Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells (2009)
Zhang, Haibing, Hou, Ying-Ju, Han, Shuang-Yin, Zhang, Eric C., Huebner, Kay, Zhang, Jianke
The mammalian Nit1 protein is homologous to plant and bacterial nitrilases. In flies and worms, Nit1 is fused to the 5′ end of Fhit, suggesting that Nit1 may functionally interact with the Fhit...
Charles Brenner, Helen C. Pace, Preston N. Garrison, Angela K. Robinson, Angelika Rosler, Xiao-hai Liu, ...
2To whom correspondence should be addressed Fragile histidine triad protein (Fhit) is a diadenosine triphosphate (ApppA) hydrolase encoded at the human chromosome 3 fragile site which is frequently...
We present results for the renormalized Polyakov loop in the three lowest irreducible representations of SU(2) gauge theory at finite temperature. We will discuss their scaling behavior near $T_c$...
Correlations of chiral condensates and quark number densities with static quark sources (2007)
We investigate correlation functions of the Polyakov loop and static meson/diquark systems with the chiral condensate and the quark number density at finite temperature. In particular the latter...
Lubet, Ronald A., Huebner, Kay, Fong, Louise Y.Y., Altieri, Dario C., Steele, Vernon E., Kopelovich, Levy, ...
The administration of 4-hydroxybutyl(butyl)nitrosamine (OH-BBN) to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers. Since prior studies demonstrated...
Lubet, Ronald A., Huebner, Kay, Fong, Louise Y. Y., Altieri, Dario C., Steele, Vernon E., Kopelovich, Levy, ...
The administration of OH-BBN to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers that were characterized for expression of certain cancer related genes (FHIT,...
YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region (1993)
Pengue, Gina, Calabrò, Viola, Cannada-Bartoli, Paola, De Luca, Pasquale, Esposito, Teresa, Taillon-Miller, Patricia, ...
The region surrounding the ZNF35 zinc finger protein gene on 3p21 is of particular interest, as this region of chromosome 3 is frequently involved in rearrangements and/or deletions associated...
Collum, Robert G., Fisher, Peter E., Datta, Milton, Mellis, Scott, Thiele, Carol, Huebner, Kay, ...
We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC encoded protein Is highly related to the POU domain potentially encoded by the rat brain-3...
Muir–Torre-like syndrome in Fhit-deficient mice
Fong, Louise Y. Y., Fidanza, Vincenzo, Zanesi, Nicola, Lock, Leslie F., Siracusa, Linda D., Mancini, Rita, ...
To investigate the role of the Fhit gene in carcinogen induction of neoplasia, we have inactivated one Fhit allele in mouse embryonic stem cells and produced (129/SvJ × C57BL/6J) F1 mice with a Fhit...
Pace, Helen C., Garrison, Preston N., Robinson, Angela K., Barnes, Larry D., Draganescu, Alexandra, Rösler, Angelika, ...
Alterations in the FHIT gene at 3p14.2 occur as early and frequent events in the development of several common human cancers. The ability of human Fhit-negative cells to form tumors in nude mice is...
Pekarsky, Yuri, Campiglio, Manuela, Siprashvili, Zurab, Druck, Teresa, Sedkov, Yurii, Tillib, Sergei, ...
The tumor suppressor gene FHIT encompasses the common human chromosomal fragile site at 3p14.2 and numerous cancer cell biallelic deletions. To study Fhit function we cloned and characterized FHIT...
Cancer-specific chromosome alterations in the constitutive fragile region FRA3B
Mimori, Koshi, Druck, Teresa, Inoue, Hiroshi, Alder, Hansjuerg, Berk, Lori, Mori, Masaki, ...
We have sequenced 870 kilobases of the FHIT/FRA3B locus, from FHIT intron 3 to intron 7. The locus is AT rich (61.5%) and Alu poor (6.2%), and it apparently does not harbor other genes. In a detailed...
Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion
Inoue, Hiroshi, Ishii, Hideshi, Alder, Hansjuerg, Snyder, Eric, Druck, Teresa, Huebner, Kay, ...
The hypothesis that chromosomal fragile sites may be “weak links” that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell...
Replacement of Fhit in cancer cells suppresses tumorigenicity
Siprashvili, Zurab, Sozzi, Gabriella, Barnes, Larry D., McCue, Peter, Robinson, Angela K., Eryomin, Vladimir, ...
The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions....
FHIT gene therapy prevents tumor development in Fhit-deficient mice
Dumon, Kristoffel R., Ishii, Hideshi, Fong, Louise Y. Y., Zanesi, Nicola, Fidanza, Vincenzo, Mancini, Rita, ...
The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant...
