Keith S. Bahjat

Dendritic cell development and distribution in Type I diabetes : overcoming genetic defects and establishing tolerance via pharmacotherapeutic manipulation of dendritic cell populations in vivo/ (2001)

Bahjat, Keith S.

Typescript.

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

Naumov, Yuri N., Bahjat, Keith S., Gausling, Rudolph, Abraham, Roshini, Exley, Mark A., Koezuka, Yasuhiko, ...

CD1d-restricted invariant NKT (iNKT) cells are immunoregulatory cells whose loss exacerbates diabetes in nonobese diabetic (NOD) female mice. Here, we show that the relative numbers of iNKT cells...

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, ...

The facultative intracellular bacterium Listeria monocytogenes is being developed as a cancer vaccine platform because of its ability to induce potent innate and adaptive immunity. For successful...

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

Naumov, Yuri N., Bahjat, Keith S., Gausling, Rudolph, Abraham, Roshini, Exley, Mark A., Koezuka, Yasuhiko, ...

CD1d-restricted invariant NKT (iNKT) cells are immunoregulatory cells whose loss exacerbates diabetes in nonobese diabetic (NOD) female mice. Here, we show that the relative numbers of iNKT cells...

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, ...

The facultative intracellular bacterium Listeria monocytogenes is being developed as a cancer vaccine platform because of its ability to induce potent innate and adaptive immunity. For successful...

Cytosolic Entry Controls CD8+-T-Cell Potency during Bacterial Infection▿

Bahjat, Keith S., Liu, Weiqun, Lemmens, Edward E., Schoenberger, Stephen P., Portnoy, Daniel A., Dubensky, Thomas W., ...

Interaction with host immunoreceptors during microbial infection directly impacts the magnitude of the ensuing innate immune response. How these signals affect the quality of the adaptive T-cell...

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains▿

Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., ...

Recombinant vaccines derived from the facultative intracellular bacterium Listeria monocytogenes are presently undergoing early-stage clinical evaluation in oncology treatment settings. This effort...

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity

Skoberne, Mojca, Yewdall, Alice, Bahjat, Keith S., Godefroy, Emmanuelle, Lauer, Peter, Lemmens, Edward, ...

Vaccine strategies that utilize human DCs to enhance antitumor immunity have yet to realize their full potential. Approaches that optimally target a spectrum of antigens to DCs are urgently needed....

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

Schmidt, Nathan W., Podyminogin, Rebecca L., Butler, Noah S., Badovinac, Vladimir P., Tucker, Brad J., Bahjat, Keith S., ...

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines....

Suppression of Cell-Mediated Immunity following Recognition of Phagosome-Confined Bacteria

Bahjat, Keith S., Meyer-Morse, Nicole, Lemmens, Edward E., Shugart, Jessica A., Dubensky, Thomas W., Brockstedt, Dirk G., ...

Listeria monocytogenes is a facultative intracellular pathogen capable of inducing a robust cell-mediated immune response to sub-lethal infection. The capacity of L. monocytogenes to escape from the...