Kevin P. Moore

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel, Joshua P., Porter, Ned A., Moore, Kevin P., Sheller, James R., Roberts, L. Jackson

Free radicals have been implicated in the pathogenesis of an increasing number of diseases. Lipids, which undergo peroxidation, are major targets of free radical attack. We report the discovery of a...

Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration

Baldus, Stephan, Eiserich, Jason P., Mani, Alireza, Castro, Laura, Figueroa, Mario, Chumley, Phillip, ...

Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil–derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this...

Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.

Mani, Ali R, Pannala, Ananth S, Orie, Nelson N, Ollosson, Richard, Harry, David, Rice-Evans, Catherine A, ...

Reactive nitrogen species, such as peroxynitrite, can nitrate tyrosine in proteins to form nitrotyrosine. Nitrotyrosine is metabolized to 3-nitro-4-hydroxyphenylacetic acid (NHPA), which is excreted...

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel, Joshua P., Porter, Ned A., Moore, Kevin P., Sheller, James R., Roberts, L. Jackson

Free radicals have been implicated in the pathogenesis of an increasing number of diseases. Lipids, which undergo peroxidation, are major targets of free radical attack. We report the discovery of a...

Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration

Baldus, Stephan, Eiserich, Jason P., Mani, Alireza, Castro, Laura, Figueroa, Mario, Chumley, Phillip, ...

Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil–derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this...

Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.

Mani, Ali R, Pannala, Ananth S, Orie, Nelson N, Ollosson, Richard, Harry, David, Rice-Evans, Catherine A, ...

Reactive nitrogen species, such as peroxynitrite, can nitrate tyrosine in proteins to form nitrotyrosine. Nitrotyrosine is metabolized to 3-nitro-4-hydroxyphenylacetic acid (NHPA), which is excreted...