Kenzie D. MacIsaac

Education Practical Strategies for Discovering Regulatory DNA Sequence Motifs (2009)

Kenzie D. Macisaac, Ernest Fraenkel

Many functionally important regions of the genome can be recognized by searching for sequence patterns, or ‘‘motifs.’’ Aside from the genes themselves, examples include CpG islands, often...

BIOINFORMATICS ORIGINAL PAPER Sequence analysis (2008)

Kenzie D. Macisaac, D. Benjamin Gordon, Lena Nekludova, Duncan T. Odom, Joerg Schreiber, David K. Gifford, ...

A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data Vol. 22 no. 4 2006, pages 423–429 doi:10.1093/bioinformatics/bti815

Education Practical Strategies for Discovering Regulatory DNA Sequence Motifs (2008)

Kenzie D. Macisaac, Ernest Fraenkel

Many functionally important regions of the genome can be recognized by searching for sequence patterns, or ‘‘motifs.’’ Aside from the genes themselves, examples include CpG islands, often...

An improved map of conserved regulatory sites for Saccharomyces cerevisiae (2006)

MacIsaac, Kenzie D, Wang, Ting, Gordon, D Benjamin, Gifford, David K, Stormo, Gary D, Fraenkel, Ernest

Abstract Background The regulatory map of a genome consists of the binding sites for proteins that determine the transcription of nearby genes. An initial regulatory map for S. cerevisiae was...

A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data (2006)

Kenzie D. Macisaac, D. Benjamin Gordon, Lena Nekludova, Duncan T. Odom, Joerg Schreiber, David K. Gifford, ...

Motivation: Genome-wide chromatin-immunoprecipitation (ChIPchip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover...

A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data (2005)

MacIsaac, Kenzie D., Gordon, D. Benjamin, Nekludova, Lena, Odom, Duncan T., Schreiber, Joerg, Gifford, David K., ...

Motivation: Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover...