Mofunanya, Adaobi, Li, Feng-Qian, Hsieh, Jen-Chih, Takemaru, Ken-Ichi
Abstract Background The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and in maintenance of organs and tissues in adults. Chibby (Cby) is an evolutionarily conserved...
structure of the transcriptional coactivator (2008)
Jun Ozaki, Ken-ichi Takemaru, Takahisa Ikegami, Masaki Mishima, Hitoshi Ueda, Susumu Hirose, ...
Identification of the core domain and the secondary
CFTR and Wnt/beta-catenin signaling in lung development (2008)
Cohen, J Craig, Larson, Janet E, Killeen, Erin, Love, Damon, Takemaru, Ken-Ichi
Abstract Background Cystic fibrosis transmembrane conductance regulator (CFTR) was shown previously to modify stretch induced differentiation in the lung. The mechanism for CFTR modulation of lung...
Takemaru, Ken-ichi, Li, Feng-Qian, Ueda, Hitoshi, Hirose, Susumu
Multiprotein bridging factor 1 (MBF1) is a transcriptional cofactor that bridges between the TATA box-binding protein (TBP) and the Drosophila melanogaster nuclear hormone receptor FTZ-F1 or its...
Yeast Coactivator MBF1 Mediates GCN4-Dependent Transcriptional Activation
Takemaru, Ken-ichi, Harashima, Satoshi, Ueda, Hitoshi, Hirose, Susumu
Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1...
Takemaru, Ken-ichi, Li, Feng-Qian, Ueda, Hitoshi, Hirose, Susumu
Multiprotein bridging factor 1 (MBF1) is a transcriptional cofactor that bridges between the TATA box-binding protein (TBP) and the Drosophila melanogaster nuclear hormone receptor FTZ-F1 or its...
Yeast Coactivator MBF1 Mediates GCN4-Dependent Transcriptional Activation
Takemaru, Ken-ichi, Harashima, Satoshi, Ueda, Hitoshi, Hirose, Susumu
Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1...
Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling▿
Li, Feng-Qian, Singh, Amar M., Mofunanya, Adaobi, Love, Damon, Terada, Naohiro, Moon, Randall T., ...
The canonical Wnt/β-catenin signaling pathway plays diverse roles in embryonic development and disease. Activation of this pathway, likely by Wnt-10b, has been shown to inhibit adipogenesis in...
The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression
Takemaru, Ken-Ichi, Moon, Randall T.
β-Catenin plays a pivotal role in the transcriptional activation of Wnt-responsive genes by binding to TCF/LEF transcription factors. Although it has been suggested that the COOH-terminal region of...
CFTR and Wnt/beta-catenin signaling in lung development
Cohen, J Craig, Larson, Janet E, Killeen, Erin, Love, Damon, Takemaru, Ken-Ichi
Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity
Li, Feng-Qian, Mofunanya, Adaobi, Harris, Kimberley, Takemaru, Ken-Ichi
β-Catenin functions in both cell–cell adhesion and as a transcriptional coactivator in the canonical Wnt pathway. Nuclear accumulation of β-catenin is the hallmark of active Wnt signaling and is...
Inactivation of Chibby affects function of motile airway cilia
Voronina, Vera A., Takemaru, Ken-Ichi, Treuting, Piper, Love, Damon, Grubb, Barbara R., Hajjar, Adeline M., ...
Chibby (Cby) is a conserved component of the Wnt–β-catenin pathway. Cby physically interacts with β-catenin to repress its activation of transcription. To elucidate the function of Cby in...