Bucks, Romola. S., Gidron, Yori, Harris, Petra, Teeling, Jessica, Wesnes, Keith. A., Perry, V. Hugh
Observational and experimentally induced infection studies show that upper respiratory tract infections (URTI) affect mood and cognition. This study tested the effects of naturally occurring URTI on...
This paper considers the suitability of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) as the gold standard in registration trials of treatments for Alzheimer's disease....
Palmer, Colin, Ellis, Kathryn A., O'Neill, Barry V., Croft, Rodney J., Leung, Sumie, Oliver, Chris, ...
N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve...
Scholey, Andrew B., Tildesley, Nicola T. J., Ballard, Clive G., Wesnes, Keith A., Tasker, Andrea, Perry, Elaine K., ...
Species of Salvia (sage) have a long-standing reputation in European medical herbalism, including for memory enhancement. In recent controlled trials, administration of sage extracts with established...
This paper considers the suitability of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) as the gold standard in registration trials of treatments for Alzheimer's disease....
Palmer, Colin, Ellis, Kathryn A., O'Neill, Barry V., Croft, Rodney J., Leung, Sumie, Oliver, Chris, ...
N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve...
Scholey, Andrew B., Tildesley, Nicola T. J., Ballard, Clive G., Wesnes, Keith A., Tasker, Andrea, Perry, Elaine K., ...
Species of Salvia (sage) have a long-standing reputation in European medical herbalism, including for memory enhancement. In recent controlled trials, administration of sage extracts with established...
Keith Wesnes of Cognitive Drug Research (CDR) examines some of the key issues facing the development of cognition enhancers, looking at the benefits they can have for a variety of mental attributes.
Keith Wesnes of Cognitive Drug Research (CDR) examines some of the key issues facing the development of cognition enhancers, looking at the benefits they can have for a variety of mental attributes.
Palmer, Colin, Ellis, Kathryn A., O'Neill, Barry V., Croft, Rodney J., Leung, Sumie, Oliver, Chris, ...
N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve...
This paper considers the suitability of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) as the gold standard in registration trials of treatments for Alzheimer's disease....
Scholey, Andrew B., Tildesley, Nicola T. J., Ballard, Clive G., Wesnes, Keith A., Tasker, Andrea, Perry, Elaine K., ...
Species of Salvia (sage) have a long-standing reputation in European medical herbalism, including for memory enhancement. In recent controlled trials, administration of sage extracts with established...
Keith Wesnes of Cognitive Drug Research (CDR) examines some of the key issues facing the development of cognition enhancers, looking at the benefits they can have for a variety of mental attributes.
Palmer, Colin, Ellis, Kathryn A., O'Neill, Barry V., Croft, Rodney J., Leung, Sumie, Oliver, Chris, ...
N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve...
This paper considers the suitability of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) as the gold standard in registration trials of treatments for Alzheimer's disease....
Keith Wesnes of Cognitive Drug Research (CDR) examines some of the key issues facing the development of cognition enhancers, looking at the benefits they can have for a variety of mental attributes.
Ryan, J., Croft, K., Mori, T., Wesnes, Keith A., Spong, Jo, Downey, Luke A., ...
The study examines the effects of the antioxidant flavonoid Pycnogenol on a range of cognitive and biochemical measures in healthy elderly individuals. The study used a double-blind,...
Bartholomeusz, Cali F., Wesnes, Keith A., Kulkarni, Jayashri, Vitetta, Luis, Croft, Rodney J., Nathan, Pradeep J.
The steroid hormone estradiol has been shown to modulate cognitive function in both animals and humans, and although the exact mechanisms associated with these effects are unknown, interactions with...
The effects of l-theanine, caffeine and their combination on cognition and mood (2008)
Haskell, Crystal F., Kennedy, David O., Milne, Anthea, Wesnes, Keith A., Scholey, Andrew B.
l-Theanine is an amino acid found naturally in tea. Despite the common consumption of l-theanine, predominantly in combination with caffeine in the form of tea, only one study to date has examined...
Scholey, Andrew B., Tildesley, Nicola T. J., Ballard, Clive G., Wesnes, Keith A., Tasker, Andrea, Perry, Elaine K., ...
Species of Salvia (sage) have a long-standing reputation in European medical herbalism, including for memory enhancement. In recent controlled trials, administration of sage extracts with established...
Palmer, Colin, Ellis, Kathryn A., O'Neill, Barry V., Croft, Rodney J., Leung, Sumie, Oliver, Chris, ...
