Hishida, Asahi, Matsuo, Keitaro, Goto, Yasuyuki, Naito, Mariko, Wakai, Kenji, Tajima, Kazuo, ...
Abstract Background Previous studies have revealed the significance of Helicobacter pylori ( H. pylori ) infection as a risk factor of gastric cancer. Cytotoxin-associated gene A ( cagA ) positivity...
Yasui, Yutaka, Hamajima, Nobuyuki, Nakamura, Tsuneya, El-Din, Noha, Tajima, Kazuo, Potter, John D
Abstract Background Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian countries, is associated with elevated IgG antibody titers against Epstein-Barr viral capcid antigen...
Keitaro Matsuo, Ritsuro Suzuki, Nobuyuki Hamajima, Michinori Ogura, Yoshitoyo Kagami, Hirofumi Taji, ...
doi:10.1182/blood.V97.10.3205 Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
Furue, Hiroki, Matsuo, Keitaro, Kumimoto, Hiroshi, Hiraki, Akio, Suzuki, Takeshi, Yatabe, Yasushi, ...
Background: NKG2D is an immune receptor on natural killer (NK) and other cells active in the immune system. It recognizes ligands expressed on mainly transformed cells and plays a role in their...
One-carbon metabolism-related gene polymorphisms and risk of breast cancer (2008)
Suzuki, Takeshi, Matsuo, Keitaro, Hirose, Kaoru, Hiraki, Akio, Kawase, Takakazu, Watanabe, Miki, ...
Environmental exposures and/or genetic background in Japanese population, which might contribute to the relatively low breast cancer incidence rates in Japan, have not been clarified in detail....
Suzuki, Takeshi, Matsuo, Keitaro, Hiraki, Akio, Saito, Toshiko, Sato, Shigeki, Yatabe, Yasushi, ...
There is substantial evidence that the decreased risk of lung cancer with high intake of vegetables and fruits is linked to folate as a specific nutrient. Functional polymorphisms in genes encoding...
Suzuki, Takeshi, Matsuo, Keitaro, Ito, Hidemi, Hirose, Kaoru, Wakai, Kenji, Saito, Toshiko, ...
Helicobacter pylori (H. pylori) is a causative agent for peptic ulcers as well as some types of gastric lymphoma; however, the relationship between a peptic ulcer history in combination with H....
Matsuo, Keitaro, Wakai, Kenji, Hirose, Kaoru, Ito, Hidemi, Saito, Toshiko, Suzuki, Takeshi, ...
Alcohol consumption is recognized as a potential risk factor for colorectal cancer (CRC). Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg,...
Ishikura, Shuhei, Matsumoto, Kengo, Sanai, Masaharu, Horie, Kenji, Matsunaga, Toshiyuki, Tajima, Kazuo, ...
Rat liver contains two cytosolic enzymes (TBER1 and TBER2) that reduce 6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione into its 4R- and 4S-hydroxy metabolites. In this study, we cloned the cDNA for...
Suzuki, Takeshi, Matsuo, Keitaro, Ito, Hidemi, Hirose, Kaoru, Wakai, Kenji, Saito, Toshiko, ...
Helicobacter pylori (H. pylori) is a causative agent for peptic ulcers as well as some types of gastric lymphoma; however, the relationship between a peptic ulcer history in combination with H....
Tanaka, Daisuke, Hishida, Asahi, Matsuo, Keitaro, Iwata, Hiroji, Shinoda, Masayuki, Yamamura, Yoshitaka, ...
Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of pyrimidine-synthesizing enzymes have been reported to be...
Yang, Chun-Xia, Matsuo, Keitaro, Ito, Hidemi, Shinoda, Masayuki, Hatooka, Shunzo, Hirose, Kaoru, ...
Folate takes part in two biological pathways involved in DNA methylation and synthesis, and a potential protective influence of this nutrient chemical against carcinogenicity has been recognized in...
Yang, Chun-Xia, Matsuo, Keitaro, Ito, Hidemi, Shinoda, Masayuki, Hatooka, Shunzo, Hirose, Kaoru, ...
Folate takes part in two biological pathways involved in DNA methylation and synthesis and a potential protective influence of this nutrient chemical against carcinogenicity has been recognized in...
Matsuo, Keitaro, Ito, Hidemi, Wakai, Kenji, Hirose, Kaoru, Saito, Toshiko, Suzuki, Takeshi, ...
One-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis and is suspected of impacting on colorectal carcinogenesis. Alcohol is well recognized as...
