Keith Kerstann

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Gattinoni, Luca, Klebanoff, Christopher A., Palmer, Douglas C., Wrzesinski, Claudia, Kerstann, Keith, Yu, Zhiya, ...

T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8+ T cells into tumor-bearing mice at various stages of...

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

Klebanoff, Christopher A., Gattinoni, Luca, Torabi-Parizi, Parizad, Kerstann, Keith, Cardones, Adela R., Finkelstein, Steven E., ...

Central memory CD8+ T cells (TCM) and effector memory CD8+ T cells (TEM) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo....

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Gattinoni, Luca, Klebanoff, Christopher A., Palmer, Douglas C., Wrzesinski, Claudia, Kerstann, Keith, Yu, Zhiya, ...

T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8+ T cells into tumor-bearing mice at various stages of...

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

Klebanoff, Christopher A., Gattinoni, Luca, Torabi-Parizi, Parizad, Kerstann, Keith, Cardones, Adela R., Finkelstein, Steven E., ...

Central memory CD8+ T cells (TCM) and effector memory CD8+ T cells (TEM) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo....

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

Hsu, Cary, Jones, Stephanie A., Cohen, Cyrille J., Zheng, Zhili, Kerstann, Keith, Zhou, Juhua, ...

Malignancies arising from retrovirally transduced hematopoietic stem cells have been reported in animal models and human gene therapy trials. Whether mature lymphocytes are susceptible to insertional...