Response to comment on "Human-specific gain of function in a developmental enhancer" (2009)
Prabhakar, Shyam, Visel, Axel, Akiyama, Jennifer A., Shoukry, Malak, Lewis, Keith D., Holt, Amy, ...
Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive...
Response to comment on "Human-specific gain of function in a developmental enhancer" (2009)
Prabhakar, Shyam, Visel, Axel, Akiyama, Jennifer A., Shoukry, Malak, Lewis, Keith D., Holt, Amy, ...
Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive...
Human-specific gain of function in a developmental enhancer (2008)
Prabhakar, Shyam, Visel, Axel, Akiyama, Jennifer A., Shoukry, Malak, Lewis, Keith D., Holt, Amy, ...
Changes in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human developmental regulatory function has remained elusive....
In Vivo Enhancer Analysis Chromosome 16 Conserved Noncoding Sequences (2006)
Pennacchio, Len A., Ahituv, Nadav, Moses, Alan M., Nobrega, Marcelo, Prabhakar, Shyam, Shoukry, Malak, ...
The identification of enhancers with predicted specificities in vertebrate genomes remains a significant challenge that is hampered by a lack of experimentally validated training sets. In this study,...
Intra-species sequence comparisons for annotating genomes (2004)
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Intraspecies sequence comparisons for annotating genomes (2004)
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Intraspecies sequence comparisons for annotating genomes (2004)
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Typescript.
Thesis (Ph. D.)--Catholic University of America, 1985.
Typescript.
Thesis (Ph. D.)--Catholic University of America, 1985.
Thesis (Ph. D.)--Catholic University of America, 1985.
Intraspecies sequence comparisons for annotating genomes
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Intraspecies sequence comparisons for annotating genomes
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...