Contextual and temporal modulation of extinction: behavioral and biological mechanisms (2006)
Bouton, Mark E., Westbrook, R. Frederick, Corcoran, Kevin A., Maren, Stephen
Extinction depends, at least partly, on new learning that is specific to the context in which it is learned. Several behavioral phenomena (renewal, reinstatement, spontaneous recovery, and rapid...
Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction (2005)
Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A., Maren, Stephen
In recent studies, inactivation of the dorsal hippocampus before the retrieval of extinguished fear memories disrupted the context-dependent expression of these memories. In the present experiments,...
Corcoran, Kevin A., Maren, Stephen
After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of...
Dissertation (Ph.D.)--University of Michigan.
Maren, Stephen, Ferrario, Carrie R., Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A.
The amygdala is an essential neural substrate for Pavlovian fear conditioning. Nevertheless, long-term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to...
Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen
Recent reports have raised concerns about the ability of long-term potentiation (LTP) to account for associative learning and memory. In this paper, we review the many mechanistic similarities...
Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction (2001)
Corcoran, Kevin A., Maren, Stephen
Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus...
Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen
One of the hallmarks of the pathology in Alzheimer's disease is the deposition of amyloid plaques throughout the brain, especially within the hippocampus and amygdala. Transgenic mice that...
Corcoran, Kevin A., Maren, Stephen
After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of...
Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen
One of the hallmarks of the pathology in Alzheimer's disease is the deposition of amyloid plaques throughout the brain, especially within the hippocampus and amygdala. Transgenic mice that...
Corcoran, Kevin A., Maren, Stephen
After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of...