Matsuo, Keitaro, Wakai, Kenji, Hirose, Kaoru, Ito, Hidemi, Saito, Toshiko, Suzuki, Takeshi, ...
Alcohol consumption is recognized as a potential risk factor for colorectal cancer (CRC). Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg,...
Matsuo, Keitaro, Ito, Hidemi, Wakai, Kenji, Hirose, Kaoru, Saito, Toshiko, Suzuki, Takeshi, ...
One-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis, and is suspected of impacting on colorectal carcinogenesis. Alcohol is well recognized as...
Ito, Hidemi, Matsuo, Keitaro, Hamajima, Nobuyuki, Mitsudomi, Tetsuya, Sugiura, Takahiko, Saito, Toshiko, ...
APE1 (apurinic/apyrimidinic endonuclease 1) and XRCC1 (X-ray cross-complementing group1) are DNA repair proteins that play important roles in the base excision repair (BER) pathway. Polymorphisms in...
Ito, Hidemi, Matsuo, Keitaro, Hamajima, Nobuyuki, Mitsudomi, Tetsuya, Sugiura, Takahiko, Saito, Toshiko, ...
APE1 (apurinic/apyrimidinic endonuclease 1) and XRCC1 (X-ray cross-complementing group 1) are DNA repair proteins that play important roles in the base excision repair (BER) pathway....
Inoue, Manami, Tajima, Kazuo, Takezaki, Toshiro, Hamajima, Nobuyuki, Hirose, Kaoru, Ito, Hidemi, ...
Background To clarify lifestyle factors that affect the risk of pancreatic cancer among the Japanese population, a nested case-control study was conducted using data from the Hospital-based...
Tamakoshi, Akiko, Hamajima, Nobuyuki, Kawase, Haruya, Wakai, Kenji, Katsuda, Nobuyuki, Saito, Toshiko, ...
Aims: Alcohol dehydrogenase β subunit (ADH2) Arg47His and aldehyde dehydrogenase 2 (ALDH2) Glu487Lys were genotyped by a duplex polymerase chain reaction (PCR) with confronting two-pair primers...
Yang, Chunxia, Hamajima, Nobuyuki, Iwata, Hiroji, Saito, Toshiko, Matsuo, Keitaro, Hirose, Kaoru, ...
Abstract Background Breast cancer is hormone related, as are cancers of the endometrium, ovary, and prostate. Several studies have suggested that higher extracellular levels of androgens are...
Ito, Lucy Sayuri, Iwata, Hiroji, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, ...
Objective: The present case-control study aimed to examine the associations between breast cancer risk and three functional polymorphisms (Interleukin (IL) –1A C-889T, IL-1B C-31T and IL-1RN 86-bp...
Re: Population-Based, CaseControl Study of HER2 Genetic Polymorphism and Breast Cancer Risk (2002)
Hishida, Asahi, Hamajima, Nobuyuki, Iwata, Hiroji, Matsuo, Keitaro, Hirose, Kaoru, Emi, Nobuhiko, ...
Huang, Xin-En, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, Iwata, Hiroji, ...
Abstract Background The involvement of β 2 -adrenergic receptor (ADRB2) and β 3 -adrenergic receptor (ADRB3) in both adipocyte lipolysis and thermogenic activity suggests that polymorphisms in the...
Matsuo, Keitaro, Hamajima, Nobuyuki, Shinoda, Masayuki, Hatooka, Shunzo, Inoue, Manami, Takezaki, Toshiro, ...
Aldehyde dehydrogenase-2 (ALDH2) degrades acetaldehyde metabolized from ethanol. Its encoding gene ALDH2 has a functional polymorphism: ALDH2 Glu487Lys. An association between this polymorphism and...
Yoo, Keun-Young, Tajima, Kazuo, Miura, Shigeto, Takeuchi, Tohru, Hirose, Kaoru, Risch, Harvey, ...
Breast cancers demonstrate a gradient of responsiveness to endocrine therapy according to hormone receptor status, with tumors positive for both estrogen and progesterone receptors responding most...
Yoo, Keun-Young, Tajima, Kazuo, Kuroishi, Tetsuo, Hirose, Kaoru, Yoshida, Minoru, Miura, Shigeto, ...
A case-control study was carried out to assess the risk of breast cancer associated with breast feeding in Japan. The data were obtained in a hospital-based case-control study of 521 women with...
Prognostic Factors for Pleural Lymphoma Patients (1991)
Aozasa, Katsuyuki, Ohsawa, Masahiko, Luchi, Keiji, Mori, Takashi, Komatsu, Hikotaro, Tajima, Kazuo, ...
