Keith D. Robertson

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions (2009)

Gopalakrishnan, Suhasni, Sullivan, Beth A., Trazzi, Stefania, Della Valle, Giuliano, Robertson, Keith D.

DNA methylation is an epigenetically imposed mark of transcriptional repression that is essential for maintenance of chromatin structure and genomic stability. Genome-wide methylation patterns are...

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function (2008)

Jin, Bilian, Tao, Qian, Peng, Jinrong, Soo, Hui Meng, Wu, Wei, Ying, Jianming, ...

Genome-wide DNA methylation patterns are established and maintained by the coordinated action of three DNA methyltransferases (DNMTs), DNMT1, DNMT3A and DNMT3B. DNMT3B hypomorphic germline mutations...

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer (2006)

Ai, Lingbao, Tao, Qian, Zhong, Sheng, Fields, C.Robert, Kim, Wan-Ju, Lee, Michael W., ...

The Wnt signaling pathway is a powerful and prominent oncogenic mechanism dysregulated in numerous cancer types. While evidence from transgenic mouse models and studies of human tumors clearly...

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer (2006)

Ai, Lingbao, Tao, Qian, Zhong, Sheng, Fields, C. Robert, Kim, Wan-Ju, Lee, Michael W., ...

The Wnt signaling pathway is a powerful and prominent oncogenic mechanism dysregulated in numerous cancer types. While evidence from transgenic mouse models and studies of human tumors clearly...

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer (2006)

Ai, Lingbao, Tao, Qian, Zhong, Sheng, Fields, C. Robert, Kim, Wan-Ju, Lee, Michael W., ...

The Wnt signaling pathway is a powerful and prominent oncogenic mechanism dysregulated in numerous cancer types. While evidence from transgenic mouse models and studies of human tumors clearly...

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery (2004)

Geiman, Theresa M., Sankpal, Umesh T., Robertson, Andrea K., Chen, Yue, Mazumdar, Manjari, Heale, Jason T., ...

Proper patterns of genome‐wide DNA methylation, mediated by DNA methyltransferases DNMT1, ‐3A and ‐3B, are essential for embryonic development and genomic stability in mammalian cells....

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription (2004)

Ling, Yan, Sankpal, Umesh T., Robertson, Andrea K., McNally, James G., Karpova, Tatiana, Robertson, Keith D.

The de novo DNA methyltransferase Dnmt3a is one of three mammalian DNA methyltransferases that has been shown to play crucial roles in embryonic development, genomic imprinting and transcriptional...

Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells (2002)

Tao, Qian, Huang, He, Geiman, Theresa M., Lim, Chai Yen, Fu, Li, Qiu, Guo-Hua, ...

ICF syndrome (immunodeficiency, centromere instability and facial anomalies) is a recessive human genetic disorder resulting from mutations in the DNA methyltransferase 3B (DNMT3B) gene. Patients...

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells (2000)

Robertson, Keith D., Keyomarsi, Khandan, Gonzales, Felicidad A., Velicescu, Mihaela, Jones, Peter A.

DNA methylation is essential for mammalian development, X-chromosome inactivation, and imprinting yet aberrant methylation patterns are one of the most common features of transformed cells. One of...

DNA methylation: past, present and future directions (2000)

Robertson, Keith D., A.Jones, Peter

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional...

Analysis of the role of DNA methylation in the regulation of the Epstein-Barr virus BamHI promoter / (1996)

Robertson, Keith D.

Thesis (Ph. D.)--Johns Hopkins University, 1997.

Hyatt Regency convention center hotel for downtown centeral business district, El Paso, Texas / (1985)

Robertson, Keith D.

Thesis (B.Arch.)--Texas Tech University, 1985.

Roles of Cell Division and Gene Transcription in the Methylation of CpG Islands

Bender, Christina M., Gonzalgo, Mark L., Gonzales, Felicidad A., Nguyen, Carvell T., Robertson, Keith D., Jones, Peter A.

De novo methylation of CpG islands within the promoters of eukaryotic genes is often associated with their transcriptional repression, yet the methylation of CpG islands located downstream of...

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

Robertson, Keith D., Keyomarsi, Khandan, Gonzales, Felicidad A., Velicescu, Mihaela, Jones, Peter A.

