Kevin John Ashton

Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress (2006)

Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick

Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts (2006)

Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...

OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...

Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress (2006)

Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick

Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts (2006)

Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...

OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...

Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress (2006)

Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick

Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts (2006)

Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...

OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...

Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress (2006)

Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick

Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts (2006)

Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...

OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn, P. Saukko

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Genetic aberrations in non-melanoma skin cancer (2002)

Ashton, Kevin John.

Facsimile of the author's original dissertation. Includes bibliographical references. Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Genetic Aberrations in Non-Melanoma Skin Cancer (2002)

Ashton, Kevin John

Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC)...