Kazuhito Toyo-oka

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia (2008)

Ikeda, Masashi, Hikita, Takao, Taya, Shinichiro, Uraguchi-Asaki, Junko, Toyo-oka, Kazuhito, Wynshaw-Boris, Anthony, ...

Schizophrenia is a complex mental disorder with a fairly high degree of heritability. Although the causes of schizophrenia remain unclear, it is now widely accepted that it is a neurodevelopmental...

NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment (2007)

Mori, Daisuke, Yano, Yoshihisa, Toyo-oka, Kazuhito, Yoshida, Noriyuki, Yamada, Masami, Muramatsu, Masami, ...

NDEL1 is a binding partner of LIS1 that participates in the regulation of cytoplasmic dynein function and microtubule organization during mitotic cell division and neuronal migration. NDEL1...

Recruitment of Katanin P60 by Phosphorylated NDEL1, a LIS1 interacting protein, is Essential for Mitotic Cell Division and Neuronal Migration (2005)

Toyo-oka, Kazuhito, Sasaki, Shinji, Yano, Yoshihisa, Mori, Daisuke, Kobayashi, Takuya, Toyoshima, Yoko Y., ...

LIS1 is mutated in the human neuronal migration defect lissencephaly, and along with NDEL1 (formerly NUDEL), participates in the regulation of cytoplasmic dynein function during neuronal development....

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome (2004)

Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...

The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of twenty genes deleted in a heterozygous fashion in Miller-Dieker syndrome (MDS), a contiguous gene...

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome (2004)

Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...

The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of 20 genes deleted in a heterozygous fashion in Miller–Dieker syndrome (MDS), a contiguous gene...

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome (2004)

Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...

The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of twenty genes deleted in a heterozygous fashion in Miller-Dieker syndrome (MDS), a contiguous gene...

Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association (1999)

Toyo-oka, Kazuhito, Yashiro-Ohtani, Yumi, Park, Cheung-Seog, Tai, Xu-Guang, Miyake, Kensuke, Hamaoka, Toshiyuki, ...

CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be...

Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin (1994)

Iwata, Hisashi, Nagano, Tetsuroh, Toyo-oka, Kazuhito, Hirose, Hajime, Hamaoka, Toshiyukl, Fujiwara, Hiromi

C57BL/6 (B6) mice were injected I.v. with class I H-2-disparate B10.QBR spleen cells (107/mouse). This regimen, termed donor alloantigen-specific I.v. pre-sensltizatlon (DSP), Induced almost...

Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

Hurlin, Peter J., Zhou, Zi-Qiang, Toyo-oka, Kazuhito, Ota, Sara, Walker, William L., Hirotsune, Shinji, ...

Mnt is a Max-interacting transcriptional repressor that has been hypothesized to function as a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice. Since mice lacking Mnt were...

Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality

Sasaki, Shinji, Mori, Daisuke, Toyo-oka, Kazuhito, Chen, Amy, Garrett-Beal, Lisa, Muramatsu, Masami, ...

Regulation of cytoplasmic dynein and microtubule dynamics is crucial for both mitotic cell division and neuronal migration. NDEL1 was identified as a protein interacting with LIS1, the protein...

Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

Hurlin, Peter J., Zhou, Zi-Qiang, Toyo-oka, Kazuhito, Ota, Sara, Walker, William L., Hirotsune, Shinji, ...

Mnt is a Max-interacting transcriptional repressor that has been hypothesized to function as a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice. Since mice lacking Mnt were...

Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3

Cardoso, Carlos, Leventer, Richard J., Ward, Heather L., Toyo-oka, Kazuhito, Chung, June, Gross, Alyssa, ...

Deletions of 17p13.3, including the LIS1 gene, result in the brain malformation lissencephaly, which is characterized by reduced gyration and cortical thickening; however, the phenotype can vary from...

Miller-Dieker Syndrome: Analysis of a Human Contiguous Gene Syndrome in the Mouse

Yingling, Jessica, Toyo-oka, Kazuhito, Wynshaw-Boris, Anthony

Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality

Sasaki, Shinji, Mori, Daisuke, Toyo-oka, Kazuhito, Chen, Amy, Garrett-Beal, Lisa, Muramatsu, Masami, ...

Regulation of cytoplasmic dynein and microtubule dynamics is crucial for both mitotic cell division and neuronal migration. NDEL1 was identified as a protein interacting with LIS1, the protein...

NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment▿ †

Mori, Daisuke, Yano, Yoshihisa, Toyo-oka, Kazuhito, Yoshida, Noriyuki, Yamada, Masami, Muramatsu, Masami, ...

NDEL1 is a binding partner of LIS1 that participates in the regulation of cytoplasmic dynein function and microtubule organization during mitotic cell division and neuronal migration. NDEL1...

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

Toyo-oka, Kazuhito, Mori, Daisuke, Yano, Yoshihisa, Shiota, Masayuki, Iwao, Hiroshi, Goto, Hidemasa, ...

Protein phosphatase 4 catalytic subunit (PP4c) is a PP2A-related protein serine/threonine phosphatase with important functions in a variety of cellular processes, including microtubule (MT)...