Shiraishi, Takeshi, Druck, Teresa, Mimori, Koshi, Flomenberg, Jacob, Berk, Lori, Alder, Hansjuerg, ...
It has been suggested that delayed DNA replication underlies fragility at common human fragile sites, but specific sequences responsible for expression of these inducible fragile sites have not been...
The tumor spectrum in FHIT-deficient mice
Zanesi, Nicola, Fidanza, Vincenzo, Fong, Louise Y., Mancini, Rita, Druck, Teresa, Valtieri, Mauro, ...
Mice carrying one inactivated Fhit allele (Fhit +/− mice) are highly susceptible to tumor induction by N-nitrosomethylbenzylamine, with 100% of Fhit +/− mice exhibiting tumors of the...
Trapasso, Francesco, Krakowiak, Agnieszka, Cesari, Rossano, Arkles, Jeffrey, Yendamuri, Sai, Ishii, Hideshi, ...
The FHIT gene is inactivated early in the development of many human tumors, and Fhit-deficient mice have increased cancer incidence. Viral reexpression of Fhit kills Fhit-deficient cells by induction...
Matsuyama, Ayumi, Shiraishi, Takeshi, Trapasso, Francesco, Kuroki, Tamotsu, Alder, Hansjuerg, Mori, Masaki, ...
Common fragile sites are regions that show elevated susceptibility to DNA damage, leading to alterations that can contribute to cancer development. FRA3B, located at chromosome region 3p14.2, is the...
Fhit is a physiological target of the protein kinase Src
Pekarsky, Yuri, Garrison, Preston N., Palamarchuk, Alexey, Zanesi, Nicola, Aqeilan, Rami I., Huebner, Kay, ...
The FHIT gene is a tumor suppressor that is frequently inactivated by genomic alterations at chromosomal region 3p14.2. In the last few years, a considerable amount of data describing inactivation of...
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
Aqeilan, Rami I., Pekarsky, Yuri, Herrero, Juan J., Palamarchuk, Alexey, Letofsky, Jean, Druck, Teresa, ...
The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein–protein interaction....
Croce, Carlo M., Huebner, Kay, Koprowski, Hilary
Somatic cell hybrids between mouse cells deficient in thymidine kinase [ATP:thymidine 5′-phosphotransferase (EC 2.7.1.75)] and two different monkey cell lines transformed by an adeno 7-SV40 hybrid...
Ishii, Hideshi, Inageta, Taeko, Mimori, Koshi, Saito, Toshiyuki, Sasaki, Hiroki, Isobe, Masaharu, ...
We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
WWOX gene restoration prevents lung cancer growth in vitro and in vivo
Fabbri, Muller, Iliopoulos, Dimitrios, Trapasso, Francesco, Aqeilan, Rami I., Cimmino, Amelia, Zanesi, Nicola, ...
The WWOX (WW domain containing oxidoreductase) gene at the common fragile site, FRA16D, is altered in many types of cancer, including lung cancer. We have examined the tumor suppressor function of...
Muir–Torre-like syndrome in Fhit-deficient mice
Fong, Louise Y. Y., Fidanza, Vincenzo, Zanesi, Nicola, Lock, Leslie F., Siracusa, Linda D., Mancini, Rita, ...
To investigate the role of the Fhit gene in carcinogen induction of neoplasia, we have inactivated one Fhit allele in mouse embryonic stem cells and produced (129/SvJ × C57BL/6J) F1 mice with a Fhit...
Pace, Helen C., Garrison, Preston N., Robinson, Angela K., Barnes, Larry D., Draganescu, Alexandra, Rösler, Angelika, ...
Alterations in the FHIT gene at 3p14.2 occur as early and frequent events in the development of several common human cancers. The ability of human Fhit-negative cells to form tumors in nude mice is...
Pekarsky, Yuri, Campiglio, Manuela, Siprashvili, Zurab, Druck, Teresa, Sedkov, Yurii, Tillib, Sergei, ...
The tumor suppressor gene FHIT encompasses the common human chromosomal fragile site at 3p14.2 and numerous cancer cell biallelic deletions. To study Fhit function we cloned and characterized FHIT...
Cancer-specific chromosome alterations in the constitutive fragile region FRA3B
Mimori, Koshi, Druck, Teresa, Inoue, Hiroshi, Alder, Hansjuerg, Berk, Lori, Mori, Masaki, ...
We have sequenced 870 kilobases of the FHIT/FRA3B locus, from FHIT intron 3 to intron 7. The locus is AT rich (61.5%) and Alu poor (6.2%), and it apparently does not harbor other genes. In a detailed...
Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion
Inoue, Hiroshi, Ishii, Hideshi, Alder, Hansjuerg, Snyder, Eric, Druck, Teresa, Huebner, Kay, ...
