Xiaorong Lin, Anastasia P. Litvintseva, Kirsten Nielsen, Sweta Patel, Anna Floyd, Thomas G. Mitchell, ...
Cryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction...
Dobson, Tara, Minic, Angela, Nielsen, Kirsten, Amiott, Elizabeth, Krushel, Les
Translational regulation of the dendritically localized mRNA encoding for the neurotrophin receptor TrkB has important ramifications for synaptic function. We examined whether the TrkB mRNA is...
NIELSEN, KIRSTEN. Antifungal activity of maize (Zea mays L.) ribosome-inactivating protein 1 against Aspergillus species. (Under the direction of Rebecca S. Boston and Gary A. Payne) Maize...
Thesis (Ph. D.)--North Carolina State University.
Thesis (Ph. D.)--North Carolina State University.
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Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates
Nielsen, Kirsten, Cox, Gary M., Wang, Ping, Toffaletti, Dena L., Perfect, John R., Heitman, Joseph
Cryptococcus neoformans is a human-pathogenic fungus that has evolved into three distinct varieties that infect most prominently the central nervous system. A sexual cycle involving haploid cells of...
Litvintseva, Anastasia P., Marra, Robert E., Nielsen, Kirsten, Heitman, Joseph, Vilgalys, Rytas, Mitchell, Thomas G.
The most common cause of fungal meningitis in humans, Cryptococcus neoformans serotype A, is a basidiomycetous yeast with a bipolar mating system. However, the vast majority (>99.9%) of C. neoformans...
Dobson, Tara, Minic, Angela, Nielsen, Kirsten, Amiott, Elizabeth, Krushel, Les
Translational regulation of the dendritically localized mRNA encoding for the neurotrophin receptor TrkB has important ramifications for synaptic function. We examined whether the TrkB mRNA is...
Nielsen, Kirsten, Cox, Gary M., Litvintseva, Anastasia P., Mylonakis, Eleftherios, Malliaris, Stephanie D., Benjamin, Daniel K., ...
Cryptococcus neoformans is a fungal pathogen that has evolved over the past 40 million years into three distinct varieties or sibling species (gattii, grubii, and neoformans). Each variety manifests...
Nielsen, Kirsten, Marra, Robert E., Hagen, Ferry, Boekhout, Teun, Mitchell, Thomas G., Cox, Gary M., ...
The study of quantitative traits provides a window on the interactions between multiple unlinked genetic loci. The interaction between hosts and pathogenic microbes, such as fungi, involves aspects...
Marra, Robert E, Huang, Johnny C, Fung, Eula, Nielsen, Kirsten, Heitman, Joseph, Vilgalys, Rytas, ...
To construct a genetic linkage map of the heterothallic yeast, Cryptococcus neoformans (Filobasidiella neoformans), we crossed two mating-compatible strains and analyzed 94 progeny for the...
Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates
Nielsen, Kirsten, Cox, Gary M., Wang, Ping, Toffaletti, Dena L., Perfect, John R., Heitman, Joseph
Cryptococcus neoformans is a human-pathogenic fungus that has evolved into three distinct varieties that infect most prominently the central nervous system. A sexual cycle involving haploid cells of...
Litvintseva, Anastasia P., Marra, Robert E., Nielsen, Kirsten, Heitman, Joseph, Vilgalys, Rytas, Mitchell, Thomas G.
The most common cause of fungal meningitis in humans, Cryptococcus neoformans serotype A, is a basidiomycetous yeast with a bipolar mating system. However, the vast majority (>99.9%) of C. neoformans...
Dobson, Tara, Minic, Angela, Nielsen, Kirsten, Amiott, Elizabeth, Krushel, Les
Translational regulation of the dendritically localized mRNA encoding for the neurotrophin receptor TrkB has important ramifications for synaptic function. We examined whether the TrkB mRNA is...
Nielsen, Kirsten, Cox, Gary M., Litvintseva, Anastasia P., Mylonakis, Eleftherios, Malliaris, Stephanie D., Benjamin, Daniel K., ...
Cryptococcus neoformans is a fungal pathogen that has evolved over the past 40 million years into three distinct varieties or sibling species (gattii, grubii, and neoformans). Each variety manifests...
Nielsen, Kirsten, Marra, Robert E., Hagen, Ferry, Boekhout, Teun, Mitchell, Thomas G., Cox, Gary M., ...
The study of quantitative traits provides a window on the interactions between multiple unlinked genetic loci. The interaction between hosts and pathogenic microbes, such as fungi, involves aspects...
Marra, Robert E, Huang, Johnny C, Fung, Eula, Nielsen, Kirsten, Heitman, Joseph, Vilgalys, Rytas, ...
To construct a genetic linkage map of the heterothallic yeast, Cryptococcus neoformans (Filobasidiella neoformans), we crossed two mating-compatible strains and analyzed 94 progeny for the...
Nielsen, Kirsten, De Obaldia, Anna L., Heitman, Joseph
The ecological niche that a species can occupy is determined by its resource requirements and the physical conditions necessary for survival. The niche to which an organism is most highly adapted is...
αADα Hybrids of Cryptococcus neoformans: Evidence of Same-Sex Mating in Nature and Hybrid Fitness
Lin, Xiaorong, Litvintseva, Anastasia P, Nielsen, Kirsten, Patel, Sweta, Floyd, Anna, Mitchell, Thomas G, ...
Cryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction...
Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus▿
Steinbach, William J., Cramer, Robert A., Perfect, B. Zachary, Henn, Christina, Nielsen, Kirsten, Heitman, Joseph, ...
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-β-d-glucan...
Rutherford, Julian C., Lin, Xiaorong, Nielsen, Kirsten, Heitman, Joseph
The conserved AmtB/Mep/Rh family of proteins mediate the transport of ammonium across cellular membranes in a wide range of organisms. Certain fungal members of this group are required to initiate...
Impact of Mating Type, Serotype, and Ploidy on the Virulence of Cryptococcus neoformans▿ †
Lin, Xiaorong, Nielsen, Kirsten, Patel, Sweta, Heitman, Joseph
Hybridization with polyploidization is a significant biological force driving evolution. The effect of combining two distinct genomes in one organism on the virulence potential of pathogenic fungi is...
Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans▿ †
Charlier, Caroline, Nielsen, Kirsten, Daou, Samira, Brigitte, Madly, Chretien, Fabrice, Dromer, Françoise
The pathogenesis of cryptococcosis, including the events leading to the production of meningoencephalitis, is still largely unknown. Evidence of a transcellular passage of Cryptococcus neoformans...