Kazuho Ikeo

DDBJ Activities: Contribution to the Research in Information Biology (2009)

Jun Mashima, Takehide Kosuge, Toshihisa Okido, Yuichi Kodama, Kazuho Ikeo, Hideaki Sugawara, ...

DDBJ (DNA Data Bank of Japan; "http://www.ddbj.nig.ac.jp/":http://www.ddbj.nig.ac.jp/)started its database activities in 1986. From the beginning, DDBJ has been one of INSDC (International...

Genome Network Project: An Integrated Genomic Platform (2009)

Jose C. Clemente, So Nakagawa, Kazuho Ikeo, Takashi Gojobori

With the objective of elucidating the structure of gene interactions in the human genome, the Genome Network Project has generated a vast quantity of experimental data, mainly focusing on...

Optimized ancestral state reconstruction using Sankoff parsimony (2009)

Clemente, José C, Ikeo, Kazuho, Valiente, Gabriel, Gojobori, Takashi

Abstract Background Parsimony methods are widely used in molecular evolution to estimate the most plausible phylogeny for a set of characters. Sankoff parsimony determines the minimum number of...

DDBJ dealing with mass data produced by the second generation sequencer (2009)

Sugawara, Hideaki, Ikeo, Kazuho, Fukuchi, Satoshi, Gojobori, Takashi, Tateno, Yoshio

DNA Data Bank of Japan (DDBJ) (http://www.ddbj.nig.ac.jp) collected and released 2 368 110 entries or 1 415 106 598 bases in the period from July 2007 to June 2008. The releases in this period...

Agrobiological Resources (2008)

Ha. Jime Kitakami, Tadasu Shin-i, Kazuho Ikeo, Yoshihiro Ugawa, Naruya Saitou, Takashi Gojobori, ...

305, Japan Recently, we newly developed a relrrtionrrl schema for eflectively building, integruting. and searching the DNA database on the relational datuhnse mcrnngement system, SYBASE, at DDBJ. The...

Cilium Evolution: Identification of a Novel Protein, Nematocilin, in the Mechanosensory Cilium of Hydra Nematocytes (2008)

Hwang, Jung Shan, Takaku, Yasuharu, Chapman, Jarrod, Ikeo, Kazuho, David, Charles N., Gojobori, Takashi

The cnidocil at the apical end of Hydra nematocytes is a mechanosensory cilium, which acts as a “trigger” for discharge of the nematocyst capsule. The cnidocil protrudes from the center of the...

Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees (2008)

Matsuya, Akihiro, Sakate, Ryuichi, Kawahara, Yoshihiro, Koyanagi, Kanako O., Sato, Yoshiharu, Fujii, Yasuyuki, ...

Orthologs are genes in different species that evolved from a common ancestral gene by speciation. Currently, with the rapid growth of transcriptome data of various species, more reliable orthology...

Structure and Developmental Expression of the Ascidian (2007)

Gene Insights Into, Shigeru Sato, Reiko Toyoda, You Katsuyama, Hidetoshi Saiga, Takaharu Numakunai, ...

The tyrosinase family in vertebrates consists of three related melanogenic enzymes: tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2. These proteins control melanin production in pigment...

Compensatory Change of Interacting Amino Acids in the Coevolution of Transcriptional Coactivator MBF1 and TATA-Box-Binding Protein (2007)

Liu, Qing-Xin, Nakashima-Kamimura, Naomi, Ikeo, Kazuho, Hirose, Susumu, Gojobori, Takashi

To elucidate the transcriptional regulation in eukaryotic genome network, it is important to understand coevolution of transcription factors, transcriptional coactivators, and TATA-box–binding...

Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana (2007)

Itoh, Takeshi, Tanaka, Tsuyoshi, Barrero, Roberto A., Yamasaki, Chisato, Fujii, Yasuyuki, Hilton, Phillip B., ...

We present here the annotation of the complete genome of rice Oryza sativa L. ssp. japonica cultivar Nipponbare. All functional annotations for proteins and non-protein-coding RNA (npRNA) candidates...

Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana (2007)

Itoh, Takeshi, Tanaka, Tsuyoshi, Barrero, Roberto A., Yamasaki, Chisato, Fujii, Yasuyuki, Hilton, Phillip B., ...

