TABLE OF CONTENTS LIST OF TABLES v (2007)
Amy E. Steffek, Professor James, H. Meador-woodruff, Kirk A. Frey
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers (2006)
Robbins, Trevor, Schuster, Charles R., Kilbourn, Michael R., Galloway, Gantt P., Roll, John, Lundahl, Leslie H., ...
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated...
Newman, Erika A., Chang, Alfred E., Newman, Lisa A., Frey, Kirk A., Diehl, Kathleen M., Cimmino, Vincent M., ...
Local recurrence (LR) after breast-conservation therapy for breast cancer occurs in 10% to 15% of cases. A subset of these represents biologically aggressive disease, yet prognostic features for...
In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses (2006)
Kuhl, David E., Koeppe, Robert A., Snyder, Scott E., Minoshima, Satoshi, Frey, Kirk A., Kilbourn, Michael R.
Objective We tested the premise that cholinesterase inhibitor therapy should target butyrylcholinesterase (BuChE) in Alzheimer's disease (AD), not acetylcholinesterase (AChE) alone, because both...
Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction (2005)
Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A., Maren, Stephen
In recent studies, inactivation of the dorsal hippocampus before the retrieval of extinguished fear memories disrupted the context-dependent expression of these memories. In the present experiments,...
Moffat, Bradford A., Hall, Daniel E., Young, John M., Desmond, Timothy J., Carter, Julie, Pietronigro, Dennis, ...
Solvent facilitated perfusion (SFP) has been proposed as a technique to increase the delivery of chemotherapeutic agents to tumors. SFP entails direct injection of the agent into the tumor in a...
Maren, Stephen, Ferrario, Carrie R., Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A.
The amygdala is an essential neural substrate for Pavlovian fear conditioning. Nevertheless, long-term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to...
Striatal monoaminergic terminals in Lewy body and Alzheimer's dementias (2002)
Suzuki, Masahiko, Desmond, Timothy J., Albin, Roger L., Frey, Kirk A.
Vesicular monoamine transporter type 2 and benzodiazepine binding site expressions were examined with quantitative autoradiography in postmortem striata from 19 patients with dementia with Lewy...
Davis, M., Meaney, M., Overall, K., Shear, M., Tecott, L., Shekhar, A., ...
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and...
Suzuki, Masahiko, Desmond, Timothy J., Albin, Roger L., Frey, Kirk A.
Markers of identified neuronal populations have previously suggested selective degeneration of projection neurons in Huntington's disease (HD) striatum. Interpretations are, however, limited by...
Minoshima, Satoshi, Foster, Norman L., Sima, Anders A. F., Frey, Kirk A., Albin, Roger L., Kuhl, David E.
Seeking antemortem markers to distinguish Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), we examined brain glucose metabolism of DLB and AD. Eleven DLB patients (7 Lewy body variant of...
Zubieta, Jon-Kar, Koeppe, Robert A., Frey, Kirk A., Kilbourn, Michael R., Mangner, Thomas J., Foster, Norman L., ...
Cerebral cholinergic deficits have been described in Alzheimer disease (AD) and as a result of normal aging. At the present time, there are very limited options for the quantification of cholinergic...
The neurochemistry of therapeutics: Levodopa pharmacodynamics in Parkinson's disease (2001)
No abstract.
Kuhl, David E., Minoshima, Satoshi, Frey, Kirk A., Foster, Norman L., Kilbourn, Michael R., Koeppe, Robert A.
No abstract.
Kuhl, David E., Minoshima, Satoshi, Frey, Kirk A., Foster, Norman L., Kilbourn, Michael R., Koeppe, Robert A.
Based on surrogate assays of peripheral red blood cells, reports state that widely prescribed doses of donepezil hydrochloride provide nearly complete inhibition of cerebral cortical...
Snyder, Scott E., Sherman, Phillip S., Desmond, Timothy J., Frey, Kirk A., Kilbourn, Michael R.
Deficits in Complex I (NADH-ubiquinone oxidoreductase) of the electron transport chain may play an important role in the inception and progression of neurodegenerative diseases such as Parkinson's...
Mulholland, G. Keith, Wieland, Donald M., Kilbourn, Michael R., Frey, Kirk A., Sherman, Phillip S., Carey, James E., ...
Loss of cholinergic transmission in the cortex and hippocampus is a characteristic feature of Alzheimer's disease, and visualization of functional cholinergic synapses in the brain with PET could be...
Macdonald, Graeme A., Frey, Kirk A, Agranoff, Bernard W., Minoshima, Saroshi, Koeppe, Robert A., Kuhl, David E., ...
Increased activation of the central benzodiazepine receptor (BZR) appears to play an important role in hepatic encephalopathy (HE). However, there is controversy regarding whether the density or...
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease (1997)
Minoshima, Saroshi, Giordani, Bruno, Berent, Stanley, Frey, Kirk A., Foster, Norman L., Kuhl, David E.
This study investigated cerebral glucose metabolism in very early Alzheimer's disease, before a clinical diagnosis of probable Alzheimer's disease is possible, using [ 18 F]fluorodeoxyglucose...
Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging (1996)
Frey, Kirk A., Koeppe, Robert A., Kilbourn, Michael R., Vander Borght, Thierry M., Albin, Roger L., Gilman, Sid, ...
We present development and human application of a method for determining the regional cerebral density of the type 2 vesicular monoamine transporter (VMAT2) using positron emission tomography (PET)...
Gilman, Sid, Junck, Larry, Lohman, Mary, Martorello, Susan, Frey, Kirk A., Koeppe, Robert A., ...
