Abu-Amero, Khaled K, Al-Dhalaan, Hesham, Bohlega, Saeed, Hellani, Ali, Taylor, Robert W
Abstract Introduction There are currently 23 missense point mutations and one 4 basepair deletion spanning different mitochondrial genes associated with mitochondrial encephalopathy, lactic acidosis...
Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions (2009)
Abu-Amero, Khaled K, Hellani, Ali, González, Ana M, Larruga, Jose M, Cabrera, Vicente M, Underhill, Peter A
Abstract Background Human origins and migration models proposing the Horn of Africa as a prehistoric exit route to Asia have stimulated molecular genetic studies in the region using uniparental loci....
Mitochondrial DNA haplogroup H structure in North Africa (2009)
Ennafaa, Hajer, Cabrera, Vicente M, Abu-Amero, Khaled K, González, Ana M, Amor, Mohamed B, Bouhaha, Rym, ...
Abstract Background The Strait of Gibraltar separating the Iberian Peninsula from North Africa is thought to be a stronger barrier to gene flow for male than for female lineages. However, the recent...
Hellani, Ali, Baghdadi, Hiba, Dabbour, Nidal, Almassri, Nidal, Abu-Amero, Khaled K
Abstract Introduction Nevoid basal cell carcinoma syndrome is a rare autosomal dominant disorder characterized by numerous basal cell carcinomas, odontogenic keratocysts of the jaws and developmental...
Absence of mtDNA mutations in leukocytes of CADASIL patients (2008)
Abu-Amero, Khaled K, Hellani, Ali, Bohlega, Saeed
Abstract Background Ultrastructural and biochemical abnormalities of mitochondria have been reported in skeletal muscle biopsies of CADASIL patients with mutations in the NOTCH3 nuclear gene....
Mitochondrial DNA structure in the Arabian Peninsula (2008)
Abu-Amero, Khaled K, Larruga, José M, Cabrera, Vicente M, González, Ana M
Abstract Background Two potential migratory routes followed by modern humans to colonize Eurasia from Africa have been proposed. These are the two natural passageways that connect both continents:...
CADASIL in Arabs: clinical and genetic findings (2007)
Bohlega, Saeed, Al Shubili, Asmahan, Edris, Abdulrahman, Alreshaid, Abdulrahman, AlKhairallah, Thamer, AlSous, M Walid, ...
Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is increasingly recognized as an inherited arterial disease leading to a...
Mitochondrial lineage M1 traces an early human backflow to Africa (2007)
González, Ana M, Larruga, José M, Abu-Amero, Khaled K, Shi, Yufei, Pestano, José, Cabrera, Vicente M
Abstract Background The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized...
Abu-Amero, Khaled K, Al-Mohanna, Futwan, Al-Boudari, Olayan M, Mohamed, Gamal H, Dzimiri, Nduna
Abstract Background The role of gene-environment interactions as risk factors for coronary heart disease (CAD) remains largely undefined. Such interactions may involve gene mutations and disease...
Eurasian and African mitochondrial DNA influences in the Saudi Arabian population (2007)
Abu-Amero, Khaled K, González, Ana M, Larruga, Jose M, Bosley, Thomas M, Cabrera, Vicente M
Abstract Background Genetic studies of the Arabian Peninsula are scarce even though the region was the center of ancient trade routes and empires and may have been the southern corridor for the...
E-selectin S128R polymorphism and severe coronary artery disease in Arabs (2006)
Abu-Amero, Khaled K, Al-Boudari, Olayan M, Mohamed, Gamal H, Dzimiri, Nduna
Abstract Background The E-selectin p. S128R (g. A561C) polymorphism has been associated with the presence of angiographic coronary artery disease (CAD) in some populations, but no data is currently...
Abu-Amero, Khaled K, Al-Boudari, Olayan M, Mohamed, Gamal H, Dzimiri, Nduna
Abstract Background The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial. In addition, no such investigation has previously been...
Abu-Amero, Khaled K, Al-Boudari, Olayan M, Mohamed, Gamal H, Dzimiri, Nduna
Abstract Background The role of the Beta2-adrenoceptor (beta2-AR) Gln27Glu polymorphism in the manifestation of cardiovascular diseases is still unclear. Methods In the present study, we evaluated...
Abu-Amero, Khaled K., Al-Boudari, Olayan M., Mohamed, Gamal H., Dzimiri, Nduna.
Human Biology - Volume 77, Number 6, December 2005
E-selectin S128R polymorphism and severe coronary artery disease in Arabs
Abu-Amero, Khaled K, Al-Boudari, Olayan M, Mohamed, Gamal H, Dzimiri, Nduna
E-selectin S128R polymorphism and severe coronary artery disease in Arabs
Abu-Amero, Khaled K, Al-Boudari, Olayan M, Mohamed, Gamal H, Dzimiri, Nduna
Eurasian and African mitochondrial DNA influences in the Saudi Arabian population
Abu-Amero, Khaled K, González, Ana M, Larruga, Jose M, Bosley, Thomas M, Cabrera, Vicente M
Mitochondrial lineage M1 traces an early human backflow to Africa
González, Ana M, Larruga, José M, Abu-Amero, Khaled K, Shi, Yufei, Pestano, José, Cabrera, Vicente M
CADASIL in Arabs: clinical and genetic findings
Bohlega, Saeed, Al Shubili, Asmahan, Edris, Abdulrahman, Alreshaid, Abdulrahman, AlKhairallah, Thamer, AlSous, M Walid, ...
Mitochondrial DNA structure in the Arabian Peninsula
Abu-Amero, Khaled K, Larruga, José M, Cabrera, Vicente M, González, Ana M
Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients
Abu-Amero, Khaled K., Morales, Jose, Mohamed, Gamal H., Osman, Mazen N., Bosley, Thomas M.
The role of mitochondrial haplogroups in glaucoma: a study in an Arab population
Abu-Amero, Khaled K., Morales, Jose, Bosley, Thomas M., Mohamed, Gamal H., Cabrera, Vicente M.
Mitochondrial DNA haplogroup H structure in North Africa
Ennafaa, Hajer, Cabrera, Vicente M, Abu-Amero, Khaled K, González, Ana M, Amor, Mohamed B, Bouhaha, Rym, ...
Mutation of C20orf7 Disrupts Complex I Assembly and Causes Lethal Neonatal Mitochondrial Disease
Sugiana, Canny, Pagliarini, David J., McKenzie, Matthew, Kirby, Denise M., Salemi, Renato, Abu-Amero, Khaled K., ...
Complex I (NADH:ubiquinone oxidoreductase) is the first and largest multimeric complex of the mitochondrial respiratory chain. Human complex I comprises seven subunits encoded by mitochondrial DNA...
High-resolution analysis of DNA copy number alterations in patients with primary open-angle glaucoma
Abu-Amero, Khaled K., Hellani, Ali, Bender, Patrick, Spaeth, George L., Myers, Jonathan, Katz, L. Jay, ...