N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve...
This paper considers the suitability of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) as the gold standard in registration trials of treatments for Alzheimer's disease....
Keith Wesnes of Cognitive Drug Research (CDR) examines some of the key issues facing the development of cognition enhancers, looking at the benefits they can have for a variety of mental attributes.
Ryan, J., Croft, K., Mori, T., Wesnes, Keith A., Spong, Jo, Downey, Luke A., ...
The study examines the effects of the antioxidant flavonoid Pycnogenol on a range of cognitive and biochemical measures in healthy elderly individuals. The study used a double-blind,...
Bartholomeusz, Cali F., Wesnes, Keith A., Kulkarni, Jayashri, Vitetta, Luis, Croft, Rodney J., Nathan, Pradeep J.
The steroid hormone estradiol has been shown to modulate cognitive function in both animals and humans, and although the exact mechanisms associated with these effects are unknown, interactions with...
The effects of l-theanine, caffeine and their combination on cognition and mood (2008)
Haskell, Crystal F., Kennedy, David O., Milne, Anthea, Wesnes, Keith A., Scholey, Andrew B.
l-Theanine is an amino acid found naturally in tea. Despite the common consumption of l-theanine, predominantly in combination with caffeine in the form of tea, only one study to date has examined...
Haskell, Crystal F., Kennedy, David O., Wesnes, Keith A., Milne, A. L., Scholey, A. B.
The present study aimed to systematically assess acute, dose-related behavioural effects of an extract of guarana plant for the first time in humans. This double-blind, counterbalanced,...
Ingwersen, Jeanet, Defeyter, Margaret A., Kennedy, David O., Wesnes, Keith A., Scholey, Andrew B.
This study investigated whether the glycaemic index (GI) of breakfast cereal differentially affects children's attention and memory. Using a balanced cross-over design, on two consecutive mornings 64...
Haskell, Crystal F., Kennedy, David O., Wesnes, Keith A., Milne, A. L., Scholey, A. B.
The present study aimed to systematically assess acute, dose-related behavioural effects of an extract of guarana plant for the first time in humans. This double-blind, counterbalanced,...
Ingwersen, Jeanet, Defeyter, Margaret A., Kennedy, David O., Wesnes, Keith A., Scholey, Andrew B.
This study investigated whether the glycaemic index (GI) of breakfast cereal differentially affects children's attention and memory. Using a balanced cross-over design, on two consecutive mornings 64...
Effects of acute macronutrient ingestion on cognition and mood. (2006)
Jones , Emma, Sünram-Lea, Sandra I., Fairley, Suzie, Wesnes, Keith A.
A wide range of studies have demonstrated that glucose and/or carbohydrate ingestion can facilitate certain aspects of cognitive performance in healthy young humans (e.g. Kennedy & Scholey, 2000;...
Ellis, Julia R., Ellis, Kathryn A., Bartholomeusz, Cali F., Harrison, Ben J., Wesnes, Keith A., Erskine, Fiona F., ...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic...
Ellis, Julia R., Ellis, Kathryn A., Bartholomeusz, Cali F., Harrison, Ben J., Wesnes, Keith A., Erskine, Fiona F., ...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic...
Ellis, Julia R., Ellis, Kathryn A., Bartholomeusz, Cali F., Harrison, Ben J., Wesnes, Keith A., Erskine, Fiona F., ...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic...
Ellis, Julia R., Ellis, Kathryn A., Bartholomeusz, Cali F., Harrison, Ben J., Wesnes, Keith A., Erskine, Fiona F., ...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic...
Ellis, Julia R., Ellis, Kathryn A., Bartholomeusz, Cali F., Harrison, Ben J., Wesnes, Keith A., Erskine, Fiona F., ...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer’s disease and schizophrenia. While the contribution of muscarinic...
Ellis, Julia R., Ellis, Kathryn A., Bartholomeusz, Cali F., Harrison, Ben J., Wesnes, Keith A., Erskine, Fiona F., ...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic...
Haskell, Crystal F., Kennedy, David O., Wesnes, Keith A., Scholey, Andrew B.
Rationale: The cognitive and mood effects of caffeine are well documented. However, the majority of studies in this area involve caffeine-deprived, habitual caffeine users. It is therefore unclear...
The psychopharmacology of herbal extracts: issues and challenges (2005)
Scholey, Andrew, Kennedy, David O., Wesnes, Keith A.