We present here the annotation of the complete genome of rice Oryza sativa L. ssp. japonica cultivar Nipponbare. All functional annotations for proteins and non-protein-coding RNA (npRNA) candidates...

The Rice Annotation Project Database (RAP-DB): hub for Oryza sativa ssp. japonica genome information (2006)

Ohyanagi, Hajime, Tanaka, Tsuyoshi, Sakai, Hiroaki, Shigemoto, Yasumasa, Yamaguchi, Kaori, Habara, Takuya, ...

With the completion of the rice genome sequencing, a standardized annotation is necessary so that the information from the genome sequence can be fully utilized in understanding the biology of rice...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms (2005)

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region (2005)

Yokomine, Takaaki, Shirohzu, Hisao, Purbowasito, Wahyu, Toyoda, Atsushi, Iwama, Hisakazu, Ikeo, Kazuho, ...

Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

The Human Anatomic Gene Expression Library (2004)

Motohiko Tanino, Marie-anne Debily, Takuro Tamura, Teruyoshi Hishiki, Osamu Ogasawara, Katsuji Murakawa, ...

(H-ANGEL), the H-Inv integrative display of human gene expression across disparate

Evolutionary Process of the Amino Acids Biosynthesis in Corynebacterium at the Whole Genome Level (2004)

Nishio, Yousuke, Nakamura, Yoji, Usuda, Yoshihiro, Sugimoto, Shinichi, Matsui, Kazuhiko, Kawarabayasi, Yutaka, ...

Corynebacterium glutamicum, which is the closest relative of Corynebacterium efficiens, is widely used for the large scale production of many kinds of amino acids, particularly glutamic acid and...

Comparative Analysis of Gene Expression for Convergent Evolution of Camera Eye Between Octopus and Human (2004)

Ogura, Atsushi, Ikeo, Kazuho, Gojobori, Takashi

Although the camera eye of the octopus is very similar to that of humans, phylogenetic and embryological analyses have suggested that their camera eyes have been acquired independently. It has been...

Evolutionary Process of Amino Acid Biosynthesis in Corynebacterium at the Whole Genome Level (2004)

Nishio, Yousuke, Nakamura, Yoji, Usuda, Yoshihiro, Sugimoto, Shinichi, Matsui, Kazuhiko, Kawarabayasi, Yutaka, ...

Corynebacterium glutamicum, which is the closest relative of Corynebacterium efficiens, is widely used for the large scale production of many kinds of amino acids, particularly glutamic acid and...

Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region (2004)

Yokomine, Takaaki, Shirohzu, Hisao, Purbowasito, Wahyu, Toyoda, Atsushi, Iwama, Hisakazu, Ikeo, Kazuho, ...

Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its...

Evolutionary Process of the Amino Acids Biosynthesis in Corynebacterium at the Whole Genome Level (2004)

Nishio, Yousuke, Nakamura, Yoji, Usuda, Yoshihiro, Sugimoto, Shinichi, Matsui, Kazuhiko, Kawarabayasi, Yutaka, ...

Corynebacterium glutamicum, which is the closest relative of Corynebacterium efficiens, is widely used for the large scale production of many kinds of amino acids, particularly glutamic acid and...

Search for the Evolutionary Origin of a Brain; Planarian Brain Characterized by Microarray (2003)

Nakazawa, Masumi, Cebrià, Francesc, Mineta, Katsuhiko, Ikeo, Kazuho, Agata, Kiyokazu, Gojobori, Takashi

The origin of the brain remains a challenging problem in evolutionary studies. To understand when and how the structural brain emerged, we analyzed the central nervous system (CNS) of a lower...

Search for the Evolutionary Origin of a Brain: Planarian Brain Characterized by Microarray (2003)

Nakazawa, Masumi, Cebrià, Francesc, Mineta, Katsuhiko, Ikeo, Kazuho, Agata, Kiyokazu, Gojobori, Takashi

The origin of the brain remains a challenging problem in evolutionary studies. To understand when and how the structural brain emerged, we analyzed the central nervous system (CNS) of a lower...

