Keith O'Neill

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain. (2006)

Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...

BACKGROUND: Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain (2006)

Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...

Background Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain (2006)

Jeffrey C. Lee, Igor Vivanco, Rameen Beroukhim, Whei L. Feng, Ralph M. DeBiasi, ...

BackgroundProtein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing (2006)

Thomas, Roman K., Nickerson, Elizabeth, Simons, Jan F., Jänne, Pasi A., Tengs, Torstein, Yuza, Yuki, ...

Assembly of polymorphic genomes: Algorithms and application to Ciona savignyi (2005)

Vinson, Jade P., Jaffe, David B., O'Neill, Keith, Karlsson, Elinor K., Stange-Thomann, Nicole, Anderson, Scott, ...

Whole-genome assembly is now used routinely to obtain high-quality draft sequence for the genomes of species with low levels of polymorphism. However, genome assembly remains extremely challenging...

Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments (2004)

Tengs, Torstein, LaFramboise, Thomas, Den, Robert B., Hayes, David N., Zhang, Jianhua, DebRoy, Saikat, ...

We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the...

A geotechnical report of a private dwelling in Northridge, California / (1995)

O'Neill, Keith.

Thesis (B.S.)--California Polytechnic State University, 1995.

Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments

Tengs, Torstein, LaFramboise, Thomas, Den, Robert B., Hayes, David N., Zhang, Jianhua, DebRoy, Saikat, ...

We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the...

Assembly of polymorphic genomes: Algorithms and application to Ciona savignyi

Vinson, Jade P., Jaffe, David B., O'Neill, Keith, Karlsson, Elinor K., Stange-Thomann, Nicole, Anderson, Scott, ...

Whole-genome assembly is now used routinely to obtain high-quality draft sequence for the genomes of species with low levels of polymorphism. However, genome assembly remains extremely challenging...

Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments

Tengs, Torstein, LaFramboise, Thomas, Den, Robert B., Hayes, David N., Zhang, Jianhua, DebRoy, Saikat, ...

We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the...

Assembly of polymorphic genomes: Algorithms and application to Ciona savignyi

Vinson, Jade P., Jaffe, David B., O'Neill, Keith, Karlsson, Elinor K., Stange-Thomann, Nicole, Anderson, Scott, ...

Whole-genome assembly is now used routinely to obtain high-quality draft sequence for the genomes of species with low levels of polymorphism. However, genome assembly remains extremely challenging...

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain

Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H. Y, Feng, Whei L, DeBiasi, Ralph M, ...

Ingo Mellinghoff and colleagues sequenced theEGFR gene in glioblastoma samples and cell lines and identified missense mutations in the extracellular domain that suggest a new mechanism for EGFR...