Abstract not available.
Tildesley, Nicola T. J., Kennedy, David O., Perry, Elaine K., Ballard, C. G., Wesnes, Keith A., Scholey, A. B.
Members of the Sage family, such as Salvia officinalis and Salvia lavandulaefolia, have a long history of use as memory-enhancing agents coupled with cholinergic properties that may potentially be...
ELLIS, KATHRYN A, MEHTA, MITUL A, WESNES, KEITH A, ARMSTRONG, STUART, NATHAN, PRADEEP J
RATIONALE: The mesocortical dopamine system is regarded as an important modulator of working memory. While it has been established that stimulation of the D1/D2 receptor in primates can improve...
Haskell, Crystal F., Kennedy, David O., Wesnes, Keith A., Scholey, Andrew B.
Rationale: The cognitive and mood effects of caffeine are well documented. However, the majority of studies in this area involve caffeine-deprived, habitual caffeine users. It is therefore unclear...
The psychopharmacology of herbal extracts: issues and challenges (2005)
Scholey, Andrew, Kennedy, David O., Wesnes, Keith A.
Abstract not available.
Tildesley, Nicola T. J., Kennedy, David O., Perry, Elaine K., Ballard, C. G., Wesnes, Keith A., Scholey, A. B.
Members of the Sage family, such as Salvia officinalis and Salvia lavandulaefolia, have a long history of use as memory-enhancing agents coupled with cholinergic properties that may potentially be...
ELLIS, KATHRYN A, MEHTA, MITUL A, WESNES, KEITH A, ARMSTRONG, STUART, NATHAN, PRADEEP J
RATIONALE: The mesocortical dopamine system is regarded as an important modulator of working memory. While it has been established that stimulation of the D1/D2 receptor in primates can improve...
The effects of protective helmet use on physiology and cognition in young cricketers (2004)
Neave, Nick J., Emmett, John., Moss, Mark C., Ayton, Rebecca, Scholey, Andrew, Wesnes, Keith A.
Many studies have reported physiological and cognitive decrements following heat stress. Of particular concern in cricket are the possible negative effects of sustained protective helmet use, as this...
Kennedy, David O., Haskell, Crystal F., Wesnes, Keith A., Scholey, A. B.
Extracts from the plant guarana (Paullinia cupana) feature as putatively stimulating ingredients in a number of foods, drinks and dietary/herbal supplements. To date, little research in humans has...
Natural products as cognition enhancing agents (2004)
Wesnes, Keith A., Zangara, Andrea, Scholey, Andrew, Kennedy, David O.
Abstract not available.
The effects of protective helmet use on physiology and cognition in young cricketers (2004)
Neave, Nick J., Emmett, John., Moss, Mark C., Ayton, Rebecca, Scholey, Andrew, Wesnes, Keith A.
Many studies have reported physiological and cognitive decrements following heat stress. Of particular concern in cricket are the possible negative effects of sustained protective helmet use, as this...
Kennedy, David O., Haskell, Crystal F., Wesnes, Keith A., Scholey, A. B.
Extracts from the plant guarana (Paullinia cupana) feature as putatively stimulating ingredients in a number of foods, drinks and dietary/herbal supplements. To date, little research in humans has...
Natural products as cognition enhancing agents (2004)
Wesnes, Keith A., Zangara, Andrea, Scholey, Andrew, Kennedy, David O.
Abstract not available.
Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers (2003)
Tildesley, N. T. J., Kennedy, David O., Perry, Elaine K., Ballard, Clive G., Savelev, S., Wesnes, Keith A., ...
Sage (Salvia) has a longstanding reputation in British herbal encyclopaedias as an agent that enhances memory, although there is little evidence regarding the efficacy of sage from systematized...
Wilkinson, Lucy, Scholey, Andrew, Wesnes, Keith A.
Abstract not available.
Kennedy, David O., Wake, G., Savelev, S., Tildesley, Nicola T. J., Perry, Elaine K., Wesnes, Keith A., ...
Melissa officinalis (Lemon balm) is a herbal medicine that has traditionally been attributed with memory-enhancing properties, but which is currently more widely used as a mild sedative and sleep...
Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers (2003)
Tildesley, N. T. J., Kennedy, David O., Perry, Elaine K., Ballard, Clive G., Savelev, S., Wesnes, Keith A., ...
Sage (Salvia) has a longstanding reputation in British herbal encyclopaedias as an agent that enhances memory, although there is little evidence regarding the efficacy of sage from systematized...
