Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer (2007)
Kaufman, Howard L, Kim-Schulze, Seunghee, Manson, Kelledy, DeRaffele, Gail, Mitcham, Josephine, Seo, Kang, ...
Abstract Purpose An open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability...
Simian immunodeficiency virus DNA vaccine trial in macaques (1996)
Lu, Shan, Arthos, James, Montefiori, David C., Yasutomi, Yasuhiro, Manson, Kelledy, Mustafa, Farah, ...
An experimental vaccine consisting of five DNA plasmids expressing different combinations and forms of simian immunodeficiency virus-macaque (SIVmac) proteins has been evaluated for the ability to...
Robinson, Harriet L., Lu, Shan, Feltquate, David Marc, Torres, Celia Aurora Tiglao, Richmond, Joann M., Boyle, Christine Margaret, ...
Yasutomi, Yasuhiro, Robinson, Harriet L., Lu, Shan, Mustafa, Farah, Lekutis, Christine, Arthos, James, ...
In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected...
Montefiori, David C., Reimann, Keith A., Wyand, Michael S., Manson, Kelledy, Lewis, Mark G., Collman, Ronald G., ...
The magnitude and breadth of neutralizing antibodies raised in response to infection with chimeric simian-human immunodeficiency virus (SHIV) in rhesus macaques were evaluated. Infection with either...
Langlois, Alphonse J., Desrosiers, Ronald C., Lewis, Mark G., KewalRamani, Vineet N., Littman, Dan R., Zhou, Ji Ying, ...
Infection with attenuated simian immunodeficiency virus (SIV) in rhesus macaques has been shown to raise antibodies capable of neutralizing an animal challenge stock of primary SIVmac251 in CEMx174...
Wang, Shainn-Wei, Kozlowski, Pamela A., Schmelz, Gretchen, Manson, Kelledy, Wyand, Michael S., Glickman, Rhona, ...
We report a pilot evaluation of a DNA vaccine producing genetically inactivated simian immunodeficiency virus (SIV) particles in primates, with a focus on eliciting mucosal immunity. Our results...
Egan, Michael A., Charini, William A., Kuroda, Marcelo J., Schmitz, Jörn E., Racz, Paul, Tenner-Racz, Klara, ...
The potential contribution of a plasmid DNA construct to vaccine-elicited protective immunity was explored in the simian immunodeficiency virus (SIV)/macaque model of AIDS. Making use of soluble...
Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge
Wyand, Michael S., Manson, Kelledy, Montefiori, David C., Lifson, Jeffrey D., Johnson, R. Paul, Desrosiers, Ronald C.
We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239Δ3, which is missing nef and vpr genes, to protect against challenge by heterologous...
Fu, Tong-Ming, Freed, Daniel C., Trigona, Wendy L., Guan, Liming, Zhu, Lan, Long, Romnie, ...
Cytotoxic T-lymphocyte (CTL) responses have been implicated as playing an important role in control of human immunodeficiency virus (HIV) infection. However, it is technically difficult to...
Voss, Gerald, Manson, Kelledy, Montefiori, David, Watkins, David I., Heeney, Jonathan, Wyand, Michael, ...
Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing...
Santra, Sampa, Barouch, Dan H., Korioth-Schmitz, Birgit, Lord, Carol I., Krivulka, Georgia R., Yu, Faye, ...
Although a consensus has emerged that an HIV vaccine should elicit a cytotoxic T lymphocyte (CTL) response, the characteristics of an effective vaccine-induced T lymphocyte response remain unclear....
Seaman, Michael S., Santra, Sampa, Newberg, Michael H., Philippon, Valerie, Manson, Kelledy, Xu, Ling, ...
The expression of particular major histocompatibility complex (MHC) class I alleles can influence the rate of disease progression following lentiviral infections. This effect is a presumed...
Kaufman, Howard L., DeRaffele, Gail, Mitcham, Josephine, Moroziewicz, Dorota, Cohen, Seth M., Hurst-Wicker, Karl S., ...
