Yamamoto, Nobuyuki, Sekine, Ikuo, Nakagawa, Kazuhiko, Takada, Minoru, Fukuoka, Masahiro, Tanigawara, Yusuke, ...
Objective The aim of this study was to investigate the safety, pharmacokinetic and pharmacodynamic profiles of pegfilgrastim (KRN125), a long-acting granulocyte colony-stimulating factor, in lung...
Nakagawa, Kazuhiko, Minami, Hironobu, Kanezaki, Masayuki, Mukaiyama, Akihira, Minamide, Yoshiyuki, Uejima, Hisao, ...
Objective The Phase I dose-escalation study was conducted to evaluate the safety and pharmacokinetics of lapatinib (GW572016), a dual ErbB-1 and -2 inhibitor, in Japanese patients with solid tumors...
Nakagawa, Kazuhiko, Yamazaki, Koichi, Kunitoh, Hideo, Hida, Toyoaki, Gemba, Kenichi, Shinkai, Tetsu, ...
Background Pemetrexed in combination with cisplatin (Pem/Cis) is used globally for the treatment of malignant pleural mesothelioma (MPM). This Phase I/II study was conducted to determine the...
Boku, Narikazu, Ohtsu, Atsushi, Hyodo, Ichinosuke, Shirao, Kuniaki, Miyata, Yoshinori, Nakagawa, Kazuhiko, ...
Background Although oxaliplatin (L-OHP) combined with infusional 5-fluorouracil (5-FU) and leucovorin (LV) is one of the standard chemotherapy regimens for metastatic or recurrent colorectal cancer,...
Induction of apoptosis during the early phase of reperfusion after rat liver ischemia (2007)
Sasaki, Hiroshi, Matsuno, Tsuyoshi, Nakagawa, Kazuhiko, Tanaka, Noriaki
This study was designed to investigate the induction of apoptosis during the reperfusion phase following warm liver ischemia in vivo. We evaluated apoptotic bodies (ABs) in sections stained with...
Nakagawa, Kazuhiko, Matsuno, Tsuyoshi, Iwagaki, Hiromi, Fujiwara, Takuzo, Tanaka, Noriaki
The immune status of thirteen living and related kidney transplant recipients with stable allografts were examined. The immunological assays consisted of a mixed lymphocyte reaction (MLR),...
Hyodo, Ichinosuke, Shirao, Kuniaki, Doi, Toshihiko, Hatake, Kiyohiko, Arai, Yasuaki, Yamaguchi, Kensei, ...
Background: Although the standard 3-week capecitabine regimen (1250 mg/m2 twice daily for 2 weeks followed by a 1-week rest) has shown superior activity and improved safety over bolus...
Hyodo, Ichinosuke, Shirao, Kuniaki, Doi, Toshihiko, Hatake, Kiyohiko, Arai, Yasuaki, Yamaguchi, Kensei, ...
Background: Although the standard 3-week capecitabine regimen (1250 mg/m2 twice daily for 2 weeks followed by a 1-week rest) has shown superior activity and improved safety over bolus...
Matsui, Kaoru, Hirashima, Tomonori, Nitta, Takashi, Kobayashi, Masashi, Ogata, Yoshitaka, Furukawa, Mitsugi, ...
Objective: Gemcitabine and docetaxel are non-platinum agents with activity in non-small cell lung cancer (NSCLC). This study was conducted to determine and evaluate the recommended regimen of...
Kakiuchi, Soji, Daigo, Yataro, Ishikawa, Nobuhisa, Furukawa, Chiyuki, Tsunoda, Tatsuhiko, Yano, Seiji, ...
Gefitinib (Iressa, ZD1839), an inhibitor of epidermal growth factor receptor-tyrosine kinase (EGFR-TK), has shown potent anti-tumor effects and improved symptom and quality-of-life of a subset of...
Kakiuchi, Soji, Daigo, Yataro, Ishikawa, Nobuhisa, Furukawa, Chiyuki, Tsunoda, Tatsuhiko, Yano, Seiji, ...
Gefitinib (Iressa, ZD1839), an inhibitor of epidermal growth factor receptor-tyrosine kinase, has shown potent anti-tumor effects and improved symptoms and quality-of-life of a subset of patients...
Kakiuchi, Soji, Daigo, Yataro, Ishikawa, Nobuhisa, Furukawa, Chiyuki, Tsunoda, Tatsuhiko, Yano, Seiji, ...
Gefitinib (Iressa, ZD1839), an inhibitor of epidermal growth factor receptor-tyrosine kinase (EGFR-TK), has shown potent anti-tumor effects and improved symptom and quality-of-life of a subset of...
Yano, Seiji, Giaccone, Giuseppe, Tamura, Tomohide, Nakagawa, Kazuhiko, Douillard, Jean-Yves, ...
PURPOSE: To evaluate the efficacy and tolerability of two doses of gefitinib (Iressa [ZD1839]; AstraZeneca, Wilmington, DE), a novel epidermal growth factor receptor tyrosine kinase inhibitor, in...
Kelley, Michael J., Nakagawa, Kazuhiko, Steinberg, Seth M., Mulshine, James L., Kamb, Alexander, Johnson, Bruce E.
Background: The CDKN2 gene encodes the human cyclin-dependent kinase 4 inhibitor. This inhibitor protein is believed to be a tumor suppressor that plays an essential role in cell cycle regulation....
