Pathological role of Toll-like receptor signaling in cerebral malaria (2007)
Coban, Cevayir, Ishii, Ken J., Uematsu, Satoshi, Arisue, Nobuko, Sato, Shintaro, Yamamoto, Masahiro, ...
Toll-like receptors (TLRs) recognize malaria parasites or their metabolites; however, their physiological roles in malaria infection in vivo are not fully understood. Here, we show that myeloid...
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
Suzuki, Koichi, Mori, Atsumi, Ishii, Ken J., Saito, Jun, Singer, Dinah S., Klinman, Dennis M., ...
Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections...
Coban, Cevayir, Ishii, Ken J., Sullivan, David J., Kumar, Nirbhay
Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro...
Coban, Cevayir, Ishii, Ken J., Stowers, Anthony W., Keister, David B., Klinman, Dennis M., Kumar, Nirbhay
Antibodies directed against Pfs25, a protein present on the surface of zygotes and ookinetes of Plasmodium falciparum, completely block pathogen transmission. We evaluated the immunomodulatory effect...
Ito, Shu-ichi, Ishii, Ken J., Shirota, Hidekazu, Klinman, Dennis M.
Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of...
Contribution of Nitric Oxide to CpG-Mediated Protection against Listeria monocytogenes
Ito, Shuichi, Ishii, Ken J., Ihata, Atsushi, Klinman, Dennis M.
Immunostimulatory CpG oligodeoxynucleotides (ODN) improve host resistance to listeriae. CpG ODN trigger immune cells to produce gamma interferon and “prime” host cells to secrete nitric oxide in...
Takeshita, Fumihiko, Tanaka, Toshiyuki, Matsuda, Tomoko, Tozuka, Miyuki, Kobiyama, Kouji, Saha, Sukumar, ...
Toll-like receptors (TLRs) recognize microbial components and trigger the signaling cascade that activates the innate and adaptive immunity. TLR adaptor molecules play a central role in this cascade;...
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
Suzuki, Koichi, Mori, Atsumi, Ishii, Ken J., Saito, Jun, Singer, Dinah S., Klinman, Dennis M., ...
Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections...
Coban, Cevayir, Ishii, Ken J., Sullivan, David J., Kumar, Nirbhay
Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro...
Coban, Cevayir, Ishii, Ken J., Stowers, Anthony W., Keister, David B., Klinman, Dennis M., Kumar, Nirbhay
Antibodies directed against Pfs25, a protein present on the surface of zygotes and ookinetes of Plasmodium falciparum, completely block pathogen transmission. We evaluated the immunomodulatory effect...
Ito, Shu-ichi, Ishii, Ken J., Shirota, Hidekazu, Klinman, Dennis M.
Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of...
Contribution of Nitric Oxide to CpG-Mediated Protection against Listeria monocytogenes
Ito, Shuichi, Ishii, Ken J., Ihata, Atsushi, Klinman, Dennis M.
Immunostimulatory CpG oligodeoxynucleotides (ODN) improve host resistance to listeriae. CpG ODN trigger immune cells to produce gamma interferon and “prime” host cells to secrete nitric oxide in...
Takeshita, Fumihiko, Tanaka, Toshiyuki, Matsuda, Tomoko, Tozuka, Miyuki, Kobiyama, Kouji, Saha, Sukumar, ...
Toll-like receptors (TLRs) recognize microbial components and trigger the signaling cascade that activates the innate and adaptive immunity. TLR adaptor molecules play a central role in this cascade;...
Contribution of interferon-β to the immune activation induced by double-stranded DNA
Shirota, Hidekazu, Ishii, Ken J, Takakuwa, Hiroki, Klinman, Dennis M
Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is...
Essential role of IPS-1 in innate immune responses against RNA viruses
Kumar, Himanshu, Kawai, Taro, Kato, Hiroki, Sato, Shintaro, Takahashi, Ken, Coban, Cevayir, ...
IFN-β promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct...
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
Jounai, Nao, Takeshita, Fumihiko, Kobiyama, Kouji, Sawano, Asako, Miyawaki, Atsushi, Xin, Ke-Qin, ...
Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the Atg5–Atg12 conjugate, a key regulator of...
Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency
Yamamoto, Masahiro, Uematsu, Satoshi, Okamoto, Toru, Matsuura, Yoshiharu, Sato, Shintaro, Kumar, Himanshu, ...
Toll-like receptors (TLRs) recognize a variety of microbial components and mediate downstream signal transduction pathways that culminate in the activation of nuclear factor κB (NF-κB) and...
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
Coban, Cevayir, Ishii, Ken J., Kawai, Taro, Hemmi, Hiroaki, Sato, Shintaro, Uematsu, Satoshi, ...
Malaria parasites within red blood cells digest host hemoglobin into a hydrophobic heme polymer, known as hemozoin (HZ), which is subsequently released into the blood stream and then captured by and...
Uematsu, Satoshi, Sato, Shintaro, Yamamoto, Masahiro, Hirotani, Tomonori, Kato, Hiroki, Takeshita, Fumihiko, ...
Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells...
Ishii, Ken J., Takeshita, Fumihiko, Gursel, Ihsan, Gursel, Mayda, Conover, Jacqueline, Nussenzweig, Andre, ...
Unmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signaling. Specifically,...