Wilkinson, Lucy, Scholey, Andrew, Wesnes, Keith A.
Abstract not available.
Kennedy, David O., Wake, G., Savelev, S., Tildesley, Nicola T. J., Perry, Elaine K., Wesnes, Keith A., ...
Melissa officinalis (Lemon balm) is a herbal medicine that has traditionally been attributed with memory-enhancing properties, but which is currently more widely used as a mild sedative and sleep...
Ford, Claire, Scholey, Andrew B., Ayre, Gareth, Wesnes, Keith A.
The effects of glucose administration and emotionality of target material on heart rate and memory were examined in a double-blind, placebo-controlled, balanced crossover study. Memory for neutral...
Chewing gum selectively improves aspects of memory in healthy volunteers (2002)
Wilkinson, Lucy, Scholey, Andrew, Wesnes, Keith A.
Abstract not available.
McCue, Patricia M., Scholey, A. B., Herman, C., Wesnes, Keith A.
We compared a computerized version of the Cognitive Drug Research (CDR) cognitive assessment test battery and a completely automated telephone version of the same battery. These assessed aspects of...
Girdler, Nicholas Martin, Fairbrother, K. J., Lyne, J. P., Neave, Nick J., Scholey, A., Hargaden, N., ...
Objective: To study the post-operative cognitive and psychomotor recovery from midazolam conscious sedation, after reversal with the benzodiazepine antagonist flumazenil over a prolonged recovery...
Kennedy, David O., Scholey, Andrew B., Tildesley, Nicola T. J., Perry, Elaine K., Wesnes, Keith A.
Melissa officinalis (lemon balm) is a traditional herbal medicine, which enjoys contemporary usage as a mild sedative, spasmolytic and antibacterial agent. It has been suggested, in light of in vitro...
Kennedy, David O., Scholey, A. B., Wesnes, Keith A.
It has previously been demonstrated in separate studies that single doses of Ginkgo biloba, Panax ginseng, and a combination of the two extracts can improve different aspects of cognitive performance...
Girdler, Nicholas Martin, Lyne, J. P., Wallace, R., Neave, Nick J., Scholey, A., Wesnes, Keith A., ...
SummaryFlumazenil is traditionally administered intravenously to reverse the adverse effects of over sedation with benzodiazepines. The aim of this study was to test postoperative cognitive and...
Ford, Claire, Scholey, Andrew B., Ayre, Gareth, Wesnes, Keith A.
The effects of glucose administration and emotionality of target material on heart rate and memory were examined in a double-blind, placebo-controlled, balanced crossover study. Memory for neutral...
Chewing gum selectively improves aspects of memory in healthy volunteers (2002)
Wilkinson, Lucy, Scholey, Andrew, Wesnes, Keith A.
Abstract not available.
McCue, Patricia M., Scholey, A. B., Herman, C., Wesnes, Keith A.
We compared a computerized version of the Cognitive Drug Research (CDR) cognitive assessment test battery and a completely automated telephone version of the same battery. These assessed aspects of...
Girdler, Nicholas Martin, Fairbrother, K. J., Lyne, J. P., Neave, Nick J., Scholey, A., Hargaden, N., ...
Objective: To study the post-operative cognitive and psychomotor recovery from midazolam conscious sedation, after reversal with the benzodiazepine antagonist flumazenil over a prolonged recovery...
Kennedy, David O., Scholey, Andrew B., Tildesley, Nicola T. J., Perry, Elaine K., Wesnes, Keith A.
Melissa officinalis (lemon balm) is a traditional herbal medicine, which enjoys contemporary usage as a mild sedative, spasmolytic and antibacterial agent. It has been suggested, in light of in vitro...
Kennedy, David O., Scholey, A. B., Wesnes, Keith A.
It has previously been demonstrated in separate studies that single doses of Ginkgo biloba, Panax ginseng, and a combination of the two extracts can improve different aspects of cognitive performance...
Girdler, Nicholas Martin, Lyne, J. P., Wallace, R., Neave, Nick J., Scholey, A., Wesnes, Keith A., ...
SummaryFlumazenil is traditionally administered intravenously to reverse the adverse effects of over sedation with benzodiazepines. The aim of this study was to test postoperative cognitive and...
Kennedy, David O., Scholey, A. B., Wesnes, Keith A.
We have previously shown differential cognitive improvements following single doses of Ginkgo biloba and of Ginseng. There is also evidence that chronic administration of a combination of...