Immunotherapy for the treatment of metastatic melanoma remains a major clinical challenge. The melanoma microenvironment may lead to local T cell tolerance in part through downregulation of...
Abdel-Motal, Ussama M., Gillis, Jacqueline, Manson, Kelledy, Wyand, Michael, Montefiori, David, Stefano-Cole, Kelly, ...
The ability of memory T cells to mount a recall response plays a key role in the ability of vaccinated animals to contain viral challenge. In this study, we intensively monitored the expansion of SIV...
Montefiori, David C., Reimann, Keith A., Wyand, Michael S., Manson, Kelledy, Lewis, Mark G., Collman, Ronald G., ...
The magnitude and breadth of neutralizing antibodies raised in response to infection with chimeric simian-human immunodeficiency virus (SHIV) in rhesus macaques were evaluated. Infection with either...
Langlois, Alphonse J., Desrosiers, Ronald C., Lewis, Mark G., KewalRamani, Vineet N., Littman, Dan R., Zhou, Ji Ying, ...
Infection with attenuated simian immunodeficiency virus (SIV) in rhesus macaques has been shown to raise antibodies capable of neutralizing an animal challenge stock of primary SIVmac251 in CEMx174...
Wang, Shainn-Wei, Kozlowski, Pamela A., Schmelz, Gretchen, Manson, Kelledy, Wyand, Michael S., Glickman, Rhona, ...
We report a pilot evaluation of a DNA vaccine producing genetically inactivated simian immunodeficiency virus (SIV) particles in primates, with a focus on eliciting mucosal immunity. Our results...
Egan, Michael A., Charini, William A., Kuroda, Marcelo J., Schmitz, Jörn E., Racz, Paul, Tenner-Racz, Klara, ...
The potential contribution of a plasmid DNA construct to vaccine-elicited protective immunity was explored in the simian immunodeficiency virus (SIV)/macaque model of AIDS. Making use of soluble...
Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge
Wyand, Michael S., Manson, Kelledy, Montefiori, David C., Lifson, Jeffrey D., Johnson, R. Paul, Desrosiers, Ronald C.
We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239Δ3, which is missing nef and vpr genes, to protect against challenge by heterologous...
Fu, Tong-Ming, Freed, Daniel C., Trigona, Wendy L., Guan, Liming, Zhu, Lan, Long, Romnie, ...
Cytotoxic T-lymphocyte (CTL) responses have been implicated as playing an important role in control of human immunodeficiency virus (HIV) infection. However, it is technically difficult to...
Voss, Gerald, Manson, Kelledy, Montefiori, David, Watkins, David I., Heeney, Jonathan, Wyand, Michael, ...
Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing...
Santra, Sampa, Barouch, Dan H., Korioth-Schmitz, Birgit, Lord, Carol I., Krivulka, Georgia R., Yu, Faye, ...
Although a consensus has emerged that an HIV vaccine should elicit a cytotoxic T lymphocyte (CTL) response, the characteristics of an effective vaccine-induced T lymphocyte response remain unclear....
Seaman, Michael S., Santra, Sampa, Newberg, Michael H., Philippon, Valerie, Manson, Kelledy, Xu, Ling, ...
The expression of particular major histocompatibility complex (MHC) class I alleles can influence the rate of disease progression following lentiviral infections. This effect is a presumed...
Kaufman, Howard L., DeRaffele, Gail, Mitcham, Josephine, Moroziewicz, Dorota, Cohen, Seth M., Hurst-Wicker, Karl S., ...
Immunotherapy for the treatment of metastatic melanoma remains a major clinical challenge. The melanoma microenvironment may lead to local T cell tolerance in part through downregulation of...
Heterologous Prime/Boost Immunization of Rhesus Monkeys by Using Diverse Poxvirus Vectors▿
Santra, Sampa, Sun, Yue, Parvani, Jenny G., Philippon, Valerie, Wyand, Michael S., Manson, Kelledy, ...
As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same...