Prognostic factors in 47 patients with pleural lymphocytic lymphoma developing in chronic tuberculous pyothorax were evaluated using Cox's proportional hazards model. There were 41 men and six women,...
Iuchi, Keiji, Aozasa, Katsuyuki, Yamamoto, Satoru, Mori, Takashi, Tajima, Kazuo, Minato, Keisuke, ...
Our previous study suggested a close relation between a preceding chronic tuberculous pyothorax and the development of non-Hodgkin's lymphoma (NHL) in the pleural cavity. To confirm this further, 37...
Shimoyama, Masanori, Ota, Kazuo, Kikuchi, Masahiro, Yunoki, Kazuo, Konda, Susumu, Takatsuki, Kiyoshi, ...
Eighty-two adult patients with advanced B-lymphoma, treated between 1981 and 1983 with VEPA (vincristine, cyclophosphamide, prednisolone and doxorubicin) or VEPA-M (VEPA plus methotrexate) in a...
A Descriptive Epidemiological Study of Hematopoietic Neoplasms in Japan (1985)
KATO, IKUKO, TAJIMA, KAZUO, HIROSE, KAORU, NAKAGAWA, NORIKO, KUROISHI, TETSUO, TOMINAGA, SUKETAMI
In 1982, the number of deaths from hematopoietic neoplasms was 5,885 for males and 4,237 for females, which corresponded to about 6%; of all malignant neoplasms. The increase in the...
Latitude and Pancreatic Cancer (1985)
KATO, IKUKO, TAJIMA, KAZUO, KUROISHI, TETSUO, TOMINAGA, SUKETAMI
With regard to the geographical distribution of pancreatic cancer mortality, the relationship of the latitude and of the average temperature to pancreatic cancer mortality was examined. Both...
Estimation of Rate of Incidence of ATL Among ATLV (HTLV-I) Carriers in Kyushu, Japan (1985)
TAJIMA, KAZUO, KUROISHI, TETSUO
From the mortality statistics on malignant lymphomas in Japan and nationwide studies on T- and B-cell malignancies, the number of deaths from adult T-cell leukemia/lymphoma (ATL) in adults older...
TAJIMA, KAZUO, AKAZA, TATSUYA, KOICHI, KOIKE, HINUMA, YORIO, SUCHI, TAIZAN, TOMINAGA, SUKETAMI
In order to study the genetical susceptibility to infection by adult T-cell leukemia virus (ATLV), which is considered to be a main causative agent of adult T-cell leukemia (ATL), the HLA profile of...
Epidemiological Features of B-Cell Lymphoma in Japan (1983)
TAJIMA, KAZUO, TOMINAGA, SUKETAMI, SUCHI, TAIZAN
Age-adjusted incidence rates for malignant lymphomas in eastern Asian countries except for the Kyushu district of Japan are lower than those in northern European, North and South American and...
Huang, Xin-En, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, Iwata, Hiroji, ...
Yang, Chunxia, Hamajima, Nobuyuki, Iwata, Hiroji, Saito, Toshiko, Matsuo, Keitaro, Hirose, Kaoru, ...
Huang, Xin-En, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, Iwata, Hiroji, ...
Yang, Chunxia, Hamajima, Nobuyuki, Iwata, Hiroji, Saito, Toshiko, Matsuo, Keitaro, Hirose, Kaoru, ...
Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Tajima, Kazuo
Polymerase chain reaction with confronting two-pair primers (PCR-CTPP) is an inexpensive, time-saving genotyping method that is applicable for most single nucleotide polymorphisms. To date, we have...
Yasui, Yutaka, Hamajima, Nobuyuki, Nakamura, Tsuneya, El-Din, Noha Sharaf, Tajima, Kazuo, Potter, John D
Gao, Chang-Ming, Takezaki, Toshiro, Wu, Jian-Zhong, Zhang, Xiao-Mei, Cao, Hai-Xia, Ding, Jian-Hua, ...
AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males.
Nakanishi, Hideo, Yamada, Ryo, Gotoh, Norimoto, Hayashi, Hisako, Yamashiro, Kenji, Shimada, Noriaki, ...
Myopia is one of the most common ocular disorders worldwide. Pathological myopia, also called high myopia, comprises 1% to 5% of the general population and is one of the leading causes of legal...
Randomized controlled trials are recognized as having the strongest type of study design for generating evidence on prevention of disease. They are, however, the most labor- and time-intensive and...