The hypothesis that chromosomal fragile sites may be “weak links” that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell...
Replacement of Fhit in cancer cells suppresses tumorigenicity
Siprashvili, Zurab, Sozzi, Gabriella, Barnes, Larry D., McCue, Peter, Robinson, Angela K., Eryomin, Vladimir, ...
The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions....
FHIT gene therapy prevents tumor development in Fhit-deficient mice
Dumon, Kristoffel R., Ishii, Hideshi, Fong, Louise Y. Y., Zanesi, Nicola, Fidanza, Vincenzo, Mancini, Rita, ...
The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant...
Shiraishi, Takeshi, Druck, Teresa, Mimori, Koshi, Flomenberg, Jacob, Berk, Lori, Alder, Hansjuerg, ...
It has been suggested that delayed DNA replication underlies fragility at common human fragile sites, but specific sequences responsible for expression of these inducible fragile sites have not been...
The tumor spectrum in FHIT-deficient mice
Zanesi, Nicola, Fidanza, Vincenzo, Fong, Louise Y., Mancini, Rita, Druck, Teresa, Valtieri, Mauro, ...
Mice carrying one inactivated Fhit allele (Fhit +/− mice) are highly susceptible to tumor induction by N-nitrosomethylbenzylamine, with 100% of Fhit +/− mice exhibiting tumors of the...
Trapasso, Francesco, Krakowiak, Agnieszka, Cesari, Rossano, Arkles, Jeffrey, Yendamuri, Sai, Ishii, Hideshi, ...
The FHIT gene is inactivated early in the development of many human tumors, and Fhit-deficient mice have increased cancer incidence. Viral reexpression of Fhit kills Fhit-deficient cells by induction...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Matsuyama, Ayumi, Shiraishi, Takeshi, Trapasso, Francesco, Kuroki, Tamotsu, Alder, Hansjuerg, Mori, Masaki, ...
Common fragile sites are regions that show elevated susceptibility to DNA damage, leading to alterations that can contribute to cancer development. FRA3B, located at chromosome region 3p14.2, is the...
Fhit is a physiological target of the protein kinase Src
Pekarsky, Yuri, Garrison, Preston N., Palamarchuk, Alexey, Zanesi, Nicola, Aqeilan, Rami I., Huebner, Kay, ...
The FHIT gene is a tumor suppressor that is frequently inactivated by genomic alterations at chromosomal region 3p14.2. In the last few years, a considerable amount of data describing inactivation of...
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
Aqeilan, Rami I., Pekarsky, Yuri, Herrero, Juan J., Palamarchuk, Alexey, Letofsky, Jean, Druck, Teresa, ...
The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein–protein interaction....
Croce, Carlo M., Huebner, Kay, Koprowski, Hilary
Somatic cell hybrids between mouse cells deficient in thymidine kinase [ATP:thymidine 5′-phosphotransferase (EC 2.7.1.75)] and two different monkey cell lines transformed by an adeno 7-SV40 hybrid...
Ishii, Hideshi, Inageta, Taeko, Mimori, Koshi, Saito, Toshiyuki, Sasaki, Hiroki, Isobe, Masaharu, ...
We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous...
WWOX gene restoration prevents lung cancer growth in vitro and in vivo
Fabbri, Muller, Iliopoulos, Dimitrios, Trapasso, Francesco, Aqeilan, Rami I., Cimmino, Amelia, Zanesi, Nicola, ...
The WWOX (WW domain containing oxidoreductase) gene at the common fragile site, FRA16D, is altered in many types of cancer, including lung cancer. We have examined the tumor suppressor function of...
Loss of FHIT Expression in Transitional Cell Carcinoma of the Urinary Bladder
Baffa, Raffaele, Gomella, Leonard G., Vecchione, Andrea, Bassi, Pierfrancesco, Mimori, Koshi, Sedor, John, ...
Cytogenetic and loss of heterozygosity (LOH) studies demonstrated chromosome 3p deletions in transitional cell carcinoma (TCC). We recently cloned the tumor suppressor gene FHIT (fragile histidine...
Fabbri, Muller, Garzon, Ramiro, Cimmino, Amelia, Liu, Zhongfa, Zanesi, Nicola, Callegari, Elisa, ...
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of...
Trapasso, Francesco, Pichiorri, Flavia, Gaspari, Marco, Palumbo, Tiziana, Aqeilan, Rami I., Gaudio, Eugenio, ...
Fhit protein is lost in most cancers, its restoration suppresses tumorigenicity, and virus-mediated FHIT gene therapy induces apoptosis and suppresses tumors in preclinical models. We have used...