DNA methylation is essential for mammalian development, X-chromosome inactivation, and imprinting yet aberrant methylation patterns are one of the most common features of transformed cells. One of...

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

Robertson, Keith D., Jones, Peter A.

The INK4a/ARF locus encodes two proteins involved in tumor suppression in a manner virtually unique in mammalian cells. Distinct first exons, driven from separate promoters, splice onto a common exon...

The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive

Tao, Qian, Robertson, Keith D., Manns, Angela, Hildesheim, Allan, Ambinder, Richard F.

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is indispensable for viral DNA replication and episome maintenance in latency. Four promoters, Cp, Wp, Qp, and Fp, are known to drive EBNA1...

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Yan, Sankpal, Umesh T., Robertson, Andrea K., McNally, James G., Karpova, Tatiana, Robertson, Keith D.

The de novo DNA methyltransferase Dnmt3a is one of three mammalian DNA methyltransferases that has been shown to play crucial roles in embryonic development, genomic imprinting and transcriptional...

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

Geiman, Theresa M., Sankpal, Umesh T., Robertson, Andrea K., Chen, Yue, Mazumdar, Manjari, Heale, Jason T., ...

Proper patterns of genome-wide DNA methylation, mediated by DNA methyltransferases DNMT1, -3A and -3B, are essential for embryonic development and genomic stability in mammalian cells. The de novo...

Roles of Cell Division and Gene Transcription in the Methylation of CpG Islands

Bender, Christina M., Gonzalgo, Mark L., Gonzales, Felicidad A., Nguyen, Carvell T., Robertson, Keith D., Jones, Peter A.

De novo methylation of CpG islands within the promoters of eukaryotic genes is often associated with their transcriptional repression, yet the methylation of CpG islands located downstream of...

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

Robertson, Keith D., Keyomarsi, Khandan, Gonzales, Felicidad A., Velicescu, Mihaela, Jones, Peter A.

DNA methylation is essential for mammalian development, X-chromosome inactivation, and imprinting yet aberrant methylation patterns are one of the most common features of transformed cells. One of...

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

Robertson, Keith D., Jones, Peter A.

The INK4a/ARF locus encodes two proteins involved in tumor suppression in a manner virtually unique in mammalian cells. Distinct first exons, driven from separate promoters, splice onto a common exon...

The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive

Tao, Qian, Robertson, Keith D., Manns, Angela, Hildesheim, Allan, Ambinder, Richard F.

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is indispensable for viral DNA replication and episome maintenance in latency. Four promoters, Cp, Wp, Qp, and Fp, are known to drive EBNA1...

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Yan, Sankpal, Umesh T., Robertson, Andrea K., McNally, James G., Karpova, Tatiana, Robertson, Keith D.

The de novo DNA methyltransferase Dnmt3a is one of three mammalian DNA methyltransferases that has been shown to play crucial roles in embryonic development, genomic imprinting and transcriptional...

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

Geiman, Theresa M., Sankpal, Umesh T., Robertson, Andrea K., Chen, Yue, Mazumdar, Manjari, Heale, Jason T., ...

Proper patterns of genome-wide DNA methylation, mediated by DNA methyltransferases DNMT1, -3A and -3B, are essential for embryonic development and genomic stability in mammalian cells. The de novo...

Methylation Status of the Epstein-Barr Virus Major Latent Promoter C in Iatrogenic B Cell Lymphoproliferative Disease : Application of PCR-Based Analysis

Tao, Qian, Swinnen, Lode J., Yang, Jie, Srivastava, Gopesh, Robertson, Keith D., Ambinder, Richard F.

The Epstein-Barr virus (EBV) major latent promoter C drives the expression of viral nuclear proteins important in lymphocyte immortalization and as targets for immune surveillance by cytotoxic T...

DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B▿

Palii, Stela S., Van Emburgh, Beth O., Sankpal, Umesh T., Brown, Kevin D., Robertson, Keith D.

Genome-wide DNA methylation patterns are frequently deregulated in cancer. There is considerable interest in targeting the methylation machinery in tumor cells using nucleoside analogs of cytosine,...

Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)

Zeng, Weihua, De Greef, Jessica C., Chen, Yen-Yun, Chien, Richard, Kong, Xiangduo, Gregson, Heather C., ...

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in which no mutation of pathogenic gene(s) has been identified. Instead, the disease is, in most cases, genetically...