Sasi, Walid, Jiang, Wen G, Sharma, Anup, Mokbel, Kefah
Abstract Background Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the...
Reefy, Sara, Patani, Neill, Anderson, Anne, Burgoyne, Gwyne, Osman, Hisham, Mokbel, Kefah
Abstract Background The management of early breast cancer (BC) with skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) is not based on level-1 evidence. In this study, the...
The mRNA expression of SATB1 and SATB2 in human breast cancer (2009)
Patani, Neill, Jiang, Wen, Mansel, Robert, Newbold, Robert, Mokbel, Kefah
Abstract Background SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly...
Walid Sasi, Wen G Jiang, Terry Roberts, Robert F Newbold, Kefah Mokbel, W Al Sarakbi, ...
PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. The mRNA expression of SETD2 in human breast cancer:...
The role of Herceptin in early breast cancer (2008)
Subramanian, Ashok, Mokbel, Kefah
Abstract Herceptin is widely regarded as the most important development in the treatment of breast cancer since Tamoxifen and the development of the multidisciplinary team (MDT). It is particularly...
Noorani, Alia, Sadiq, Zaid, Minakaran, Neda, Coleman, Catherine, Thomas, Val A, Mokbel, Kefah
Abstract Paraneoplastic cerebellar degeneration is part of a rare spectrum of neurological syndromes whereby gynaecological, lung or breast cancers present primarily with neurological manifestations....
Lymphangiogenesis and lymph node metastasis in breast cancer (2008)
Cunnick, Giles H, Jiang, Wen G, Douglas-Jones, Tony, Watkins, Gareth, Gomez, Kelvin F, Morgan, Mike J, ...
Abstract Introduction There have been few studies on lymphangiogenesis in the past due to the lack of specific lymphatic endothelial markers, and lymphatic-specific growth factors. Recently, these...
Mansfield, Lucy, Sosa, Isi, Dionello, Roberta, Subramanian, Ash, Devalia, Haresh, Mokbel, Kefah
Abstract Background Precise knowledge of axillary lymph node status is essential in the treatment of operable carcinoma of the breast. For many years, axillary nodal clearance (ANC) has been an...
Mansfield, Lucy, Devalia, Haresh, Rehman, Nadeem, Mokbel, Kefah
Abstract The concept of the sentinel node describes a primary or sentinel lymph node (SLN), which exists and through which tumour cells from a primary tumour in a particular location must first...
Chaudhry, Anushka, Puntis, Michael L, Gikas, Panos, Mokbel, Kefah
Abstract There is some evidence that breast cancer surgery during the luteal phase in pre-menopausal women is associated with a better clinical outcome, however the evidence for this is still...
Skin-sparing mastectomy and radiotherapy: an update (2006)
Abstract Despite the lack of randomised controlled trials and paucity of the published data, the current evidence suggests that the post-mastectomy radiation therapy (PMRT) does not represent a...
Mokbel, Ramia, Karat, Isabella, Mokbel, Kefah
Abstract There is overwhelming evidence that optimal adjuvant endocrine therapy for hormone sensitive breast cancer in postmenopausal women should include a third generation aromatase inhibitor (AI)....
Hosseini-Asl, Saied, Atri, Morteza, Modarressi, Mohammad H, Salhab, Mohamed, Mokbel, Kefah, Mehdipour, Parvin
Abstract Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization. Telomerase has...
Hosseini-Asl, Saied, Modarressi, Mohammad H, Atri, Morteza, Salhab, Mohamed, Mokbel, Kefah, Mehdipour, Parvin
Abstract Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not...
Jiang, Wen Guo, Watkins, Gareth, Douglas-Jones, Anthony Gordon, Mokbel, Kefah, Mansel, Robert Edward, Fodstad, Oystein
Com-1 is a recently discovered molecule that has putative action on the metastatic nature of cancer cells. The molecular action and clinical implication in cancer and prognosis are yet to be...
Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer (2004)
Jiang, Wen Guo, Watkins, Gareth, Fodstad, Oystein, Douglas-Jones, Anthony Gordon, Mokbel, Kefah, Mansel, Robert Edward
The CCN family members cysteine-rich 61 (Cyr61/CCN1), connective tissue growth factor (CTGF/CCN2) and nephroblastoma over-expressed (Nov/CCN3) play diverse roles in cells, are known to regulate cell...
Singh-Ranger, Gurpreet, Mokbel, Kefah
Abstract Capsular contraction following implantation of breast prostheses occurs in 2–33% of patients undergoing breast augmentation. This condition can be debilitating for patients, and often...
Kirkpatrick, Katharine L, Newbold, Robert F, Mokbel, Kefah
Abstract Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation....
The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression (2004)
Kirkpatrick, Katharine L, Newbold, Robert F, Mokbel, Kefah
Abstract Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation. hTERT (human...