Masuda, Noriyuki, Fukuoka, Masahiro, Matsui, Kaoru, Kusunoki, Yoko, Kudoh, Shinzoh, Negoro, Shunichi, ...
We studied tumor samples from 39 patients, who entered our study from January 1989 to May 1990, to assess whether the ability to establish a continually growing tumor cell line from fresh tumor...
Shinkai, Tetsu, Sakurai, Masanori, Eguchi, Kenji, Sasaki, Yasutsuna, Tamura, Tomohide, Fujiwara, Yasuhiro, ...
Consecutive series involving 172 patients with small cell lung cancer were analyzed retrospectively using eight pretreatment and two treatment-related prognostic factors in respect of their influence...
Shinkai, Tetsu, Saijo, Nagahiro, Eguchi, Kenji, Sasaki, Yasutsuna, Tamura, Tomohide, Fujiwara, Yasuhiro, ...
Forty-two patients with advanced lung cancer undergoing chemotherapy containing cisplatin (80 mg/m2 were submitted to a randomized controlled trial to evaluate the effect of the combination of...
Phase II Study of Carboplatin in Non-small Cell Lung Cancer (1989)
Tamura, Tomohide, Shinkai, Testu, Eguchi, Kenji, Sasaki, Yasutsuna, Fujiwara, Yasuhiro, Fukuda, Masaaki, ...
Forty four patients with advanced non-small cell lung cancer (NSCLC) were treated with carboplatin (CBDCA; cis-diammine-1, 1-cyclobutane dicarboxylate platinum II) at a dose of 400–450 mg/m2...
Nakagawa, Kazuhiko, Tada, Mariko, Morita, Toshiteru, Utsunomiya, Joji, Ishikawa, Takatoshi
4–Hydroxyaminoquinoline 1-oxide (4HAQO)-DNA adducts were immunohistochemically demonstrated in the nuclei of various organs of mice with the use of an antibody directed against 4HAQO-modified DNA....
Nakagawa, Kazuhiko, Utsunomiya, Joji, Ishikawa, Takatoshi
To clarify the biological role of poly(ADP-ribose) in cancer induction in vivo, the influence of the poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide (3-AB), on initiation of carcinogenesis in...
Phase II Study of Carboplatin in Small Cell Lung Cancer (1988)
Tamura, Tomohide, Saijo, Nagahiro, Shinkai, Tetsu, Eguchi, Kenji, Sasaki, Yasutsuna, Sakurai, Masanori, ...
Carboplatin (CBDCA; cis-diammine-1, 1-cyclobutane dicarboxylate platinum II), a new platinum analogue, was administered to 18 patients with small cell lung cancer (SCLC) at a dose of 300–450...
O6-Methylguanine DNA methyltransferase activity in liver from various fish species (1987)
Nakatsuru, Yoko, Nemoto, Nobuo, Nakagawa, Kazuhiko, Masahito, Prince, Ishikawa, Takatoshi
O6-Methylguanine DNA methyltransferase (O6-MT) is considered to play an important role in the repair of alkylating carcinogen-induced lesions in a wide range of mammalian species. Fish are used...
Akiba, Tadashi, Saijo, Nagahiro, Miyamoto, Kengo, Sakurai, Masanori, Tamura, Tomohide, Sasaki, Yasutsuna, ...
A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a...
Akiba, Tadashi, Saijo, Nagahiro, Miyamoto, Kengo, Taguchi, Junichi, Taito, Hiroyuki, Sakurai, Masanori, ...
A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B0 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed...
Single GST-P positive liver cells -- putative initiated. hepatocytes (1987)
Moore, Malcolm A., Nakagawa, Kazuhiko, Satoh, Kimihiko, Ishikawa, Takatoshi, Sato, Kiyomi
Immunohistochemical investigation of liver tissue 48 h after single doses of the hepatocarcinogens diethylnitrosamine (DEN), dimethylnitrosamine, aflatoxin B1 and methylazoxy-methanol acetate...
Chemosensitivity Test for Human Small Cell Lung Cancer Cell Lines In Vitro (1986)
TAKAHASHI, HIDENOBU, SAIJO, NAGAHIRO, SHINKAI, TETSU, EGUCHI, KENJI, SASAKI, YASUTSUNA, TAMURA, TOMOHIDE, ...
The in vitro response to seven chemotherapeutic drugs of three established human small cell lung cancer (SCLC) cell lines (NCI H69, H 128, N231) was tested by a double soft agar clonogenic assay....
SHINKAI, TETSU, SAIJO, NAGAHIRO, EGUCHI, KENJI, SASAKI, YASUTSUNA, TAMURA, TOMOHIDE, TOMINAGA, KEIGO, ...
High-dose intravenous (IV) metoclopramide has shown efficacy with few side effects for the treatment of nausea and vomiting on the day of cisplatin administration. From November 1984 to January 1986,...
Long-Term Survival in Patients with Small Cell Lung Cancer (1986)
SUGA, JUNJI, SAIJO, NAGAHIRO, SHINKAI, TETSU, EGUCHI, KENJI, SASAKI, YASUTSUNA, TAMURA, TOMOHIDE, ...
Of the 66 patients with small cell lung cancer (SCLC) who were treated by combination chemotherapy with or without radiation therapy from July 1978 to December 1983 at the National Cancer Center...