Keith M. Godfrey

Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring (2009)

Schlotz, Wolff, Jones, Alexander, Phillips, David I.W., Gale, Catharine R., Robinson, Sian M., Godfrey, Keith M.

Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary...

Do women change their health behaviours in pregnancy? Findings from the Southampton Women's Survey (2009)

Crozier, Sarah R., Robinson, Siân. M., Borland, Sharon E., Godfrey, Keith M., Cooper, Cyrus, Inskip, Hazel M.

A woman's life style choices before and during pregnancy have important implications for her unborn child, but information on behaviour can be unreliable when data are collected retrospectively. In...

Variations in infant feeding practice are associated with body composition in childhood: a prospective cohort study. (2009)

Robinson, Siân. M., Marriott, Lynne D., Harvey, Nick C., Gale, Catharine R., Inskip, Hazel M., ...

Context: most studies of infant diet and later body composition focus on milk feeding; few consider the influence of variations in the weaning diet. Objective: our objective was to examine how...

Dietary patterns in infancy and cognitive and neuropsychological function in childhood (2009)

Gale, Catharine R., Martyn, Christopher N., Marriott, Lynne D., Limmond, Jennifer, Crozier, Sarah, Inskip, Hazel M., ...

Background: trials in developing countries suggest that improving young children's diet may benefit cognitive development. Whether dietary composition influences young children's cognition in...

Breast-feeding and adherence to infant feeding guidelines do not influence bone mass at age 4 years (2009)

Harvey, Nicholas C., Robinson, Sian M., Crozier, Sarah R., Marriott, Lynne D., Gale, Catharine R., Cole, Zoe A., ...

The impact of variations in current infant feeding practice on bone mineral accrual is not known. We examined the associations between duration of breast-feeding and compliance with infant dietary...

Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study (2009)

Cole, Zoe A., Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine M., Boucher, Barbara J., ...

Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption...

Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study (2009)

Cole, Zoe A., Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine, Boucher, Barbara J., ...

Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption...

Fetal superior mesenteric artery: longitudinal reference ranges and evidence of regulatory link to portal liver circulation (2009)

Ebbing, Cathrine, Rasmussen, Svein, Godfrey, Keith M., Hanson, Mark A., Kiserud, Torvid

Objective: To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PISMA). Also to examine the hemodynamic relationship to...

Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study (2009)

Inskip, Hazel M., Crozier, Sarah R., Godfrey, Keith M., Borland, Sharon E., Cooper, Cyrus, Robinson, Siân M.

Objective To examine the extent to which women planning a pregnancy comply with recommendations for nutrition and lifestyle. Design Prospective cohort study. Setting Southampton, United Kingdom....

The use of 3D ultrasound to investigate fetal bone development (2009)

Mahon, Pamela A., Cooper, Cyrus, Crozier, Sarah R., Godfrey, Keith M.

Epidemiological studies suggest impaired fetal skeletal development has lifelong consequences for bone health. To examine the feasibility of using 3-dimensional ultrasound (3DUS) to investigate...

Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study (2009)

Inskip, Hazel M., Crozier, Sarah R., Godfrey, Keith M., Borland, Sharon E., Cooper, Cyrus, Robinson, Sian M.

Objective: to examine the extent to which women planning a pregnancy comply with recommendations for nutrition and lifestyle. Design: prospective cohort study. Setting: Southampton, United Kingdom....

Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children (2008)

Schlotz, Wolff, Jones, Alexander, Godfrey, Keith M., Phillips, David I.W.

Background: Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on...

Oily fish intake during pregnancy: association with lower hyperactivity but not with higher full-scale IQ in offspring (2008)

Gale, Catharine R., Robinson, Sian M., Godfrey, Keith M., Law, Catherine M., Schlotz, Wolff, O'Callaghan, F.J.

Background: Long-chain omega-3 polyunsaturated fatty acids are thought to be important for fetal neurodevelopment. Animal studies suggest that a deficiency of omega-3 fatty acids may lead to...

