Keith Aubin

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope

Schmitz, Christian, Marchant, David, Neil, Stuart J. D., Aubin, Keith, Reuter, Sandra, Dittmar, Matthias T., ...

The characterization of restrictions to lentivirus replication in cells identifies critical steps in the viral life cycle and potential therapeutic targets. We previously reported that a human...

Detection of Antibody-Dependent Complement-Mediated Inactivation of both Autologous and Heterologous Virus in Primary Human Immunodeficiency Virus Type 1 Infection†

Aasa-Chapman, Marlén M. I., Holuigue, Sophie, Aubin, Keith, Wong, MaiLee, Jones, Nicola A., Cornforth, David, ...

Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication. The...

An Envelope-Determined, pH-Independent Endocytic Route of Viral Entry Determines the Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 to Lv2 Restriction

Marchant, David, Neil, Stuart J. D., Aubin, Keith, Schmitz, Christian, McKnight, Áine

We identified a postentry restriction, termed Lv2, which determines the cellular tropism of two related human immunodeficiency virus type 2 (HIV-2) isolates and is dependent on the sequence of the...

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope

Schmitz, Christian, Marchant, David, Neil, Stuart J. D., Aubin, Keith, Reuter, Sandra, Dittmar, Matthias T., ...

The characterization of restrictions to lentivirus replication in cells identifies critical steps in the viral life cycle and potential therapeutic targets. We previously reported that a human...

Detection of Antibody-Dependent Complement-Mediated Inactivation of both Autologous and Heterologous Virus in Primary Human Immunodeficiency Virus Type 1 Infection†

Aasa-Chapman, Marlén M. I., Holuigue, Sophie, Aubin, Keith, Wong, MaiLee, Jones, Nicola A., Cornforth, David, ...

Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication. The...

An Envelope-Determined, pH-Independent Endocytic Route of Viral Entry Determines the Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 to Lv2 Restriction

Marchant, David, Neil, Stuart J. D., Aubin, Keith, Schmitz, Christian, McKnight, Áine

We identified a postentry restriction, termed Lv2, which determines the cellular tropism of two related human immunodeficiency virus type 2 (HIV-2) isolates and is dependent on the sequence of the...