Sensitive and accurate detection of copy number variants using read depth of coverage (2009)
Yoon, Seungtai, Xuan, Zhenyu, Makarov, Vladimir, Ye, Kenny, Sebat, Jonathan
Methods for the direct detection of copy number variation (CNV) genome-wide have become effective instruments for identifying genetic risk factors for disease. The application of next-generation...
Hodges, Emily, Smith, Andrew D., Kendall, Jude, Xuan, Zhenyu, Ravi, Kandasamy, Rooks, Michelle, ...
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common feature of cancer genomes. Presently, few...
Aviv Bergman, Gil Atzmon, Kenny Ye, Thomas MacCarthy, Nir Barzilai
An unrealized potential to understand the genetic basis of aging in humans, is to consider the immense survival advantage of the rare individuals who live 100 years or more. The Longevity Gene Study...
Aviv Bergman, Gil Atzmon, Kenny Ye, Thomas MacCarthy, Nir Barzilai
An unrealized potential to understand the genetic basis of aging in humans, is to consider the immense survival advantage of the rare individuals who live 100 years or more. The Longevity Gene Study...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Novel patterns of genome rearrangement and their association with survival in breast cancer (2006)
Hicks, James, Krasnitz, Alexander, Lakshmi, B., Navin, Nicholas E., Riggs, Michael, Leibu, Evan, ...
Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of ∼50 kb. We have used this technique to examine...
A Bayesian approach for applying Haseman-Elston methods (2005)
Yoon, Seungtai, Suh, Young, Mendell, Nancy, Ye, Kenny
Abstract The main goal of this paper is to couple the Haseman-Elston method with a simple yet effective Bayesian factor-screening approach. This approach selects markers by considering a set of...
Sources of uncertainty and error in the simulation of flow in porous media (2004)
Glimm,James, Hou,Shuling, Lee,Yoon-Ha, Sharp,David H., Ye,Kenny
We are concerned here with the analysis and partition of uncertainty into component pieces, for a model prediction problem for flow in porous media.
Don X. Sun, William Li, Kenny Ye
We propose an algorithm for sequentially constructing non-isomorphic orthogonal designs (including both regular and non-regular orthogonal designs). An essential element of the algorithm is using...
Optimal Foldover Plans for Non-regular Orthogonal Designs (2001)
This article constructs optimal foldover plans for non-regular designs. By using the indicator function, we define words with fractional lengths. The extended word length pattern is then used to...
A Probability Model For Errors in the Numerical Solutions of a Partial Differential Equation (1999)
James Glimm, Shuling Hou, Hongjoong Kim, David H. Sharp, Kenny Ye
We consider numerical solutions of the Darcy and Buckley-Leverett equations for flow in porous media. These solutions depend on the geology of the porous media, which is given here as a realization...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Novel patterns of genome rearrangement and their association with survival in breast cancer
Hicks, James, Krasnitz, Alexander, Lakshmi, B., Navin, Nicholas E., Riggs, Michael, Leibu, Evan, ...
Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of ∼50 kb. We have used this technique to examine...
Polo, Jose M., Juszczynski, Przemyslaw, Monti, Stefano, Cerchietti, Leandro, Ye, Kenny, Greally, John M., ...
Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers. In a subset of DLBCLs, BCL6 is deregulated by...
Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging
Bergman, Aviv, Atzmon, Gil, Ye, Kenny, MacCarthy, Thomas, Barzilai, Nir
An unrealized potential to understand the genetic basis of aging in humans, is to consider the immense survival advantage of the rare individuals who live 100 years or more. The Longevity Gene Study...
A unified genetic theory for sporadic and inherited autism
Zhao, Xiaoyue, Leotta, Anthony, Kustanovich, Vlad, Lajonchere, Clara, Geschwind, Daniel H., Law, Kiely, ...
Autism is among the most clearly genetically determined of all cognitive-developmental disorders, with males affected more often than females. We have analyzed autism risk in multiplex families from...
An Integrative Genomic and Epigenomic Approach for the Study of Transcriptional Regulation
Figueroa, Maria E., Reimers, Mark, Thompson, Reid F., Ye, Kenny, Li, Yushan, Selzer, Rebecca R., ...
The molecular heterogeneity of acute leukemias and other tumors constitutes a major obstacle towards understanding disease pathogenesis and developing new targeted-therapies. Aberrant gene regulation...
Sohal, Davendra, Yeatts, Andrew, Ye, Kenny, Pellagatti, Andrea, Zhou, Li, Pahanish, Perry, ...
Microarray-based studies of global gene expression (GE) have resulted in a large amount of data that can be mined for further insights into disease and physiology. Meta-analysis of these data is...
Hodges, Emily, Smith, Andrew D., Kendall, Jude, Xuan, Zhenyu, Ravi, Kandasamy, Rooks, Michelle, ...
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common feature of cancer genomes. Presently, few...
Sensitive and accurate detection of copy number variants using read depth of coverage
Yoon, Seungtai, Xuan, Zhenyu, Makarov, Vladimir, Ye, Kenny, Sebat, Jonathan
Methods for the direct detection of copy number variation (CNV) genome-wide have become effective instruments for identifying genetic risk factors for disease. The application of next-generation...