Sex-specific programming of cardiovascular physiology in children (2008)

Jones, Alexander, Beda, Alessandro, Osmond, Clive, Godfrey, Keith M., Simpson, David M., Phillips, David I.W.

Aims: Increasing evidence suggests that adverse prenatal environments, as indicated by low birth weight, cause long-term changes in cardiovascular physiology that predispose to circulatory disease....

What do babies eat: evaluation of a food frequency questionnaire to assess the diets of infants aged twelve months. (2008)

Marriott, Lynne D., Inskip, Hazel M., Borland, Sharon E., Godfrey, Keith M., Law, Catherine M., Robinson, Sian M.

Objective: to evaluate the relative validity of an FFQ for assessing nutrient intakes in 12-month-old infants. Design and setting: the FFQ was developed to assess the diets of infants born to women...

Cut-off points for anthropometric indices of adiposity: differential classification in a large population of young women (2008)

Duggleby, Sarah L., Jackson, Alan A., Godfrey, Keith M., Robinson, Siân M., Inskip, Hazel M.

Anthropometric indices of adiposity include BMI, waist circumference and waist:height ratio. In the recruitment phase of a prospective cohort study carried out between 1998 and 2002 we studied a...

Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies (2008)

Johnsen, Synnøve L, Wilsgaard, Tom, Rasmussen, Svein, Hanson, Mark A, Godfrey, Keith M, Kiserud, Torvid

Abstract Background Conventionally, the pregnancy duration is accepted to be 280–282 days. Fetuses determined by ultrasound biometry to be small in early pregnancy, have an increased risk of...

Is birth weight associated with risk of depressive symptoms in young women? Evidence from the Southampton Women's Survey (2008)

Inskip, Hazel M., Dunn, Nick, Godfrey, Keith M., Cooper, Cyrus, Kendrick, Tony

Although some studies have shown negative associations between birth weight and risk of depression, others have not. Studies also differ regarding the age and gender specificity of reported...

Sex-specific programming of cardiovascular physiology in children (2008)

Jones, Alexander, Beda, Alessandro, Osmond, Clive, Godfrey, Keith M., Simpson, David M., Phillips, David I.W.

Aims Increasing evidence suggests that adverse prenatal environments, as indicated by low birth weight, cause long-term changes in cardiovascular physiology that predispose to circulatory disease....

Is Birth Weight Associated with Risk of Depressive Symptoms in Young Women? Evidence from the Southampton Women's Survey (2008)

Inskip, Hazel M., Dunn, Nick, Godfrey, Keith M., Cooper, Cyrus, Kendrick, Tony

Although some studies have shown negative associations between birth weight and risk of depression, others have not. Studies also differ regarding the age and gender specificity of reported...

Size at birth and motor activity during stress in children aged 7-9 years (2007)

Schlotz, Wolff, Jones, Alexander, Phillips, Naomi M.M., Godfrey, Keith M., Phillips, David I.W.

Objective: Small size at birth is linked with metabolic and cardiovascular disease. There is increasing evidence that it is also linked with physiological stress responses and abnormal behaviour, in...

Is birth weight associated with risk of depressive symptoms in young women? Evidence from the Southampton Women's Survey (2007)

Inskip, Hazel M., Dunn, Nick, Godfrey, Keith M., Cooper, Cyrus, Kendrick, Tony

Although some studies have shown negative associations between birth weight and risk of depression, others have not. Studies also differ regarding the age and gender specificity of reported...

Maternal size in pregnancy and body composition in children (2007)

Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine M., Godfrey, Keith M., Cooper, Cyrus

Context: Evidence suggests that babies' fat mass at birth is greater if their mothers were themselves fatter during pregnancy, but it is unclear whether this association persists into childhood....

Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro (2007)

Cleal, Jane K., Brownbill, Paul, Godfrey, Keith M., Jackson, John M., Jackson, Alan A., Sibley, Colin P., ...