Comparative Complete Genome Sequence Analysis of the Amino Acid Replacements Responsible for the Thermostability of Corynebacterium efficiens (2003)

Nishio, Yousuke, Nakamura, Yoji, Kawarabayasi, Yutaka, Usuda, Yoshihiro, Kimura, Eiichiro, Sugimoto, Shinichi, ...

Corynebacterium efficiens is the closest relative of Corynebacterium glutamicum, a species widely used for the industrial production of amino acids. C. efficiens but not C. glutamicum can grow above...

Search for the Evolutionary Origin of a Brain; Planarian Brain Characterized by Microarray (2003)

Nakazawa, Masumi, Cebrià, Francesc, Mineta, Katsuhiko, Ikeo, Kazuho, Agata, Kiyokazu, Gojobori, Takashi

The origin of the brain remains a challenging problem in evolutionary studies. To understand when and how the structural brain emerged, we analyzed the central nervous system (CNS) of a lower...

The evolutionary position of nematodes (2002)

Blair, Jaime E, Ikeo, Kazuho, Gojobori, Takashi, Hedges, S Blair

Abstract Background The complete genomes of three animals have been sequenced by global research efforts: a nematode worm ( Caenorhabditis elegans ), an insect ( Drosophila melanogaster ), and a...

HOX genes in the sepiolid squid Euprymna scolopes: Implications for the evolution of complex body plans

Callaerts, Patrick, Lee, Patricia N., Hartmann, Britta, Farfan, Claudia, Choy, Darrett W. Y., Ikeo, Kazuho, ...

Molluscs display a rich diversity of body plans ranging from the wormlike appearance of aplacophorans to the complex body plan of the cephalopods with highly developed sensory organs, a complex...

Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs

Mineta, Katsuhiko, Nakazawa, Masumi, Cebrià, Francesc, Ikeo, Kazuho, Agata, Kiyokazu, Gojobori, Takashi

Among the bilateral animals, a centralized nervous system is found in both the deuterostome and protostome. To address the question of whether the CNS was derived from a common ancestor of...

Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence

Anzai, Tatsuya, Shiina, Takashi, Kimura, Natsuki, Yanagiya, Kazuyo, Kohara, Sakae, Shigenari, Atsuko, ...

Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

Comparative Complete Genome Sequence Analysis of the Amino Acid Replacements Responsible for the Thermostability of Corynebacterium efficiens

Nishio, Yousuke, Nakamura, Yoji, Kawarabayasi, Yutaka, Usuda, Yoshihiro, Kimura, Eiichiro, Sugimoto, Shinichi, ...

Corynebacterium efficiens is the closest relative of Corynebacterium glutamicum, a species widely used for the industrial production of amino acids. C. efficiens but not C. glutamicum can grow above...

Comparative Analysis of Gene Expression for Convergent Evolution of Camera Eye Between Octopus and Human

Ogura, Atsushi, Ikeo, Kazuho, Gojobori, Takashi

Although the camera eye of the octopus is very similar to that of humans, phylogenetic and embryological analyses have suggested that their camera eyes have been acquired independently. It has been...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2–Igf2–H19 region

Yokomine, Takaaki, Shirohzu, Hisao, Purbowasito, Wahyu, Toyoda, Atsushi, Iwama, Hisakazu, Ikeo, Kazuho, ...

Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its...

The Rice Annotation Project Database (RAP-DB): hub for Oryza sativa ssp. japonica genome information

Ohyanagi, Hajime, Tanaka, Tsuyoshi, Sakai, Hiroaki, Shigemoto, Yasumasa, Yamaguchi, Kaori, Habara, Takuya, ...

With the completion of the rice genome sequencing, a standardized annotation is necessary so that the information from the genome sequence can be fully utilized in understanding the biology of rice...

Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity

Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, ...

A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an...

HOX genes in the sepiolid squid Euprymna scolopes: Implications for the evolution of complex body plans

Callaerts, Patrick, Lee, Patricia N., Hartmann, Britta, Farfan, Claudia, Choy, Darrett W. Y., Ikeo, Kazuho, ...

Molluscs display a rich diversity of body plans ranging from the wormlike appearance of aplacophorans to the complex body plan of the cephalopods with highly developed sensory organs, a complex...

Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs

Mineta, Katsuhiko, Nakazawa, Masumi, Cebrià, Francesc, Ikeo, Kazuho, Agata, Kiyokazu, Gojobori, Takashi

Among the bilateral animals, a centralized nervous system is found in both the deuterostome and protostome. To address the question of whether the CNS was derived from a common ancestor of...

Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence

Anzai, Tatsuya, Shiina, Takashi, Kimura, Natsuki, Yanagiya, Kazuyo, Kohara, Sakae, Shigenari, Atsuko, ...

Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

Comparative Complete Genome Sequence Analysis of the Amino Acid Replacements Responsible for the Thermostability of Corynebacterium efficiens

Nishio, Yousuke, Nakamura, Yoji, Kawarabayasi, Yutaka, Usuda, Yoshihiro, Kimura, Eiichiro, Sugimoto, Shinichi, ...

Corynebacterium efficiens is the closest relative of Corynebacterium glutamicum, a species widely used for the industrial production of amino acids. C. efficiens but not C. glutamicum can grow above...

Comparative Analysis of Gene Expression for Convergent Evolution of Camera Eye Between Octopus and Human

Ogura, Atsushi, Ikeo, Kazuho, Gojobori, Takashi

Although the camera eye of the octopus is very similar to that of humans, phylogenetic and embryological analyses have suggested that their camera eyes have been acquired independently. It has been...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2–Igf2–H19 region

Yokomine, Takaaki, Shirohzu, Hisao, Purbowasito, Wahyu, Toyoda, Atsushi, Iwama, Hisakazu, Ikeo, Kazuho, ...

Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its...

The Rice Annotation Project Database (RAP-DB): hub for Oryza sativa ssp. japonica genome information

Ohyanagi, Hajime, Tanaka, Tsuyoshi, Sakai, Hiroaki, Shigemoto, Yasumasa, Yamaguchi, Kaori, Habara, Takuya, ...

With the completion of the rice genome sequencing, a standardized annotation is necessary so that the information from the genome sequence can be fully utilized in understanding the biology of rice...

Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity

Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, ...

A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an...

Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana

Itoh, Takeshi, Tanaka, Tsuyoshi, Barrero, Roberto A., Yamasaki, Chisato, Fujii, Yasuyuki, Hilton, Phillip B., ...

We present here the annotation of the complete genome of rice Oryza sativa L. ssp. japonica cultivar Nipponbare. All functional annotations for proteins and non-protein-coding RNA (npRNA) candidates...

Transcriptional Interferences in cis Natural Antisense Transcripts of Humans and Mice

Osato, Naoki, Suzuki, Yoshiyuki, Ikeo, Kazuho, Gojobori, Takashi

For a significant fraction of mRNAs, their expression is regulated by other RNAs, including cis natural antisense transcripts (cis-NATs) that are complementary mRNAs transcribed from opposite strands...

Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees

Matsuya, Akihiro, Sakate, Ryuichi, Kawahara, Yoshihiro, Koyanagi, Kanako O., Sato, Yoshiharu, Fujii, Yasuyuki, ...

Orthologs are genes in different species that evolved from a common ancestral gene by speciation. Currently, with the rapid growth of transcriptome data of various species, more reliable orthology...

The evolutionary emergence of cell type-specific genes inferred from the gene expression analysis of Hydra

Hwang, Jung Shan, Ohyanagi, Hajime, Hayakawa, Shiho, Osato, Naoki, Nishimiya-Fujisawa, Chiemi, Ikeo, Kazuho, ...

Cell lineages of cnidarians including Hydra represent the fundamental cell types of metazoans and provides us a unique opportunity to study the evolutionary diversification of cell type in the animal...

DDBJ dealing with mass data produced by the second generation sequencer

Sugawara, Hideaki, Ikeo, Kazuho, Fukuchi, Satoshi, Gojobori, Takashi, Tateno, Yoshio

DNA Data Bank of Japan (DDBJ) (http://www.ddbj.nig.ac.jp) collected and released 2 368 110 entries or 1 415 106 598 bases in the period from July 2007 to June 2008. The releases in this period...