 residues that bind the neutralizing antibody...

Protein Minimization of the gp120 Binding Region of Human CD4 \dagger (2005)

Sharma, Deepak, Balamurali, MM, Chakraborty, Kausik, Kumaran, Sowmini, Jeganathan, Sadasivam, Rashid, Umar, ...

CD4 is an important component of the immune system and is also the cellular receptor for HIV-1. CD4 consists of a cytoplasmic tail, one transmembrane region, and four extracellular domains, D1-D4....

Protein Stabilization by Introduction of Cross-Strand Disulfides (2005)

Chakraborty, Kausik, Thakurela, Sudhir, Prajapati, Ravindra Singh, Indu, S, Ali, Shaik Syed P, Ramakrishnan, C, ...

Disulfides cross-link residues in a protein that are separated in primary sequence and stabilize the protein through entropic destabilization of the unfolded state. While the removal of naturally...

Characterization of gp120 and its Single-Chain Derivatives, $gp120-CD4_D_1_2$ and gp120-M9: Implications for Targeting the $CD4_i$ Epitope in Human Immunodeficiency Virus Vaccine Design (2005)

Varadarajan, Raghavan, Sharma, Deepak, Chakraborty, Kausik, Patel, Mayuri, Citron, Michael, Sinha, Prem, ...

Single-chain derivatives of JRFL gp120 linked to the first two domains of human CD4 $(gp120-CD4_D_1_2)$ or to the CD4 miniprotein analog CD4M9 (gp120-M9), have been constructed. Biacore studies...

Characterization of gp120 and Its Single-Chain Derivatives, gp120-CD4D12 and gp120-M9: Implications for Targeting the CD4i Epitope in Human Immunodeficiency Virus Vaccine Design

Varadarajan, Raghavan, Sharma, Deepak, Chakraborty, Kausik, Patel, Mayuri, Citron, Michael, Sinha, Prem, ...

Single-chain derivatives of JRFL gp120 linked to the first two domains of human CD4 (gp120-CD4D12) or to the CD4 miniprotein analog CD4M9 (gp120-M9), have been constructed. Biacore studies revealed...

NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water

Chakraborty, Kausik, Shivakumar, P., Raghothama, S., Varadarajan, Raghavan

gp120 is a subunit of the Env (viral envelope protein) of HIV-1. The protein consists of inner and outer domains linked by a bridging sheet. Several gp120 residues that bind the neutralizing antibody...

Characterization of gp120 and Its Single-Chain Derivatives, gp120-CD4D12 and gp120-M9: Implications for Targeting the CD4i Epitope in Human Immunodeficiency Virus Vaccine Design

Varadarajan, Raghavan, Sharma, Deepak, Chakraborty, Kausik, Patel, Mayuri, Citron, Michael, Sinha, Prem, ...

Single-chain derivatives of JRFL gp120 linked to the first two domains of human CD4 (gp120-CD4D12) or to the CD4 miniprotein analog CD4M9 (gp120-M9), have been constructed. Biacore studies revealed...

NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water

Chakraborty, Kausik, Shivakumar, P., Raghothama, S., Varadarajan, Raghavan

gp120 is a subunit of the Env (viral envelope protein) of HIV-1. The protein consists of inner and outer domains linked by a bridging sheet. Several gp120 residues that bind the neutralizing antibody...

Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies

Chakraborty, Kausik, Durani, Venuka, Miranda, Edward Roshan, Citron, Michael, Liang, Xiaoping, Schleif, William, ...

gp120 is a subunit of the envelope glycoprotein of HIV-1. The third variable loop region of gp120 (V3 loop) contains multiple immunodominant epitopes and is also functionally important for deciding...