Kennedy, David O., Scholey, A. B., Wesnes, Keith A.
Recent evidence suggests that chronic administration of Ginseng can improve cognitive performance in animals and in humans. No previous study has examined the possibility of cognitive effects...
Neave, N., Scholey, A. B., Emmett, J. R., Moss, Mark C., Kennedy, David O., Wesnes, Keith A.
Abstract not available.
Kennedy, David O., Scholey, A. B., Wesnes, Keith A.
We have previously shown differential cognitive improvements following single doses of Ginkgo biloba and of Ginseng. There is also evidence that chronic administration of a combination of...
Kennedy, David O., Scholey, A. B., Wesnes, Keith A.
Recent evidence suggests that chronic administration of Ginseng can improve cognitive performance in animals and in humans. No previous study has examined the possibility of cognitive effects...
Neave, N., Scholey, A. B., Emmett, J. R., Moss, Mark C., Kennedy, David O., Wesnes, Keith A.
Abstract not available.
Neave, Nick J., Reid, C., Scholey, A. B., Thompson, J. M., Moss, Mark C., Ayre, G., ...
Objectives: To assess the possible effects of flumazenil on cognitive processing, physiology, and mood. Design: A double-blind, placebo controlled, four-way cross-over study, using healthy...
Kennedy, David O., Scholey, Andrew B., Wesnes, Keith A.
Rationale: Chronic administration of extracts from the leaves of the tree Ginkgo biloba is known to improve aspects of cognitive performance. However, little is known about the effects of acute doses...
Neave, Nick J., Reid, C., Scholey, A. B., Thompson, J. M., Moss, Mark C., Ayre, G., ...
Objectives: To assess the possible effects of flumazenil on cognitive processing, physiology, and mood. Design: A double-blind, placebo controlled, four-way cross-over study, using healthy...
Kennedy, David O., Scholey, Andrew B., Wesnes, Keith A.
Rationale: Chronic administration of extracts from the leaves of the tree Ginkgo biloba is known to improve aspects of cognitive performance. However, little is known about the effects of acute doses...
Thompson, J. M., Neave, Nick J., Moss, Mark C., Scholey, A. B., Wesnes, Keith A., Girdler, Nicholas Martin
Objectives: To compare the effects of nitrous oxide and midazolam on cognition and mood. Design: A three-way, counterbalanced, cross-over study, using patients receiving conscious sedation for...
Scholey, Andrew B., Moss, Mark C., Neave, Nick J., Wesnes, Keith A.
It was recently established that supplemental oxygen administration significantly enhances memory formation in healthy young adults. In the present study, a double-blind, placebo-controled design was...
Thompson, J. M., Neave, Nick J., Moss, Mark C., Scholey, A. B., Wesnes, Keith A., Girdler, Nicholas Martin
Objectives: To compare the effects of nitrous oxide and midazolam on cognition and mood. Design: A three-way, counterbalanced, cross-over study, using patients receiving conscious sedation for...
Scholey, Andrew B., Moss, Mark C., Neave, Nick J., Wesnes, Keith A.
It was recently established that supplemental oxygen administration significantly enhances memory formation in healthy young adults. In the present study, a double-blind, placebo-controled design was...
Moss, Mark C., Scholey, Andrew B., Wesnes, Keith A.
It was recently demonstrated that oxygen administration can improve performance on a simple word recall task in healthy young adults. This study was aimed at determining the impact of various...
Scholey, Andrew B., Moss, Mark C., Wesnes, Keith A.
Oxygen administration coinciding with word presentation enhances word recall in humans, suggesting that elevated levels of circulating blood oxygen may be available to neural memory consolidation...
Moss, Mark C., Scholey, Andrew B., Wesnes, Keith A.
It was recently demonstrated that oxygen administration can improve performance on a simple word recall task in healthy young adults. This study was aimed at determining the impact of various...
Scholey, Andrew B., Moss, Mark C., Wesnes, Keith A.
Oxygen administration coinciding with word presentation enhances word recall in humans, suggesting that elevated levels of circulating blood oxygen may be available to neural memory consolidation...
Czeisler, Charles A., Walsh, James K., Wesnes, Keith A., Arora, Sanjay, Roth, Thomas
OBJECTIVE: To assess the effect of armodafinil, 150 mg, on the physiologic propensity for sleep and cognitive performance during usual night shift hours in patients with excessive sleepiness...