Fetal growth is dependent on both the quantity and relative composition of amino acids delivered to the fetal circulation, and impaired placental amino acid supply is associated with restricted fetal...

Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro (2007)

Cleal, Jane K., Brownbill, Paul, Godfrey, Keith M., Jackson, John M., Jackson, Alan A., Sibley, Colin P., ...

Fetal growth is dependent on both the quantity and relative composition of amino acids delivered to the fetal circulation, and impaired placental amino acid supply is associated with restricted fetal...

Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease (2007)

Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D., Hanson, Mark A.

There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that environmental influences acting during...

Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits (2007)

Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V.E., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...

The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...

Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits17 (2007)

Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...

The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...

Size at birth and motor activity during stress in children aged 7 to 9 years (2007)

Schlotz, Wolff, Jones, Alexander, Phillips, Naomi M.M., Godfrey, Keith M., Phillips, David I.W.

OBJECTIVES: Small size at birth is linked with metabolic and cardiovascular disease. There is increasing evidence that it is also linked with physiologic stress responses and abnormal behavior, in...

Maternal diet during pregnancy and carotid intima-media thickness in children (2006)

Gale, Catharine R., Jiang, Benyu, Robinson, Sian M., Godfrey, Keith M., Law, Catherine M., Martyn, Christopher N.

OBJECTIVE: Autopsy studies show that intimal lipid accumulations in arteries are often present at birth, suggesting that the prenatal environment plays a role in the pathogenesis of atherosclerosis....

Maternal diet during pregnancy and carotid intima-media thickness in children (2006)

Gale, Catharine R., Jiang, Benyu, Robinson, Sian M., Godfrey, Keith M., Law, Catherine M., Martyn, Christopher N.

OBJECTIVE: Autopsy studies show that intimal lipid accumulations in arteries are often present at birth, suggesting that the prenatal environment plays a role in the pathogenesis of atherosclerosis....

The role of the placenta in the developmental origins of health and disease: implications for practice (2006)

Lewis, Rohan M., Poore, Kirsten R., Godfrey, Keith M.

The placenta is actively involved in transporting nutrients to the fetus, it has both direct and indirect effects on fetal cardiovascular function and has endocrine influences on the mother and...

Birth weight and cardiac structure in children (2006)

Jiang, Benyu, Godfrey, Keith M., Martyn, Christopher N., Gale, Catharine R.

OBJECTIVE: Epidemiologic studies have shown associations between impaired fetal growth and risk for coronary heart disease in adults. The underlying mechanisms are unknown. We investigated whether...

Cohort profile: the Southampton women's survey (2006)

Inskip, Hazel M., Godfrey, Keith M., Robinson, Siân M., Law, Catherine M., Barker, David J.P., Cooper, Cyrus

Inverse associations between birthweight and later risk of major chronic diseases, notably cardiovascular disease, diabetes, and osteoporosis, have been found in various studies.1 Birthweight is...

Fetal growth and the adrenocortical response to psychological stress (2006)

Jones, Alexander, Godfrey, Keith M., Wood, Peter, Osmond, Clive, Goulden, Peter, Phillips, David I.W.

Context: Experimental studies in animals show that adverse prenatal environments lead to lifelong alterations in the activity of the hypothalamic-pituitary-adrenal axis which mediates the stress...

Fetal growth and the adrenocortical response to psychological stress (2006)

Jones, Alexander, Godfrey, Keith M., Wood, Peter, Osmond, Clive, Goulden, Peter, Phillips, David I.

CONTEXT: Experimental studies in animals show that adverse prenatal environments lead to lifelong alterations in the activity of the hypothalamic-pituitary-adrenal axis, which mediates the stress...

Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet (2005)

Haugen, Guttorm, Hanson, Mark, Kiserud, Torvid, Crozier, Sarah, Inskip, Hazel, Godfrey, Keith M.

Fetal adaptations to impaired maternoplacental nutrient supply include altered regional blood flow. Whether such responses operate within the normal range of maternal body composition or diet is...

