Kuhn, Alexandre, Goldstein, Darlene R., Hodges, Angela, Strand, Andrew D., Sengstag, Thierry, Kooperberg, Charles, ...
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in...
Dalrymple, Annette, Wild, Edward, Joubert, Richard, Sathasivam, Kirupa, Bjorkqvist, Maria, Petersén, Asa, ...
Abstract is not available
Re Kuhn, Darlene R. Goldstein, Angela Hodges, Andrew D. Str, Thierry Sengstag, Charles Kooperberg, ...
Mutant huntingtin's effects on striatal gene expression in mice
Benn, Caroline L., Landles, Christian, Li, He, Strand, Andrew D., Woodman, Ben, Sathasivam, Kirupa, ...
In postmortem Huntington's disease brains, mutant htt is present in both nuclear and cytoplasmic compartments. To dissect the impact of nuclear and extranuclear mutant htt on the initiation and...
Benn, Caroline L., Landles, Christian, Li, He, Strand, Andrew D., Woodman, Ben, Sathasivam, Kirupa, ...
In postmortem Huntington's disease brains, mutant htt is present in both nuclear and cytoplasmic compartments. To dissect the impact of nuclear and extranuclear mutant htt on the initiation and...
Hay, David G., Sathasivam, Kirupa, Tobaben, Sönke, Stahl, Bernd, Marber, Michael, Mestril, Ruben, ...
The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in cell culture, S. cerevisiae, C. elegans and D. melanogaster models of Huntington's disease (HD)...
Hay, David G., Sathasivam, Kirupa, Tobaben, Sönke, Stahl, Bernd, Marber, Michael, Mestril, Ruben, ...
The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and cell culture...
Hay, David G., Sathasivam, Kirupa, Tobaben, Sönke, Stahl, Bernd, Marber, Michael, Mestril, Ruben, ...
The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in cell culture, S. cerevisiae, C. elegans and D. melanogaster models of Huntington's disease (HD)...
Waelter, Stephanie, Scherzinger, Eberhard, Hasenbank, Renate, Nordhoff, Eckhard, Lurz, Rudi, Goehler, Heike, ...
The huntingtin interacting protein (HIP1) is enriched in membrane-containing cell fractions and has been implicated in vesicle trafficking. It is a multidomain protein containing an N-terminal ENTH...
Sathasivam, Kirupa, Woodman, Ben, Mahal, Amabirpal, Bertaux, Fabien, Wanker, Erich E., Shima, Dave T., ...
Huntington’s disease (HD) is a progressive neurological disorder caused by a CAG/polyglutamine repeat expansion. We have previously generated the R6/2 mouse model that expresses exon 1 of...
Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, ...
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence...
Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, ...
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence...
DNA instability in postmitotic neurons
Gonitel, Roman, Moffitt, Hilary, Sathasivam, Kirupa, Woodman, Ben, Detloff, Peter J., Faull, Richard L. M., ...
Huntington's disease (HD) is caused by a CAG repeat expansion that is unstable upon germ-line transmission and exhibits mosaicism in somatic tissues. We show that region-specific CAG repeat mosaicism...