Suzuki, Go, Harper, Kathryn M., Hiramoto, Takeshi, Sawamura, Takehito, Lee, MoonSook, Kang, Gina, ...
Deletion or duplication of the human chromosome 22q11.2 is associated with many behavioral traits and neuropsychiatric disorders, including autism spectrum disorders and schizophrenia. However, why...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Han, Hua, Tanigaki, Kenji, Yamamoto, Norio, Kuroda, Kazuki, Yoshimoto, Momoko, Nakahata, Tatsutoshi, ...
The transcription factor recombination signal binding protein‐J (RBP‐J) functions immediately downstream of the cell surface receptor Notch and mediates transcriptional activation by the...
RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2
Qin, Hongyan, Wang, Jishu, Liang, Yingmin, Taniguchi, Yoshihito, Tanigaki, Kenji, Han, Hua
The DNA-binding protein recombination signal binding protein-Jκ (RBP-J) mediates transcriptional activation of the Notch intracellular domain (NIC). In the absence of transcriptional activators,...
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
RBP-Jκ-Dependent Notch Signaling Is Dispensable for Mouse Early Embryonic Development
Souilhol, Céline, Cormier, Sarah, Tanigaki, Kenji, Babinet, Charles, Cohen-Tannoudji, Michel
The Notch signaling pathway is an evolutionarily conserved signaling system which has been shown to be essential in cell fate specification and in numerous aspects of embryonic development in all...
RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2
Qin, Hongyan, Wang, Jishu, Liang, Yingmin, Taniguchi, Yoshihito, Tanigaki, Kenji, Han, Hua
The DNA-binding protein recombination signal binding protein-Jκ (RBP-J) mediates transcriptional activation of the Notch intracellular domain (NIC). In the absence of transcriptional activators,...
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
RBP-Jκ-Dependent Notch Signaling Is Dispensable for Mouse Early Embryonic Development
Souilhol, Céline, Cormier, Sarah, Tanigaki, Kenji, Babinet, Charles, Cohen-Tannoudji, Michel
The Notch signaling pathway is an evolutionarily conserved signaling system which has been shown to be essential in cell fate specification and in numerous aspects of embryonic development in all...