We used [ 11 C]dihydrotetrabenazine, a new ligand for the type 2 vesicular monoamine transporter (VMAT2), with positron emission tomography to study striatal monoaminergic presynaptic terminals in 4...
Kuhl, David E., Minoshima, Saroshi, Fessler, Jeffrey A., Ficaro, E. P., Wieland, D. M., Koeppe, Robert A., ...
To map presynaptic cholinergic terminal densities in normal aging (n = 36), Alzheimer's disease (AD) (n = 22), and Parkinson's disease (PD) (n = 15), we performed single-photon emission computed...
Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain (1994)
Levey, A. I., Edmunds, S. M., Heilman, C. J., Desmond, Timothy J., Frey, Kirk A
A family of receptor subtypes, defined either by molecular (ml-m5) or pharmacological (M1-M4) analysis, mediates muscarinic cholinergic neurotransmission in brain. The distribution and functions of...
Albin, Roger L., Howland, Morgan M., Frey, Kirk A., Higgins, Donald S.
We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of...
Schwartz, Donald R., Schacht, Jochen, Miller, Josef M., Frey, Kirk A, Altschuler, Richard A.
The [14C]-2-deoxyglucose (2-DG) autoradiographic technique was used to study how auditory-related metabolic activity changes with deafness, and how chronic electrical stimulation of the deafened...
Positron emission tomography measures of benzodiazepine receptors in Huntington's disease (1993)
Holthoff, Vjera A., Koeppe, Robert A., Frey, Kirk A., Penney, John B., Markel, Dorene S., Kuhl, David E., ...
We performed positron emission tomographic (PET) measurements of the regional distribution volume of benzodiazepine receptors and regional glucose metabolism in 6 drug-free patients with early...
Parametric in vivo imaging of benzodiazepine receptor distribution in human brain (1991)
Frey, Kirk A., Holthoff, Vjera A., Koeppe, Robert A., Jewett, Douglas M., Kilbourn, Michael R., Kuhl, David E.
Emission computed tomographic methods for the in vivo quantification of radioligand-binding sites in human brain have previously been limited either by a lack of correction for possible effects of...
Frey, Kirk A, Ciliax, Brian J., Agranoff, Bernard W.
Newly-developed methods for estimation of in vivo binding to neurotransmitter receptors should enable the detection and quantification of physiologic or pathologic changes in receptor numbers. In the...
Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey (1988)
Shimoyama, Ichiro, Dauth, George W., Gilman, Sid, Frey, Kirk A., Penney, John B.
Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a contralateral hemiplegia that resolves partially with time. During the phase of dense hemiplegia,...
Experimental hemiplegia in the monkey: Basal ganglia glucose activity during recovery (1987)
Gilman, Sid, Dauth, George W., Frey, Kirk A., Penney, John B.
Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a dense contralateral hemiplegia that recovers partially with time. During the phase of dense...
Olds, James L., Frey, Kirk A., Ehrenkaufer, Richard L., Agranoff, Bernard W.
An autoradiographic sequential double-label variant of the deoxyglucose method for measurement of local glucose utilization has been developed. This technique takes advantage of the short half-life...
Basal ganglia glucose utilization after recent precentral ablation in the monkey (1985)
Dauth, George W., Gilman, Sid, Frey, Kirk A, Penney, John B.
In the macaque monkey, unilateral ablation of areas 4 and 6 of Brodmann result initially in a signficant decrease of glucose metabolic activity in the ipsilateral caudate nucleus, putamen, globus...
A regional metabolic contrast method for the study of brain pathology (1984)
Agranoff, Bernard W., Frey, Kirk A.
The use of 2-deoxyglucose for the measurement of regional cerebral glucose utilization in both animals and humans has gained widespread application. An attractive aspect of regional brain glucose...
A densitometer for quantitative autoradiography (1983)
Dauth, George W., Frey, Kirk A., Gilman, Sid
A low cost spot densitometer system is described. This system is useful for quantitative autoradiography of local cerebral glucose utilization, blood flow, receptor binding and other applications...
Development of a tomographic myelin scan (1981)
Frey, Kirk A, Wieland, Donald M., Brown, Lawrence E., Rogers, W. Leslie, Agranoff, Bernard W.
The principle that myelin can be imaged nonivnvasiely using the emission tomographic distribution of a lipophilic radioactive tracer was investigated. Properties of agents suitable for noninvasive...
Quantitative autoradiography of neurotransmitter receptors using tritium-sensitive film (1981)
Penney, John B., Frey, Kirk A, Young, Anne B.
Peer Reviewed
Gau, Jen-Tzer, Steinhilb, Michelle L., Kao, Tzu-Cheg, D’Amato, Constance J., Gaut, James R., Frey, Kirk A., ...
We examined presynaptic cholinergic markers and β-secretase activity during progressive central nervous system amyloidogenesis in Tg2576 Alzheimer mice (transgenic for human amyloid precursor...
Imaging butyrylcholinesterase activity in Alzheimer's disease
Kuhl, David E., Koeppe, Robert A., Snyder, Scott E., Minoshima, Satoshi, Frey, Kirk A., Kilbourn, Michael R., ...
No abstract.
Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome
Mink, Jonathan W., Walkup, John, Frey, Kirk A., Como, Peter, Cath, Danielle, DeLong, Mahlon R., ...
In response to recent publicity regarding the potential use of deep brain stimulation (DBS) for reducing tic severity in Tourette's syndrome (TS), the Tourette Syndrome Association convened a group...