Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Dll4, a novel Notch ligand expressed in arterial endothelium (2000)
Shutter, John R., Scully, Sheila, Fan, Wei, Richards, William G., Kitajewski, Jan, Deblandre, Gisele A., ...
Notch signaling is essential for vascular morphogenesis in mice (2000)
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
Dll4, a novel Notch ligand expressed in arterial endothelium
Shutter, John R., Scully, Sheila, Fan, Wei, Richards, William G., Kitajewski, Jan, Deblandre, Gisele A., ...
We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand,...
Notch signaling is essential for vascular morphogenesis in mice
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Dll4, a novel Notch ligand expressed in arterial endothelium
Shutter, John R., Scully, Sheila, Fan, Wei, Richards, William G., Kitajewski, Jan, Deblandre, Gisele A., ...
We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand,...
Notch signaling is essential for vascular morphogenesis in mice
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...