Jiang, Wen Guo, Watkins, Gareth, Lane , Jane, Cunnick, Giles Harvey, Douglas-Jones, Anthony Gordon, Mokbel, Kefah, ...
PURPOSE: Rho family members are small GTPases that are known to regulate malignant transformation and motility of cancer cells. The activities of Rhos are regulated by molecules such as guanine...
Jiang, Wen Guo, Watkins, Gareth, Lane, Jane, Cunnick, Giles Harvey, Douglas-Jones, Anthony Gordon, Mokbel, Kefah, ...
PURPOSE: Rho family members are small GTPases that are known to regulate malignant transformation and motility of cancer cells. The activities of Rhos are regulated by molecules such as guanine...
Elkak, Abd E, Newbold, Robert F, Thomas, Valene, Mokbel, Kefah
Abstract Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable...
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer
Singh-Ranger, Gurpreet, Mokbel, Kefah
Capsular contraction following implantation of breast prostheses occurs in 2–33% of patients undergoing breast augmentation. This condition can be debilitating for patients, and often requires...
Hosseini-Asl, Saied, Modarressi, Mohammad H, Atri, Morteza, Salhab, Mohamed, Mokbel, Kefah, Mehdipour, Parvin
Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in...
Hosseini-Asl, Saied, Atri, Morteza, Modarressi, Mohammad H, Salhab, Mohamed, Mokbel, Kefah, Mehdipour, Parvin
Mokbel, Ramia, Karat, Isabella, Mokbel, Kefah
There is overwhelming evidence that optimal adjuvant endocrine therapy for hormone sensitive breast cancer in postmenopausal women should include a third generation aromatase inhibitor (AI). On...
Skin-sparing mastectomy and radiotherapy: an update
Despite the lack of randomised controlled trials and paucity of the published data, the current evidence suggests that the post-mastectomy radiation therapy (PMRT) does not represent a...
Chaudhry, Anushka, Puntis, Michael L, Gikas, Panos, Mokbel, Kefah
There is some evidence that breast cancer surgery during the luteal phase in pre-menopausal women is associated with a better clinical outcome, however the evidence for this is still equivocal.
Mansfield, Lucy, Devalia, Haresh, Rehman, Nadeem, Mokbel, Kefah
The concept of the sentinel node describes a primary or sentinel lymph node (SLN), which exists and through which tumour cells from a primary tumour in a particular location must first travel to...
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer
Singh-Ranger, Gurpreet, Mokbel, Kefah
Capsular contraction following implantation of breast prostheses occurs in 2–33% of patients undergoing breast augmentation. This condition can be debilitating for patients, and often requires...
Hosseini-Asl, Saied, Modarressi, Mohammad H, Atri, Morteza, Salhab, Mohamed, Mokbel, Kefah, Mehdipour, Parvin
Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in...
Hosseini-Asl, Saied, Atri, Morteza, Modarressi, Mohammad H, Salhab, Mohamed, Mokbel, Kefah, Mehdipour, Parvin
Mokbel, Ramia, Karat, Isabella, Mokbel, Kefah
There is overwhelming evidence that optimal adjuvant endocrine therapy for hormone sensitive breast cancer in postmenopausal women should include a third generation aromatase inhibitor (AI). On...
Skin-sparing mastectomy and radiotherapy: an update
Despite the lack of randomised controlled trials and paucity of the published data, the current evidence suggests that the post-mastectomy radiation therapy (PMRT) does not represent a...
Chaudhry, Anushka, Puntis, Michael L, Gikas, Panos, Mokbel, Kefah
There is some evidence that breast cancer surgery during the luteal phase in pre-menopausal women is associated with a better clinical outcome, however the evidence for this is still equivocal.
Mansfield, Lucy, Devalia, Haresh, Rehman, Nadeem, Mokbel, Kefah
The concept of the sentinel node describes a primary or sentinel lymph node (SLN), which exists and through which tumour cells from a primary tumour in a particular location must first travel to...
Lymphangiogenesis and lymph node metastasis in breast cancer
Cunnick, Giles H, Jiang, Wen G, Douglas-Jones, Tony, Watkins, Gareth, Gomez, Kelvin F, Morgan, Mike J, ...
Noorani, Alia, Sadiq, Zaid, Minakaran, Neda, Coleman, Catherine, Thomas, Val A, Mokbel, Kefah
Paraneoplastic cerebellar degeneration is part of a rare spectrum of neurological syndromes whereby gynaecological, lung or breast cancers present primarily with neurological manifestations. The...
The role of Herceptin in early breast cancer
Subramanian, Ashok, Mokbel, Kefah
Herceptin is widely regarded as the most important development in the treatment of breast cancer since Tamoxifen and the development of the multidisciplinary team (MDT). It is particularly exciting...
The mRNA expression of SATB1 and SATB2 in human breast cancer
Patani, Neill, Jiang, Wen, Mansel, Robert, Newbold, Robert, Mokbel, Kefah