Critical periods of brain growth and cognitive function in children (2004)

Gale, Catharine R., O'Callaghan, Finbar J., Godfrey, Keith M., Law, Catherine M., Martyn, Christopher N.

There is evidence that IQ tends to be higher in those who were heavier at birth or who grew taller in childhood and adolescence. Although these findings imply that growth in both foetal and postnatal...

Developmental plasticity and human health (2004)

Bateson, Patrick, Barker, David, Clutton-Brock, Timothy, Deb, Debal, D'Udine, Bruno, Foley, Robert A., ...

Many plants and animals are capable of developing in a variety of ways, forming characteristics that are well adapted to the environments in which they are likely to live. In adverse circumstances,...

Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function (2004)

Lucas, Jane S., Inskip, Hazel M., Godfrey, Keith M., Foreman, Claire T., Warner, John O., Gregson, Rachael K., ...

Recent evidence suggests that impaired lung development is linked with diminished lung function and an increased risk of chronic obstructive airway disease in adulthood. To examine environmental...

Critical periods of brain growth and cognitive function in children (2004)

Gale, Catharine R., O’Callaghan, Finbar J., Godfrey, Keith M., Law, Catherine M., Martyn, Christopher N.

There is evidence that IQ tends to be higher in those who were heavier at birth or who grew taller in childhood and adolescence. Although these findings imply that growth in both foetal and postnatal...

Maternal consumption of a high-meat, low-carbohydrate diet in late pregnancy: relation to adult cortisol concentrations in the offspring (2003)

Herrick, Kirsten, Phillips, David I. W., Haselden, Soraya, Shiell, Alistair W., Campbell-Brown, Mary, Godfrey, Keith M.

Recent studies have linked maternal consumption of an unbalanced high-protein, low-carbohydrate diet in late pregnancy with raised adult blood pressure in the offspring. Because high-protein diets...

Critical periods of brain growth and cognitive function in children (2003)

Gale, Catharine R., O’Callaghan, Finbar J., Godfrey, Keith M., Law, Catherine M., Martyn, Christopher N.

There is evidence that IQ tends to be higher in those who were heavier at birth or who grew taller in childhood and adolescence. Although these findings imply that growth in both foetal and postnatal...

Critical periods of brain growth and cognitive function in children (2003)

Gale, Catharine R., O’Callaghan, Finbar J., Godfrey, Keith M., Law, Catherine M., Martyn, Christopher N.

There is evidence that IQ tends to be higher in those who were heavier at birth or who grew taller in childhood and adolescence. Although these findings imply that growth in both foetal and postnatal...

The role of the placenta in fetal programming-a review (2002)

Godfrey, Keith M.

The fetal origins hypothesis proposes that adult cardiovascular and metabolic disease originate through developmental plasticity and fetal adaptations arising from failure of the materno-placental...

Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy (2001)

Godfrey, Keith M., Walker-Bone, Karen E., Robinson, Sian, Taylor, Pat, Shore, Sarah, Wheeler, Timothy, ...

Evidence is accumulating that intrauterine growth and development may influence an individual's risk of osteoporosis in later adult life. To examine maternal and paternal influences on intrauterine...

High-meat, low-carbohydrate diet in pregnancy: relation to adult blood pressure in the offspring (2001)

Shiell, Alistair W., Campbell-Brown, Mary, Haselden, Soraya, Robinson, Sian, Godfrey, Keith M., Barker, David J.P.

To examine the hypothesis that a high–animal protein, low-carbohydrate diet in pregnancy is associated with raised blood pressure in the adult offspring, we performed a follow-up study of 626 men...

Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro

Cleal, Jane K, Brownbill, Paul, Godfrey, Keith M, Jackson, John M, Jackson, Alan A, Sibley, Colin P, ...

Fetal growth is dependent on both the quantity and relative composition of amino acids delivered to the fetal circulation, and impaired placental amino acid supply is associated with restricted fetal...